IndraLab

Statements

USP46 activates GLR1.1. 6 / 6
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"Furthermore, the co-localization of mCherry : : USP-46 and the endosomal marker Venus : : RAB-5 in the cell body and VNC (XREF_SUPPLEMENTARY) support a model in which USP-46 functions at an endosomal compartment to prevent the targeting of GLR-1 for degradation."
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"Taken together with our previous data, these results suggest that USP-46 prevents the degradation of GLR-1 and promotes its surface expression in the VNC."
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"These data suggest a model whereby USP-46 promotes the abundance of GLR-1 at synapses by acting in a pre-MVB compartment (i.e. endosome) to deubiquitinate GLR-1 and thus prevent its lysosomal degradation (XREF_FIG)."
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"This result suggests that the deubiquitinating activity of USP-46 is required in glr-1-expressing interneurons to promote GLR-1 abundance."
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"Together with data showing that USP-46 partially colocalizes with endosomes, Kowalski et al. (2011) proposed a model where USP-46 acts at endosomes to promote GLR-1 stability and recycling to the cell surface."
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"Several lines of evidence indicate that USP-46 negatively regulates GLR-1 degradation by deubiquitinating the receptor."
21273419