IndraLab

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USP46 binds WDR proteins. 5 / 5
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"We highlight recent structural insights into how WDR proteins interact with and regulate USP46, and discuss functions for the USP46/WDR protein complex in the nervous system and across phylogeny.AMPA-type glutamate receptors (AMPARs) mediate the majority of fast excitatory transmission in the brain, and regulation of synaptic AMPAR levels is important for controlling synapse development and function."
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"We highlight recent structural insights into how WDR proteins interact with and regulate USP46, and discuss functions for the USP46 and WDR protein complex in the nervous system and across phylogeny."
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"Together, these structural studies suggest that binding of the WDR proteins to USP12 or USP46 relatively far from the active site results in the rearrangement of several structural elements, which propagates to the catalytic triad increasing enzyme catalysis."
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"Biochemical and proteomic studies showed that two WDR proteins, WDR48 (also known as USP1 associated factor, UAF1) and WDR20, interact with USP46 and USP12."
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"Together, these structural studies suggest that binding of the WDR proteins to USP12 or USP46 relatively far from the active site results in the rearrangement of several structural elements, which propagates to the catalytic triad increasing enzyme catalysis.These recent structural and biochemical studies complement in vivo studies of the USP-46/WDR-48/WDR-20 complex in C. elegans."
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