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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP46 inhibits GRIA1. 2 / 2

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"We showed that in HEK cells USP46 over-expression negatively regulates the turnover rate of GluA1 and thus stabilizes GluA1 from degradation."

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"Internalized GluA1 puncta density was also significantly reduced by USP46 over-expression (XREF_FIG) (Control : 6.42 +/- 0.40 puncta per 10 mum, n = 12 neurons; USP46 : 4.73 +/- 0.61 puncta per 10 mum, n = 12 neurons, p = 0.03)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...