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USP46 activates cell population proliferation. 7 / 7
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"Consistently, the depletion of USP46 substantially inhibited cell proliferation of NRAS Q61R-transformed melanocytes in vitro and in vivo (Fig. 5b–d), whereas the depletion of USP46 in cells expressing FLAG-NRAS Q61R-2KR did not exert these effects (Supplementary Fig. 6a–d)."
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"AKT inhibition slows the proliferation of lung cancer cells that have been downregulated by USP46 and exposed to radiation."
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"As shown in Supplementary Fig. 6e, the depletion of USP46 in genetically engineered human immortalized melanocytes (hTERT/CDK4 /p53 ) expressing NRAS Q61R induced a significant reduction of cell proliferation as assessed by Ki67 staining, and a significant increase of apoptotic cell death as assessed by cleaved caspase-3 staining."
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"In functional investigations, USP46 knockdown increased cell proliferation and invasiveness in vitro and in vivo whereas overexpression of USP46 decreased HCC cell proliferation and metastasis."
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"As shown in Fig. 4 , overexpression of YAP1 enhanced HCC cell proliferation and invasion abilities, and re-expression of YAP1 attenuated the decrease in proliferation and invasion induced by overexpre[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Collectively, our results indicated that miR-27a targets USP46 to promote EC cell proliferation and migration, suggesting an oncogene role of miR-27a in EC."
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"In contrast, a different study showed that USP46 promotes proliferation and tumor growth of HPV-transformed cancers [ 27 ]."
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