IndraLab

Statements

USP46 dephosphorylates AKT. 3 / 3
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"Loss of USP46-induced upregulation of Akt dephosphorylation is similar as that observed by knocking down of PHLPP directly ( xref , xref )."
22391563
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"Deubiquitylase ovarian tumor deubiquitinase 1(OTUD1) and Ubiquitin-specific peptidase 46 (USP46) have been shown to decrease the phosphorylation of AKT at its N-terminus."
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"On the contrary, the depletion of USP46 markedly promoted AKT phosphorylation and S6K1 phosphorylation ( Fig. 4 B)."
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