IndraLab

Statements

USP46 phosphorylates AKT. 3 / 3
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"Deubiquitylase ovarian tumor deubiquitinase 1(OTUD1) and Ubiquitin-specific peptidase 46 (USP46) have been shown to decrease the phosphorylation of AKT at its N-terminus."
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"In the present study, it was revealed that downregulation of USP46 expression levels could also promote the phosphorylation of AKT and mTOR, while the overexpression of USP46 could inhibit the phosphorylation levels."
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"On the contrary, the depletion of USP46 markedly promoted AKT phosphorylation and S6K1 phosphorylation ( Fig. 4 B)."
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