IndraLab

Statements

E6 activates USP46. 3 / 3
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"In conclusion, E6 causes degradation of Set8 and modifications in gene regulation in HPV-transformed cells, increases the deubiquitinase activity of USP46, and stabilizes Cdt2 by using numerous sites on Cdt2."
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"The presence of oncogenic E6 enables the USP46 deubiquitinase to enter the nucleus and interact with Cdt2, an event that causes the reversal of CRL1 Fbxo11 -mediated ubiquitination, leading to Cdt2 st[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Third, does pure recombinant E6 activate recombinant USP46 in the complete absence of known cellular activators of USP46 like UAF1 and WDR20?"
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