IndraLab

Statements

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"In functional investigations, USP46 knockdown increased cell proliferation and invasiveness in vitro and in vivo whereas overexpression of USP46 decreased HCC cell proliferation and metastasis."
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"These results indicated that USP46 promotes ESCC cell metastasis through regulating ENO1.To further validate the relationship of USP46 and ENO1 in ESCC, we examined the expression of ENO1 in 48 clinic[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Besides, USP46 promotes ESCC metastasis by regulating EMT process and has an effect of inhibiting ubiquitination of ENO1 protein."
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"Functionally, USP46 promotes ESCC metastasis in vitro and in vivo by inducing the EMT process."
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"Our studies illustrated that USP46 could strikingly promote cell migration, invasion and tumor metastasis of ESCC."
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"However, we noticed that USP46 is a contributor of ESCC tumor metastasis in vitro and in vivo ."
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"Moreover, knockdown USP46 particularly suppressed mobility of ESCC cells and tumor metastasis in vitro and in vivo ."
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"These results implicated that USP46 promotes ESCC tumor metastasis in a catalytic-dependent way."
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"Collectively, these results displayed that USP46 enhances the metastatic capacity of ESCC cells through inducing the process of EMT in a catalytic-dependent way.Given that USP46 promotes ESCC cell met[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition to affecting the proliferation of cancer cells, USP46 has also been demonstrated to promote tumor metastasis by stabilizing ENO1 in human esophageal squamous cell carcinoma [ 28 ]."
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