IndraLab

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USP46 deubiquitinates GRIA1. 4 / 5
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"Mammalian USP46 can deubiquitinate both GluA1 and GluA2 subunits and protect AMPARs from degradation."
29302259
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"Similarly, overexpression of USP46 downregulates the ubiquitination of GluA1 and reduces the accumulation of internalized GluA1 in neurons [177]; therefore, it has been suggested that ubiquitination of AMPARs is necessary for internalization and thus occurs prior."
38203282
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"We observed that USP46 is able to deubiquitinate not only GluA1 but also GluA2, indicating a relative stringency in contrast to the distinct E3 ligases that are employed for GluA1 and GluA2."
26077708
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"In a similar manner to USP8, the reduction in USP46 through knockdown enhances basal GluA1 ubiquitination while diminishing its neuronal expression [177]."
38203282