IndraLab

Statements

USP46 activates PHLPP1. 6 / 6
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"If USP46 enhances the stability of PHLPP1, then human tumors with downregulation of PHLPP1 protein might also have decreased expression of USP46."
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"Functionally, USP46 mediated stabilization of PHLPP and the subsequent inhibition of Akt result in a decrease in cell proliferation and tumorigenesis of colon cancer cells in vivo."
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"More importantly, co-expression of USP46 markedly enhanced the ability of PHLPP1 to suppress tumor formation (XREF_FIG)."
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"USP46 potentiates the tumor suppressor function of PHLPP1 in vivo."
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"USP46 enhances PHLPP mediated negative regulation of Akt in cells."
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"Furthermore, knockdown of USP46 attenuated the ability of PHLPP1 to dephosphorylate Akt and to inhibit cell proliferation (XREF_FIG)."
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