IndraLab

Statements

USP46 activates GRIA. 2 / 2
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"In contrast, RNA interference (RNAi)-mediated knockdown of USP46 results in increased AMPAR ubiquitination and decreased surface AMPARs at neuronal synapses."
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"These functions of CYLD were implied in a study on another K63-DUB, USP46, which can cleave K63-linked ubiquitination chains from AMPARs and modulate AMPAR internalization and turnover in cultured rat cortical and hippocampal neurons; in this way, USP46 is thought to regulate AMPAR-mediated excitatory synaptic transmission (Huo et al., 2015)."
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