IndraLab

Statements

USP46 inhibits AKT. 3 / 3
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"USP46 activates the Bcl-2 and caspase-3 apoptotic signaling pathway and inactivates AKT activity."
33576437
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"Here, we show that USP46 and PHLPP function together to suppress Akt signaling in a mutually dependent manner."
22391563
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"Functionally, USP46 mediated stabilization of PHLPP and the subsequent inhibition of Akt result in a decrease in cell proliferation and tumorigenesis of colon cancer cells in vivo."
22391563