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HYCC1 activates USP46. 5 / 5
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"When knocking down USP46, the proliferation activity of HCC cells was significantly enhanced, while it was significantly inhibited after over-expressing USP4."
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"Our research confirmed that USP46 regulates YAP1.To further demonstrate whether YAP1 inhibition was responsible for the tumor suppressor functions of USP46 in HCC, we transfected a YAP1 overexpression[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Importantly, ectopic expression of YAP1 abolished the reduced proliferation and invasion phenotypes in USP46-overexpressing HCC cells, indicating that USP46 exerts its function by regulating YAP1."
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"Inhibition of MST1 rescued YAP1 protein expression in USP46-overexpressing HCC cells."
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"In addition, upregulation of YAP1 promoted lung metastasis in USP46-overexpressing HCC cells ( Fig. 4 H)."
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