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USP46 deubiquitinates Histone-H2A. 3 / 3
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"Joo et al. demonstrated that USP46 and USP12 containing fractions from HeLa cells can deubiquitinate histones H2A and H2B to control cell fate and gastrulation during Xenopus development [XREF_BIBR]."
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"Several DUBs have been implicated in histone deubiquitination, including USP3, USP12, USP22, and USP46, which deubiquitinate both histones H2A and histones H2B [XREF_BIBR]."
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"In other species, USP46 deubiquitinates deubiquitinate histones H2A and H2B associated to USP12 and WDR48 proteins, reinforcing its epigenetic function [40]."
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