IndraLab

Statements

USP46 deubiquitinates PHLPP1. 3 / 4
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"Emerging studies have reported that USP46 could deubiquitinate and reduce proteasome-mediated degradation of PHLPP, a family member of Ser/Thr protein phosphatases that acts as a tumor suppressor by n[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Previous research has shown that USP46 antagonized AKT activity by deubiquitinating PHLPP1 in colorectal cancer (15)."
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"USP46 inhibits AKT signaling by antagonizing PHLPP1 ubiquitination, and inhibits LC cell proliferation under normal growing environment and radiation-induced DNA damage."
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