IndraLab

Statements

USP46 inhibits Neoplasm Invasiveness. 6 / 6
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"In functional investigations, USP46 knockdown increased cell proliferation and invasiveness in vitro and in vivo whereas overexpression of USP46 decreased HCC cell proliferation and metastasis."
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"We found that USP46 suppresses HCC cell proliferation, migration and invasion in vitro and metastasis in vivo , implying that USP46 may serve as a tumor suppressor in HCC."
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"In functional experiments , overexpression of USP46 impaired proliferation and metastasis of HCC cells , whereas knockdown of USP46 enhanced cell proliferation and invasiveness in vitro and in vivo ."
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"As shown in Fig. 3 A and B, upregulation of USP46 inhibited Huh-7 cell migration and invasion abilities in vitro ."
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"These experimental results indicate that USP46 inhibits the invasion and metastasis of hepatoma cells in vivo and in vitro ."
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"However, tumor cells were resuspended in serum-free medium when we conducted invasion and migration assays, which showed that USP46 inhibits both the proliferation and invasion of HCC cells."
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