IndraLab
Statements
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reach
"Mammalian USP46 can deubiquitinate both GluA1 and GluA2 subunits and protect AMPARs from degradation (Huo et al., 2015)."
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"We observed that USP46 is able to deubiquitinate not only GluA1 but also GluA2, indicating a relative stringency in contrast to the distinct E3 ligases that are employed for GluA1 and GluA2."
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"Mammalian USP46 can deubiquitinate both GluA1 and GluA2 subunits and protect AMPARs from degradation."
"This Editorial Highlight discusses the relevance of a study published in the current issue of Journal of Neurochemistry, in which the authors Huo and collaborators now identified ubiquitin-specific peptidase 46 (USP46) as a specific AMPAR deubiquitinase."