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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

USP46 activates GRIA. 1 / 1

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"These functions of CYLD were implied in a study on another K63-DUB, USP46, which can cleave K63-linked ubiquitination chains from AMPARs and modulate AMPAR internalization and turnover in cultured rat cortical and hippocampal neurons; in this way, USP46 is thought to regulate AMPAR-mediated excitatory synaptic transmission (Huo et al., 2015)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...