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USP46 inhibits YAP1. 6 / 6
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"Moreover, we discovered that USP46 inhibits YAP1 to reduce HCC cell growth and metastasis."
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"Mechanistically , USP46 promotes the degradation of YAP1 by increasing expression of MST1 , and the increase in MST1 protein antagonizes YAP1 to suppress HCC progression ."
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"Indeed, USP46 inhibition significantly increased YAP1, as well as the proliferation and metastasis of HCC cells."
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"USP46 may promote degradation of YAP1 by stabilizing MST1 but not LATS1."
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"Our results revealed that the tumor suppressor function of USP46 in HCC was accomplished by inhibiting YAP1 expression.To explore the molecular mechanism by which USP46 regulates YAP1, we examined the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The results indicate that USP46 indirectly promotes the degradation of YAP1."
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