IndraLab

Statements

USP46 inhibits AKT. 6 / 6
| 5 1
reach
"Here, we show that USP46 and PHLPP function together to suppress Akt signaling in a mutually dependent manner."
22391563
reach
"Verification of AKT inactivation by USP46 is also employed in different tumor scenarios."
39410943
reach
"We thus conclude that the USP46 downregulated AKT pathway accounts for the inhibition of cell proliferation and migration in renal cell carcinoma, and USP46 functions as a tumor suppressor to repress [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31542232
reach
"USP46 activates the Bcl-2 and caspase-3 apoptotic signaling pathway and inactivates AKT activity."
33576437
reach
"Functionally, USP46 mediated stabilization of PHLPP and the subsequent inhibition of Akt result in a decrease in cell proliferation and tumorigenesis of colon cancer cells in vivo."
22391563
sparser
"Verification of AKT inactivation by USP46 is also employed in different tumor scenarios."
39410943