IndraLab

Statements

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"Some studies have shown that expression of USP46 is reduced in renal cell carcinoma (RCC), lung cancer and colon cancer and that USP46 suppresses cancer cell proliferation [ 24–26 ]."
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"CCK-8 and cell proliferation assays showed that overexpression of USP46 suppressed the proliferation capacity of Huh-7 cells ( Fig. 2 C and D)."
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"This result indicates that upregulation of USP46 inhibits tumor proliferation and growth.In contrast, we used two USP46-specific short hairpin RNA (shUSP46-1, shUSP46-2) plasmids to reduce USP46 expre[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In summary, our results confirm that USP46 suppresses HCC proliferation and growth in vivo and in vitro ."
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"USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1 and AKT Pathway."
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"USP46 is downregulated in lung cancer and suppresses the proliferation of lung cancer cells by inhibiting the PHLPP1 and AKT pathway."
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"To determine if PHLPP and USP46 function together to negatively regulate cell proliferation, increasing amount of PHLPP1 plasmids was transfected into HCT116 cells alone or in combination with USP46."
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"We found that USP46 suppresses HCC cell proliferation, migration and invasion in vitro and metastasis in vivo , implying that USP46 may serve as a tumor suppressor in HCC."
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"However, tumor cells were resuspended in serum-free medium when we conducted invasion and migration assays, which showed that USP46 inhibits both the proliferation and invasion of HCC cells."
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"In functional experiments , overexpression of USP46 impaired proliferation and metastasis of HCC cells , whereas knockdown of USP46 enhanced cell proliferation and invasiveness in vitro and in vivo ."
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"Indeed, USP46 inhibition significantly increased YAP1, as well as the proliferation and metastasis of HCC cells."
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"MiR-27a-3p targets USP46 to inhibit the cell proliferation of hepatocellular carcinoma."
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"USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway."
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"Furthermore, our results demonstrated that USP46 suppresses HCC proliferation and metastasis by inhibiting the MST1/YAP1 axis."
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"Functionally, ectopic USP46 expression reduced cell proliferation and tumor cell migration in vitro and vice versa."
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"There are several lines of experimental evidence suggesting that USP46 inhibits cancer cell proliferation and metastasis."
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"In functional investigations, USP46 knockdown increased cell proliferation and invasiveness in vitro and in vivo whereas overexpression of USP46 decreased HCC cell proliferation and metastasis."
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"We conclude that the Usp46 complex restricts ISC proliferation but is dispensable for asymmetric stem cell division, properties shared with known positive regulators in the Wingless signaling pathway.In the adult posterior midgut, the ability of enterocytes to non-autonomously restrict the proliferation of neighboring ISCs requires Wingless signaling ."
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"These findings reveal that in a manner similar to known Wingless pathway components, the Usp46 complex non-autonomously restricts proliferation of neighboring ISCs, providing additional evidence that Usp46 promotes Wingless signaling during intestinal homeostasis."
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"The mechanism by which USP46 inhibits LC proliferation involves deubiquitinating Pleckstrin homologous domain leucine-rich repeating protein phosphatases 1 (PHLPP1), which in turn inhibits AKT activation."
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"In vitro, ectopic USP46 expression significantly decreased tumor cell motility and cell proliferation, and vice versa."
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