IndraLab

Statements

USP46 binds WDR20. 22 / 22
13 | 8 1
sparser
"These findings imply that the complex formation and USP46 activity regulation are significantly influenced by the residues participating in the USP46-WDR20 interaction ( xref ). xref "
39410943
biogrid
No evidence text available
33961781
biogrid
No evidence text available
32296183
reach
"The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans."
24356955
biogrid
No evidence text available
33844468
biogrid
No evidence text available
24981860
reach
"We propose that WDR-20 and WDR-48 form a complex with USP-46 and stimulate the DUB to deubiquitinate and stabilize GLR-1 in vivo."
24356955
biogrid
No evidence text available
21183687
biogrid
No evidence text available
20147737
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
19615732
biogrid
No evidence text available
33961781
biogrid
No evidence text available
40437099
biogrid
No evidence text available
37798301
reach
"Together, these results indicate that the amino-terminal 1 MEIL 4 motif is necessary for the efficient recruitment of USP12/WDR20 to the PM, but is not sufficient to confer PM localization to a USP46/[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30466959
biogrid
No evidence text available
19615732
reach
"WDR20 binding to USP12 and USP46 showed a significant increase in the catalytic activity in vitro [71,76]."
32512887
reach
"Besides, USP12 and USP46 can also bind with WDR20 but USP1 cannot; and the activity of USP12 and USP46 can be activated by WDR48 and WDR20 independently and synergistically [38, 39]."
37752518
reach
"This observation suggests that, in the absence of a strong NLS in USP12, recruitment to the PM largely prevails over slow diffusion into the nucleus upon formation of a USP12/WDR20 complex.On the othe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30466959
reach
"Image analysis showed that the nuclear to cytoplasmic ratio of YFP-USP46 was significantly higher when expressed with Myc-WDR20 NESm than with wild type Myc-WDR20 (Additional File 4b), suggesting that[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30466959
reach
"Mechanistically, USP46 can bind with WD40-repeat (WDR) proteins WDR-20 and WDR-48 to stimulate USP46 catalytic activity and increase GLR-1 levels."
26528125