IndraLab

Statements

USP46 inhibits GRIA1. 3 / 3
| 3
reach
"Internalized GluA1 puncta density was also significantly reduced by USP46 over-expression (XREF_FIG) (Control : 6.42 +/- 0.40 puncta per 10 mum, n = 12 neurons; USP46 : 4.73 +/- 0.61 puncta per 10 mum, n = 12 neurons, p = 0.03)."
26077708
reach
"Similarly, overexpression of USP46 downregulates the ubiquitination of GluA1 and reduces the accumulation of internalized GluA1 in neurons [177]; therefore, it has been suggested that ubiquitination of AMPARs is necessary for internalization and thus occurs prior."
38203282
reach
"We showed that in HEK cells USP46 over-expression negatively regulates the turnover rate of GluA1 and thus stabilizes GluA1 from degradation."
26077708