IndraLab

Statements

METTL3 affects EIF3H
3 | 22 91
METTL3 binds EIF3H.
3 | 19 91
EIF3H binds METTL3. 10 / 112
3 | 18 91
sparser
"The METTL3-eIF3h interaction was found to promote translation and drive malignant transformation by facilitating mRNA circularization [ xref ]."
38302992
reach
"The interaction between METTL3 and eIF3h is essential for translation and oncogenic transformation in lung cancer (31)."
34568001
sparser
"The interaction between the deubiquitinase EIF3H and METTL3 is influenced by O-GlcNAcylation."
40495163
reach
"This promotes transcription [150] and translation of Myc [152] while enhancing the translation of BRD4 through BRD4 mRNA looping and ribosome recycling through the interaction of METTL3 with eIF3h and promoting oncogenesis [Fig. 5] [151]."
35866356
reach
"METTL3 can interact with the transcription factor eIF3h to promote the translation of oncogenes and ultimately to catalyze and accelerate tumor growth and metastasis."
33643384
sparser
"sEV-circLPAR1 was internalized by CRC cells and directly bound to eIF1h specifically inhibiting METTL3-eIF3h translation and suppressing the expression of oncogene BRD4, which in turn inhibited the growth of CRC cells."
37519298
sparser
"As a promising predictor in colorectal cancer diagnosis, exosomal circLPAR1 suppresses colorectal cancer development through decreasing BRD4 via METTL3-eIF3h interaction[ xref ]."
36814375
sparser
"Additionally, exosome-derived circLPAR1 suppresses CRC growth by binding to eIF3h, disrupting the METTL3-eIF3h interaction, and reducing BRD4 translation, providing new insights into early diagnosis and disease mechanisms ( xref )."
40291917
sparser
"During m 6 A addition to the mRNA, METTL3 binds to the eIF3h subunit and circularises the mRNA molecule to bring eIF3 closer to the translation initiation site, allowing the complex to recruit both YTHDF proteins and ribosomes ( xref A) ( xref ; xref )."
36513580
sparser
"We next tested the functional interaction between METTL3 and eIF3h, and found depletion of eIF3h abrogated the enhanced translation by METTL3 ( xref and xref )."
30232453
METTL3 binds EIF3H and 6 A. 1 / 1
| 1
reach
"The authors thus proposed a novel " mRNA looping " mechanism, in which METTL3 binds to the m 6 A modified 3 ' UTR of target mRNA and then recruits eIF3h as well as translation initiation factors such as CBP800 and eIF4e, thus facilitating the ribosome recycling and promoting translation efficiency [XREF_BIBR, XREF_BIBR]."
32854717
METTL3 activates EIF3H.
| 3
METTL3 activates EIF3H. 3 / 3
| 3
reach
"For instance, independent of m A readers, METTL3 in human lung cancer can promote translation of a large subset of oncogenic mRNAs though recruiting eukaryotic translation initiation factor 3 subunit h (eIF3h) (Choe et al., 2018)."
38545555
reach
"METTL3 can promote cancer cell growth, survival, and invasion by recruiting eIF3h to the translation initiation complex and directly promotes oncogene translation independently of its MTase activity (34)."
31921660
reach
"In addition, METTL3 can promote oncogene translation independently of m A readers by recruiting eIF3h."
31921660
EIF3H affects METTL3
3 | 21 91
EIF3H binds METTL3.
3 | 19 91
EIF3H binds METTL3. 10 / 112
3 | 18 91
sparser
"The METTL3-eIF3h interaction was found to promote translation and drive malignant transformation by facilitating mRNA circularization [ xref ]."
38302992
reach
"The interaction between METTL3 and eIF3h is essential for translation and oncogenic transformation in lung cancer (31)."
34568001
sparser
"The interaction between the deubiquitinase EIF3H and METTL3 is influenced by O-GlcNAcylation."
40495163
reach
"This promotes transcription [150] and translation of Myc [152] while enhancing the translation of BRD4 through BRD4 mRNA looping and ribosome recycling through the interaction of METTL3 with eIF3h and promoting oncogenesis [Fig. 5] [151]."
35866356
reach
"METTL3 can interact with the transcription factor eIF3h to promote the translation of oncogenes and ultimately to catalyze and accelerate tumor growth and metastasis."
33643384
sparser
"sEV-circLPAR1 was internalized by CRC cells and directly bound to eIF1h specifically inhibiting METTL3-eIF3h translation and suppressing the expression of oncogene BRD4, which in turn inhibited the growth of CRC cells."
37519298
sparser
"As a promising predictor in colorectal cancer diagnosis, exosomal circLPAR1 suppresses colorectal cancer development through decreasing BRD4 via METTL3-eIF3h interaction[ xref ]."
36814375
sparser
"Additionally, exosome-derived circLPAR1 suppresses CRC growth by binding to eIF3h, disrupting the METTL3-eIF3h interaction, and reducing BRD4 translation, providing new insights into early diagnosis and disease mechanisms ( xref )."
40291917
sparser
"During m 6 A addition to the mRNA, METTL3 binds to the eIF3h subunit and circularises the mRNA molecule to bring eIF3 closer to the translation initiation site, allowing the complex to recruit both YTHDF proteins and ribosomes ( xref A) ( xref ; xref )."
36513580
sparser
"We next tested the functional interaction between METTL3 and eIF3h, and found depletion of eIF3h abrogated the enhanced translation by METTL3 ( xref and xref )."
30232453
METTL3 binds EIF3H and 6 A. 1 / 1
| 1
reach
"The authors thus proposed a novel " mRNA looping " mechanism, in which METTL3 binds to the m 6 A modified 3 ' UTR of target mRNA and then recruits eIF3h as well as translation initiation factors such as CBP800 and eIF4e, thus facilitating the ribosome recycling and promoting translation efficiency [XREF_BIBR, XREF_BIBR]."
32854717
EIF3H inhibits METTL3.
| 2
EIF3H inhibits METTL3. 2 / 2
| 2
reach
"Knockdown of eIF3h suppressed the ability of METTL3 to promote cellular invasion (XREF_FIG and XREF_FIG)."
30232453
reach
"They demonstrated that circLPAR1 encapsulated in exosomes could be internalized by colorectal cancer cells, and further suppressed tumour growth by directly bound with eukaryotic translation initiation factor 3 subunit h (eIF3h), suppressing the methyltransferase-like 3 (METTL3)-eIF3h interaction and decreasing the translation of oncogene bromodomain containing 4 [44]."
38711144
EIF3H is modified
8 | 1 47 3
EIF3H is phosphorylated. 10 / 48
| 1 45 2
sparser
"Ribosome fractionation experiments indicated that, in response to auxin, polysomes show increased accumulation of uORF-containing mRNAs (indicating enhanced translation), phosphorylated and thus activated TOR, and, interestingly, phosphorylated eIF3h."
29281028
sparser
"We therefore analyzed the levels of phosphorylation of eIF3H in the cervical cancer cell line HeLa."
22304650
sparser
"Upon auxin treatment, AtTORC1 associate with the polysome, phosphorylates AtS6K1, which in turns phosphorylates eIF3h."
33778006
sparser
"TAV triggers TOR hyperactivation and S6 kinase1 (S6K1) phosphorylation in planta , and the whole process is fueled by a kinase cascade involving phosphorylation of TOR, S6K1, RISP and eIF3h ( Figure 4[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24063990
sparser
"We measured levels of phosphorylated neurofilament subunit H (pNF-H), tau (reflecting axonal damage), myelin basic protein (MBP) (reflecting demyelination), S100b (reflecting astrocyte damage), and neuron-specific enolase (NSE) (reflecting neuronal damage)."
29557051
sparser
"SAA1 levels also correlated with markers such as S100B and GFAP, NSE, tau and phosphorylated axonal neurofilament subunit H (pNFH)."
39001884
sparser
"Elevated serum tau protein [ xref ], phosphorylated axonal neurofilament subunit H (pNF-H) [ xref ], and blood glutamate [ xref ] were also found to predict poor outcome in ICH."
25208676
sparser
"This regulation is possibly modulated by the TOR signaling cascade, which can promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h ( xref )."
25514925
sparser
"The loading of the translation initiation factor eIF3h into polysomes in response to auxin is impaired in TOR-deficient mutants with an inactive S6K form, suggesting that eIF3h is possibly phosphorylated by the TOR/S6K1 pathway ( xref )."
28491073
sparser
"In Arabidopsis, TOR promotes the translational re-initiation of uORF-containing mRNAs by directly phosphorylating eIF3h, a factor known to promote re-initiation."
37437121
EIF3H is phosphorylated on S183. 8 / 8
5 | 2 1
hprd
No evidence text available
20068231
hprd
No evidence text available
18691976
hprd
No evidence text available
18767875
hprd
No evidence text available
19651622
hprd
No evidence text available
17322306
rlimsp
"This oncogenic potential of eIF3h is enhanced by phosphorylation at Ser(183)."
18544531
sparser
"This observation coincides with the critical in vivo effects of eIF3h’s ser-183 phosphorylation during malignant transformation of NIH 3T3 cells [ xref , xref ]."
24979134
sparser
"Consistent with this idea, phosphorylation at residue Ser183 of eIF3h, located just above the domain that interacts with eIF4A (Extended Data Fig. xref ), has been implicated in the process of reinitiation in plants xref ."
38287194
EIF3H is phosphorylated on S10. 1 / 1
1 |
hprd
No evidence text available
17924679
EIF3H is phosphorylated on T8. 1 / 1
1 |
hprd
No evidence text available
17924679
EIF3H is phosphorylated on S31. 1 / 1
1 |
hprd
No evidence text available
20068230
reach
"EIF3h potentiates the cell proliferation and inhibits the cell apoptosis of gastric cancer cells 13."
31423012
reach
"As shown in XREF_FIG, knockdown of endogenous EIF3H significantly inhibited the proliferation of Saos-2 and U2OS cells at 24, 48, 72, 96 and 120 h after viral infection."
29805516
eidos
"Besides , we demonstrated that the knockdown of EIF3H significantly reduced OGT protein expression , cell proliferation and invasion , and caused G1 / S arrest of HCC ."
37559097
reach
"Our results suggest that eIF3h content is near a threshold in Hap1 cells, since overexpression of SNAP-eIF3H appears to diminish wild-type eIF3h protein levels and fails to increase the proliferation rate of wild-type cells."
29136179
reach
"EIF3H overexpression increases tumor cell proliferation, growth, and survival."
27340783
reach
"Reduction of EIF3H has previously been shown to reduce cell proliferation and anchorage independent growth in soft agar [XREF_BIBR]."
27340783
reach
"The elevation of EIF3H activity could promote cell proliferation through regulating protein biosynthesis [ 26 ]."
33508274
reach
"We observed that EIF3H overexpression in both KYSE150 and KYSE510 cells increased cell proliferation in vitro, whereas depletion of EIF3H significantly reduced cell proliferation."
32867821
reach
"Knockdown of EIF3H could effectively inhibit cell proliferation through inducing cell apoptosis and arrest of cell cycle."
33508274
reach
"Moreover, we also observed that EIF3H promoted cell proliferation and invasion by regulating ferroptosis."
37559097
EIF3H inhibits cell population proliferation. 9 / 9
| 9
reach
"Furthermore, the loss-of-function assays demonstrated that knockdown of EIF3H could inhibit the progression of pancreatic cancer cells by reducing proliferation capacity, promoting apoptosis, arresting cell cycle in G2 and suppressing cell migration."
35809300
reach
"This indicated that EIF3H might suppress the viability and proliferation of colon cancer cells.Effects of EIF3H on cell colony formationTo investigate the effect of EIF3H knockdown on colon tumour formation, a colony formation assay was performed to detect the ability of cell to form colonies."
30022709
reach
"EIF3H depletion in ESCC cells significantly decreased the ability of cell proliferation and mobility, examined by CCK8 assay, colony formation assay and transwell assay in vitro and xenograft and tail-vein lung metastatic mouse models in vivo."
32867821
reach
"Knockdown of the translation initiation factor EIF3H, which scored as essential in 8 BrCa, 5 PDAC, and 3 HGS-OvCa cell lines, by any of three independent shRNAs significantly reduced cell proliferation in the HGS-OvCa cell lines tested (OVCAR5, OVCAR8 and A2780) (XREF_FIG)."
22585861
reach
"Knockdown of EIF3H significantly inhibited the proliferation and colony formation of OS cells in vitro, and tumour growth in nude mice in vivo."
29805516
reach
"Immunohistochemistry (IHC) staining on orthotopic tumor showed that EIF3H KD led to reduced levels of EIF3H, HAX1 and pERK1/2, and repressed cell proliferation (Ki67 staining), while HAX1 overexpression reversed these impacts caused by EIF3H KD (Fig. 5d)."
38514606
reach
"Taken together, these results suggested that the lentivirus expressing shEIF3H may significantly downregulate the expression of EIF3H in MM cells.Knockdown of EIF3H inhibited cell proliferation and in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33508274
reach
"We observed that EIF3H overexpression in both KYSE150 and KYSE510 cells increased cell proliferation in vitro, whereas depletion of EIF3H significantly reduced cell proliferation."
32867821
reach
"EIF3H depletion inhibits the proliferation and colony formation of HCT116 and SW1116 cells."
30022709
EIF3H affects YAP1
7 | 1 12 21
EIF3H binds YAP1.
7 | 8 21
EIF3H binds YAP1. 10 / 36
7 | 8 21
sparser
"Our blast analysis further suggests the potential role for the four conserved proline residues in this region that facilitate the interaction between YAP and EIF3H ( xref )."
32269044
sparser
"Mutated EIF3H catalytic core or disrupted EIF3H-YAP binding affect YAP expression independent on translation."
32269044
sparser
"These results implicated that mutated EIF3H catalytic core (EIF3H DDQ/AAA ) or disrupted EIF3H-YAP binding (EIF3H YW/AA ) has no effect on eIF3 complex integrity, YAP mRNA binds to eIF3 complex."
32269044
sparser
"We further attempted to address the effect on the upstream signaling that participate to modulate the EIF3H-YAP cascade in cancer status."
32269044
sparser
"In addition, we anticipated to determining the clinical relevance for dysregulated EIF3H-YAP axis in breast tumor the lung metastasis using human breast cancer mouse metastasis model."
32269044
sparser
"Thus, we asked whether these signals play a role in regulating the EIF3H-YAP axis."
32269044
sparser
"As shown in xref and xref – xref , we found that the inhibitors for PI3K (LY294002), S6K1 (PF4708671), Src (dasatinib) and mTOR (rapamycin) block EIF3H Ser/Thr phosphorylation, EIF3H-YAP binding and EIF3H-governed YAP accumulation but no effect for EIF3H/EIF3A binding."
32269044
reach
"However, YW-AA (Trp119, Tyr140 to alanine) mutant of EIF3H, two residues known for binding between EIF3H and YAP, still bound to HAX1 (Supplementary Fig. 5b)."
38514606
sparser
"To further determine the clinical relevance for dysregulated EIF3H-YAP axis in breast tumor lung metastasis, we have utilized both mouse and human breast cancer mouse metastasis models ( xref )."
32269044
sparser
"In the primary tumor growth, while the loss of EIF3H decrease cell proliferation and tumor growth, overexpression of both wild-type and mutant EIF3H resulted in full recovery of tumor growth suggesting a minor effect of EIF3H-YAP on tumor growth ( xref – xref and xref – xref )."
32269044
EIF3H activates YAP1.
| 1 3
EIF3H activates YAP1. 4 / 4
| 1 3
reach
"Further analysis through immunohistochemical staining of the tumor tissues indicated that EIF3H suppression reduced YAP accumulation (Figure 7C)."
39868848
reach
"Overall, these findings reveal a critical interplay between adipocyte-mediated metabolic reprogramming and EIF3H-mediated YAP proteolytic control, offering promising therapeutic strategies to mitigate the adverse effects of obesity on TNBC progression."
39868848
eidos
"EIF3H catalyzed YAP for deubiquitylation , resulting in its stabilization ."
32269044
reach
"It was also reported that EIF3H could enhance the Hippo signal by stabilizing YAP, and that it promotes breast cancer invasion and metastasis."
34802261
EIF3H deubiquitinates YAP1.
| 1
EIF3H deubiquitinates YAP1. 1 / 1
| 1
reach
"The deubiquitination enzymes ubiquitin specific peptidase 10 (USP10), ubiquitin specific peptidase 47 (USP47), OUT deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2), and eukaryotic translation initiation factor 3 subunit H (EIF3H) deubiquitinated YAP1 to maintain protein stability [61, 62, 63]."
37005481
YAP1 affects EIF3H
7 | 9 21
YAP1 binds EIF3H.
7 | 8 21
EIF3H binds YAP1. 10 / 36
7 | 8 21
sparser
"Our blast analysis further suggests the potential role for the four conserved proline residues in this region that facilitate the interaction between YAP and EIF3H ( xref )."
32269044
sparser
"Mutated EIF3H catalytic core or disrupted EIF3H-YAP binding affect YAP expression independent on translation."
32269044
sparser
"These results implicated that mutated EIF3H catalytic core (EIF3H DDQ/AAA ) or disrupted EIF3H-YAP binding (EIF3H YW/AA ) has no effect on eIF3 complex integrity, YAP mRNA binds to eIF3 complex."
32269044
sparser
"We further attempted to address the effect on the upstream signaling that participate to modulate the EIF3H-YAP cascade in cancer status."
32269044
sparser
"In addition, we anticipated to determining the clinical relevance for dysregulated EIF3H-YAP axis in breast tumor the lung metastasis using human breast cancer mouse metastasis model."
32269044
sparser
"Thus, we asked whether these signals play a role in regulating the EIF3H-YAP axis."
32269044
sparser
"As shown in xref and xref – xref , we found that the inhibitors for PI3K (LY294002), S6K1 (PF4708671), Src (dasatinib) and mTOR (rapamycin) block EIF3H Ser/Thr phosphorylation, EIF3H-YAP binding and EIF3H-governed YAP accumulation but no effect for EIF3H/EIF3A binding."
32269044
reach
"However, YW-AA (Trp119, Tyr140 to alanine) mutant of EIF3H, two residues known for binding between EIF3H and YAP, still bound to HAX1 (Supplementary Fig. 5b)."
38514606
sparser
"To further determine the clinical relevance for dysregulated EIF3H-YAP axis in breast tumor lung metastasis, we have utilized both mouse and human breast cancer mouse metastasis models ( xref )."
32269044
sparser
"In the primary tumor growth, while the loss of EIF3H decrease cell proliferation and tumor growth, overexpression of both wild-type and mutant EIF3H resulted in full recovery of tumor growth suggesting a minor effect of EIF3H-YAP on tumor growth ( xref – xref and xref – xref )."
32269044
YAP1 activates EIF3H.
| 1
YAP1 activates EIF3H. 1 / 1
| 1
reach
"To investigate whether obesity‐induced metabolic disorders mediate the interaction between O‐GlcNAcylation and deubiquitylation of YAP, influencing therapy responses in triple‐negative breast cancer, we established stable EIF3H knockdown (shEIF3H) as well as CRISPR/Cas9‐mediated EIF3H knockout (EIF3H KO) in MDA‐MB‐231 and 4T1 cell lines (Figure S8A, Supporting Information)."
39868848
EIF3H affects EIF3F
14 | 3 16
EIF3H binds EIF3F. 10 / 26
14 | 3 8
biogrid
No evidence text available
33961781
sparser
"In vitro GST-pulldown experiments confirmed that DTrc8 specifically interacted with eIF3f and eIF3h in addition to Csn5 ( xref )."
20068067
biogrid
No evidence text available
35831314
sparser
"In fact, interactions between DTrc8 and eIF3f or eIF3h were stronger than observed with Csn5."
20068067
biogrid
No evidence text available
40593561
sparser
"Moreover, both eIF3f and eIF3h interact directly with each other, supporting a possible scaffolding role for these subunits ( xref )."
23769948
sparser
"xDnd1 directly binds eIF3f and in IP experiments, brings down eIF3m and eIF3h, which associate with eIF3f ( xref )."
30230100
biogrid
No evidence text available
32269044
biogrid
No evidence text available
22939629
biogrid
No evidence text available
26186194
EIF3F binds EIF3E and EIF3H. 5 / 5
| 5
sparser
"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
sparser
"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
sparser
"A polysome mRNA analysis on HeLa, HEK293 and NIH3T3 cells has revealed that eIF3e, eIF3f and eIF3h mRNAs are mainly associated with subpolysomal particles in quiescent or growth-arrested cells, but mostly associated with polysomes in growing cells [ xref ]."
23354061
sparser
"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
sparser
"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."
20444226
RNF139 binds EIF3F and EIF3H. 2 / 2
| 2
sparser
"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."
20068067
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
23354061
EIF3D binds EIF3E, EIF3F, EIF3H, and EIF3L. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3H affects SNAI1
4 1 | 20 1 5
EIF3H binds SNAI1.
4 | 13 1
EIF3H binds SNAI1. 10 / 18
4 | 13 1
biogrid
No evidence text available
32867821
reach
"The interaction between EIF3H and Snail suggests the ability of EIF3H to regulate Snail expression."
32867821
sparser
"Our study reveals a critical EIF3H-Snail signaling axis in tumor aggressiveness in ESCC and provides EIF3H as a promising biomarker for ESCC treatment."
32867821
biogrid
No evidence text available
32867821
biogrid
No evidence text available
32867821
biogrid
No evidence text available
32867821
reach
"We demonstrated that EIF3H interacts with and stabilizes Snail through deubiquitination."
32867821
reach
"In order to get a comprehensive understanding about the significance of EIF3H and the mechanism of its function in ESCC, we performed a liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis and identified that EIF3H could interact with Snail and correlate positively with Snail expression."
32867821
reach
"EIF3H interacts with Snail."
32867821
reach
"To confirm the interaction between EIF3H and Snail, we then performed a co-IP assay with co-expressed EIF3H-Flag and Snail in HEK293T cells."
32867821
EIF3H increases the amount of SNAI1.
| 5
EIF3H increases the amount of SNAI1. 5 / 5
| 5
isi
"The Snail and EIF3H expression were analyzed by immunoblotting (left panel)."
32867821
isi
"Clinically, the levels of EIF3H were positively correlated with Snail expression."
32867821
isi
"The interaction between EIF3H and Snail suggests the ability of EIF3H to regulate Snail expression."
32867821
isi
"In concordance with our findings in xenograft model, the expression levels of EIF3H were positively correlated with Snail expression in the ESCC tissue samples (Fig.7c)."
32867821
isi
"Expression of Snail and EIF3H was detected (left) and the intensity of Snail expression was quantified by Image J software (right).cSnail-Flag, HA-UB plasmids with or without EIF3H were co-transfected in HEK293T cells for 24 h. After another 4 h 10 muM MG132 incubation, the ubiquitination assay was performed to detect the poly-ubiquitination of Snail.dandeThe CHX pulse-chase assay was performed on EIF3H stably overexpressed in KYSE150 and KYSE510 cells."
32867821
EIF3H deubiquitinates SNAI1.
1 | 3
EIF3H deubiquitinates SNAI1. 4 / 4
1 | 3
reach
"Furthermore, we demonstrated Snail, as the novel identified substrate of EIF3H, could be deubiquitinated and stabilized by EIF3H."
32867821
ubibrowser
"Moreover, we identified <span class="match term0">EIF3H</span> as a novel deubiquitinating enzyme of <span class="match term1">Snail</span>"
32867821
reach
"We observed overexpression of EIF3H deubiquitinated endogenous Snail, but knockdown of EIF3H facilitated ubiquitination of endogenous Snail."
32867821
reach
"EIF3H interacts with and deubiquitinates Snail to prolong its half-life."
32867821
EIF3H activates SNAI1.
| 3
EIF3H activates SNAI1. 3 / 3
| 3
reach
"EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability."
32867821
reach
"Results showed that EIF3H obviously upregulated the Snail protein, but did not affect the mRNA level of Snail."
32867821
reach
"We further validated whether EIF3H modulates Snail stability through deubiquitination."
32867821
EIF3H decreases the amount of SNAI1.
| 1
EIF3H decreases the amount of ubiquitinated SNAI1. 1 / 1
| 1
reach
"EIF3H significantly decreased the poly-ubiquitin level of ubiquitinated Snail in an in vitro ubiquitination assay."
32867821
EIF3H affects OGT
2 | 24 5
EIF3H binds OGT.
2 | 5 5
EIF3H binds OGT. 10 / 12
2 | 5 5
reach
"EIF3H could interact with, deubiquitylate, and stabilize OGT in a deubiquitylase-dependent manner."
37559097
biogrid
No evidence text available
37559097
biogrid
No evidence text available
37559097
sparser
"Consistently, we performed an immunohistochemistry analysis of tissue microarrays from Xiangya hospital, which showed that OGT was positively associated with EIF3H, and that high expression of EIF3H was associated with unfavorable prognosis (Fig.  xref F-H)."
37559097
sparser
"EIF3H interacts with OGT in HCC."
37559097
reach
"55 To comprehensively address the mechanism by which the interplay of OGT‐mediated YAP‐ GlcNAcylation and EIF3H‐mediated deubiquitylation regulates YAP stability control, we conducted structural modeling of the interaction between YAP, OGT, and EIF3H by integrated use of docking simulations followed by experimental validation."
39868848
reach
"We further analyzed the linkage of ubiquitin chains in interaction between EIF3H and OGT."
37559097
reach
"This will provide a clearer understanding of how O‐GlcNAcylation regulates YAP stability and interacts with EIF3H in breast tumorigenesis and therapeutic outcomes.In addition, previous findings suggest that EIF3H can interact with and stabilize OGT, enhancing its activity in a deubiquitinase‐dependent manner."
39868848
sparser
"Firstly, EIF3H and OGT interacted with each other directly."
37559097
sparser
"Endogenous EIF3H and OGT were co-immunoprecipitated in LM3 cells, suggesting that the interaction between EIF3H and OGT is physiological."
37559097
EIF3H activates OGT.
| 7
EIF3H activates OGT. 7 / 7
| 7
reach
"The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT [17]."
39715739
reach
"EIF3H depletion inhibits O-GlcNac pathway activity in HCC."
37559097
reach
"We then treated cells by CHX to inhibit protein synthesis, and discovered that EIF3H depletion reduced OGT half-life, whereas overexpression of wild-type EIF3H prolonged it."
37559097
reach
"EIF3H enhances the stability of OGT in HCC."
37559097
reach
"These findings demonstrated that EIF3H increased the stability of OGT in a DUB-dependent manner."
37559097
reach
"EIF3H has been found to promote HCC progression by stabilizing OGT (O-GlcNAc transferase) and inhibiting ferroptosis, a form of regulated cell death."
38419066
reach
"The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis."
37559097
EIF3H increases the amount of OGT.
| 6
EIF3H increases the amount of OGT. 6 / 6
| 6
reach
"By employing two nonoverlapping siRNAs targeting EIF3H, we further explored that EIF3H depletion decreased the OGT protein levels in both LM3 and Hep3B cells (Fig. 1B)."
37559097
reach
"Depletion of EIF3H significantly reduced OGT protein levels and inhibited O-GlcNac signaling activity."
37559097
reach
"We found that the knockdown of EIF3H significantly repressed OGT protein levels."
37559097
reach
"Besides, we demonstrated that the knockdown of EIF3H significantly reduced OGT protein expression, cell proliferation and invasion, and caused G1/S arrest of HCC."
37559097
reach
"Taken together, these results confirmed that EIF3H promoted OGT expression and inhibited ferroptosis in HCC cells."
37559097
reach
"We discovered that EIF3H depletion caused a decrease in total O-GlcNac levels (Fig. 1A)."
37559097
EIF3H deubiquitinates OGT.
| 5
EIF3H deubiquitinates OGT. 5 / 5
| 5
reach
"We further assessed whether OGT was deubiquitinated by EIF3H."
37559097
reach
"EIF3H deubiquitylates OGT in HCC."
37559097
reach
"As EIF3H is a member of the JAMM family of deubiquitylase, we continued to determine the possibility that EIF3H deubiquitylates OGT."
37559097
reach
"Inversely, ectopic expression of EIF3H-WT, but not its EIF3H , markedly reduced OGT ubiquitylation in cells (Fig. 3B)."
37559097
reach
"We further discovered that EIF3H deubiquitylated OGT in a dose-dependent manner through in vitro deubiquitylation assays (Fig. 3C)."
37559097
EIF3H decreases the amount of OGT.
| 1
EIF3H decreases the amount of OGT. 1 / 1
| 1
reach
"We observed that the depletion of EIF3H by siRNA decreased the OGT protein level apparently (Fig. 2G)."
37559097
EIF3H affects EIF3E
13 | 2 11
EIF3H binds EIF3E. 10 / 19
13 | 2 4
biogrid
No evidence text available
26186194
biogrid
No evidence text available
22939629
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
biogrid
No evidence text available
24981860
biogrid
No evidence text available
22863883
biogrid
No evidence text available
32269044
sparser
"AteIF3f encodes a protein that is highly expressed in pollen grains, developing embryos and root tips, and interacts with Arabidopsis eIF3e and eIF3h proteins."
20444226
sparser
"AteIF3f protein interacts with the Arabidopsis regulatory subunit eIF3e and eIF3h in yeast and plant cells."
20444226
sparser
"EIF3e and eIF3h interact directly with each other in Arabidopsis ( xref )."
20444226
EIF3F binds EIF3E and EIF3H. 5 / 5
| 5
sparser
"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
sparser
"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
sparser
"A polysome mRNA analysis on HeLa, HEK293 and NIH3T3 cells has revealed that eIF3e, eIF3f and eIF3h mRNAs are mainly associated with subpolysomal particles in quiescent or growth-arrested cells, but mostly associated with polysomes in growing cells [ xref ]."
23354061
sparser
"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
sparser
"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."
20444226
EIF3D binds EIF3E, EIF3F, EIF3H, and EIF3L. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3H binds EIF3A, EIF3B, EIF3C, and EIF3E. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3H affects apoptotic process
| 23
EIF3H inhibits apoptotic process.
| 14
EIF3H inhibits apoptotic process. 10 / 15
| 14
reach
"Our results are in agreement with previous reports suggesting that apoptosis of CRC cells was induced by EIF3H knockdown through upregulation of Bad, BAX, cleaved caspase-3, caspase9, cleaved PARP, and cytochrome C and downregulation of Bcl-2."
30022709
reach
"The results showed that silencing of EIF3H weakened cell growth and promoted apoptosis."
30022709
reach
"These results demonstrated that knockdown of EIF3H induced CRC cell apoptosis."
30022709
reach
"EIF3h potentiates the cell proliferation and inhibits the cell apoptosis of gastric cancer cells 13."
31423012
reach
"Flow cytometry showed that inhibition of EIF3H expression induced G0/G1 phase arrest and promote apoptosis in osteosarcoma cells."
40176793
reach
"EIF3H knockdown inhibited cell growth, migration, colony formation, and promoted apoptosis, and this was confirmed with GFP expressing infected cells that were counted daily for 5 days."
27340783
reach
"The knockdown of EIF3H, TPPP3, or DOCK2 promoted apoptosis of stem cells."
33509274
reach
"Furthermore, overexpressed eIF3h inhibits Myc dependent induction of apoptosis of primary prostate cells."
18544531
reach
"Overexpression of eIF3h has recently been shown to inhibit Myc dependent induction of apoptosis of primary prostate cells and EIF3H and MYC and may cooperate in enhanced protein translation either in a general way or for a specific subset of mRNAs XREF_BIBR."
20862326
reach
"XREF_BIBR Coamplification of EIF3H may also reduce MYC dependent apoptosis in prostate epithelial cells."
19204574
EIF3H activates apoptotic process.
| 9
EIF3H activates apoptotic process. 9 / 9
| 9
reach
"Knockdown of EIF3H promotes apoptosis in HCT116 and SW1116 cells."
30022709
reach
"Knockdown of EIF3H led to cell cycle arrest and promoted apoptosis in OS cells."
29805516
reach
"These results indicated that suppression of EIF3H had a significant negative effect on colon cancer cell growth.Knockdown of EIF3H promoted apoptosis in human CRC cellsAs shown in Figure 4 (a), the percentages of early apoptotic cells (Annexin V+ and 7-AAD-) and late apoptotic cells (Annexin V+ and 7-AAD+) were significantly higher in shEIF3H infected HCT116 cells and obviously higher in shEIF3H infected SW1116 cells when compared to the corresponding numbers in control cells."
30022709
reach
"The inhibition of CYPOR increases drug accumulation, and the EIF3H/HIF1α axis induces DNA break-mediated apoptosis, resulting in enhanced activity of DOX in tongue cancer cells."
40339976
reach
"Taken together, these results confirmed that EIF3H accelerated the proliferation and migration through increasing OGT stability.Ferroptosis is a new non-apoptotic programmed cell death triggered by lipid ROS and has been regarded as a potential therapeutic target for cancer therapy."
37559097
reach
"Knockdown of EIF3H inhibits the development and progression of pancreatic cancer by regulating cell proliferation and apoptosis in vitro."
35809300
reach
"Taken together, these results suggested that the lentivirus expressing shEIF3H may significantly downregulate the expression of EIF3H in MM cells.Knockdown of EIF3H inhibited cell proliferation and in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33508274
reach
"In addition, we showed that EIF3H knock-down led to cell apoptosis."
30022709
reach
"Furthermore, the loss-of-function assays demonstrated that knockdown of EIF3H could inhibit the progression of pancreatic cancer cells by reducing proliferation capacity, promoting apoptosis, arresting cell cycle in G2 and suppressing cell migration."
35809300
EIF3H affects EIF3A
23 | 1
EIF3A binds EIF3H. 10 / 23
23 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
37071682
biogrid
No evidence text available
14519125
biogrid
No evidence text available
38334954
biogrid
No evidence text available
33961781
biogrid
No evidence text available
35235311
biogrid
No evidence text available
22939629
biogrid
No evidence text available
9822659
biogrid
No evidence text available
39422127
biogrid
No evidence text available
26186194
EIF3H binds EIF3A, EIF3B, EIF3C, and EIF3E. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3H affects EIF3D
20 | 1 2
EIF3H binds EIF3D.
20 | 2
EIF3H binds EIF3D. 10 / 20
20 |
biogrid
No evidence text available
40593561
biogrid
No evidence text available
33961781
biogrid
No evidence text available
37071682
biogrid
No evidence text available
33961781
biogrid
No evidence text available
35831314
biogrid
No evidence text available
39358380
biogrid
No evidence text available
26186194
biogrid
No evidence text available
22939629
biogrid
No evidence text available
32269044
biogrid
No evidence text available
22863883
EIF3D binds EIF3E, EIF3F, EIF3H, and EIF3L. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3B binds EIF3D and EIF3H. 1 / 1
| 1
sparser
"For instance, we observe that the association of eukaryote translation initiation factor 3 (eIF3) components, such as EIF3B, EIF3D and EIF3H, with translating ribosomes was significantly stabilized upon formaldehyde cross-linking ( xref ), consistent with previously published studies ( xref )."
28625553
EIF3H inhibits EIF3D.
| 1
EIF3H inhibits EIF3D. 1 / 1
| 1
reach
"Depletion of eIF3d, but not eIF3e or eIF3h, reduced the inhibitory effect of SXL, suggesting that eIF3d is a potential target of the repressor complex within the translational machinery."
29635389
EIF3H affects Neoplasm Metastasis
| 4 18
reach
"Thus, functional knockdown of EIF3H expression inhibits HCC growth and metastasis in vitro and in vivo."
27340783
reach
"EIF3H/HAX1 axis promotes CRC tumorigenesis and metastasis in mouse orthotopic cancer model."
38514606
reach
"PSMD14, OTUB1, USP26, and EIF3H, by stabilizing Snail, promote the occurrence of metastasis[24-27]."
38463028
reach
"Further, EIF3H promotes CRC tumorigenesis and metastasis via HAX1 activity in mouse model."
38514606
reach
"Conversely, genetic inhibition of EIF3H represses ESCC tumor growth and metastasis in vitro and in vivo."
32867821
reach
"To find out whether EIF3H enhances cancer metastasis ability in vivo, we then performed lung metastatic model assay."
32867821
reach
"Taken together, these results indicate that EIF3H knockdown inhibits cell mobility and tumor metastasis in ESCC."
32867821
eidos
"Other than the translation-initiation function of EIF3H , in the present study , our finding that EIF3H promotes metastasis through stabilizing YAP addresses a knowledge gap for YAP turnover regulation ."
32269044
reach
"Besides, it also takes part in EMT process and the knockdown of EIF3H suppressed tumor metastasis in vivo."
32867821
reach
"Our results exhibited that ectopic expression of EIF3H promoted ESCC metastasis with the increase of Snail, N-Cadherin and Vimentin, and decrease of E-cadherin, while knockdown of EIF3H exerted an opposite effect."
32867821
EIF3H bound to PDCD4 activates Neoplasm Metastasis. 1 / 1
| 1
reach
"EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis."
32064160
Mutated EIF3H activates Neoplasm Metastasis. 1 / 1
| 1
reach
"To our surprise, we observed, while only overexpression of the wild-type EIF3H fully recapitulates lung metastasis, the expression of mutant EIF3H fails to restore lung metastasis, indicating that EIF3H-YAP axis is critical for EIF3H driven tumor invasion and metastasis (XREF_FIG and XREF_SUPPLEMENTARY)."
32269044
EIF3D affects EIF3H
20 | 2
EIF3H binds EIF3D. 10 / 20
20 |
biogrid
No evidence text available
40593561
biogrid
No evidence text available
33961781
biogrid
No evidence text available
37071682
biogrid
No evidence text available
33961781
biogrid
No evidence text available
35831314
biogrid
No evidence text available
39358380
biogrid
No evidence text available
26186194
biogrid
No evidence text available
22939629
biogrid
No evidence text available
32269044
biogrid
No evidence text available
22863883
EIF3D binds EIF3E, EIF3F, EIF3H, and EIF3L. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3B binds EIF3D and EIF3H. 1 / 1
| 1
sparser
"For instance, we observe that the association of eukaryote translation initiation factor 3 (eIF3) components, such as EIF3B, EIF3D and EIF3H, with translating ribosomes was significantly stabilized upon formaldehyde cross-linking ( xref ), consistent with previously published studies ( xref )."
28625553
SNAI1 affects EIF3H
4 | 13 1 3
SNAI1 binds EIF3H.
4 | 13 1
EIF3H binds SNAI1. 10 / 18
4 | 13 1
biogrid
No evidence text available
32867821
reach
"The interaction between EIF3H and Snail suggests the ability of EIF3H to regulate Snail expression."
32867821
sparser
"Our study reveals a critical EIF3H-Snail signaling axis in tumor aggressiveness in ESCC and provides EIF3H as a promising biomarker for ESCC treatment."
32867821
biogrid
No evidence text available
32867821
biogrid
No evidence text available
32867821
biogrid
No evidence text available
32867821
reach
"We demonstrated that EIF3H interacts with and stabilizes Snail through deubiquitination."
32867821
reach
"In order to get a comprehensive understanding about the significance of EIF3H and the mechanism of its function in ESCC, we performed a liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis and identified that EIF3H could interact with Snail and correlate positively with Snail expression."
32867821
reach
"EIF3H interacts with Snail."
32867821
reach
"To confirm the interaction between EIF3H and Snail, we then performed a co-IP assay with co-expressed EIF3H-Flag and Snail in HEK293T cells."
32867821
SNAI1 increases the amount of EIF3H.
| 3
SNAI1 increases the amount of EIF3H. 3 / 3
| 3
isi
"In clinical ESCC samples, there is also a positive correlation between EIF3H and Snail expression."
32867821
isi
"Scale bars, 100 mum.cThe positive correlation was obtained in ESCC samples between EIF3H and Snail protein expression"
32867821
isi
"Expression of Snail and EIF3H was detected (left) and the intensity of Snail expression was quantified by Image J software (right).cSnail-Flag, HA-UB plasmids with or without EIF3H were co-transfected in HEK293T cells for 24 h. After another 4 h 10 muM MG132 incubation, the ubiquitination assay was performed to detect the poly-ubiquitination of Snail.dandeThe CHX pulse-chase assay was performed on EIF3H stably overexpressed in KYSE150 and KYSE510 cells."
32867821
EIF3H affects translation
| 21
EIF3H activates translation.
| 18
EIF3H activates translation. 10 / 17
| 17
reach
"These risk variants, conferring an approximate 10%-18% increase in risk per allele, are located either inside or near protein coding genes that include TFEB (lysosome biogenesis and autophagy), EIF3H (initiation of translation), CYP17A1 (steroidogenesis), SPSB2 (proteasome degradation), and RPS21 (ribosome biogenesis)."
26965516
reach
"EIF3h, a subunit of eIF3 can promote protein synthesis and cell proliferation."
29908282
reach
"Our results are in agreement with these ideas and suggest an eIF3H mediated control of HIF-1alpha translation that could explain in part its oncogenic properties."
25166596
reach
"Earlier studies found that the elevation of eIF3h could stimulate protein synthesis."
32708122
reach
"High levels of eIF3h directly stimulated protein synthesis and played a key role in establishing and maintaining a malignant state in cells (62)."
35856412
reach
"This is an important TOR effect, since the S6K pathway not only stimulates overall protein synthesis but also eIF3h mediated translation reinitiation after an upstream open reading frame (uORF), a frequent feature found in plant mRNAs."
28491073
reach
"In zebrafish, it was shown that eIF3H promotes target gene translation during embryogenesis by targeting specific mRNAs to polysomes (Choudhuri et al., 2013) ."
38434221
reach
"Furthermore, m A drives extensive mRNA circularization by METTL3‐eIF3h, which enhances translation (Choe et al., 2018)."
39229972
reach
"Interestingly, the oncogenic function of METTL3 in NSCLC is complicated, where METTL3 could methylate YAP mRNA and recruit YTHDF1/3 and eIF3b to promote translation of YAP mRNA, or could interact with eIF3h to promote translation of target mRNAs (e.g., BRD4) independent of its enzymatic activity."
32183948
reach
"EIF3H can enhance protein synthesis and promote tumor progression, especially promote the translation of certain oncogenes ."
38514606
EIF3H bound to METTL3 activates translation. 1 / 1
| 1
reach
"In addition, most recent studies demonstrate that eIF3H at the 5′UTR directly binds to METTL3 at the 3′UTR-m A sites, promoting mRNA circularization and increasing cap-dependent or cap-independent ribosome translation efficiency ."
36446846
EIF3H inhibits translation.
| 3
EIF3H inhibits translation. 3 / 3
| 3
reach
"Additionally, mHTT interacts with proteins involved in protein translation, such as Mapk3, Eif3h, and Eef1a2, potentially disrupting the protein translation process [80]."
38612657
reach
"We next tested the functional interaction between METTL3 and eIF3h, and found depletion of eIF3h abrogated the enhanced translation by METTL3 (XREF_FIG and XREF_FIG)."
30232453
reach
"They demonstrated that circLPAR1 encapsulated in exosomes could be internalized by colorectal cancer cells, and further suppressed tumour growth by directly bound with eukaryotic translation initiation factor 3 subunit h (eIF3h), suppressing the methyltransferase-like 3 (METTL3)-eIF3h interaction and decreasing the translation of oncogene bromodomain containing 4 [44]."
38711144
EIF3H affects HAX1
| 11 9
EIF3H binds HAX1.
| 3 9
EIF3H binds HAX1. 10 / 12
| 3 9
sparser
"Co-immunoprecipitation (co-IP) studies indicated the exogenous and endogenous interaction between EIF3H and HAX1 (Fig.  xref )."
38514606
sparser
"Future screening of inhibitors targeting EIF3H/HAX1 or molecules blocking EIF3H-HAX1 binding may provide a promising therapeutic approach for CRC treatment."
38514606
sparser
"Given the HAX1-EIF3H link, EIF3H KD also decreased the interaction of RAF1 with MEK1 and with ERK1/2 (Fig.  xref )."
38514606
sparser
"The EIF3H-HAX1 increased RAF-MEK-ERK signaling activity to enhance colorectal cancer progression [ xref ]."
40427533
sparser
"In situ proximity ligation assay (PLA) confirmed EIF3H–HAX1 proximity in HCT116 cells, and most interactions between EIF3H and HAX1 were detected in the cytoplasm though few was present in the nucleus (Fig.  xref )."
38514606
sparser
"Taken together, these data suggest that EIF3H interacts with HAX1."
38514606
sparser
"To further support that EIF3H and HAX1 can form a complex in vivo, cellular proteins extracted from HCT116 cells were fractionated by gel-filtration chromatography."
38514606
sparser
"Taken together, these results indicate that mutated EIF3H catalytic core compromises EIF3H-HAX1 interaction/regulation, and subsequent biological activities."
38514606
sparser
"Given that activation of Wnt/β-catenin signaling induced EIF3H expression and that EIF3H-HAX1 enhanced phosphorylation of ERK1/2 in CRC, we next investigated whether combined targeting Wnt and RAF1-ERK1/2 signaling synergistically inhibited CRC cell growth."
38514606
reach
"Co-immunoprecipitation (co-IP) studies indicated the exogenous and endogenous interaction between EIF3H and HAX1 (Fig. 2b)."
38514606
EIF3H decreases the amount of HAX1.
| 3
EIF3H decreases the amount of HAX1. 3 / 3
| 3
reach
"We also re-introduced shRNA-resistant WT and mutant EIF3H (EIF3H and EIF3H ) expression plasmids into EIF3H stable knockdown cells, and found that knockdown EIF3H could decrease steady-state expression of HAX1, while re-introduced WT EIF3H or EIF3H , but not EIF3H , could rescue steady-state expression of HAX1 caused by EIF3H knockdown (Supplementary Fig. 5c)."
38514606
reach
"Furthermore, EIF3H overexpression decreased the ubiquitination level of HAX1 (Fig. 2h)."
38514606
reach
"Immunohistochemistry (IHC) staining on orthotopic tumor showed that EIF3H KD led to reduced levels of EIF3H, HAX1 and pERK1/2, and repressed cell proliferation (Ki67 staining), while HAX1 overexpression reversed these impacts caused by EIF3H KD (Fig. 5d)."
38514606
EIF3H increases the amount of HAX1.
| 2
EIF3H increases the amount of HAX1. 2 / 2
| 2
reach
"EIF3H knockdown decreases HAX1 protein level in CRC cells."
38514606
reach
"We also re-introduced shRNA-resistant WT and mutant EIF3H (EIF3H and EIF3H ) expression plasmids into EIF3H stable knockdown cells, and found that knockdown EIF3H could decrease steady-state expression of HAX1, while re-introduced WT EIF3H or EIF3H , but not EIF3H , could rescue steady-state expression of HAX1 caused by EIF3H knockdown (Supplementary Fig. 5c)."
38514606
EIF3H activates HAX1.
| 2
EIF3H activates HAX1. 2 / 2
| 2
reach
"Overexpression of EIF3H prolonged the HAX1 protein half-life in HEK293T cells (Fig. 2f)."
38514606
reach
"As expected, WT EIF3H and EIF3H could both increase HAX1 protein half-life, while EIF3H failed to do so when compared with control (Supplementary Fig. 5d)."
38514606
EIF3H deubiquitinates HAX1.
| 1
EIF3H leads to the deubiquitination of HAX1. 1 / 1
| 1
reach
"Also, βTrCP-mediated HAX1 ubiquitination can be antagonized by EIF3H with intact MPN domain."
38514606
EIF3H affects Neoplasm Invasiveness
| 1 16
EIF3H activates Neoplasm Invasiveness.
| 1 15
reach
"We observed, while the elevation of EIF3H drastically increases the tumor invasion in various breast cancer cell lines, including MDA-MB-231, 4T1, depletion of EIF3H by RNA interference largely attenuates tumor invasion (XREF_FIG - XREF_FIG & XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."
32269044
reach
"We found that EIF3H overexpression significantly increased the abilities of migration and invasion in KYSE150 and KYSE510 cells."
32867821
reach
"EIF3H promotes CRC cell growth, migration and invasion."
38514606
eidos
"Besides , we demonstrated that the knockdown of EIF3H significantly reduced OGT protein expression , cell proliferation and invasion , and caused G1 / S arrest of HCC ."
37559097
reach
"Moreover, we also observed that EIF3H promoted cell proliferation and invasion by regulating ferroptosis."
37559097
reach
"A comparison of 1964 CRC cases and 2081 healthy controls identified the region harbouring rs16888589 as an allele specific transcriptional repressor that interacts with the promoter of EIF3H, which increases CRC growth and invasiveness [29]."
30022709
reach
"To further determine whether YAP is a physiologically relevant substrate for EIF3H that mediates EIF3H promoted tumor cell invasion, we have characterized catalytic function for EIF3H in regulating YAP abundance, YAP turnover rate and YAP ubiquitylation."
32269044
reach
"Transwell assays showed EIF3H silencing decreased the migration and invasion of CRC cells (Supplementary Fig. 3f, g)."
38514606
reach
"We show that increased expression of EIF3H gene increases CRC growth and invasiveness thereby providing a biological mechanism for the 8q23.3 association."
20862326
reach
"As shown in XREF_FIG - XREF_FIG and XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY, knockdown of either the YAP and CTGF expression abrogated EIF3H driven tumor cell invasion."
32269044
EIF3H inhibits Neoplasm Invasiveness. 1 / 1
| 1
reach
"We observed, while the elevation of EIF3H drastically increases the tumor invasion in various breast cancer cell lines, including MDA-MB-231, 4T1, depletion of EIF3H by RNA interference largely attenuates tumor invasion (XREF_FIG - XREF_FIG & XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."
32269044
EIF3L affects EIF3H
15 | 1
EIF3H binds EIF3L. 10 / 15
15 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22863883
biogrid
No evidence text available
28514442
biogrid
No evidence text available
24981860
biogrid
No evidence text available
32269044
biogrid
No evidence text available
35831314
biogrid
No evidence text available
35235311
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
38334954
EIF3D binds EIF3E, EIF3F, EIF3H, and EIF3L. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3H affects EIF3C
13 | 2 1
EIF3H binds EIF3C. 10 / 15
13 | 2
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
reach
"In Arabidopsis, eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits."
27703462
biogrid
No evidence text available
40593561
biogrid
No evidence text available
35235311
biogrid
No evidence text available
26344197
biogrid
No evidence text available
32269044
biogrid
No evidence text available
39358380
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
biogrid
No evidence text available
35831314
EIF3H binds EIF3A, EIF3B, EIF3C, and EIF3E. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3H affects EIF3B
13 | 1 2
EIF3H binds EIF3B. 10 / 14
13 | 1
biogrid
No evidence text available
18599441
biogrid
No evidence text available
32269044
biogrid
No evidence text available
18599441
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26344197
biogrid
No evidence text available
24981860
biogrid
No evidence text available
22939629
biogrid
No evidence text available
18628297
EIF3H binds EIF3A, EIF3B, EIF3C, and EIF3E. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3B binds EIF3D and EIF3H. 1 / 1
| 1
sparser
"For instance, we observe that the association of eukaryote translation initiation factor 3 (eIF3) components, such as EIF3B, EIF3D and EIF3H, with translating ribosomes was significantly stabilized upon formaldehyde cross-linking ( xref ), consistent with previously published studies ( xref )."
28625553
EIF3C affects EIF3H
13 | 2 1
EIF3H binds EIF3C. 10 / 15
13 | 2
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
reach
"In Arabidopsis, eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits."
27703462
biogrid
No evidence text available
40593561
biogrid
No evidence text available
35235311
biogrid
No evidence text available
26344197
biogrid
No evidence text available
32269044
biogrid
No evidence text available
39358380
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
biogrid
No evidence text available
35831314
EIF3H binds EIF3A, EIF3B, EIF3C, and EIF3E. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3B affects EIF3H
13 | 1 2
EIF3H binds EIF3B. 10 / 14
13 | 1
biogrid
No evidence text available
18599441
biogrid
No evidence text available
32269044
biogrid
No evidence text available
18599441
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26344197
biogrid
No evidence text available
24981860
biogrid
No evidence text available
22939629
biogrid
No evidence text available
18628297
EIF3H binds EIF3A, EIF3B, EIF3C, and EIF3E. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3B binds EIF3D and EIF3H. 1 / 1
| 1
sparser
"For instance, we observe that the association of eukaryote translation initiation factor 3 (eIF3) components, such as EIF3B, EIF3D and EIF3H, with translating ribosomes was significantly stabilized upon formaldehyde cross-linking ( xref ), consistent with previously published studies ( xref )."
28625553
EIF3M affects EIF3H
14 | 1
EIF3H binds EIF3M. 10 / 15
14 | 1
biogrid
No evidence text available
19615732
biogrid
No evidence text available
40593561
biogrid
No evidence text available
24981860
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
biogrid
No evidence text available
32867821
biogrid
No evidence text available
35271311
biogrid
No evidence text available
22939629
biogrid
No evidence text available
35831314
biogrid
No evidence text available
26186194
RPS6KB1 affects EIF3H
1 | 7 5
RPS6KB1 binds EIF3H.
1 | 3 3
RPS6KB1 binds EIF3H. 7 / 7
1 | 3 3
sparser
"By contrast, treatment with Torin-1 leads to dephosphorylation of TOR and S6K1, which promotes the formation of the S6K1–eIF3h complex on polysomes."
37437121
reach
"When TOR is inactive, S6K1 binds to eIF3h; when TOR is activated by auxin, TOR binds to and phosphorylates eIF3h."
37437121
reach
"Because plant eIF3h physically interacts with S6K1, it was further suggested that eIF3h might be the downstream target of activated S6K1."
29281028
reach
"By contrast, treatment with Torin-1 leads to dephosphorylation of TOR and S6K1, which promotes the formation of the S6K1–eIF3h complex on polysomes."
37437121
biogrid
No evidence text available
16286006
sparser
"Because plant eIF3h physically interacts with S6K1, it was further suggested that eIF3h might be the downstream target of activated S6K1 (Schepetilnikov et al. xref )."
29281028
sparser
"When TOR is inactive, S6K1 binds to eIF3h; when TOR is activated by auxin, TOR binds to and phosphorylates eIF3h."
37437121
RPS6KB1 phosphorylates EIF3H.
| 4 2
RPS6KB1 phosphorylates EIF3H. 6 / 6
| 4 2
sparser
"In response to auxin, eIF3h phosphorylation by TOR-activated S6K1 enhances translation reinitiation of mRNAs with uORFs ( xref )."
36909402
sparser
"The previous report demonstrated EIF3H is regulated in response to mTOR-S6K1 cascade, where EIF3H can be phosphorylated by S6K1 kinase through the serine 183 on EIF3H ( xref )."
32269044
reach
"The loading of the translation initiation factor eIF3h into polysomes in response to auxin is impaired in TOR deficient mutants with an inactive S6K form, suggesting that eIF3h is possibly phosphorylated by the TOR and S6K1 pathway."
28491073
reach
"Moreover, TOR-mediated phosphorylation of the 40S RIBOSOMAL S6 KINASE 1 (S6K1) triggers phosphorylation of the eukaryotic translation initiation factor 3 subunit h (elF3h) which promotes translation r[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37603910
reach
"S6K1 in turn phosphorylates the subunit h of eukaryotic Initiation Factor 3 (eIF3h), which promotes loading of mRNAs that carry upstream open reading frames (uORFs) within their 5' untranslated regions (5'UTRs) into the ribosome for translation re-initiation (Figure 1) (Schepetilnikov et al., 2013)."
32117365
reach
"Upregulated TOR is recruited to polysomes where it phosphorylates S6K1, which shortly before its release from polysomes phosphorylates eIF3h."
29281028
HAX1 affects EIF3H
| 4 9
HAX1 binds EIF3H.
| 3 9
EIF3H binds HAX1. 10 / 12
| 3 9
sparser
"Co-immunoprecipitation (co-IP) studies indicated the exogenous and endogenous interaction between EIF3H and HAX1 (Fig.  xref )."
38514606
sparser
"Future screening of inhibitors targeting EIF3H/HAX1 or molecules blocking EIF3H-HAX1 binding may provide a promising therapeutic approach for CRC treatment."
38514606
sparser
"Given the HAX1-EIF3H link, EIF3H KD also decreased the interaction of RAF1 with MEK1 and with ERK1/2 (Fig.  xref )."
38514606
sparser
"The EIF3H-HAX1 increased RAF-MEK-ERK signaling activity to enhance colorectal cancer progression [ xref ]."
40427533
sparser
"In situ proximity ligation assay (PLA) confirmed EIF3H–HAX1 proximity in HCT116 cells, and most interactions between EIF3H and HAX1 were detected in the cytoplasm though few was present in the nucleus (Fig.  xref )."
38514606
sparser
"Taken together, these data suggest that EIF3H interacts with HAX1."
38514606
sparser
"To further support that EIF3H and HAX1 can form a complex in vivo, cellular proteins extracted from HCT116 cells were fractionated by gel-filtration chromatography."
38514606
sparser
"Taken together, these results indicate that mutated EIF3H catalytic core compromises EIF3H-HAX1 interaction/regulation, and subsequent biological activities."
38514606
sparser
"Given that activation of Wnt/β-catenin signaling induced EIF3H expression and that EIF3H-HAX1 enhanced phosphorylation of ERK1/2 in CRC, we next investigated whether combined targeting Wnt and RAF1-ERK1/2 signaling synergistically inhibited CRC cell growth."
38514606
reach
"Co-immunoprecipitation (co-IP) studies indicated the exogenous and endogenous interaction between EIF3H and HAX1 (Fig. 2b)."
38514606
HAX1 activates EIF3H.
| 1
HAX1 activates EIF3H. 1 / 1
| 1
reach
"Thus, our results show that HAX1 mediates EIF3H oncogenic phenotypes in CRC cells."
38514606
OGT affects EIF3H
2 | 5 5
EIF3H binds OGT. 10 / 12
2 | 5 5
reach
"EIF3H could interact with, deubiquitylate, and stabilize OGT in a deubiquitylase-dependent manner."
37559097
biogrid
No evidence text available
37559097
biogrid
No evidence text available
37559097
sparser
"Consistently, we performed an immunohistochemistry analysis of tissue microarrays from Xiangya hospital, which showed that OGT was positively associated with EIF3H, and that high expression of EIF3H was associated with unfavorable prognosis (Fig.  xref F-H)."
37559097
sparser
"EIF3H interacts with OGT in HCC."
37559097
reach
"55 To comprehensively address the mechanism by which the interplay of OGT‐mediated YAP‐ GlcNAcylation and EIF3H‐mediated deubiquitylation regulates YAP stability control, we conducted structural modeling of the interaction between YAP, OGT, and EIF3H by integrated use of docking simulations followed by experimental validation."
39868848
reach
"We further analyzed the linkage of ubiquitin chains in interaction between EIF3H and OGT."
37559097
reach
"This will provide a clearer understanding of how O‐GlcNAcylation regulates YAP stability and interacts with EIF3H in breast tumorigenesis and therapeutic outcomes.In addition, previous findings suggest that EIF3H can interact with and stabilize OGT, enhancing its activity in a deubiquitinase‐dependent manner."
39868848
sparser
"Firstly, EIF3H and OGT interacted with each other directly."
37559097
sparser
"Endogenous EIF3H and OGT were co-immunoprecipitated in LM3 cells, suggesting that the interaction between EIF3H and OGT is physiological."
37559097
GPHN affects EIF3H
| 6 6
GPHN binds EIF3H. 8 / 8
| 5 3
sparser
"These results demonstrate that gephyrin also interacts with eIF3H in mammalian cells."
20858277
reach
"These results demonstrate that gephyrin also interacts with eIF3H in mammalian cells."
20858277
reach
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
sparser
"In addition, we demonstrated that gephyrin also interacts with eIF3H in non-neuronal cells and forms a complex with eIF3 in the brain."
20858277
sparser
"In addition, we showed that gephyrin also interacts with eIF3H in 293T cells and that CB, gephyrin and eIF3H seem to assemble into a trimeric protein complex."
20858277
reach
"In addition, we demonstrated that gephyrin also interacts with eIF3H in non neuronal cells and forms a complex with eIF3 in the brain."
20858277
reach
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
reach
"We then examined the possibility that gephyrin may also interact with eIF3H."
20858277
CB binds GPHN and EIF3H. 2 / 2
| 2
sparser
"Although we cannot rule out the possibility that these results are due to the formation of two independent protein complexes, CB-gephyrin and gephyrin-eIF3H, they suggest that these interactions are not mutually exclusive (as both could potentially form at the same time), and raise the possibility that CB, gephyrin and eIF3H can form a trimeric protein complex in mammalian cells."
20858277
sparser
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
GPHN binds EIF3H and 293T. 1 / 1
| 1
reach
"In addition, we showed that gephyrin also interacts with eIF3H in 293T cells and that CB, gephyrin and eIF3H seem to assemble into a trimeric protein complex."
20858277
Collybistin binds GPHN and EIF3H. 1 / 1
| 1
sparser
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
EIF3H affects ferroptosis
| 12
EIF3H activates ferroptosis.
| 8
EIF3H activates ferroptosis. 8 / 8
| 8
reach
"By preventing ferroptosis, EIF3H may contribute to the survival of cancer cells [19]."
38419066
reach
"N6-methyladenosine-mediated EIF3H promotes anaplastic thyroid cancer progression and ferroptosis resistance by stabilizing β-catenin."
39984062
reach
"These data indicated that OGT expression can suppress ferroptosis promoted by EIF3H in HCC cells."
37559097
reach
"Meanwhile, OGT expression can suppress ferroptosis promoted by EIF3H in HCC."
37559097
reach
"EIF3H has been found to promote HCC progression by stabilizing OGT (O-GlcNAc transferase) and inhibiting ferroptosis, a form of regulated cell death."
38419066
reach
"Moreover, we also observed that EIF3H promoted cell proliferation and invasion by regulating ferroptosis."
37559097
reach
"The knockdown of EIF3H could inhibit ATC cell proliferation, invasion, and ferroptosis resistance by regulating β-catenin."
39984062
reach
"The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis."
37559097
EIF3H inhibits ferroptosis.
| 4
EIF3H inhibits ferroptosis. 4 / 4
| 4
reach
"Inhibition of EIF3H induces ferroptosis, which is reversed by OGT overexpression (120)."
37838167
reach
"In addition, we further explored whether EIF3H inhibits the HCC cell ferroptosis through OGT."
37559097
reach
"Taken together, our results indicate that the deletion of EIF3H promoted the ferroptosis in HCC cells."
37559097
reach
"Correspondingly, our findings are the first to reveal that EIF3H inhibits ferroptosis by interacting with OGT, thereby accelerating HCC cell growth and tumor progression.In conclusion, our study investigated the biological functions of EIF3H in HCC, and we revealed that EIF3H is a post-translational modulator in regulating OGT stabilization and deubiquitination."
37559097
EIF3H affects GPHN
| 6 6
GPHN binds EIF3H. 8 / 8
| 5 3
sparser
"These results demonstrate that gephyrin also interacts with eIF3H in mammalian cells."
20858277
reach
"These results demonstrate that gephyrin also interacts with eIF3H in mammalian cells."
20858277
reach
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
sparser
"In addition, we demonstrated that gephyrin also interacts with eIF3H in non-neuronal cells and forms a complex with eIF3 in the brain."
20858277
sparser
"In addition, we showed that gephyrin also interacts with eIF3H in 293T cells and that CB, gephyrin and eIF3H seem to assemble into a trimeric protein complex."
20858277
reach
"In addition, we demonstrated that gephyrin also interacts with eIF3H in non neuronal cells and forms a complex with eIF3 in the brain."
20858277
reach
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
reach
"We then examined the possibility that gephyrin may also interact with eIF3H."
20858277
CB binds GPHN and EIF3H. 2 / 2
| 2
sparser
"Although we cannot rule out the possibility that these results are due to the formation of two independent protein complexes, CB-gephyrin and gephyrin-eIF3H, they suggest that these interactions are not mutually exclusive (as both could potentially form at the same time), and raise the possibility that CB, gephyrin and eIF3H can form a trimeric protein complex in mammalian cells."
20858277
sparser
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
GPHN binds EIF3H and 293T. 1 / 1
| 1
reach
"In addition, we showed that gephyrin also interacts with eIF3H in 293T cells and that CB, gephyrin and eIF3H seem to assemble into a trimeric protein complex."
20858277
Collybistin binds GPHN and EIF3H. 1 / 1
| 1
sparser
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
EIF3H affects EIF3G
11 1 |
EIF3H binds EIF3G. 10 / 12
11 1 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
35831314
hprd
No evidence text available
9822659
biogrid
No evidence text available
9822659
biogrid
No evidence text available
24981860
biogrid
No evidence text available
22939629
biogrid
No evidence text available
19615732
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
32269044
EIF3K affects EIF3H
9 1 |
EIF3H binds EIF3K. 10 / 10
9 1 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
35831314
hprd
No evidence text available
14519125
biogrid
No evidence text available
24981860
biogrid
No evidence text available
35271311
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22939629
EIF3I affects EIF3H
9 | 1
EIF3H binds EIF3I. 10 / 10
9 | 1
biogrid
No evidence text available
35271311
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
biogrid
No evidence text available
32867821
biogrid
No evidence text available
24981860
biogrid
No evidence text available
35831314
biogrid
No evidence text available
26186194
reach
"Thus it is not clear what functional role the interactions between eIF3i and eIF3h may play, if any, in eIF3 assembly."
27210288
biogrid
No evidence text available
22939629
biogrid
No evidence text available
33961781
EIF3H affects HYCC1
| 10
EIF3H activates HYCC1. 10 / 10
| 10
reach
"EIF3H depletion inhibits O-GlcNac pathway activity in HCC."
37559097
reach
"EIF3h is upregulation in the breast cancer, HCC, lung cancer, and colon cancer et al [ 2 , 99 , 100 ]."
33189778
reach
"EIF3H enhances the stability of OGT in HCC."
37559097
reach
"Finally, EIF3H could promote cancer progression in HCC via OGT."
37559097
reach
"EIF3H promotes HCC progression in vitro and in vivo."
37559097
reach
"Our results showed that the depletion of EIF3H markedly decreased the proliferation and migration of HCC both in vitro and in vivo."
37559097
reach
"In addition, we also confirmed that EIF3H promoted HCC cell proliferation and migration via upregulation of OGT."
37559097
reach
"The results illustrated that EIF3H depletion by lentivirus-based shRNA suppressed the HCC tumor growth markedly (Fig. 4G, H)."
37559097
reach
"Moreover, we also demonstrated that EIF3H may accelerate the HCC progression via the regulation of OGT expression and ferroptosis."
37559097
reach
"EIF3H has been found to promote HCC progression by stabilizing OGT (O-GlcNAc transferase) and inhibiting ferroptosis, a form of regulated cell death."
38419066
EIF3H affects EIF3K
9 1 |
EIF3H binds EIF3K. 10 / 10
9 1 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26344197
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
35831314
hprd
No evidence text available
14519125
biogrid
No evidence text available
24981860
biogrid
No evidence text available
35271311
biogrid
No evidence text available
19615732
biogrid
No evidence text available
22939629
EIF3H affects EIF3I
9 | 1
EIF3H binds EIF3I. 10 / 10
9 | 1
biogrid
No evidence text available
35271311
biogrid
No evidence text available
28514442
biogrid
No evidence text available
19615732
biogrid
No evidence text available
32867821
biogrid
No evidence text available
24981860
biogrid
No evidence text available
35831314
biogrid
No evidence text available
26186194
reach
"Thus it is not clear what functional role the interactions between eIF3i and eIF3h may play, if any, in eIF3 assembly."
27210288
biogrid
No evidence text available
22939629
biogrid
No evidence text available
33961781
EIF3H affects RPS6KB1
1 | 5 3
EIF3H binds RPS6KB1.
1 | 3 3
RPS6KB1 binds EIF3H. 7 / 7
1 | 3 3
sparser
"By contrast, treatment with Torin-1 leads to dephosphorylation of TOR and S6K1, which promotes the formation of the S6K1–eIF3h complex on polysomes."
37437121
reach
"When TOR is inactive, S6K1 binds to eIF3h; when TOR is activated by auxin, TOR binds to and phosphorylates eIF3h."
37437121
reach
"Because plant eIF3h physically interacts with S6K1, it was further suggested that eIF3h might be the downstream target of activated S6K1."
29281028
reach
"By contrast, treatment with Torin-1 leads to dephosphorylation of TOR and S6K1, which promotes the formation of the S6K1–eIF3h complex on polysomes."
37437121
biogrid
No evidence text available
16286006
sparser
"Because plant eIF3h physically interacts with S6K1, it was further suggested that eIF3h might be the downstream target of activated S6K1 (Schepetilnikov et al. xref )."
29281028
sparser
"When TOR is inactive, S6K1 binds to eIF3h; when TOR is activated by auxin, TOR binds to and phosphorylates eIF3h."
37437121
EIF3H activates RPS6KB1.
| 2
EIF3H activates RPS6KB1. 2 / 2
| 2
reach
"Because plant eIF3h physically interacts with S6K1, it was further suggested that eIF3h might be the downstream target of activated S6K1."
29281028
reach
"In response to auxin, eIF3h phosphorylation by TOR-activated S6K1 enhances translation reinitiation of mRNAs with uORFs (Schepetilnikov et al., 2013)."
36909402
PTPRA affects EIF3H
| 8
PTPRA binds EIF3H. 8 / 8
| 8
sparser
"In a subsequent study from the same group, Wong et al. demonstrated that PtpA binds to subunit H of the host vacuolar ATPase (V-ATPase) in the phagosome membrane and that the macrophage class C sorting complex associates with the V-ATPase during phagosome maturation ( xref )."
25429354
sparser
"PtpA also binds to subunit H of macrophage V-ATPase and blocks its activity required for phagosome acidification xref ."
24346161
sparser
"PtpA binds subunit H of the V-ATPase (Wong et al., xref ) and it also binds to and dephosphorylates VPS33B (Bach et al., xref ), a protein enabling endosome to lysosome trafficking (Galmes et al., xref )."
33194845
sparser
"However, the interaction between PtpA and subunit H was found to be through protein-protein interaction, suggesting that V-ATPase is not the catalytic substrate of PtpA ( xref )."
35880173
sparser
"PtpA, which binds subunit H of V-ATPase and thereby excludes the proton pump from phagosomes, is a candidate for this missing SecA2-exported effector [ xref ]."
29709019
sparser
"Recent study identified that PtpA-mediated exhaustion of host V-ATPase is a two-step process: PtpA interacts with the subunit H of the host V-ATPase machinery initially disrupts the membrane tethering[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34986388
sparser
"Subsequent studies suggested that PtpA also binds to the subunit H of vacuolar-H(+)–ATPase (V-ATPase) machinery (identified by a ‘substrate trapping’ assay), a multisubunit protein complex."
25327725
sparser
"Wong et al. ( xref ) demonstrated that PtpA directly binds to the V1 subunit H to: i) block the trafficking of this subunit to the mycobacterial phagosome and ii) block its interaction with Vps33B ( xref )."
33717183
PDCD4 affects EIF3H
1 | 1 5 1
PDCD4 binds EIF3H.
1 | 1 2 1
EIF3H binds PDCD4. 5 / 5
1 | 1 2 1
trips
"EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis."
32064160
sparser
"Co-immunoprecipitation assays combined with mass spectrometry and immunofluorescent co-localization indicated that PDCD4 interacted with EIF3H. Overexpression of PDCD4 in LUAD cells reduced EIF3H mRNA and protein levels by suppressing c-Jun-induced EIF3H transcription."
32064160
reach
"EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis."
32064160
reach
"Co-immunoprecipitation assays combined with mass spectrometry and immunofluorescent co-localization indicated that PDCD4 interacted with EIF3H."
32064160
biogrid
No evidence text available
26344197
PDCD4 inhibits EIF3H.
| 2
PDCD4 inhibits EIF3H. 2 / 2
| 2
reach
"Furthermore, we discovered that introduction of PDCD4 to EIF3H overexpressing LUAD cells abrogated the function of EIF3H, reducing migration and invasion of LUAD cells by downregulating EMT signaling."
32064160
reach
"Overexpression of PDCD4 in LUAD cells reduced EIF3H mRNA and protein levels by suppressing c-Jun-induced EIF3H transcription."
32064160
PDCD4 decreases the amount of EIF3H.
| 1
PDCD4 decreases the amount of EIF3H. 1 / 1
| 1
reach
"It has been reported that overexpression of PDCD4 in lung cancer reduced EIF3H expression by inhibiting c-Jun-induced EIF3H transcription."
34802261
M affects EIF3H
1 3 | 3 1
EIF3H binds M. 3 / 3
3 |
virhostnet
No evidence text available
17287294
virhostnet
No evidence text available
17287294
virhostnet
No evidence text available
17287294
EIF3H binds M. 3 / 3
| 3
reach
"We resorted to surface plasmon resonance assays to obtain further confirmation of a direct interaction between eIF3h and M, and to determine the characteristics of such an interaction."
17287294
reach
"If it is the interaction between M and eIF3h that inhibits canonical initiation of protein synthesis, this inhibition should be overcome when the role of eIF3 in translation initiation is different."
17287294
reach
"This result allowed us to put forth the hypothesis that translation initiation on factor dependent mRNAs could be inhibited by RV M protein, by a mechanism that involves an interaction between M and eIF3h."
17287294
M binds EIF3H. 2 / 2
1 | 1
sparser
"Measles N protein binds eIF3g, whereas rabies M protein binds eIF3h to impede host translation [ xref , xref ]."
32455727
biogrid
No evidence text available
37314180
EIF3H affects PTPRA
| 8
PTPRA binds EIF3H. 8 / 8
| 8
sparser
"In a subsequent study from the same group, Wong et al. demonstrated that PtpA binds to subunit H of the host vacuolar ATPase (V-ATPase) in the phagosome membrane and that the macrophage class C sorting complex associates with the V-ATPase during phagosome maturation ( xref )."
25429354
sparser
"PtpA also binds to subunit H of macrophage V-ATPase and blocks its activity required for phagosome acidification xref ."
24346161
sparser
"PtpA binds subunit H of the V-ATPase (Wong et al., xref ) and it also binds to and dephosphorylates VPS33B (Bach et al., xref ), a protein enabling endosome to lysosome trafficking (Galmes et al., xref )."
33194845
sparser
"However, the interaction between PtpA and subunit H was found to be through protein-protein interaction, suggesting that V-ATPase is not the catalytic substrate of PtpA ( xref )."
35880173
sparser
"PtpA, which binds subunit H of V-ATPase and thereby excludes the proton pump from phagosomes, is a candidate for this missing SecA2-exported effector [ xref ]."
29709019
sparser
"Recent study identified that PtpA-mediated exhaustion of host V-ATPase is a two-step process: PtpA interacts with the subunit H of the host V-ATPase machinery initially disrupts the membrane tethering[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34986388
sparser
"Subsequent studies suggested that PtpA also binds to the subunit H of vacuolar-H(+)–ATPase (V-ATPase) machinery (identified by a ‘substrate trapping’ assay), a multisubunit protein complex."
25327725
sparser
"Wong et al. ( xref ) demonstrated that PtpA directly binds to the V1 subunit H to: i) block the trafficking of this subunit to the mycobacterial phagosome and ii) block its interaction with Vps33B ( xref )."
33717183
EIF3H affects M
1 3 | 3 1
EIF3H binds M. 3 / 3
3 |
virhostnet
No evidence text available
17287294
virhostnet
No evidence text available
17287294
virhostnet
No evidence text available
17287294
EIF3H binds M. 3 / 3
| 3
reach
"We resorted to surface plasmon resonance assays to obtain further confirmation of a direct interaction between eIF3h and M, and to determine the characteristics of such an interaction."
17287294
reach
"If it is the interaction between M and eIF3h that inhibits canonical initiation of protein synthesis, this inhibition should be overcome when the role of eIF3 in translation initiation is different."
17287294
reach
"This result allowed us to put forth the hypothesis that translation initiation on factor dependent mRNAs could be inhibited by RV M protein, by a mechanism that involves an interaction between M and eIF3h."
17287294
M binds EIF3H. 2 / 2
1 | 1
sparser
"Measles N protein binds eIF3g, whereas rabies M protein binds eIF3h to impede host translation [ xref , xref ]."
32455727
biogrid
No evidence text available
37314180
RORC affects EIF3H
| 7
RORC phosphorylates EIF3H.
| 5
RORC phosphorylates EIF3H. 5 / 5
| 5
reach
"TOR activation by auxin results in the phosphorylation of eIF3h, a component of elF3 complex that promotes translation reinitiation [80] ."
26684391
reach
"When TOR is inactive, S6K1 binds to eIF3h; when TOR is activated by auxin, TOR binds to and phosphorylates eIF3h."
37437121
reach
"Moreover, TOR-mediated phosphorylation of the 40S RIBOSOMAL S6 KINASE 1 (S6K1) triggers phosphorylation of the eukaryotic translation initiation factor 3 subunit h (elF3h) which promotes translation r[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37603910
reach
"In response to auxin, eIF3h phosphorylation by TOR-activated S6K1 enhances translation reinitiation of mRNAs with uORFs (Schepetilnikov et al., 2013)."
36909402
reach
"The authors proposed that TOR, when activated, promotes phosphorylation of eIF3h and maintains its active phosphorylation status in Arabidopsis to ensure efficient reinitiation events (Schepetilnikov and Ryabova, 2018)."
30984977
RORC binds EIF3H.
| 2
RORC binds EIF3H. 2 / 2
| 2
reach
"When TOR is inactive, S6K1 binds to eIF3h; when TOR is activated by auxin, TOR binds to and phosphorylates eIF3h."
37437121
reach
"Furthermore, the TOR–eIF3h complex is bound to polysomes, which is important for the re-initiation of uORF-containing mRNAs, including that of ARFs and bZIP11."
37437121
EIF3H affects cell growth
| 7
EIF3H activates cell growth. 7 / 7
| 7
reach
"EIF3H promotes CRC cell growth, migration and invasion."
38514606
reach
"50 Recent studies have shown that EIF3H promoted cancer cell growth by stimulating protein synthesis."
26965516
reach
"These data suggest that EIF3H promotes CRC cell growth, migration and invasion."
38514606
reach
"EIF3H knockdown inhibited cell growth, migration, colony formation, and promoted apoptosis, and this was confirmed with GFP expressing infected cells that were counted daily for 5 days."
27340783
reach
"Overexpression of EIF3H promotes cancer cell growth [XREF_BIBR], results in a malignant phenotype [XREF_BIBR], and serves as a prognostic marker of recurrence and metastasis [XREF_BIBR, XREF_BIBR]."
32867821
reach
"Besides, the mechanism of EIF3H mediated cell growth and migration also needs further study."
32867821
reach
"Overexpression of EIF3S3 promotes cancer cell growth."
16652384
EIF3H inhibits ATP hydrolysis activity. 4 / 4
| 4
sparser
"Together with biochemical data, the structure supports a mechanistic model wherein subunit H inhibits ATPase activity by stabilizing an open catalytic site that results in tight binding of inhibitory ADP at another site."
27295975
sparser
"Previous study suggested that subunit H inhibits the ATPase activity of the dissociated V1 domain, thereby preventing its nonproductive ATP hydrolysis ( Beyenbach & Wieczorek, 2006 )."
17897871
sparser
"This structure appears to be an inhibitory state wherein the subunit H inhibits the ATPase activity by stabilizing ADP binding to the catalytic site."
27807367
sparser
"Previous structural studies of V 1 subcomplexes showed that while subunit H inhibited V 1 -ATPase is mostly in state 2 (Oot et al, xref ; Vasanthakumar et al, xref ), Oxr1p-bound V 1 is found exclusively in state 1 (Khan et al, xref )."
38565737
EIF3H binds ATP hydrolysis activity. 3 / 3
| 3
sparser
"The isothermal titration calorimetry results show a substantial interaction between subunit H of compound D with the ATPase enzyme and show highly significant activity with a lower LD 50 value (28.0 µg g −1 ) than celangulin (344.0 µg g −1 ). xref Various p -twerelsulfonamide (E) derivatives containing alkyl N -substituents were found to have a favorable inhibitory effect against the CA IX enzyme with an IC 50 of 94 nM. xref Aliphatic sulfonamido-quaternary ammonium salts (F, G) caused apoptosis by upregulating RhoB. xref "
41280208
sparser
"This is a two step process which involves initial binding to the macrophage H + -ATPase (V-ATPase) through its subunit H [13] ."
25535696
sparser
"The structural similarity suggests how subunit H may interact with the ATPase itself or with other proteins."
11416198
Bisphenol A affects EIF3H
6 |
Bisphenol A increases the amount of EIF3H.
4 |
Bisphenol A increases the amount of EIF3H. 4 / 4
4 |
ctd
No evidence text available
25181051
ctd
No evidence text available
32156529
ctd
No evidence text available
33441873
ctd
No evidence text available
30816183
Bisphenol A decreases the amount of EIF3H.
2 |
Bisphenol A decreases the amount of EIF3H. 2 / 2
2 |
ctd
No evidence text available
36041667
ctd
No evidence text available
33221593
V ATPase I affects EIF3H
| 6
sparser
"By contrast, the experiments of V-ATPase activity and interaction with subunit H were conducted in vitro , where the compounds form direct contact with proteins."
26999207
sparser
"Mtb PtpA can prevent phagosome-lysosome fusion by dephosphorylating host protein VPS33B, and prevent phagosome acidification by binding to subunit H of the macrophage V-ATPase complex to block V-ATPase trafficking xref , xref ."
28811474
sparser
"Following this study, PtpA was also found to bind subunit H of the V-ATPase complex during infection [5] ."
23084287
sparser
"Although the function of these importin domains is not known, it has been suggested that they might mediate the interaction of subunit H with other V-ATPase subunits or with other cellular proteins ou[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12788495
sparser
"Characterization of the Binding Interaction between JW-3 and the Subunit H of V-ATPase by Isothermal Titration Calorimetry Measurements."
29019960
sparser
"One of these strategies is the secretion of protein effectors that disrupt the macrophage’s innate antimicrobial defenses, such as protein-tyrosine phosphatase A (PtpA). xref , xref PtpA blocks phagosomal acidification and maturation by binding to subunit H of the macrophage V-ATPase complex and dephosphorylating VPS33B of the class C VPS macrophage complex. xref , xref Recent studies show that Mtb modulates host intracellular signaling xref , xref and that PtpA has a broader global effect on host cell signaling proteins. xref , xref , xref This, together with the promising properties of host kinase inhibitors as modulators of Mtb intracellular growth, xref , xref merits screening libraries of signaling inhibitors to identify associated cellular pathways that can be exploited as HDTs in the fight against TB."
39175770
MYH9 affects EIF3H
| 6
EIF3H binds MYH9. 6 / 6
| 6
sparser
"Driver_plot visualizes supporting SV and CNV profile in the HCC1395BL sample for driver fusion gene “MYH9-EIF3H”."
35113898
sparser
"Driver_domain plots domain information of the driver fusion gene “MYH9-EIF3H”."
35113898
sparser
"Driver_result reports the “MYH9-EIF3H” fusion gene as a driver for the HCC1395BL sample."
35113898
sparser
"In the case of the breast cancer dataset, DriverFuse reports the “MYH9-EIF3H” fusion gene as a driver for the HCC1395BL sample."
35113898
sparser
"Driver_object reports SV and CNV profile in the HCC1395BL sample responsible for the formation of driver fusion gene “MYH9-EIF3H”."
35113898
sparser
"Driver_correlation_coefficient calculates the correlation coefficient of the input fusion gene “MYH9-EIF3H” in the HCC1395BL sample."
35113898
EIF3H affects V ATPase I
| 6
sparser
"By contrast, the experiments of V-ATPase activity and interaction with subunit H were conducted in vitro , where the compounds form direct contact with proteins."
26999207
sparser
"Mtb PtpA can prevent phagosome-lysosome fusion by dephosphorylating host protein VPS33B, and prevent phagosome acidification by binding to subunit H of the macrophage V-ATPase complex to block V-ATPase trafficking xref , xref ."
28811474
sparser
"Following this study, PtpA was also found to bind subunit H of the V-ATPase complex during infection [5] ."
23084287
sparser
"Although the function of these importin domains is not known, it has been suggested that they might mediate the interaction of subunit H with other V-ATPase subunits or with other cellular proteins ou[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12788495
sparser
"Characterization of the Binding Interaction between JW-3 and the Subunit H of V-ATPase by Isothermal Titration Calorimetry Measurements."
29019960
sparser
"One of these strategies is the secretion of protein effectors that disrupt the macrophage’s innate antimicrobial defenses, such as protein-tyrosine phosphatase A (PtpA). xref , xref PtpA blocks phagosomal acidification and maturation by binding to subunit H of the macrophage V-ATPase complex and dephosphorylating VPS33B of the class C VPS macrophage complex. xref , xref Recent studies show that Mtb modulates host intracellular signaling xref , xref and that PtpA has a broader global effect on host cell signaling proteins. xref , xref , xref This, together with the promising properties of host kinase inhibitors as modulators of Mtb intracellular growth, xref , xref merits screening libraries of signaling inhibitors to identify associated cellular pathways that can be exploited as HDTs in the fight against TB."
39175770
EIF3H affects Neoplasms
| 6
EIF3H activates Neoplasms. 6 / 6
| 6
reach
"We analyzed change in mRNA level of Eif3h from datasets of colon tumors isolated from Apc and AOM-treated mice (GSE5204), and found that Eif3h mRNA level was elevated in tumors of Apc and AOM-induced mice compared with normal mice colon tissues (Supplementary Fig. 8a)."
38514606
reach
"Therefore, targeting HAX1 may also attenuate the activation of RAF.In the orthotopic CRC model, EIF3H knockdown decreases orthotopic tumor growth, and attenuates liver and lung metastasis, while HAX1 can rescue these phenomena under EIF3H knockdown."
38514606
reach
"In some of the earliest studies of advanced PCa, researchers found that upregulated eIF3S3 gene expression was a common phenomenon, suggesting that eIF3S3 overexpression promoted tumor growth (55–57)."
35856412
reach
"EIF3H can enhance protein synthesis and promote tumor progression, especially promote the translation of certain oncogenes ."
38514606
reach
"The results illustrated that EIF3H depletion by lentivirus-based shRNA suppressed the HCC tumor growth markedly (Fig. 4G, H)."
37559097
reach
"While our study focused on EIF3H‐YAP interactions, future investigations should also explore whether EIF3H‐mediated OGT stabilization contributes to YAP regulation and obesity‐driven tumor progression.3.3 Retatrutide: A Metabolic Drug's Potential in Reversing Chemoresistance in TNBC."
39868848
EIF3H affects MYH9
| 6
EIF3H binds MYH9. 6 / 6
| 6
sparser
"Driver_plot visualizes supporting SV and CNV profile in the HCC1395BL sample for driver fusion gene “MYH9-EIF3H”."
35113898
sparser
"Driver_domain plots domain information of the driver fusion gene “MYH9-EIF3H”."
35113898
sparser
"Driver_result reports the “MYH9-EIF3H” fusion gene as a driver for the HCC1395BL sample."
35113898
sparser
"In the case of the breast cancer dataset, DriverFuse reports the “MYH9-EIF3H” fusion gene as a driver for the HCC1395BL sample."
35113898
sparser
"Driver_object reports SV and CNV profile in the HCC1395BL sample responsible for the formation of driver fusion gene “MYH9-EIF3H”."
35113898
sparser
"Driver_correlation_coefficient calculates the correlation coefficient of the input fusion gene “MYH9-EIF3H” in the HCC1395BL sample."
35113898
EIF3H affects MYC
1 | 4 1
EIF3H inhibits MYC.
| 4
EIF3H inhibits MYC. 4 / 4
| 4
reach
"Overexpression of eIF3h has recently been shown to inhibit Myc dependent induction of apoptosis of primary prostate cells and EIF3H and MYC and may cooperate in enhanced protein translation either in a general way or for a specific subset of mRNAs XREF_BIBR."
20862326
reach
"XREF_BIBR Coamplification of EIF3H may also reduce MYC dependent apoptosis in prostate epithelial cells."
19204574
reach
"Furthermore, overexpressed eIF3h inhibits Myc dependent induction of apoptosis of primary prostate cells."
18544531
reach
"However, it was recently reported that overexpression of EIF3H inhibited Myc dependent induction of apoptosis in primary prostate cells, which suggests that EIF3H and MYC may cooperate to enhance protein translation [38]."
30022709
EIF3H binds MYC.
1 | 1
MYC binds EIF3H. 2 / 2
1 | 1
sparser
"Among patients with amplification of both HER2 and MYC , the addition of trastuzumab to chemotherapy reduced the risk of cancer recurrence by 76% and reduced the risk of death by 64%, while in individuals with HER2 amplification alone the addition of trastuzumab to chemotherapy did not reduce the risk of death. xref In our study, we observed that both MYC and EIF3H were associated with a better outcome after gefitinib therapy, and among EGFR+ patients (FISH+ and/or mutated), only individuals with increased MYC/EIF3H gene copy number had a significant tumor shrinkage."
19204574
biogrid
No evidence text available
36424410
EIF3H affects EIF3CL
6 |
EIF3H binds EIF3CL. 6 / 6
6 |
biogrid
No evidence text available
30021884
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
37071682
biogrid
No evidence text available
26344197
EIF3H affects Carcinogenesis
| 6
reach
"Conditional Eif3h deletion suppresses colorectal tumorigenesis in AOM/DSS model."
38514606
reach
"Taken together, these data suggest that EIF3H deletion attenuates colitis-induced colorectal tumorigenesis."
38514606
reach
"EIF3H/HAX1 axis promotes CRC tumorigenesis and metastasis in mouse orthotopic cancer model."
38514606
reach
"EIF3H promotes CRC tumorigenesis/metastasis via HAX1 in an orthotopic CRC model."
38514606
reach
"Further, EIF3H promotes CRC tumorigenesis and metastasis via HAX1 activity in mouse model."
38514606
reach
"Taken together, these results suggest that EIF3H/HAX1 axis promotes CRC tumorigenesis and metastasis."
38514606
EIF3H affects CB
| 6
CB binds EIF3H. 4 / 4
| 4
sparser
"Also, through YTH assay, we showed that the SH3 domain of CB is not required for interaction with eIF3H. Interaction of CB and eIF3H was further substantiated by coimmunoprecipitation of transiently expressed proteins in 293T cells."
20858277
sparser
"To investigate whether CB and eIF3H associate in a mammalian cell context, coimmunoprecipitation assays were carried out."
20858277
sparser
"These results demonstrate that CB interacts with eIF3H in mammalian cells."
20858277
sparser
"Yeast-two-hybrid assay using the human CB lacking the SH3 domain (bait protein GAL4BD-CB SH3- ) showed that this truncated form of CB can also interact with eIF3H, indicating that this domain is not required to mediate the interaction with eIF3H (Figure xref )."
20858277
CB binds GPHN and EIF3H. 2 / 2
| 2
sparser
"Although we cannot rule out the possibility that these results are due to the formation of two independent protein complexes, CB-gephyrin and gephyrin-eIF3H, they suggest that these interactions are not mutually exclusive (as both could potentially form at the same time), and raise the possibility that CB, gephyrin and eIF3H can form a trimeric protein complex in mammalian cells."
20858277
sparser
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
EIF3F affects EIF3E
| 6
EIF3F binds EIF3E and EIF3H. 5 / 5
| 5
sparser
"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
sparser
"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
sparser
"A polysome mRNA analysis on HeLa, HEK293 and NIH3T3 cells has revealed that eIF3e, eIF3f and eIF3h mRNAs are mainly associated with subpolysomal particles in quiescent or growth-arrested cells, but mostly associated with polysomes in growing cells [ xref ]."
23354061
sparser
"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
sparser
"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."
20444226
EIF3D binds EIF3E, EIF3F, EIF3H, and EIF3L. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3CL affects EIF3H
6 |
EIF3H binds EIF3CL. 6 / 6
6 |
biogrid
No evidence text available
30021884
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
biogrid
No evidence text available
37071682
biogrid
No evidence text available
26344197
CCT_complex affects EIF3H
| 5 1
CCT_complex activates EIF3H.
| 5
CCT_complex activates EIF3H. 5 / 5
| 5
reach
"58 In addition, CCT mediates the correct folding and translation activity of two subunits of the translation initiation factors eIF3i and eIF3h."
38363102
reach
"Moreover, CCT binds to newly synthesized eukaryotic initiation factor 3 (eIF3b) and promotes the correct folding of eIF3h and eIF3i subunits [31,32]."
39457028
reach
"Chaperonin containing TCP-1 (tail-less complex polypeptide 1) (CCT) can interact with newly synthesized eIF3b and promotes the accurate folding of eIF3h and eIF3i 27."
30416377
reach
"CCT effectively promotes the correct folding of eIF3h and eIF3i by binding to newly synthesized eIF3b."
38596045
reach
"In the present study, we show that the eukaryotic cytosolic chaperonin CCT [chaperonin containing TCP-1 (tailless complex polypeptide 1)] binds to newly synthesized eIF3b and promotes the correct folding of eIF3h and eIF3i."
24320561
CCT_complex binds EIF3H.
| 1
CCT_complex binds EIF3H. 1 / 1
| 1
sparser
"We also identified eIF3h as a regulator of dendrite development ( xref ), although how CCT interacts with eIF3h in dendrites awaits further study."
33100975
CB affects EIF3H
| 6
CB binds EIF3H. 4 / 4
| 4
sparser
"Also, through YTH assay, we showed that the SH3 domain of CB is not required for interaction with eIF3H. Interaction of CB and eIF3H was further substantiated by coimmunoprecipitation of transiently expressed proteins in 293T cells."
20858277
sparser
"To investigate whether CB and eIF3H associate in a mammalian cell context, coimmunoprecipitation assays were carried out."
20858277
sparser
"These results demonstrate that CB interacts with eIF3H in mammalian cells."
20858277
sparser
"Yeast-two-hybrid assay using the human CB lacking the SH3 domain (bait protein GAL4BD-CB SH3- ) showed that this truncated form of CB can also interact with eIF3H, indicating that this domain is not required to mediate the interaction with eIF3H (Figure xref )."
20858277
CB binds GPHN and EIF3H. 2 / 2
| 2
sparser
"Although we cannot rule out the possibility that these results are due to the formation of two independent protein complexes, CB-gephyrin and gephyrin-eIF3H, they suggest that these interactions are not mutually exclusive (as both could potentially form at the same time), and raise the possibility that CB, gephyrin and eIF3H can form a trimeric protein complex in mammalian cells."
20858277
sparser
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
Rep affects EIF3H
5 |
Rep binds EIF3H. 4 / 4
4 |
biogrid
No evidence text available
32680882
biogrid
No evidence text available
36180527
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
34597346
Rep binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
33060197
RPL24 affects EIF3H
| 3 2
EIF3H binds RPL24. 5 / 5
| 3 2
reach
"However, the precise role of Rpl24 and eL24 and the molecular details of the functional interaction between eIF3h and Rpl24 and eL24 are unknown."
29281028
reach
"The mode of interaction between eIF3h and RPL24 could be physically direct or indirect, or they may act independently."
20799971
reach
"An indirect interaction between RPL24 and eIF3h would occur if eIF3 was attached to an 80S ribosome."
20799971
sparser
"The mode of interaction between eIF3h and RPL24 could be physically direct or indirect, or they may act independently."
20799971
sparser
"An indirect interaction between RPL24 and eIF3h would occur if eIF3 was attached to an 80S ribosome."
20799971
EIF3H affects rep
5 |
Rep binds EIF3H. 4 / 4
4 |
biogrid
No evidence text available
32680882
biogrid
No evidence text available
36180527
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
34597346
Rep binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
33060197
EIF3H affects RPL24
| 3 2
EIF3H binds RPL24. 5 / 5
| 3 2
reach
"However, the precise role of Rpl24 and eL24 and the molecular details of the functional interaction between eIF3h and Rpl24 and eL24 are unknown."
29281028
reach
"The mode of interaction between eIF3h and RPL24 could be physically direct or indirect, or they may act independently."
20799971
reach
"An indirect interaction between RPL24 and eIF3h would occur if eIF3 was attached to an 80S ribosome."
20799971
sparser
"The mode of interaction between eIF3h and RPL24 could be physically direct or indirect, or they may act independently."
20799971
sparser
"An indirect interaction between RPL24 and eIF3h would occur if eIF3 was attached to an 80S ribosome."
20799971
EIF3H affects PDCD4
1 | 1 2 1
EIF3H binds PDCD4. 5 / 5
1 | 1 2 1
trips
"EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis."
32064160
sparser
"Co-immunoprecipitation assays combined with mass spectrometry and immunofluorescent co-localization indicated that PDCD4 interacted with EIF3H. Overexpression of PDCD4 in LUAD cells reduced EIF3H mRNA and protein levels by suppressing c-Jun-induced EIF3H transcription."
32064160
reach
"EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis."
32064160
reach
"Co-immunoprecipitation assays combined with mass spectrometry and immunofluorescent co-localization indicated that PDCD4 interacted with EIF3H."
32064160
biogrid
No evidence text available
26344197
EIF3H affects CSNK2A2
5 |
EIF3H binds CSNK2A2. 5 / 5
5 |
biogrid
No evidence text available
32707033
biogrid
No evidence text available
35271311
biogrid
No evidence text available
19615732
biogrid
No evidence text available
36736316
biogrid
No evidence text available
35831314
EIF3H affects CSNK2A1
5 |
EIF3H binds CSNK2A1. 5 / 5
5 |
biogrid
No evidence text available
36736316
biogrid
No evidence text available
32707033
biogrid
No evidence text available
19615732
biogrid
No evidence text available
35271311
biogrid
No evidence text available
26344197
EIF3H affects CRC
| 4 1
EIF3H activates CRC.
| 4
EIF3H activates CRC. 4 / 4
| 4
reach
"Taken together, these data suggest that EIF3H interacts with HAX1.To further determine whether HAX1 was a potential substrate that mediated EIF3H-promoted CRC progression, we first checked whether EIF3H could regulate HAX1 abundance."
38514606
reach
"Taken together, these results suggest that EIF3H/HAX1 axis promotes CRC tumorigenesis and metastasis."
38514606
reach
"Pittman ( Pittman et al., 2010 ) showed that increasing of eIF3h stimulates CRC growth which seems to be due to amplification of the 8q23 region."
29908282
reach
"EIF3H/HAX1 axis promotes CRC tumorigenesis and metastasis in mouse orthotopic cancer model."
38514606
EIF3H phosphorylates CRC.
| 1
EIF3H phosphorylates CRC. 1 / 1
| 1
sparser
"Given that activation of Wnt/β-catenin signaling induced EIF3H expression and that EIF3H-HAX1 enhanced phosphorylation of ERK1/2 in CRC, we next investigated whether combined targeting Wnt and RAF1-ERK1/2 signaling synergistically inhibited CRC cell growth."
38514606
EIF3H affects AteIF3f
| 5
AteIF3f binds EIF3H. 5 / 5
| 5
reach
"Co-expression of these bait and target constructs showed that AteIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast (XREF_FIG)."
20444226
reach
"This result shows that AteIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
reach
"Our results show that AteIF3f interacts with eIF3h."
20444226
reach
"In this study, we demonstrated that AteIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
reach
"We also demonstrated that AteIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
EIF3H affects ABI3
4 1 |
EIF3H binds ABI3. 5 / 5
4 1 |
biogrid
No evidence text available
25416956
biogrid
No evidence text available
16189514
biogrid
No evidence text available
32296183
biogrid
No evidence text available
19060904
hprd
No evidence text available
16189514
EIF3E affects EIF3F, and EIF3H
| 5
EIF3F binds EIF3E and EIF3H. 5 / 5
| 5
sparser
"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
sparser
"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
sparser
"A polysome mRNA analysis on HeLa, HEK293 and NIH3T3 cells has revealed that eIF3e, eIF3f and eIF3h mRNAs are mainly associated with subpolysomal particles in quiescent or growth-arrested cells, but mostly associated with polysomes in growing cells [ xref ]."
23354061
sparser
"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
sparser
"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."
20444226
CSNK2A2 affects EIF3H
5 |
EIF3H binds CSNK2A2. 5 / 5
5 |
biogrid
No evidence text available
32707033
biogrid
No evidence text available
35271311
biogrid
No evidence text available
19615732
biogrid
No evidence text available
36736316
biogrid
No evidence text available
35831314
CSNK2A1 affects EIF3H
5 |
EIF3H binds CSNK2A1. 5 / 5
5 |
biogrid
No evidence text available
36736316
biogrid
No evidence text available
32707033
biogrid
No evidence text available
19615732
biogrid
No evidence text available
35271311
biogrid
No evidence text available
26344197
CGREF1 affects EIF3H
| 5
CGREF1 increases the amount of EIF3H.
| 3
CGREF1 increases the amount of EIF3H. 3 / 3
| 3
reach
"Our results indicated that overexpression of CGREF1 led to a significant increase in EIF3H expression levels, and knockdown of CGREF1 resulted in down-regulation of EIF3H (Fig. 4E)."
40069645
reach
"CGREF1 positively regulates the expression of EIF3H in HCC cells."
40069645
reach
"We have not yet fully elucidated the mechanisms by which CGREF1 upregulates the expression of EIF3H."
40069645
CGREF1 activates EIF3H.
| 2
CGREF1 activates EIF3H. 2 / 2
| 2
reach
"These findings suggested that CGREF1 could activate the Wnt/β-Catenin pathway through upregulating EIF3H."
40069645
reach
"In conclusion, we found that CGREF1 activates the Wnt/β-catenin signaling by upregulating EIF3H in HCC."
40069645
AteIF3f affects EIF3H
| 5
AteIF3f binds EIF3H. 5 / 5
| 5
reach
"Co-expression of these bait and target constructs showed that AteIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast (XREF_FIG)."
20444226
reach
"This result shows that AteIF3f interacts with eIF3e and eIF3h in plant cells."
20444226
reach
"Our results show that AteIF3f interacts with eIF3h."
20444226
reach
"In this study, we demonstrated that AteIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."
20444226
reach
"We also demonstrated that AteIF3f interacts with Arabidopsis eIF3e and eIF3h."
20444226
ABI3 affects EIF3H
4 1 |
EIF3H binds ABI3. 5 / 5
4 1 |
biogrid
No evidence text available
25416956
biogrid
No evidence text available
16189514
biogrid
No evidence text available
32296183
biogrid
No evidence text available
19060904
hprd
No evidence text available
16189514
TOR affects EIF3H
| 1 3
TOR phosphorylates EIF3H.
| 1 1
TOR phosphorylates EIF3H. 2 / 2
| 1 1
reach
"The loading of the translation initiation factor eIF3h into polysomes in response to auxin is impaired in TOR deficient mutants with an inactive S6K form, suggesting that eIF3h is possibly phosphorylated by the TOR and S6K1 pathway."
28491073
sparser
"When TOR is inactive, S6K1 binds to eIF3h; when TOR is activated by auxin, TOR binds to and phosphorylates eIF3h."
37437121
TOR binds EIF3H.
| 2
TOR binds EIF3H. 2 / 2
| 2
sparser
"When TOR is inactive, S6K1 binds to eIF3h; when TOR is activated by auxin, TOR binds to and phosphorylates eIF3h."
37437121
sparser
"Furthermore, the TOR–eIF3h complex is bound to polysomes, which is important for the re-initiation of uORF-containing mRNAs, including that of ARF s and bZIP11 ."
37437121
PRRC2B affects EIF3H
4 |
EIF3H binds PRRC2B. 4 / 4
4 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
N affects EIF3H
2 2 |
N binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
38043095
EIF3H binds N. 2 / 2
2 |
virhostnet
No evidence text available
17686838
virhostnet
No evidence text available
17686838
EIF4G1 affects EIF3H
4 |
EIF3H binds EIF4G1. 4 / 4
4 |
biogrid
No evidence text available
24981860
biogrid
No evidence text available
32269044
biogrid
No evidence text available
19615732
biogrid
No evidence text available
24248602
reach
"We observed that disruption of EIF3H by RNA interference results in attenuation of EMT as indicated by upregulation of E-cadherin and suppression of vimentin as well as fibronectin, while elevation of EIF3H significantly enhances EMT phenotypes in breast cancer cells with dramatic alteration of morphology, loss of E-cadherin and accumulation of vimentin as well as fibronectin (XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."
32269044
eidos
"We observed that disruption of EIF3H by RNA interference results in attenuation of EMT as indicated by upregulation of E-cadherin and suppression of vimentin as well as fibronectin , while elevation of EIF3H significantly enhances EMT phenotypes in breast cancer cells with dramatic alteration of morphology , loss of E-cadherin and accumulation of vimentin as well as fibronectin ( Fig. S1G-J ) ."
32269044
reach
"A recent publication in lung adenocarcinoma demonstrated that EIF3H overexpression could also induce EMT signaling pathway [XREF_BIBR]."
32867821
EIF3H inhibits epithelial to mesenchymal transition. 1 / 1
| 1
reach
"Knockdown of EIF3H inhibits the EMT process and cell mobility induced by Snail."
32867821
EIF3H affects cell migration
| 4
EIF3H activates cell migration.
| 3
EIF3H activates cell migration. 3 / 3
| 3
reach
"Functional analyses showed that EIF3H overexpression promoted LUAD cell migration and invasion in vitro as well as metastasis in nude mice by activating epithelial-mesenchymal transition (EMT) signaling."
32064160
reach
"The outcomes of Transwell assay demonstrated that knockdown of EIF3H could significantly decrease the cell migration ability of A375 and SK-MEL-28 ( P < 0.001, Fig. 4 A)."
33508274
reach
"Moreover, transwell assays showed that the depletion of EIF3H decreased cell migration capacity (Fig. 4F)."
37559097
EIF3H inhibits cell migration.
| 1
EIF3H inhibits cell migration. 1 / 1
| 1
reach
"Furthermore, the loss-of-function assays demonstrated that knockdown of EIF3H could inhibit the progression of pancreatic cancer cells by reducing proliferation capacity, promoting apoptosis, arresting cell cycle in G2 and suppressing cell migration."
35809300
EIF3H affects Wnt/β-catenin
| 4
EIF3H activates Wnt/β-catenin. 4 / 4
| 4
reach
"For instance, EIF3H can activate the Wnt/β-catenin signaling pathway in cholangiocarcinoma [19]."
40069645
reach
"Meanwhile, inhibition of EIF3H expression suppressed the activation of the Wnt/β-catenin signaling pathway."
40069645
reach
"Therefore, we propose that EIF3H can activate the Wnt/β-catenin signaling in HCC, possibly in a manner consistent with that in cholangiocarcinoma."
40069645
reach
"We found that EIF3H was positively correlated with β-catenin, and the knockdown of EIF3H deactivated the Wnt/β-catenin signaling pathway in ATC."
39984062
EIF3H affects PRRC2B
4 |
EIF3H binds PRRC2B. 4 / 4
4 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
biogrid
No evidence text available
26186194
EIF3H affects N
2 2 |
N binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
38043095
EIF3H binds N. 2 / 2
2 |
virhostnet
No evidence text available
17686838
virhostnet
No evidence text available
17686838
EIF3H affects EIF4G1
4 |
EIF3H binds EIF4G1. 4 / 4
4 |
biogrid
No evidence text available
24981860
biogrid
No evidence text available
32269044
biogrid
No evidence text available
19615732
biogrid
No evidence text available
24248602
EIF3H affects DTrc8
| 4
EIF3H binds DTrc8.
| 3
DTrc8 binds EIF3H. 3 / 3
| 3
reach
"In fact, interactions between DTrc8 and eIF3f or eIF3h were stronger than observed with Csn5."
20068067
reach
"DTrc8 genetically and physicially interacted with two eIF3 subunits, eIF3f and eIF3h."
20068067
reach
"In vitro GST-pulldown experiments confirmed that DTrc8 specifically interacted with eIF3f and eIF3h in addition to Csn5 (XREF_FIG)."
20068067
EIF3H inhibits DTrc8.
| 1
EIF3H inhibits DTrc8. 1 / 1
| 1
reach
"Because downregulation of eIF3f or eIF3h suppresses DTrc8 induced growth inhibition in flies, we suspect these components form a bridge by which TRC8 affects its targets."
20068067
EIF3H affects DISC1
3 1 |
DISC1 binds EIF3H. 4 / 4
3 1 |
biogrid
No evidence text available
12812986
biogrid
No evidence text available
12812986
hprd
No evidence text available
12812986
biogrid
No evidence text available
17043677
reach
"These results suggested that EIF3H promoted hepatocellular carcinoma cell proliferation via the regulation of OGT."
37559097
reach
"The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT [17]."
39715739
reach
"EIF3h is elevated in breast, prostate, NSCLC, hepatocellular carcinoma as well as promoting the malignant transformation of immortalized NIH 3T3 cells ( Wu, 2013 )."
29908282
reach
"The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis."
37559097
DISC1 affects EIF3H
3 1 |
DISC1 binds EIF3H. 4 / 4
3 1 |
biogrid
No evidence text available
12812986
biogrid
No evidence text available
12812986
hprd
No evidence text available
12812986
biogrid
No evidence text available
17043677
Methyltransferase-like affects EIF3H
| 3
Methyltransferase-like binds EIF3H. 3 / 3
| 3
sparser
"Exosomal circLPAR1 and methyltransferase-like 3 (METTL3) competitively bind RBP eIF3h, effectively reducing the translation of brominated protein 4 (BRD4) and subsequently inhibiting the proliferation, invasion, and migration of colorectal cancer cells ( xref )."
37168995
sparser
"They demonstrated that circLPAR1 encapsulated in exosomes could be internalized by colorectal cancer cells, and further suppressed tumour growth by directly bound with eukaryotic translation initiation factor 3 subunit h (eIF3h), suppressing the methyltransferase-like 3 (METTL3)-eIF3h interaction and decreasing the translation of oncogene bromodomain containing 4 [ xref ]."
38711144
sparser
"Mechanistically, circLPAR1 diminishes expression of the oncogene bromodomain-containing protein 4 ( BRD4 ) by sponging eukaryotic translation initiation factor 3 subunit h (eIF3h) and preventing the interaction between methyltransferase-like 3 (METTL3) and eIF3h [ xref ]."
38741166
Gag-pol affects EIF3H
3 |
Gag-pol binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
22190034
biogrid
No evidence text available
20016921
biogrid
No evidence text available
20016921
Benzo[a]pyrene affects EIF3H
3 |
Benzo[a]pyrene increases the amount of EIF3H. 3 / 3
3 |
ctd
No evidence text available
21839799
ctd
No evidence text available
35678645
ctd
No evidence text available
22228805
RSPH9 affects EIF3H
3 |
RSPH9 binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
RNF139 affects EIF3H
| 1 2
RNF139 binds EIF3F and EIF3H. 2 / 2
| 2
sparser
"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."
20068067
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
23354061
EIF3H binds RNF139. 1 / 1
| 1
reach
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [XREF_BIBR], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [XREF_BIBR]."
23354061
PRKN affects EIF3H
3 |
PRKN binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
35256949
biogrid
No evidence text available
35987950
biogrid
No evidence text available
32929329
HERC2 affects EIF3H
3 |
HERC2 binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
25476789
biogrid
No evidence text available
30279242
biogrid
No evidence text available
25476789
EIF4A2 affects EIF3H
3 |
EIF4A2 binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
17353931
biogrid
No evidence text available
24981860
biogrid
No evidence text available
29395067
EIF3H activates signal transduction. 3 / 3
| 3
reach
"We found that EIF3H was positively correlated with β-catenin, and the knockdown of EIF3H deactivated the Wnt/β-catenin signaling pathway in ATC."
39984062
reach
"Meanwhile, inhibition of EIF3H expression suppressed the activation of the Wnt/β-catenin signaling pathway."
40069645
reach
"For instance, EIF3H can activate the Wnt/β-catenin signaling pathway in cholangiocarcinoma [19]."
40069645
EIF3H affects methyltransferase-like
| 3
Methyltransferase-like binds EIF3H. 3 / 3
| 3
sparser
"Exosomal circLPAR1 and methyltransferase-like 3 (METTL3) competitively bind RBP eIF3h, effectively reducing the translation of brominated protein 4 (BRD4) and subsequently inhibiting the proliferation, invasion, and migration of colorectal cancer cells ( xref )."
37168995
sparser
"They demonstrated that circLPAR1 encapsulated in exosomes could be internalized by colorectal cancer cells, and further suppressed tumour growth by directly bound with eukaryotic translation initiation factor 3 subunit h (eIF3h), suppressing the methyltransferase-like 3 (METTL3)-eIF3h interaction and decreasing the translation of oncogene bromodomain containing 4 [ xref ]."
38711144
sparser
"Mechanistically, circLPAR1 diminishes expression of the oncogene bromodomain-containing protein 4 ( BRD4 ) by sponging eukaryotic translation initiation factor 3 subunit h (eIF3h) and preventing the interaction between methyltransferase-like 3 (METTL3) and eIF3h [ xref ]."
38741166
EIF3H affects hydrolysis
| 3
EIF3H inhibits hydrolysis. 3 / 3
| 3
sparser
"Subunit H of the vacuolar (H+) ATPase inhibits ATP hydrolysis by the free V1 domain by interaction with the rotary subunit F."
18156183
sparser
"275, 21761-21767) showed that subunit H (part of the stator) inhibits ATP hydrolysis by free V1."
18156183
sparser
"Based upon the observed cross-linking between subunit H in the i peripheral stalk and subunit F in the central stalk in isolated V 1 , but not intact V 1 V 0 , it i was proposed that subunit H inhibited ATP hydrolysis by free V 1 by interacting with subunit F in the central rotor and preventing rotation [ xref ]."
26410601
EIF3H affects gag-pol
3 |
Gag-pol binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
22190034
biogrid
No evidence text available
20016921
biogrid
No evidence text available
20016921
EIF3H affects Snail protein
| 3
EIF3H activates Snail protein. 3 / 3
| 3
eidos
"As shown in Fig. 6a , EIF3H expression increased Snail protein level ."
32867821
eidos
"The results exhibited that knockdown of EIF3H inhibited Snail protein level , and upregulated E-cadherin protein , whereas downregulated expression of N-Cadherin and Vimentin ( Fig. 6b ) ."
32867821
eidos
"Results showed that EIF3H obviously upregulated the Snail protein , but did not affect the mRNA level of Snail ( Fig. 5a ) ."
32867821
EIF3H affects RSPH9
3 |
RSPH9 binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
EIF3H affects RNF139
| 1 2
RNF139 binds EIF3F and EIF3H. 2 / 2
| 2
sparser
"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."
20068067
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
23354061
EIF3H binds RNF139. 1 / 1
| 1
reach
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [XREF_BIBR], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [XREF_BIBR]."
23354061
EIF3H affects PRKN
3 |
PRKN binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
35256949
biogrid
No evidence text available
35987950
biogrid
No evidence text available
32929329
EIF3H affects HERC2
3 |
HERC2 binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
25476789
biogrid
No evidence text available
30279242
biogrid
No evidence text available
25476789
EIF3H affects ESCC cells
| 3
EIF3H activates ESCC cells. 3 / 3
| 3
eidos
"* * * P < 0.001 ; NS : not significant EIF3H promotes Snail-mediated EMT in ESCC cells Considering that Snail is a pivotal EMT-related transcription factor [ 45 ] , we investigated the expression of Snail and EMT-related markers in EIF3H overexpression cells ."
32867821
eidos
"In summary , we demonstrated that EIF3H is responsible for tumorigenesis , tumor growth and metastasis of ESCC through stabilizing Snail , thus promoting the EMT phenotype in ESCC cells ."
32867821
eidos
"Collectively , these results indicate that EIF3H could promote Snail-mediated EMT in ESCC cells ."
32867821
EIF3H affects ERK
| 2 1
EIF3H leads to the phosphorylation of ERK. 3 / 3
| 2 1
reach
"Our results show that HAX1 binds to RAF1 directly and EIF3H or HAX1 deletion in CRC cells can reduce the phosphorylation of ERK1/2."
38514606
sparser
"Given that activation of Wnt/β-catenin signaling induced EIF3H expression and that EIF3H-HAX1 enhanced phosphorylation of ERK1/2 in CRC, we next investigated whether combined targeting Wnt and RAF1-ERK1/2 signaling synergistically inhibited CRC cell growth."
38514606
reach
"Mechanistically, EIF3H functions as a deubiquitinase for HAX1 and stabilize it, which in turn enhanced the interaction between RAF1, MEK1 and ERK1, thereby potentiating phosphorylation of ERK1/2 and subsequent growth/metastasis promotion."
38514606
EIF3H affects EIF4A2
3 |
EIF4A2 binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
17353931
biogrid
No evidence text available
24981860
biogrid
No evidence text available
29395067
EIF3H affects EIF3H
| 3
EIF3H inhibits EIF3H.
| 1
EIF3H inhibits EIF3H. 1 / 1
| 1
reach
"Overexpression of eIF3h has recently been shown to inhibit Myc dependent induction of apoptosis of primary prostate cells and EIF3H and MYC and may cooperate in enhanced protein translation either in a general way or for a specific subset of mRNAs XREF_BIBR."
20862326
EIF3H decreases the amount of EIF3H.
| 1
EIF3H decreases the amount of EIF3H. 1 / 1
| 1
reach
"Immunohistochemistry (IHC) staining on orthotopic tumor showed that EIF3H KD led to reduced levels of EIF3H, HAX1 and pERK1/2, and repressed cell proliferation (Ki67 staining), while HAX1 overexpression reversed these impacts caused by EIF3H KD (Fig. 5d)."
38514606
EIF3H activates EIF3H.
| 1
EIF3H activates EIF3H. 1 / 1
| 1
reach
"The expression of EIF3H is upregulated in HCC tissues compared with paired non tumor tissues from the same donor, thus linking upregulation of EIF3H to pathological hepatic changes."
27340783
EIF3H affects DDX3X
3 |
DDX3X binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
29395067
biogrid
No evidence text available
18628297
biogrid
No evidence text available
35831314
EIF3H affects CYTH1
| 3
EIF3H binds CYTH1. 3 / 3
| 3
sparser
"In bulk isoform sequencing, fractions of reads corresponding to fusion isoforms by long and short reads were significantly positively correlated, with specific examples such as CYTH1::EIF3H demonstrating near-perfect correlation."
38464114
sparser
"In concordance with the literature, we detected known fusions in BC cell lines like ACACA::STAC2 in BT-474, ARGEF2::SULF2 in MCF-7, and CYTH1::EIF3H in SK-BR3 [ xref ]."
38391914
sparser
"Seven fusion genes were found with at least three fusion splicing isoforms each, including CYTH1::EIF3H in cell line SKBR3 with five alternatively spliced fusion isoforms with near perfectly positively correlated fusion expression as measured from long or short reads (R=0.997, p=1.9e-4, xref , xref )."
38464114
EIF3A affects EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, and EIF3J
3 |
EIF3J binds EIF3A, EIF3I, EIF3H, EIF3G, EIF3F, EIF3E, EIF3D, EIF3C, and EIF3B. 3 / 3
3 |
hprd
No evidence text available
8995409
hprd
No evidence text available
9822659
hprd
No evidence text available
8995410
DTrc8 affects EIF3H
| 3
DTrc8 binds EIF3H. 3 / 3
| 3
reach
"In fact, interactions between DTrc8 and eIF3f or eIF3h were stronger than observed with Csn5."
20068067
reach
"DTrc8 genetically and physicially interacted with two eIF3 subunits, eIF3f and eIF3h."
20068067
reach
"In vitro GST-pulldown experiments confirmed that DTrc8 specifically interacted with eIF3f and eIF3h in addition to Csn5 (XREF_FIG)."
20068067
DDX3X affects EIF3H
3 |
DDX3X binds EIF3H. 3 / 3
3 |
biogrid
No evidence text available
29395067
biogrid
No evidence text available
18628297
biogrid
No evidence text available
35831314
CYTH1 affects EIF3H
| 3
EIF3H binds CYTH1. 3 / 3
| 3
sparser
"In bulk isoform sequencing, fractions of reads corresponding to fusion isoforms by long and short reads were significantly positively correlated, with specific examples such as CYTH1::EIF3H demonstrating near-perfect correlation."
38464114
sparser
"In concordance with the literature, we detected known fusions in BC cell lines like ACACA::STAC2 in BT-474, ARGEF2::SULF2 in MCF-7, and CYTH1::EIF3H in SK-BR3 [ xref ]."
38391914
sparser
"Seven fusion genes were found with at least three fusion splicing isoforms each, including CYTH1::EIF3H in cell line SKBR3 with five alternatively spliced fusion isoforms with near perfectly positively correlated fusion expression as measured from long or short reads (R=0.997, p=1.9e-4, xref , xref )."
38464114
COE affects EIF3H
| 3
COE decreases the amount of EIF3H. 3 / 3
| 3
reach
"Our results indicate that COE could inhibit the stemness of GCSCs by regulating the expression of PDCD4 and EIF3H."
34802261
reach
"Moreover, western blot and immunohistochemistry (IHC) analysis showed that COE upregulated PDCD4 and downregulated EIF3H expression both in GCSCs and xenografts."
34802261
reach
"The results of previous studies indicated that COE may be able to inhibit the stemness of gastric cancer stem cells (GCSCs) by regulating PDCD4 and EIF3H expression."
34802261
EIF3H binds ATP hydrolysis activity. 3 / 3
| 3
sparser
"The isothermal titration calorimetry results show a substantial interaction between subunit H of compound D with the ATPase enzyme and show highly significant activity with a lower LD 50 value (28.0 µg g −1 ) than celangulin (344.0 µg g −1 ). xref Various p -twerelsulfonamide (E) derivatives containing alkyl N -substituents were found to have a favorable inhibitory effect against the CA IX enzyme with an IC 50 of 94 nM. xref Aliphatic sulfonamido-quaternary ammonium salts (F, G) caused apoptosis by upregulating RhoB. xref "
41280208
sparser
"This is a two step process which involves initial binding to the macrophage H + -ATPase (V-ATPase) through its subunit H [13] ."
25535696
sparser
"The structural similarity suggests how subunit H may interact with the ATPase itself or with other proteins."
11416198
2,3,7,8-tetrachlorodibenzodioxine increases the amount of EIF3H.
2 |
2,3,7,8-tetrachlorodibenzodioxine increases the amount of EIF3H. 2 / 2
2 |
ctd
No evidence text available
34747641
ctd
No evidence text available
17942748
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of EIF3H.
1 |
2,3,7,8-tetrachlorodibenzodioxine decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
21215274
eidos
"We observed , while the elevation of EIF3H drastically increases the tumor invasion in various breast cancer cell lines , including MDA-MB-231 , 4T1 , depletion of EIF3H by RNA interference largely attenuates tumor invasion ( Fig. 1B-F & Fig. S1A-C ) ."
32269044
eidos
"We observed that disruption of EIF3H by RNA interference results in attenuation of EMT as indicated by upregulation of E-cadherin and suppression of vimentin as well as fibronectin , while elevation of EIF3H significantly enhances EMT phenotypes in breast cancer cells with dramatic alteration of morphology , loss of E-cadherin and accumulation of vimentin as well as fibronectin ( Fig. S1G-J ) ."
32269044
Perfluorooctanoic acid increases the amount of EIF3H. 2 / 2
2 |
ctd
No evidence text available
18804290
ctd
No evidence text available
35678645
Hsa-mir-4522 affects EIF3H
2 |
Hsa-mir-4522 decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-mir-3672 affects EIF3H
2 |
Hsa-mir-3672 decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-mir-3609 affects EIF3H
2 |
Hsa-mir-3609 decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-939-3p affects EIF3H
2 |
Hsa-miR-939-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-873-3p affects EIF3H
2 |
Hsa-miR-873-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-6888-3p affects EIF3H
2 |
Hsa-miR-6888-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-6864-3p affects EIF3H
2 |
Hsa-miR-6864-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-6860 affects EIF3H
2 |
Hsa-miR-6860 decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-6849-3p affects EIF3H
2 |
Hsa-miR-6849-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-548ah-5p affects EIF3H
2 |
Hsa-miR-548ah-5p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-520g-3p affects EIF3H
2 |
Hsa-miR-520g-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-5189-5p affects EIF3H
2 |
Hsa-miR-5189-5p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27292025
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3664-5p affects EIF3H
2 |
Hsa-miR-3664-5p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-3187-5p affects EIF3H
2 |
Hsa-miR-3187-5p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-3120-5p affects EIF3H
2 |
Hsa-miR-3120-5p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-3065-5p affects EIF3H
2 |
Hsa-miR-3065-5p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-196a-3p affects EIF3H
2 |
Hsa-miR-196a-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Hsa-miR-1285-3p affects EIF3H
2 |
Hsa-miR-1285-3p decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Doxycycline affects EIF3H
| 2
Doxycycline inhibits EIF3H.
| 1
Doxycycline inhibits EIF3H. 1 / 1
| 1
reach
"Then we performed shRNA-mediated and doxycycline induced EIF3H knockdown (KD) in CRC cells DLD1, HCT116 and RKO, and the knockdown efficiency was confirmed by western blot and qRT-PCR (Supplementary Fig. 3b, c)."
38514606
Doxycycline activates EIF3H.
| 1
Doxycycline activates EIF3H. 1 / 1
| 1
reach
"Appropriated number of DLD1 and HCT116 cells were plated into 96-well plates with/without doxycycline induction of EIF3H KD for 48 h."
38514606
Collybistin affects EIF3H
| 2
EIF3H binds MTOR and collybistin. 1 / 1
| 1
sparser
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron-specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD xref ."
33441873
Collybistin binds GPHN and EIF3H. 1 / 1
| 1
sparser
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
CircLPAR1 affects EIF3H
| 2
CircLPAR1 binds EIF3H. 2 / 2
| 2
reach
"Zheng et al. have reported that circLPAR1 exosomal direct interaction with eIF3h inhibited the METTL3-eIF3h interaction and reduced the translation of the oncogene BRD4 [39]."
38057879
reach
"CircRPN2 accelerated ENO1 degradation and promoted glycolytic reprogramming through the AKT/mTOR pathway, thereby inhibiting HCC aerobic glycolysis and metastasis (35); plasma exosomal circLPAR1 specifically bound to eIF3h and inhibited the METTL3-eIF3h interaction, which reduced the translation of the oncogene BRD4 and inhibited CRC growth (36)."
36698408
Wnt affects EIF3H
| 2
Wnt increases the amount of EIF3H. 2 / 2
| 2
reach
"In addition, activation of Wnt/beta-catenin signaling induces EIF3H expression."
38514606
reach
"Activation of Wnt/beta-catenin signaling induces EIF3H expression in CRC cells."
38514606
UBC affects EIF3H
2 |
UBC binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
16196087
biogrid
No evidence text available
32269044
TP53 affects EIF3H
2 |
TP53 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
29653964
biogrid
No evidence text available
32807901
SSB affects EIF3H
2 |
EIF3H binds SSB. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
32269044
SRP68 affects EIF3H
2 |
EIF3H binds SRP68. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
32269044
SORBS3 affects EIF3H
2 |
EIF3H binds SORBS3. 2 / 2
2 |
biogrid
No evidence text available
25416956
biogrid
No evidence text available
32296183
SERBP1 affects EIF3H
2 |
EIF3H binds SERBP1. 2 / 2
2 |
biogrid
No evidence text available
37223481
biogrid
No evidence text available
32269044
SART3 affects EIF3H
2 |
EIF3H binds SART3. 2 / 2
2 |
biogrid
No evidence text available
37448957
biogrid
No evidence text available
35831314
RNF139 affects EIF3F
| 2
RNF139 binds EIF3F and EIF3H. 2 / 2
| 2
sparser
"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."
20068067
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
23354061
RNA-directed RNA polymerase NS5 affects EIF3H
2 |
RBM39 affects EIF3H
2 |
RBM39 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
28302793
biogrid
No evidence text available
32269044
reach
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
reach
"These results demonstrate that CB interacts with eIF3H in mammalian cells."
20858277
PSMD12 affects EIF3H
2 |
EIF3H binds PSMD12. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
NTS affects EIF3H
| 2
NTS binds EIF3H. 2 / 2
| 2
sparser
"Especially the interaction between V 1 and a NT peptides is interesting as these interactions suggest that binding of cytoplasmic V 1 to V o in the vacuole may be initiated by binding of subunit H to a NT as illustrated in xref ."
23071676
sparser
"In the intact V-ATPase, a NT binds to subunit H, subunit C, and the peripheral stalk subunits E and G. Upon dissociation, these interactions are broken and a NT , which forms part of the stator, binds[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32001091
NPM1 affects EIF3H
2 |
NPM1 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
23402259
biogrid
No evidence text available
35831314
NOX1 affects EIF3H
| 2
NOX1 binds EIF3H. 2 / 2
| 2
sparser
"Proteins from β1 subunit H-NOX (Heme-Nitric oxide and Oxygen) domain of the reduced and oxidized forms of sGC were selected as possible targets and were categorized as signaling proteins [ 21 ]."
34923187
sparser
"The heme moiety of the sGC in its reduced iron (Fe 2+ ) state is bound to the β subunit H-NOX domain through the axial ligand histidine 105 (His 105), building a penta-coordinate hystidyl–heme complex."
32046325
NCK2 affects EIF3H
2 |
NCK2 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
32296183
biogrid
No evidence text available
25416956
NAP1L1 affects EIF3H
2 |
EIF3H binds NAP1L1. 2 / 2
2 |
biogrid
No evidence text available
32269044
biogrid
No evidence text available
26344197
MYC affects EIF3H
1 | 1
MYC binds EIF3H. 2 / 2
1 | 1
sparser
"Among patients with amplification of both HER2 and MYC , the addition of trastuzumab to chemotherapy reduced the risk of cancer recurrence by 76% and reduced the risk of death by 64%, while in individuals with HER2 amplification alone the addition of trastuzumab to chemotherapy did not reduce the risk of death. xref In our study, we observed that both MYC and EIF3H were associated with a better outcome after gefitinib therapy, and among EGFR+ patients (FISH+ and/or mutated), only individuals with increased MYC/EIF3H gene copy number had a significant tumor shrinkage."
19204574
biogrid
No evidence text available
36424410
MTOR affects EIF3H
| 1 1
EIF3H binds MTOR. 1 / 1
| 1
reach
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD 92."
33441873
EIF3H binds MTOR and collybistin. 1 / 1
| 1
sparser
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron-specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD xref ."
33441873
MIR661 affects EIF3H
2 |
MIR661 decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
MIR612 affects EIF3H
2 |
MIR612 decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
MIR520H affects EIF3H
2 |
MIR520H decreases the amount of EIF3H. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
27292025
Itsn2 affects EIF3H
2 |
Itsn2 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
26496610
biogrid
No evidence text available
20360068
ILF3 affects EIF3H
2 |
EIF3H binds ILF3. 2 / 2
2 |
biogrid
No evidence text available
32269044
biogrid
No evidence text available
35271311
HNRNPA2B1 affects EIF3H
| 2
HNRNPA2B1 increases the amount of EIF3H.
| 1
HNRNPA2B1 increases the amount of EIF3H. 1 / 1
| 1
reach
"These data indicated that hnRNP A2B1 promoted the expressions of EIF3H, TPPP3, and DOCK2 and inhibited the expressions of DAPK1, SYT7, and RNF128 in melanoma stem cells."
33509274
HNRNPA2B1 binds EIF3H.
| 1
reach
"The analysis of the eCLIP (cross linking immunoprecipitation) data in the encyclopedia of DNA elements (ENCODE) project (https://www.encodeproject.org) using USCS tool (Gene Interaction) revealed that hnRNP A2B1 interacted with EIF3H, which was consistent with our results."
33509274
GPHN affects CB
| 2
CB binds GPHN and EIF3H. 2 / 2
| 2
sparser
"Although we cannot rule out the possibility that these results are due to the formation of two independent protein complexes, CB-gephyrin and gephyrin-eIF3H, they suggest that these interactions are not mutually exclusive (as both could potentially form at the same time), and raise the possibility that CB, gephyrin and eIF3H can form a trimeric protein complex in mammalian cells."
20858277
sparser
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
GPBP1L1 affects EIF3H
2 |
GPBP1L1 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
Eif3a affects EIF3H
2 |
Eif3a binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
20360068
biogrid
No evidence text available
26496610
EIF6 affects EIF3H
| 2
EIF3H binds EIF6. 2 / 2
| 2
reach
"As shown in XREF_FIG and XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY, we found that the inhibitors for PI3K (LY294002), S6K1 (PF4708671), Src (dasatinib) and mTOR (rapamycin) block EIF3H Ser/Thr phosphorylation, EIF3H-YAP binding and EIF3H governed YAP accumulation but no effect for EIF3H and EIF3A binding."
32269044
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
EIF4G3 affects EIF3H
2 |
EIF3H binds EIF4G3. 2 / 2
2 |
biogrid
No evidence text available
24981860
biogrid
No evidence text available
19615732
EIF4B affects EIF3H
2 |
EIF4B binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
32269044
biogrid
No evidence text available
29228324
EIF4A1 affects EIF3H
2 |
EIF3H binds EIF4A1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
EIF4A affects EIF3H
| 1 1
EIF4A binds EIF3H. 2 / 2
| 1 1
reach
"Of the two RecA domains of eIF4A, the C-terminal domain (CTD) is in close proximity to eIF3l, while the NTD makes contact with eIF3c, eIF3e and eIF3h.The interactions between eIF4A and eIF3h raise many questions."
38287194
sparser
"The interactions between eIF4A and eIF3h raise many questions."
38287194
EIF3J affects EIF3H
2 |
EIF3H binds EIF3J. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
19615732
EIF3H affects glutathione
| 2
EIF3H activates glutathione. 2 / 2
| 2
reach
"Moreover, we also found that the knockdown of EIF3H increased the intracellular concentration of lipid ROS (Fig. 5I, J), ferrous iron (Fig. 5L), and decreased Glutathione (GSH) (Fig. 5K)."
37559097
reach
"In the current study, we demonstrated that the depletion of EIF3H increased the intracellular concentration of lipid ROS, ferrous iron concentration, and decreased GSH, indicating its inhibitory role in ferroptosis."
37559097
EIF3H affects competence
| 2
EIF3H activates competence. 2 / 2
| 2
reach
"In plants, eIF3 non core subunit h (eIF3h) greatly elevates the reinitiation competence of mRNAs coding for the Arabidopsis basic zipper transcription factors (bZIPs) and several ARFs; while the 60S ribosomal protein L24B (RPL24B), which is encoded by SHORT VALVE1, lifts translation of uORF containing mRNAs that encode ARF3 (ETTIN) and ARF5."
28659957
reach
"It was proposed that, by analogy with the function of yeast eIF3a and Tif32 discussed above, eIF3h (specifically its N-terminal part) might support efficient REI by preserving the competence of a fraction of uORF translating ribosomes to resume traversing downstream."
29281028
EIF3H affects collybistin
| 2
EIF3H binds MTOR and collybistin. 1 / 1
| 1
sparser
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron-specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD xref ."
33441873
Collybistin binds GPHN and EIF3H. 1 / 1
| 1
sparser
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
EIF3H affects circLPAR1
| 2
CircLPAR1 binds EIF3H. 2 / 2
| 2
reach
"Zheng et al. have reported that circLPAR1 exosomal direct interaction with eIF3h inhibited the METTL3-eIF3h interaction and reduced the translation of the oncogene BRD4 [39]."
38057879
reach
"CircRPN2 accelerated ENO1 degradation and promoted glycolytic reprogramming through the AKT/mTOR pathway, thereby inhibiting HCC aerobic glycolysis and metastasis (35); plasma exosomal circLPAR1 specifically bound to eIF3h and inhibited the METTL3-eIF3h interaction, which reduced the translation of the oncogene BRD4 and inhibited CRC growth (36)."
36698408
EIF3H affects cell cycle
| 2
EIF3H inhibits cell cycle. 2 / 2
| 2
reach
"Mahmood et al demonstrated that EIF3H knockdown with specific small interfering RNA induced cell cycle arrest and apoptosis in breast tumour cells."
29805516
reach
"Furthermore, the loss-of-function assays demonstrated that knockdown of EIF3H could inhibit the progression of pancreatic cancer cells by reducing proliferation capacity, promoting apoptosis, arresting cell cycle in G2 and suppressing cell migration."
35809300
EIF3H affects UBC
2 |
UBC binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
16196087
biogrid
No evidence text available
32269044
EIF3H affects TP53
2 |
TP53 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
29653964
biogrid
No evidence text available
32807901
EIF3H affects TOR
| 2
TOR binds EIF3H. 2 / 2
| 2
sparser
"When TOR is inactive, S6K1 binds to eIF3h; when TOR is activated by auxin, TOR binds to and phosphorylates eIF3h."
37437121
sparser
"Furthermore, the TOR–eIF3h complex is bound to polysomes, which is important for the re-initiation of uORF-containing mRNAs, including that of ARF s and bZIP11 ."
37437121
EIF3H affects SSB
2 |
EIF3H binds SSB. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
32269044
EIF3H affects SRP68
2 |
EIF3H binds SRP68. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
32269044
EIF3H affects SORBS3
2 |
EIF3H binds SORBS3. 2 / 2
2 |
biogrid
No evidence text available
25416956
biogrid
No evidence text available
32296183
EIF3H affects SERBP1
2 |
EIF3H binds SERBP1. 2 / 2
2 |
biogrid
No evidence text available
37223481
biogrid
No evidence text available
32269044
EIF3H affects SART3
2 |
EIF3H binds SART3. 2 / 2
2 |
biogrid
No evidence text available
37448957
biogrid
No evidence text available
35831314
reach
"In the current study, we demonstrated that the depletion of EIF3H increased the intracellular concentration of lipid ROS, ferrous iron concentration, and decreased GSH, indicating its inhibitory role in ferroptosis."
37559097
reach
"Moreover, we also found that the knockdown of EIF3H increased the intracellular concentration of lipid ROS (Fig. 5I, J), ferrous iron (Fig. 5L), and decreased Glutathione (GSH) (Fig. 5K)."
37559097
EIF3H affects RORC
| 2
RORC binds EIF3H. 2 / 2
| 2
reach
"When TOR is inactive, S6K1 binds to eIF3h; when TOR is activated by auxin, TOR binds to and phosphorylates eIF3h."
37437121
reach
"Furthermore, the TOR–eIF3h complex is bound to polysomes, which is important for the re-initiation of uORF-containing mRNAs, including that of ARFs and bZIP11."
37437121
EIF3H affects RNA-directed RNA polymerase NS5
2 |
EIF3H affects RBM39
2 |
RBM39 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
28302793
biogrid
No evidence text available
32269044
reach
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
reach
"These results demonstrate that CB interacts with eIF3H in mammalian cells."
20858277
EIF3H affects PSMD12
2 |
EIF3H binds PSMD12. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
EIF3H affects NTS
| 2
NTS binds EIF3H. 2 / 2
| 2
sparser
"Especially the interaction between V 1 and a NT peptides is interesting as these interactions suggest that binding of cytoplasmic V 1 to V o in the vacuole may be initiated by binding of subunit H to a NT as illustrated in xref ."
23071676
sparser
"In the intact V-ATPase, a NT binds to subunit H, subunit C, and the peripheral stalk subunits E and G. Upon dissociation, these interactions are broken and a NT , which forms part of the stator, binds[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32001091
EIF3H affects NPM1
2 |
NPM1 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
23402259
biogrid
No evidence text available
35831314
EIF3H affects NOX1
| 2
NOX1 binds EIF3H. 2 / 2
| 2
sparser
"Proteins from β1 subunit H-NOX (Heme-Nitric oxide and Oxygen) domain of the reduced and oxidized forms of sGC were selected as possible targets and were categorized as signaling proteins [ 21 ]."
34923187
sparser
"The heme moiety of the sGC in its reduced iron (Fe 2+ ) state is bound to the β subunit H-NOX domain through the axial ligand histidine 105 (His 105), building a penta-coordinate hystidyl–heme complex."
32046325
EIF3H affects NCK2
2 |
NCK2 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
32296183
biogrid
No evidence text available
25416956
EIF3H affects NAP1L1
2 |
EIF3H binds NAP1L1. 2 / 2
2 |
biogrid
No evidence text available
32269044
biogrid
No evidence text available
26344197
EIF3H affects MTOR
| 1 1
EIF3H binds MTOR. 1 / 1
| 1
reach
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD 92."
33441873
EIF3H binds MTOR and collybistin. 1 / 1
| 1
sparser
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron-specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD xref ."
33441873
EIF3H affects MAPK
| 2
EIF3H activates MAPK. 2 / 2
| 2
reach
"TGF-betaand MAPK pathways are potentially targeted by EIF3H."
27340783
reach
"Zhu and colleagues identified that the transforming growth factor-beta and mitogen activated protein kinase pathways are potentially targeted by EIF3H using microarray analysis."
29805516
EIF3H affects Itsn2
2 |
Itsn2 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
26496610
biogrid
No evidence text available
20360068
EIF3H affects ILF3
2 |
EIF3H binds ILF3. 2 / 2
2 |
biogrid
No evidence text available
32269044
biogrid
No evidence text available
35271311
EIF3H affects GPBP1L1
2 |
GPBP1L1 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
EIF3H affects FN1
| 1 1
EIF3H activates FN1. 2 / 2
| 1 1
reach
"We observed that disruption of EIF3H by RNA interference results in attenuation of EMT as indicated by upregulation of E-cadherin and suppression of vimentin as well as fibronectin, while elevation of EIF3H significantly enhances EMT phenotypes in breast cancer cells with dramatic alteration of morphology, loss of E-cadherin and accumulation of vimentin as well as fibronectin (XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."
32269044
eidos
"We observed that disruption of EIF3H by RNA interference results in attenuation of EMT as indicated by upregulation of E-cadherin and suppression of vimentin as well as fibronectin , while elevation of EIF3H significantly enhances EMT phenotypes in breast cancer cells with dramatic alteration of morphology , loss of E-cadherin and accumulation of vimentin as well as fibronectin ( Fig. S1G-J ) ."
32269044
EIF3H affects Eif3a
2 |
Eif3a binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
20360068
biogrid
No evidence text available
26496610
EIF3H affects EIF6
| 2
EIF3H binds EIF6. 2 / 2
| 2
reach
"As shown in XREF_FIG and XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY, we found that the inhibitors for PI3K (LY294002), S6K1 (PF4708671), Src (dasatinib) and mTOR (rapamycin) block EIF3H Ser/Thr phosphorylation, EIF3H-YAP binding and EIF3H governed YAP accumulation but no effect for EIF3H and EIF3A binding."
32269044
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
EIF3H affects EIF4G3
2 |
EIF3H binds EIF4G3. 2 / 2
2 |
biogrid
No evidence text available
24981860
biogrid
No evidence text available
19615732
EIF3H affects EIF4B
2 |
EIF4B binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
32269044
biogrid
No evidence text available
29228324
EIF3H affects EIF4A1
2 |
EIF3H binds EIF4A1. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
EIF3H affects EIF4A
| 1 1
EIF4A binds EIF3H. 2 / 2
| 1 1
reach
"Of the two RecA domains of eIF4A, the C-terminal domain (CTD) is in close proximity to eIF3l, while the NTD makes contact with eIF3c, eIF3e and eIF3h.The interactions between eIF4A and eIF3h raise many questions."
38287194
sparser
"The interactions between eIF4A and eIF3h raise many questions."
38287194
EIF3H affects EIF3J
2 |
EIF3H binds EIF3J. 2 / 2
2 |
biogrid
No evidence text available
35831314
biogrid
No evidence text available
19615732
EIF3H affects Cell Survival
| 2
reach
"Knockdown of EIF3H could decrease cell viability through both cell cycle arrest and apoptosis induction and inhibited the formation of colonies in anchorage independent conditions in breast cancer cells."
29805516
reach
"The results showed that MYSM1 or EIF3H overexpression decreased cell viability, while PSMD14 overexpression increased cell viability under DOX treatment (Fig. 1C)."
39695708
EIF3H affects CTNNB1
| 2
EIF3H binds CTNNB1.
| 1
EIF3H binds CTNNB1. 1 / 1
| 1
reach
"Further exploration revealed that EIF3H interacted with, deubiquitylated, and stabilized β-catenin by acting as a deubiquitinating enzyme."
39984062
EIF3H activates CTNNB1.
| 1
EIF3H activates CTNNB1. 1 / 1
| 1
reach
"The knockdown of EIF3H could inhibit ATC cell proliferation, invasion, and ferroptosis resistance by regulating β-catenin."
39984062
EIF3H affects CPNE2
2 |
CPNE2 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
EIF3H affects CCDC85B
1 1 |
EIF3H binds CCDC85B. 2 / 2
1 1 |
hprd
No evidence text available
16189514
biogrid
No evidence text available
16189514
EIF3H affects ANLN
2 |
ANLN binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
36526897
biogrid
No evidence text available
31586073
EIF3H affects ABI2
2 |
EIF3H binds ABI2. 2 / 2
2 |
biogrid
No evidence text available
29892012
biogrid
No evidence text available
25416956
EIF3H affects ABCE1
2 |
EIF3H binds ABCE1. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
19615732
EIF3H affects 8
2 |
8 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
38043095
EIF3H affects 6
2 |
6 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
37314180
biogrid
No evidence text available
33766124
EIF3F affects RNF139
| 2
RNF139 binds EIF3F and EIF3H. 2 / 2
| 2
sparser
"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."
20068067
sparser
"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."
23354061
CTNNB1 affects EIF3H
| 2
CTNNB1 binds EIF3H.
| 1
EIF3H binds CTNNB1. 1 / 1
| 1
reach
"Further exploration revealed that EIF3H interacted with, deubiquitylated, and stabilized β-catenin by acting as a deubiquitinating enzyme."
39984062
CTNNB1 activates EIF3H.
| 1
CTNNB1 activates EIF3H. 1 / 1
| 1
reach
"Congruently, overexpression of β-catenin and TCF4 led to the increase of EIF3H mRNA and protein expression (Fig. 6h, i)."
38514606
CPNE2 affects EIF3H
2 |
CPNE2 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
CCDC85B affects EIF3H
1 1 |
EIF3H binds CCDC85B. 2 / 2
1 1 |
hprd
No evidence text available
16189514
biogrid
No evidence text available
16189514
CB affects GPHN
| 2
CB binds GPHN and EIF3H. 2 / 2
| 2
sparser
"Although we cannot rule out the possibility that these results are due to the formation of two independent protein complexes, CB-gephyrin and gephyrin-eIF3H, they suggest that these interactions are not mutually exclusive (as both could potentially form at the same time), and raise the possibility that CB, gephyrin and eIF3H can form a trimeric protein complex in mammalian cells."
20858277
sparser
"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."
20858277
ANLN affects EIF3H
2 |
ANLN binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
36526897
biogrid
No evidence text available
31586073
ABI2 affects EIF3H
2 |
EIF3H binds ABI2. 2 / 2
2 |
biogrid
No evidence text available
29892012
biogrid
No evidence text available
25416956
ABCE1 affects EIF3H
2 |
EIF3H binds ABCE1. 2 / 2
2 |
biogrid
No evidence text available
35271311
biogrid
No evidence text available
19615732
A2B1 affects EIF3H
| 2
A2B1 activates EIF3H. 2 / 2
| 2
reach
"On the other hand, the hnRNP A2B1 overexpression resulted in significant upregulations of TPPP3, EIF3H, and DOCK2 and downregulations of DAPK1, RNF128, and SYT7 in melanoma stem cells."
33509274
reach
"Our findings revealed that the hnRNP A2B1 mediated splicing triggered the upregulation of TPPP3, DOCK2, and EIF3H, and the downregulation of RNF128, DAPK1, and SYT7 in melanoma stem cells, leading to the suppression of apoptosis of cancer stem cells."
33509274
8 affects EIF3H
2 |
8 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
38043095
6 affects EIF3H
2 |
6 binds EIF3H. 2 / 2
2 |
biogrid
No evidence text available
37314180
biogrid
No evidence text available
33766124
5-fluorouracil affects EIF3H
2 |
5-fluorouracil increases the amount of EIF3H. 2 / 2
2 |
ctd
No evidence text available
15585135
ctd
No evidence text available
16803524
4,4'-sulfonyldiphenol increases the amount of EIF3H.
1 |
4,4'-sulfonyldiphenol increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
39298647
4,4'-sulfonyldiphenol decreases the amount of EIF3H.
1 |
4,4'-sulfonyldiphenol decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
36041667
Vorinostat affects EIF3H
| 1
Vorinostat activates EIF3H. 1 / 1
| 1
reach
"Moreover, when eIF3H silenced cells were treated with SAHA, we observed a further reduction in HIF-1alpha expression relative to that seen with either treatment alone (XREF_FIG), suggesting that SAHA and sieIF3H target HIF-1alpha via parallel pathways."
25166596
Vinclozolin affects EIF3H
1 |
Vinclozolin decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
23034163
Sodium arsenite affects EIF3H
1 |
Sodium arsenite decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
30528433
Rs16888589 risk region affects EIF3H
| 1
Rs16888589 risk region binds EIF3H. 1 / 1
| 1
reach
"Thus, the rs16888589 risk region physically interacts with EIF3H."
20862326
Rotenone affects EIF3H
1 |
Rotenone decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
35544339
Pregnenolone 16alpha-carbonitrile increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
28903501
Polyphenol affects EIF3H
1 |
Polyphenol decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
16293270
Pentabrominated diphenyl ether 100 decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
31675489
Nanocage affects EIF3H
| 1
Nanocage activates EIF3H. 1 / 1
| 1
reach
"NanoCAGE data obtained on MCF7 cells supports eIF3H, but not eIF3E or eIF3A mRNAs possessing 5′TOP motifs ( Table 1 , ( Gandin et al., 2016 ))."
29414693
Methyltestosterone decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
29191790
Methylparaben affects EIF3H
1 |
Methylparaben decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
31745603
Methylmercury chloride decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
28001369
Ketone body affects EIF3H
1 |
Ketone body increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
16807920
Hsa-miR-6830-3p affects EIF3H
1 |
Hsa-miR-6830-3p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-5571-5p affects EIF3H
1 |
Hsa-miR-5571-5p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22291592
Hsa-miR-511-5p affects EIF3H
1 |
Hsa-miR-511-5p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4423-3p affects EIF3H
1 |
Hsa-miR-4423-3p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22291592
Hsa-miR-3622a-5p affects EIF3H
1 |
Hsa-miR-3622a-5p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22291592
Hsa-miR-3613-3p affects EIF3H
1 |
Hsa-miR-3613-3p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22291592
Hsa-miR-16-5p affects EIF3H
1 |
Hsa-miR-16-5p decreases the amount of EIF3H. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18668040
Hexabromocyclododecane decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
29177809
Folic acid affects EIF3H
1 |
Folic acid decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
22206623
EL24 affects EIF3H
| 1
EIF3H binds eL24. 1 / 1
| 1
reach
"However, the precise role of Rpl24 and eL24 and the molecular details of the functional interaction between eIF3h and Rpl24 and eL24 are unknown."
29281028
EIF3kl dimer affects EIF3H
| 1
EIF3kl dimer binds EIF3H. 1 / 1
| 1
reach
"Affinity purification of N-terminally tagged eIF3k in the absence of eIF3h (strain DeltaeIF3hk, + N-k) yielded an eIF3kl dimer (XREF_FIG) indicating that eIF3k and l are either pre-assembled as a dimer and interact with eIF3 already containing the h subunit or alternatively the eIF3kl dimer binds to eIF3h and assembles with eIF3 as a trimer."
24250809
Doxorubicin affects EIF3H
1 |
Doxorubicin increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
29803840
Deltamethrin affects EIF3H
1 |
Deltamethrin decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
37019170
Cyclosporin A affects EIF3H
1 |
Cyclosporin A increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
25562108
Collybistin affects MTOR
| 1
EIF3H binds MTOR and collybistin. 1 / 1
| 1
sparser
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron-specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD xref ."
33441873
Collybistin affects GPHN
| 1
Collybistin binds GPHN and EIF3H. 1 / 1
| 1
sparser
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
CircPAR1 affects EIF3H
| 1
CircPAR1 binds EIF3H. 1 / 1
| 1
reach
"In addition, it was found that circPAR1 encapsulated by exosomes could directly bind to eIF3h and inhibit its interaction with METTL3."
37781524
Cas9 affects EIF3H
| 1
Cas9 activates EIF3H. 1 / 1
| 1
reach
"Hap1 cells were genetically modified with a construct encoding S. pyogenes Cas9 protein and guide strand construct targeting exon 1 of eIF3H."
29136179
Cadmium dichloride increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
18804290
Arsenic disulfide affects EIF3H
1 |
Arsenic disulfide increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
33878415
Aristolochic acid A decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
33212167
Antirheumatic drug increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
24449571
All-trans-retinoic acid decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
33167477
ZNF598 affects EIF3H
1 |
ZNF598 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
28685749
ZFP36L2 affects EIF3H
1 |
ZFP36L2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29449217
YTHDF2 affects EIF3H
1 |
EIF3H binds YTHDF2. 1 / 1
1 |
biogrid
No evidence text available
22863883
YTHDF1 affects EIF3H
| 1
YTHDF1 binds EIF3H. 1 / 1
| 1
sparser
"METTL3 phosphorylation assembles in a translational complex with m6A reader proteins YTHDF1 and YTHDF2 and the translation initiation factor subunit eIF3h, possibly forming small mRNA loops [ 163 , 16[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37690652
YBX1 affects EIF3H
1 |
EIF3H binds YBX1. 1 / 1
1 |
biogrid
No evidence text available
32269044
XPO1 affects EIF3H
1 |
XPO1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26673895
WWP2 affects EIF3H
1 |
WWP2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
31048545
WDR48 affects EIF3H
1 |
WDR48 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
19615732
Vehicle Emissions affects EIF3H
1 |
Vehicle Emissions methylates EIF3H. 1 / 1
1 |
ctd
No evidence text available
25560391
VIRMA affects EIF3H
1 |
VIRMA binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29507755
UTP23 affects EIF3H
| 1
UTP23 binds EIF3H. 1 / 1
| 1
sparser
"Top SNPs for the hyperthymic temperament were also involved in chromatin interactions in neural progenitor cells with EIF3S3:UTP23 in GSE87112 database (Supplementary Table S xref )."
34075027
UNK affects EIF3H
1 |
UNK binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
25737280
UBE2H affects EIF3H
1 |
UBE2H binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
38113892
TUFM affects EIF3H
1 |
EIF3H binds TUFM. 1 / 1
1 |
biogrid
No evidence text available
32269044
TRAM2 affects EIF3H
| 1
TRAM2 activates EIF3H. 1 / 1
| 1
reach
"1, TPT1-AS1, PXN-AS1, and AC107464.3 were up-regulated; LINC00922, FENDRR, and AC107375.1 were down-regulated), nine TFs (U2AF1, PTBP1, GTF2F1, NONO, ZNF184, RBFOX2, TARDBP, FUS, and LARP7), one RBP (SRSF1 was up-regulated), two miRNAs (hsa-miR-15b-5p was up-regulated, and hsa-miR-29c-3p was down-regulated) and eight mRNAs (TAB1, CAMKK2, TRAM2, DLL4, and RBBP6 were up-regulated; FRMD4B, PLPP1, and EIF3H were down-regulated)."
38200098
TOPBP1 affects EIF3H
1 |
TOPBP1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
41524403
TOP1 affects EIF3H
1 |
TOP1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
TMEM203 affects EIF3H
1 |
EIF3H binds TMEM203. 1 / 1
1 |
biogrid
No evidence text available
19615732
TIPARP affects EIF3H
1 |
TIPARP binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35439318
TGFB affects EIF3H
| 1
EIF3H binds TGFB. 1 / 1
| 1
sparser
"We tried to explore the interactions between subunit H and TGF-β receptor I through their reported interacted proteins such as μ2 and β2 subunits."
29782852
TCP1 affects EIF3H
1 |
EIF3H binds TCP1. 1 / 1
1 |
biogrid
No evidence text available
35831314
TARDBP affects EIF3H
1 |
TARDBP binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
20020773
TADA2A affects EIF3H
1 |
TADA2A binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
20508642
Snail.EIF3H affects EIF3H
| 1
EIF3H binds Snail.EIF3H. 1 / 1
| 1
isi
"These results revealed the interaction between EIF3H and Snail mediated by the S-P rich domain of Snail.EIF3H interacts with Snail.aVector or EIF3H-Flag plasmid was transfected in HEK293T cells for 24 h. After a 4 h treatment of 10 muM MG132, cell lysate was immunoprecipitated with anti-FLAG M2 beads, and the proteins interact with EIF3H were analyzed by mass spectrometry."
32867821
SYK affects EIF3H
1 |
SYK binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
21472591
SRRM1 affects EIF3H
1 |
SRRM1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
16159877
SRP9 affects EIF3H
1 |
SRP9 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
SRP72 affects EIF3H
1 |
SRP72 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
SRP19 affects EIF3H
1 |
SRP19 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
SRGN affects EIF3H
1 |
SRGN binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
40140646
SPTBN1 affects EIF3H
1 |
SPTBN1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
21866423
SNAP-eIF3H affects EIF3H
| 1
Modified SNAP-eIF3H decreases the amount of EIF3H. 1 / 1
| 1
reach
"Our results suggest that eIF3h content is near a threshold in Hap1 cells, since overexpression of SNAP-eIF3H appears to diminish wild-type eIF3h protein levels and fails to increase the proliferation rate of wild-type cells."
29136179
SLFN11 affects EIF3H
1 |
SLFN11 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
33863777
SLCO1B7 affects EIF3H
1 |
SLCO1B7 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
40355756
SLC6A16 affects EIF3H
1 |
SLC6A16 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
40355756
SLC45A3 affects EIF3H
1 |
SLC45A3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
40355756
SLC39A5 affects EIF3H
1 |
SLC39A5 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
40355756
SLC35G3 affects EIF3H
1 |
SLC35G3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
40355756
SLC25A13 affects EIF3H
1 |
EIF3H binds SLC25A13. 1 / 1
1 |
biogrid
No evidence text available
32269044
SHANK3 affects EIF3H
1 |
SHANK3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
36950384
SFN affects EIF3H
1 |
SFN binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
17361185
SEC24B affects EIF3H
| 1
SEC24B binds EIF3H. 1 / 1
| 1
sparser
"The interaction network showed that FTO interacted with ACTB and PPARG, PRRC2A interacted with SEC24B and EIF3H ( xref C), and there were interactions between m 6 A methylase, demethylase, and the reading protein which jointly regualted the m 6 A modification level ( xref D)."
41096371
S affects EIF3H
1 |
S binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
40593736
Rpl35 affects EIF3H
1 |
Rpl35 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26496610
RT-PCR affects EIF3H
| 1
RT-PCR inhibits EIF3H. 1 / 1
| 1
reach
"We assessed the efficiency of EIF3H knockdown by RT-PCR and westernCONTACT Lin Zhang 18930170167@163.com * These authors contribute equally to this manuscript."
30022709
RRM1 affects EIF3H
1 |
EIF3H binds RRM1. 1 / 1
1 |
biogrid
No evidence text available
35831314
RPSA affects EIF3H
1 |
EIF3H binds RPSA. 1 / 1
1 |
biogrid
No evidence text available
39358380
RPS20 affects EIF3H
1 |
EIF3H binds RPS20. 1 / 1
1 |
biogrid
No evidence text available
22863883
RPS11 affects EIF3H
1 |
RPS11 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
RPL6 affects EIF3H
1 |
EIF3H binds RPL6. 1 / 1
1 |
biogrid
No evidence text available
32867821
RPL5 affects EIF3H
1 |
RPL5 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
RPL4 affects EIF3H
1 |
EIF3H binds RPL4. 1 / 1
1 |
biogrid
No evidence text available
32269044
RPA3 affects EIF3H
1 |
RPA3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
37827155
RPA2 affects EIF3H
1 |
RPA2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
37827155
RPA1 affects EIF3H
1 |
RPA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
37827155
RIGI affects EIF3H
1 |
RIGI binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
32513696
RIBOSOMAL affects EIF3H
| 1
RIBOSOMAL leads to the phosphorylation of EIF3H. 1 / 1
| 1
reach
"Moreover, TOR-mediated phosphorylation of the 40S RIBOSOMAL S6 KINASE 1 (S6K1) triggers phosphorylation of the eukaryotic translation initiation factor 3 subunit h (elF3h) which promotes translation r[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37603910
RFP affects EIF3H
| 1
RFP binds EIF3H. 1 / 1
| 1
sparser
"The data showed that the signal of GFP-tagged OsMTA2 (OsMTA2-GFP) was diffusely distributed in both nucleus and cytoplasm ( xref A) and indeed largely overlapped with eIF3h-RFP signal ( xref A)."
34070794
RECQL4 affects EIF3H
1 |
RECQL4 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29229926
RBM42 affects EIF3H
1 |
RBM42 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
RACK1 affects EIF3H
1 |
RACK1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
RAB5A affects EIF3H
1 |
RAB5A binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
31980649
PSPC1 affects EIF3H
1 |
PSPC1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
PSEN1 affects EIF3H
| 1
EIF3H binds PSEN1. 1 / 1
| 1
sparser
"In comparison with the rat V-ATPase structure ( xref ), our human V-ATPase structure contains the essential subunit H, which interacts extensively with PS-1 and a-NTD ( xref and xref – xref )."
33065002
PPFIA1 affects EIF3H
| 1
PPFIA1 binds EIF3H. 1 / 1
| 1
sparser
"Here, we show that the secreted Mtb protein tyrosine phosphatase (PtpA) binds to subunit H of the macrophage vacuolar-H(+)-ATPase (V-ATPase) machinery, a multisubunit protein complex in the phagosome membrane that drives luminal acidification."
22087003
PEBP1 affects EIF3H
1 |
PEBP1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
31980649
PDZD8 affects EIF3H
1 |
PDZD8 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
PAN2 affects EIF3H
1 |
PAN2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23398456
PABPC1 affects EIF3H
| 1
EIF3H binds PABPC1. 1 / 1
| 1
reach
"Similarly, we found strong statistical associations between EIF3E, EIF3H, and PABPC1, likely due to their chromosomal proximity at 8q23.EIF4G1, EIF4A2, EIF3E, and EIF3H are frequently duplicated or amplified in most TCGA cancer types, particularly in lung squamous cell carcinoma and head & neck squamous cell carcinoma (Fig. 1D and SI Appendix, Figs."
38266053
PA2G4 affects EIF3H
1 |
EIF3H binds PA2G4. 1 / 1
1 |
biogrid
No evidence text available
32269044
ORF10 affects EIF3H
1 |
ORF10 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
37314180
Non-alcoholic Fatty Liver Disease increases the amount of EIF3H. 1 / 1
| 1
reach
"NAFLD liver samples had increased METTL3, METTL15, FTO, and EIF3H (an m6A writer) expression, while WTAP, RBM15, YTHDC1, YTHDC2, IGF2BP2, HNRNPC, and HNRNPA2B1 expression was decreased [171]."
37628704
NUMA1 affects EIF3H
1 |
NUMA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26344197
NTRK1 affects EIF3H
1 |
NTRK1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
25921289
NP_705926 affects EIF3H
1 |
NP_705926 binds EIF3H. 1 / 1
1 |
virhostnet
No evidence text available
22190034
NP affects EIF3H
1 |
EIF3H binds NP. 1 / 1
1 |
virhostnet
No evidence text available
25464832
NCL affects EIF3H
1 |
EIF3H binds NCL. 1 / 1
1 |
biogrid
No evidence text available
32269044
NCB0846 affects EIF3H
| 1
NCB0846 decreases the amount of EIF3H. 1 / 1
| 1
reach
"Treatment with three inhibitors of Wnt/β-catenin signaling, ICG-001, NCB0846 and LGK974, reduced the expression of EIF3H at both mRNA and protein levels in a dose-dependent manner (Fig. 6b, c and Supplementary Fig. 8c) ."
38514606
NCAPH affects EIF3H
1 |
NCAPH binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
NAA38 affects EIF3H
1 |
NAA38 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
33961781
NA affects EIF3H
1 |
EIF3H binds NA. 1 / 1
1 |
virhostnet
No evidence text available
25464832
N-nitrosomorpholine increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
19716841
N-methyl-4-phenylpyridinium decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
26558463
Mesaconitine affects EIF3H
1 |
Mesaconitine increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
37182599
Melanoma affects EIF3H
| 1
reach
"However, the association between EIF3H and MM is still not clear and rarely reported.In this study, clinical specimens and corresponding information were collected for preliminarily revealing the role[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33508274
MeV N protein affects EIF3H
| 1
MeV N protein binds EIF3H. 1 / 1
| 1
reach
"There are several reports of paramyxoviruses blocking canonical translation pathways, including the MeV N protein binding to the eukaryotic initiation factor 3 (eIF3-p40) (Sato et al. 2007), whilst the P and V proteins of simian virus 5 (SV5) limit activation of the double-stranded RNA (dsRNA)-dependent protein kinase (PKR) to limit both host and viral protein translation (Gainey et al. 2008)."
28674944
MTOR affects collybistin
| 1
EIF3H binds MTOR and collybistin. 1 / 1
| 1
sparser
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron-specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD xref ."
33441873
MKI67 affects EIF3H
1 |
MKI67 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26949251
MINDY4 affects EIF3H
1 |
MINDY4 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29795372
METTL3 affects 6 A
| 1
METTL3 binds EIF3H and 6 A. 1 / 1
| 1
reach
"The authors thus proposed a novel " mRNA looping " mechanism, in which METTL3 binds to the m 6 A modified 3 ' UTR of target mRNA and then recruits eIF3h as well as translation initiation factors such as CBP800 and eIF4e, thus facilitating the ribosome recycling and promoting translation efficiency [XREF_BIBR, XREF_BIBR]."
32854717
METAP2 affects EIF3H
1 |
METAP2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
MEPCE affects EIF3H
1 |
MEPCE binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29845934
LTV1 affects EIF3H
1 |
EIF3H binds LTV1. 1 / 1
1 |
biogrid
No evidence text available
32269044
LRRC47 affects EIF3H
1 |
EIF3H binds LRRC47. 1 / 1
1 |
biogrid
No evidence text available
32269044
LNX1 affects EIF3H
1 |
LNX1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29121065
LMNB1 affects EIF3H
1 |
EIF3H binds LMNB1. 1 / 1
1 |
biogrid
No evidence text available
32269044
LIMA1 affects EIF3H
1 |
LIMA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26496610
LGK974 affects EIF3H
| 1
LGK974 decreases the amount of EIF3H. 1 / 1
| 1
reach
"Treatment with three inhibitors of Wnt/β-catenin signaling, ICG-001, NCB0846 and LGK974, reduced the expression of EIF3H at both mRNA and protein levels in a dose-dependent manner (Fig. 6b, c and Supplementary Fig. 8c) ."
38514606
LARP7 affects EIF3H
1 |
LARP7 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29845934
KRT9 affects EIF3H
1 |
EIF3H binds KRT9. 1 / 1
1 |
biogrid
No evidence text available
32269044
KRT18 affects EIF3H
1 |
EIF3H binds KRT18. 1 / 1
1 |
biogrid
No evidence text available
32269044
KRAS affects EIF3H
1 |
KRAS binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
37682707
KLF8 affects EIF3H
1 |
KLF8 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35140242
KLF16 affects EIF3H
1 |
KLF16 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35140242
KIF14 affects EIF3H
1 |
KIF14 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
31586073
KAT6A affects EIF3H
1 |
KAT6A binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
36537216
IGSF8 affects EIF3H
1 |
IGSF8 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23463506
ICG-001 affects EIF3H
| 1
ICG-001 decreases the amount of EIF3H. 1 / 1
| 1
reach
"Treatment with three inhibitors of Wnt/β-catenin signaling, ICG-001, NCB0846 and LGK974, reduced the expression of EIF3H at both mRNA and protein levels in a dose-dependent manner (Fig. 6b, c and Supplementary Fig. 8c) ."
38514606
HSP90AB1 affects EIF3H
1 |
HSP90AB1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
16263121
HSP90AA1 affects EIF3H
1 |
HSP90AA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
16263121
HNRNPU affects EIF3H
1 |
EIF3H binds HNRNPU. 1 / 1
1 |
biogrid
No evidence text available
32269044
HNRNPM affects EIF3H
1 |
EIF3H binds HNRNPM. 1 / 1
1 |
biogrid
No evidence text available
32269044
HNRNPL affects EIF3H
1 |
EIF3H binds HNRNPL. 1 / 1
1 |
biogrid
No evidence text available
32269044
HNRNP affects EIF3H
| 1
HNRNP binds EIF3H and A18. 1 / 1
| 1
reach
"RNP-IP performed with hnRNP A18 antibody validated this prediction and indicated that indeed hnRNP A18 could efficiently bind to eIF3H, eEF1A1, eIF4E-BP1, eIF5A and eIF4G3."
26824423
HMG20A affects EIF3H
1 |
EIF3H binds HMG20A. 1 / 1
1 |
biogrid
No evidence text available
35831314
HEXIM1 affects EIF3H
1 |
HEXIM1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29845934
HECW2 affects EIF3H
1 |
HECW2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
24163370
HECTD1 affects EIF3H
1 |
HECTD1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35915203
HADHB affects EIF3H
1 |
EIF3H binds HADHB. 1 / 1
1 |
biogrid
No evidence text available
32269044
GPHN affects collybistin
| 1
Collybistin binds GPHN and EIF3H. 1 / 1
| 1
sparser
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
GPHN affects 293T
| 1
GPHN binds EIF3H and 293T. 1 / 1
| 1
reach
"In addition, we showed that gephyrin also interacts with eIF3H in 293T cells and that CB, gephyrin and eIF3H seem to assemble into a trimeric protein complex."
20858277
GABRA1 affects EIF3H
1 |
GABRA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
36030824
G3BP2 affects EIF3H
1 |
G3BP2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
G3BP1 affects EIF3H
1 |
G3BP1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26777405
FR900359 affects EIF3H
1 |
FR900359 phosphorylates EIF3H. 1 / 1
1 |
ctd
No evidence text available
37730182
FAS affects EIF3H
1 |
FAS binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
34917906
Eif3i affects EIF3H
1 |
Eif3i binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26496610
Eif3e affects EIF3H
1 |
Eif3e binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26496610
EZH2 affects EIF3H
1 |
EZH2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
27634302
ESR1 affects EIF3H
1 |
ESR1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
31527615
EP300 affects EIF3H
1 |
EP300 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
33742100
ENY2 affects EIF3H
1 |
ENY2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EMC9 affects EIF3H
1 |
EMC9 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
ELK1 affects EIF3H
1 |
ELK1 decreases the amount of EIF3H. 1 / 1
1 |
biopax:msigdb
No evidence text available
EIF5 affects EIF3H
1 |
EIF5 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF4ENIF1 affects EIF3H
1 |
EIF3H binds EIF4ENIF1. 1 / 1
1 |
biogrid
No evidence text available
24981860
EIF4E affects EIF3H
1 |
EIF4E binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
24981860
EIF3L affects EIF3F
| 1
EIF3D binds EIF3E, EIF3F, EIF3H, and EIF3L. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3H affects zinc(2+)
| 1
EIF3H activates zinc(2+). 1 / 1
| 1
reach
"The above result suggests that the complexation of EIF3H with EIF3F further supports the binding of the zinc ion to the same site (XREF_FIG)."
32269044
EIF3H affects xenograft tumor growth
| 1
EIF3H activates xenograft tumor growth. 1 / 1
| 1
eidos
"I EIF3H knockdown suppressed xenograft tumor growth in vivo in mice ."
32867821
EIF3H affects ubiquitinated-OGT
| 1
EIF3H decreases the amount of ubiquitinated-OGT. 1 / 1
| 1
reach
"As illustrated in Fig. 3A, we observed that the depletion of EIF3H significantly elevated the level of ubiquitinated-OGT in LM3 cells."
37559097
reach
"CCT, which is required for the correct folding of the eIF3h and eIF3i subunits, indirectly affects gene expression through eIF3i overexpression, enhancing CAP and IRES (internal ribosome entry fragments) - dependent translation initiation, while eIF3h overexpression selectively increases IRES-dependent translation initiation [74]."
38596045
EIF3H activates translation reinitiation. 1 / 1
| 1
reach
"In response to auxin, eIF3h phosphorylation by TOR-activated S6K1 enhances translation reinitiation of mRNAs with uORFs (Schepetilnikov et al., 2013)."
36909402
reach
"In fission yeast, the non-core eIF3 subunits, eIF3e and eIF3h, are not required for the initiation of translation, but the deletion of eIF3e and eIF3h impairs spore formation, which indicates that the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25888243
EIF3H affects rs16888589 risk region
| 1
Rs16888589 risk region binds EIF3H. 1 / 1
| 1
reach
"Thus, the rs16888589 risk region physically interacts with EIF3H."
20862326
EIF3H affects response to auxin
| 1
EIF3H activates response to auxin. 1 / 1
| 1
reach
"In response to auxin, eIF3h phosphorylation by TOR-activated S6K1 enhances translation reinitiation of mRNAs with uORFs (Schepetilnikov et al., 2013)."
36909402
EIF3H affects removal poly-ubiquitin chain
| 1
EIF3H activates removal poly-ubiquitin chain. 1 / 1
| 1
eidos
"Under oncogenic circumstances , EIF3H directly interacts with YAP and catalyzes the removal of poly-ubiquitin chain on YAP , resulting in YAP stabilization and its transactivation ( 4 ) ."
32269044
EIF3H affects process
| 1
EIF3H activates process. 1 / 1
| 1
eidos
"Therefore , EIF3H could promote Snail-mediated EMT process in ESCC ."
32867821
EIF3H affects poly-ubiquitin ubiquitinated Snail
| 1
EIF3H inhibits poly-ubiquitin ubiquitinated Snail. 1 / 1
| 1
eidos
"EIF3H significantly decreased the poly-ubiquitin level of ubiquitinated Snail in an in vitro ubiquitination assay ."
32867821
EIF3H affects mTORC1
| 1
EIF3H bound to MTOR inhibits mTORC1. 1 / 1
| 1
reach
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD 92."
33441873
EIF3H affects mTORC1 signaling cascade
| 1
EIF3H inhibits mTORC1 signaling cascade. 1 / 1
| 1
eidos
"Although the role of Eif3h in ASD is not clearly understood , a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin ( mTOR ) and collybistin ( a neuron-specific Rho-GEF ) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD92 ."
33441873
EIF3H affects lung metastasis
| 1
EIF3H activates lung metastasis. 1 / 1
| 1
eidos
"E EIF3H knockdown suppressed lung metastasis in vivo in mice ."
32867821
EIF3H affects lung metastasis nodules
| 1
EIF3H activates lung metastasis nodules. 1 / 1
| 1
eidos
"In the spontaneous lung metastasis model , we observed that loss of EIF3H significantly decreased lung metastasis nodules ."
32269044
EIF3H affects iron atom
| 1
EIF3H inhibits iron atom. 1 / 1
| 1
reach
"Moreover, we also found that the knockdown of EIF3H increased the intracellular concentration of lipid ROS (Fig. 5I, J), ferrous iron (Fig. 5L), and decreased Glutathione (GSH) (Fig. 5K)."
37559097
EIF3H affects induction
| 1
EIF3H inhibits induction. 1 / 1
| 1
sparser
"Furthermore, overexpressed eIF3h inhibits Myc-dependent induction of apoptosis of primary prostate cells."
18544531
EIF3H affects guanine
| 1
EIF3H inhibits guanine. 1 / 1
| 1
reach
"Similarly, receptor tyrosine protein kinase erbB-2, growth factor receptor-bound protein 7, eukaryotic translation initiation factor 3 subunit H, and brefeldin A-inhibited guanine nucleotide-exchange protein 2 were the most discriminative protein markers for serum-derived SEVs from HER2-positive patient."
37893211
EIF3H activates embryo development. 1 / 1
| 1
reach
"Underexpression of eIF3h causes defects in zebrafish embryo development, suggesting that eIF3h could be directly involved in translation initiation of specific transcripts during embryogenesis."
27210288
EIF3H affects eL24
| 1
EIF3H binds eL24. 1 / 1
| 1
reach
"However, the precise role of Rpl24 and eL24 and the molecular details of the functional interaction between eIF3h and Rpl24 and eL24 are unknown."
29281028
EIF3H affects eIF3kl dimer
| 1
EIF3kl dimer binds EIF3H. 1 / 1
| 1
reach
"Affinity purification of N-terminally tagged eIF3k in the absence of eIF3h (strain DeltaeIF3hk, + N-k) yielded an eIF3kl dimer (XREF_FIG) indicating that eIF3k and l are either pre-assembled as a dimer and interact with eIF3 already containing the h subunit or alternatively the eIF3kl dimer binds to eIF3h and assembles with eIF3 as a trimer."
24250809
EIF3H affects development pancreatic cancer
| 1
EIF3H activates development pancreatic cancer. 1 / 1
| 1
eidos
"Knockdown of EIF3H inhibits the development and progression of pancreatic cancer by regulating cell proliferation and apoptosis in vitro ."
35809300
EIF3H affects decrease YAP protein
| 1
EIF3H inhibits decrease YAP protein. 1 / 1
| 1
eidos
"EIF3H knockdown leads to decrease of YAP protein expression and increases ubiquitination , especially the K48-linkage specific polyubiquitination ( Fig. 4I and Fig. S6A ) ."
32269044
EIF3H affects colony
| 1
EIF3H activates colony. 1 / 1
| 1
eidos
"Knockdown of EIF3H inhibited cell proliferation and colony formation ."
32867821
EIF3H affects circPAR1
| 1
CircPAR1 binds EIF3H. 1 / 1
| 1
reach
"In addition, it was found that circPAR1 encapsulated by exosomes could directly bind to eIF3h and inhibit its interaction with METTL3."
37781524
EIF3H affects cell mobility
| 1
EIF3H activates cell mobility. 1 / 1
| 1
eidos
"Taken together , these results indicate that EIF3H knockdown inhibits cell mobility and tumor metastasis in ESCC ."
32867821
EIF3H affects cell death
| 1
EIF3H activates cell death. 1 / 1
| 1
reach
"EIF3H has been found to promote HCC progression by stabilizing OGT (O-GlcNAc transferase) and inhibiting ferroptosis, a form of regulated cell death."
38419066
EIF3H affects aggressiveness squamous cell carcinoma
| 1
EIF3H activates aggressiveness squamous cell carcinoma. 1 / 1
| 1
eidos
"EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability Background Overexpression of eukaryotic translation initiation factor 3H ( EIF3H ) predicts cancer progression and poor prognosis , but the mechanism underlying EIF3H as an oncogene remains unclear in esophageal squamous cell carcinoma ( ESCC ) ."
32867821
EIF3H affects ZNF598
1 |
ZNF598 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
28685749
EIF3H affects ZFP36L2
1 |
ZFP36L2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29449217
EIF3H affects YTHDF2
1 |
EIF3H binds YTHDF2. 1 / 1
1 |
biogrid
No evidence text available
22863883
EIF3H affects YTHDF1
| 1
YTHDF1 binds EIF3H. 1 / 1
| 1
sparser
"METTL3 phosphorylation assembles in a translational complex with m6A reader proteins YTHDF1 and YTHDF2 and the translation initiation factor subunit eIF3h, possibly forming small mRNA loops [ 163 , 16[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37690652
EIF3H affects YBX1
1 |
EIF3H binds YBX1. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects YAP ENO2 CTGF
| 1
EIF3H activates YAP ENO2 CTGF. 1 / 1
| 1
eidos
"We first established EIF3H knockdown cells and then added back the wildtype and mutant EIF3H ( EIF3HDDQ / AAA and EIF3HYW / AA ) and found that knockdown EIF3H could decrease YAP , ENO2 and CTGF expression , add back wildtype EIF3H could recover all these proteins expression in MDA-MB-231 and MDA-MB-468 cells ( Fig. 6A ) ."
32269044
EIF3H affects XPO1
1 |
XPO1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26673895
EIF3H affects WWP2
1 |
WWP2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
31048545
EIF3H affects WDR48
1 |
WDR48 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects VIRMA
1 |
VIRMA binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29507755
EIF3H affects UTP23
| 1
UTP23 binds EIF3H. 1 / 1
| 1
sparser
"Top SNPs for the hyperthymic temperament were also involved in chromatin interactions in neural progenitor cells with EIF3S3:UTP23 in GSE87112 database (Supplementary Table S xref )."
34075027
EIF3H affects UNK
1 |
UNK binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
25737280
EIF3H affects UBE2H
1 |
UBE2H binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
38113892
reach
"N6-methyladenosine-mediated EIF3H promotes anaplastic thyroid cancer progression and ferroptosis resistance by stabilizing β-catenin."
39984062
EIF3H affects TUFM
1 |
EIF3H binds TUFM. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects TOPBP1
1 |
TOPBP1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
41524403
EIF3H affects TOP1
1 |
TOP1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects TMEM203
1 |
EIF3H binds TMEM203. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects TIPARP
1 |
TIPARP binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35439318
EIF3H affects TGFB
| 1
EIF3H binds TGFB. 1 / 1
| 1
sparser
"We tried to explore the interactions between subunit H and TGF-β receptor I through their reported interacted proteins such as μ2 and β2 subunits."
29782852
EIF3H affects TCP1
1 |
EIF3H binds TCP1. 1 / 1
1 |
biogrid
No evidence text available
35831314
EIF3H affects TARDBP
1 |
TARDBP binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
20020773
EIF3H affects TADA2A
1 |
TADA2A binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
20508642
EIF3H affects Stomach Neoplasms
| 1
EIF3H activates Stomach Neoplasms. 1 / 1
| 1
reach
"In particular, the strategy of inhibiting EIF3H expression may suppress the progression of GC and improve patient prognosis (131)."
31897112
EIF3H affects Stemness Gastric Cancer Stem Cells
| 1
EIF3H inhibits Stemness Gastric Cancer Stem Cells. 1 / 1
| 1
eidos
"Celastrus orbiculatus Extract Reduces Stemness of Gastric Cancer Stem Cells by Targeting PDCD4 and EIF3H ."
34802261
EIF3H affects Snail.EIF3H
| 1
EIF3H binds Snail.EIF3H. 1 / 1
| 1
isi
"These results revealed the interaction between EIF3H and Snail mediated by the S-P rich domain of Snail.EIF3H interacts with Snail.aVector or EIF3H-Flag plasmid was transfected in HEK293T cells for 24 h. After a 4 h treatment of 10 muM MG132, cell lysate was immunoprecipitated with anti-FLAG M2 beads, and the proteins interact with EIF3H were analyzed by mass spectrometry."
32867821
EIF3H affects Snail switch
| 1
EIF3H activates Snail switch. 1 / 1
| 1
eidos
"The results demonstrated that knockdown of EIF3H suppressed the expression of Snail and Snail-mediated EMT switch in vivo ."
32867821
EIF3H affects Snail stability
| 1
EIF3H activates Snail stability. 1 / 1
| 1
eidos
"We further validated whether EIF3H modulates Snail stability through deubiquitination ."
32867821
EIF3H affects SYK
1 |
SYK binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
21472591
EIF3H affects SRRM1
1 |
SRRM1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
16159877
EIF3H affects SRP9
1 |
SRP9 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects SRP72
1 |
SRP72 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects SRP19
1 |
SRP19 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects SRGN
1 |
SRGN binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
40140646
EIF3H affects SPTBN1
1 |
SPTBN1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
21866423
EIF3H affects SLFN11
1 |
SLFN11 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
33863777
EIF3H affects SLCO1B7
1 |
SLCO1B7 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
40355756
EIF3H affects SLC6A16
1 |
SLC6A16 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
40355756
EIF3H affects SLC45A3
1 |
SLC45A3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
40355756
EIF3H affects SLC39A5
1 |
SLC39A5 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
40355756
EIF3H affects SLC35G3
1 |
SLC35G3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
40355756
EIF3H affects SLC25A13
1 |
EIF3H binds SLC25A13. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects SHANK3
1 |
SHANK3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
36950384
EIF3H affects SFN
1 |
SFN binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
17361185
EIF3H affects SEC24B
| 1
SEC24B binds EIF3H. 1 / 1
| 1
sparser
"The interaction network showed that FTO interacted with ACTB and PPARG, PRRC2A interacted with SEC24B and EIF3H ( xref C), and there were interactions between m 6 A methylase, demethylase, and the reading protein which jointly regualted the m 6 A modification level ( xref D)."
41096371
EIF3H affects S
1 |
S binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
40593736
EIF3H affects Rpl35
1 |
Rpl35 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26496610
EIF3H affects RRM1
1 |
EIF3H binds RRM1. 1 / 1
1 |
biogrid
No evidence text available
35831314
EIF3H affects RPSA
1 |
EIF3H binds RPSA. 1 / 1
1 |
biogrid
No evidence text available
39358380
EIF3H affects RPS20
1 |
EIF3H binds RPS20. 1 / 1
1 |
biogrid
No evidence text available
22863883
EIF3H affects RPS11
1 |
RPS11 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects RPL6
1 |
EIF3H binds RPL6. 1 / 1
1 |
biogrid
No evidence text available
32867821
EIF3H affects RPL5
1 |
RPL5 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects RPL4
1 |
EIF3H binds RPL4. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects RPA3
1 |
RPA3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
37827155
EIF3H affects RPA2
1 |
RPA2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
37827155
EIF3H affects RPA1
1 |
RPA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
37827155
EIF3H affects RIGI
1 |
RIGI binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
32513696
EIF3H affects RHEB
| 1
EIF3H increases the amount of RHEB. 1 / 1
| 1
reach
"To determine if eIF3h downregulation potentially mediates eIF3a regulation of Rheb expression and AMPK activity, we knocked down eIF3h as well as eIF3g as another representative eIF3 subunit."
35595099
EIF3H affects RFP
| 1
RFP binds EIF3H. 1 / 1
| 1
sparser
"The data showed that the signal of GFP-tagged OsMTA2 (OsMTA2-GFP) was diffusely distributed in both nucleus and cytoplasm ( xref A) and indeed largely overlapped with eIF3h-RFP signal ( xref A)."
34070794
EIF3H affects RECQL4
1 |
RECQL4 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29229926
EIF3H affects RBM42
1 |
RBM42 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects RAF1
| 1
EIF3H inhibits RAF1. 1 / 1
| 1
reach
"Given the HAX1-EIF3H link, EIF3H KD also decreased the interaction of RAF1 with MEK1 and with ERK1/2 (Fig. 4j)."
38514606
EIF3H affects RACK1
1 |
RACK1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects RAB5A
1 |
RAB5A binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
31980649
EIF3H affects Polyubiquitin
| 1
EIF3H decreases the amount of Polyubiquitin. 1 / 1
| 1
reach
"EIF3H significantly decreased the poly-ubiquitin level of ubiquitinated Snail in an in vitro ubiquitination assay."
32867821
EIF3H affects PSPC1
1 |
PSPC1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects PSEN1
| 1
EIF3H binds PSEN1. 1 / 1
| 1
sparser
"In comparison with the rat V-ATPase structure ( xref ), our human V-ATPase structure contains the essential subunit H, which interacts extensively with PS-1 and a-NTD ( xref and xref – xref )."
33065002
EIF3H affects PPFIA1
| 1
PPFIA1 binds EIF3H. 1 / 1
| 1
sparser
"Here, we show that the secreted Mtb protein tyrosine phosphatase (PtpA) binds to subunit H of the macrophage vacuolar-H(+)-ATPase (V-ATPase) machinery, a multisubunit protein complex in the phagosome membrane that drives luminal acidification."
22087003
EIF3H affects PERK12
| 1
EIF3H decreases the amount of PERK12. 1 / 1
| 1
reach
"Immunohistochemistry (IHC) staining on orthotopic tumor showed that EIF3H KD led to reduced levels of EIF3H, HAX1 and pERK1/2, and repressed cell proliferation (Ki67 staining), while HAX1 overexpression reversed these impacts caused by EIF3H KD (Fig. 5d)."
38514606
EIF3H affects PEBP1
1 |
PEBP1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
31980649
EIF3H affects PDZD8
1 |
PDZD8 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects PAN2
1 |
PAN2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23398456
EIF3H affects PABPC1
| 1
EIF3H binds PABPC1. 1 / 1
| 1
reach
"Similarly, we found strong statistical associations between EIF3E, EIF3H, and PABPC1, likely due to their chromosomal proximity at 8q23.EIF4G1, EIF4A2, EIF3E, and EIF3H are frequently duplicated or amplified in most TCGA cancer types, particularly in lung squamous cell carcinoma and head & neck squamous cell carcinoma (Fig. 1D and SI Appendix, Figs."
38266053
EIF3H affects PA2G4
1 |
EIF3H binds PA2G4. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects ORF10
1 |
ORF10 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
37314180
EIF3H affects NUMA1
1 |
NUMA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26344197
EIF3H affects NTRK1
1 |
NTRK1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
25921289
EIF3H affects NP_705926
1 |
NP_705926 binds EIF3H. 1 / 1
1 |
virhostnet
No evidence text available
22190034
EIF3H affects NP
1 |
EIF3H binds NP. 1 / 1
1 |
virhostnet
No evidence text available
25464832
EIF3H affects NCL
1 |
EIF3H binds NCL. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects NCAPH
1 |
NCAPH binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects NAA38
1 |
NAA38 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
33961781
EIF3H affects NA
1 |
EIF3H binds NA. 1 / 1
1 |
virhostnet
No evidence text available
25464832
EIF3H affects Melanoma
| 1
reach
"However, the association between EIF3H and MM is still not clear and rarely reported.In this study, clinical specimens and corresponding information were collected for preliminarily revealing the role[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33508274
EIF3H affects MeV N protein
| 1
MeV N protein binds EIF3H. 1 / 1
| 1
reach
"There are several reports of paramyxoviruses blocking canonical translation pathways, including the MeV N protein binding to the eukaryotic initiation factor 3 (eIF3-p40) (Sato et al. 2007), whilst the P and V proteins of simian virus 5 (SV5) limit activation of the double-stranded RNA (dsRNA)-dependent protein kinase (PKR) to limit both host and viral protein translation (Gainey et al. 2008)."
28674944
EIF3H affects MTOR, and collybistin
| 1
EIF3H binds MTOR and collybistin. 1 / 1
| 1
sparser
"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron-specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD xref ."
33441873
EIF3H affects MKI67
1 |
MKI67 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26949251
EIF3H affects MINDY4
1 |
MINDY4 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29795372
EIF3H affects METAP2
1 |
METAP2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects MEPCE
1 |
MEPCE binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29845934
EIF3H affects LTV1
1 |
EIF3H binds LTV1. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects LRRC47
1 |
EIF3H binds LRRC47. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects LNX1
1 |
LNX1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29121065
EIF3H affects LMNB1
1 |
EIF3H binds LMNB1. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects LM3
| 1
EIF3H activates LM3. 1 / 1
| 1
reach
"We observed that the depletion of EIF3H decreased cell proliferation rate (Fig. 5A, B) and clonogenic potential (Fig. 5C, D) in both LM3 and Hep3B cell lines in response to different concentrations of Erastin."
37559097
EIF3H affects LIMA1
1 |
LIMA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26496610
EIF3H affects LARP7
1 |
LARP7 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29845934
EIF3H affects KRT9
1 |
EIF3H binds KRT9. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects KRT18
1 |
EIF3H binds KRT18. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects KRAS
1 |
KRAS binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
37682707
EIF3H affects KLF8
1 |
KLF8 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35140242
EIF3H affects KLF16
1 |
KLF16 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35140242
EIF3H affects KIF14
1 |
KIF14 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
31586073
EIF3H affects KAT6A
1 |
KAT6A binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
36537216
EIF3H affects IGSF8
1 |
IGSF8 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23463506
EIF3H affects Hippo
| 1
EIF3H activates Hippo. 1 / 1
| 1
reach
"It was also reported that EIF3H could enhance the Hippo signal by stabilizing YAP, and that it promotes breast cancer invasion and metastasis."
34802261
EIF3H affects HSP90AB1
1 |
HSP90AB1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
16263121
EIF3H affects HSP90AA1
1 |
HSP90AA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
16263121
EIF3H affects HNRNPU
1 |
EIF3H binds HNRNPU. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects HNRNPM
1 |
EIF3H binds HNRNPM. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects HNRNPL
1 |
EIF3H binds HNRNPL. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects HNRNPA2B1
| 1
reach
"The analysis of the eCLIP (cross linking immunoprecipitation) data in the encyclopedia of DNA elements (ENCODE) project (https://www.encodeproject.org) using USCS tool (Gene Interaction) revealed that hnRNP A2B1 interacted with EIF3H, which was consistent with our results."
33509274
EIF3H affects HNRNP
| 1
HNRNP binds EIF3H and A18. 1 / 1
| 1
reach
"RNP-IP performed with hnRNP A18 antibody validated this prediction and indicated that indeed hnRNP A18 could efficiently bind to eIF3H, eEF1A1, eIF4E-BP1, eIF5A and eIF4G3."
26824423
EIF3H affects HMG20A
1 |
EIF3H binds HMG20A. 1 / 1
1 |
biogrid
No evidence text available
35831314
EIF3H affects HEXIM1
1 |
HEXIM1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29845934
EIF3H affects HECW2
1 |
HECW2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
24163370
EIF3H affects HECTD1
1 |
HECTD1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35915203
EIF3H affects HADHB
1 |
EIF3H binds HADHB. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects GPHN, and collybistin
| 1
Collybistin binds GPHN and EIF3H. 1 / 1
| 1
sparser
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
EIF3H affects GABRA1
1 |
GABRA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
36030824
EIF3H affects G3BP2
1 |
G3BP2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects G3BP1
1 |
G3BP1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26777405
EIF3H affects G1 phase
| 1
EIF3H inhibits G1 phase. 1 / 1
| 1
reach
"Depletion of EIF3H increased the proportion of cells in G1 phase of the cell cycle, implying that EIF3H may participate in the regulation of G1 to S transition in HCC cells (Fig. 4B)."
37559097
EIF3H affects FBXO25
| 1
EIF3H inhibits FBXO25. 1 / 1
| 1
reach
"Whether EIF3H can antagonize FBXO25 or collaborate with HBZ warrants further investigation.The dysfunction and mutants of the RAF-MEK/ERK1/2 signaling pathway are involved in tumorigenesis and metastasis and are activated in various cancers including CRC ."
38514606
EIF3H affects FAS
1 |
FAS binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
34917906
EIF3H affects Eif3i
1 |
Eif3i binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26496610
EIF3H affects Eif3e
1 |
Eif3e binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26496610
EIF3H affects EZH2
1 |
EZH2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
27634302
EIF3H affects ESR1
1 |
ESR1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
31527615
EIF3H affects ESCC
| 1
EIF3H activates ESCC. 1 / 1
| 1
reach
"Our results exhibited that ectopic expression of EIF3H promoted ESCC metastasis with the increase of Snail, N-Cadherin and Vimentin, and decrease of E-cadherin, while knockdown of EIF3H exerted an opposite effect."
32867821
EIF3H affects EP300
1 |
EP300 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
33742100
EIF3H affects ENY2
1 |
ENY2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects ENO2
| 1
Modified EIF3H decreases the amount of ENO2. 1 / 1
| 1
reach
"We observed that loss of EIF3H in 4T1 cells led to decreased YAP and ENO2 expression."
32269044
EIF3H affects EMT process cell mobility induced
| 1
EIF3H activates EMT process cell mobility induced. 1 / 1
| 1
eidos
"Knockdown of EIF3H inhibits the EMT process and cell mobility induced by Snail ."
32867821
EIF3H affects EMT phenotypes
| 1
EIF3H activates EMT phenotypes. 1 / 1
| 1
eidos
"We observed that disruption of EIF3H by RNA interference results in attenuation of EMT as indicated by upregulation of E-cadherin and suppression of vimentin as well as fibronectin , while elevation of EIF3H significantly enhances EMT phenotypes in breast cancer cells with dramatic alteration of morphology , loss of E-cadherin and accumulation of vimentin as well as fibronectin ( Fig. S1G-J ) ."
32269044
EIF3H affects EMC9
1 |
EMC9 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects EIF5
1 |
EIF5 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects EIF4ENIF1
1 |
EIF3H binds EIF4ENIF1. 1 / 1
1 |
biogrid
No evidence text available
24981860
EIF3H affects EIF4E
1 |
EIF4E binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
24981860
EIF3H affects EIF3FP3
1 |
EIF3H binds EIF3FP3. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects EIF2S3
1 |
EIF2S3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects EEF1A1
1 |
EIF3H binds EEF1A1. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H activates DNA-templated transcription. 1 / 1
| 1
reach
"Translation assays revealed that eIF3h supports the efficient translation of the mRNAs for CLV1 and the leaf transcription factor, AS1, which contain uORFs in their 5 ' UTR."
24736281
EIF3H activates DNA biosynthetic process. 1 / 1
| 1
reach
"Consistently, EdU incorporation assay revealed that knockdown of EIF3H inhibited the DNA synthesis in LM3 and Hep3B cell lines (Fig. 4D, E)."
37559097
EIF3H affects DHX29
1 |
EIF3H binds DHX29. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects DFO-
| 1
EIF3H activates DFO-. 1 / 1
| 1
reach
"We noted that the silencing of eIF3H alone was able to reverse the DFO- and MG132 mediated HIF-1alpha up-regulation (XREF_FIG), resulting in a ~ 2-fold decrease in cellular HIF-1alpha protein levels relative to control (siScramble (siScr) + MG132 or DFO)."
25166596
EIF3H affects DDX21
1 |
DDX21 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects DCP1A
1 |
EIF3H binds DCP1A. 1 / 1
1 |
biogrid
No evidence text available
32269044
reach
"For instance, EIF3H can activate the Wnt/β-catenin signaling pathway in cholangiocarcinoma [19]."
40069645
EIF3H affects Cebpb
1 |
Cebpb binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
30884312
EIF3H affects CSNK2B
1 |
EIF3H binds CSNK2B. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects CSNK2A3
1 |
CSNK2A3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
36736316
EIF3H affects CSN7
| 1
EIF3H binds CSN7. 1 / 1
| 1
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
EIF3H affects CPEB2B
| 1
EIF3H activates CPEB2B. 1 / 1
| 1
reach
"Furthermore, we provide data indicating that the EIF3H subunit of the pre and initiation complex may aid CPEB2B in initiating HIF1alpha translation via preferential association with this protein.Therefore, the alternative splicing of CPEB2 is a novel regulator of HIF1alpha during hypoxia and targeting the expression of CPEB2B could in turn be used to regulate HIF1 in patients suffering from chronic hypoxic disorders.Seminal studies in the field have demonstrated that CPEB2 localizes via a low complexity sequence to stress granules which also contain mRNA transcripts (22)."
| DOI
EIF3H affects COPS8
| 1
EIF3H binds COPS8. 1 / 1
| 1
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
EIF3H affects CLTC
1 |
EIF3H binds CLTC. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects CIC
1 |
CIC binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29844126
EIF3H affects CGREF1
| 1
EIF3H increases the amount of CGREF1. 1 / 1
| 1
reach
"Furthermore, partial inhibition of EIF3H attenuated the effects of CGREF1 overexpression on the proliferation, migration, and invasion of HCC cells."
40069645
EIF3H affects CDK2
1 |
CDK2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
21319273
EIF3H affects CDK12
1 |
CDK12 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
36736316
EIF3H affects CDK11B
1 |
CDK11B binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
36736316
EIF3H affects CDK11A
1 |
CDK11A binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
36736316
EIF3H affects CDH1
1 |
CDH1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
37756605
EIF3H affects CD81
1 |
CD81 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23463506
EIF3H affects CD74
1 |
CD74 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
30833792
EIF3H affects CCT_complex
| 1
CCT_complex binds EIF3H. 1 / 1
| 1
sparser
"We also identified eIF3h as a regulator of dendrite development ( xref ), although how CCT interacts with eIF3h in dendrites awaits further study."
33100975
EIF3H affects CCT3
1 |
EIF3H binds CCT3. 1 / 1
1 |
biogrid
No evidence text available
35831314
EIF3H affects CCNF
1 |
CCNF binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
33729478
EIF3H affects CCND1
| 1
EIF3H inhibits CCND1. 1 / 1
| 1
reach
"Mechanistically, we found that EIF3H knockdown can promote the degradation of CCND1 and the proteolysis of CCND1 is mediated by ubiquitin-proteasome system (UPS)."
36350008
EIF3H affects CASP3
| 1
EIF3H inhibits CASP3. 1 / 1
| 1
reach
"This evidence demonstrated that knockdown of EIF3H could promote caspase-3 cleavage dependent apoptosis of CRC cells.DiscussionCRC is a common cancer with high morbidity and mortality rates."
30022709
EIF3H affects CAPZB
1 |
CAPZB binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects CALM3
1 |
CALM3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects CALD1
1 |
CALD1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects BRD4
| 1
EIF3H inhibits BRD4. 1 / 1
| 1
reach
"They demonstrated that circLPAR1 encapsulated in exosomes could be internalized by colorectal cancer cells, and further suppressed tumour growth by directly bound with eukaryotic translation initiation factor 3 subunit h (eIF3h), suppressing the methyltransferase-like 3 (METTL3)-eIF3h interaction and decreasing the translation of oncogene bromodomain containing 4 [44]."
38711144
EIF3H affects BRCA1
1 |
BRCA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26831064
EIF3H affects BIRC5
| 1
BIRC5 binds EIF3H. 1 / 1
| 1
sparser
"Survivin binds histone subunit H3, localizing the chromosomal passenger complex to the inner centromere."
28564620
EIF3H affects BAP1
1 |
BAP1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35446349
EIF3H affects BAG6
1 |
BAG6 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26496610
EIF3H affects BAD
| 1
EIF3H decreases the amount of BAD. 1 / 1
| 1
reach
"These results suggest that EIF3H promotes the proliferation of CRC cells.Further analysis showed EIF3H knockdown led to higher expression of Bad, BAX, cleaved caspase-3, caspase9, cleaved PARP, and cytochrome C and downregulation of Bcl-2."
30022709
EIF3H affects AteIF3f protein
| 1
AteIF3f protein binds EIF3H. 1 / 1
| 1
reach
"AteIF3f protein interacts with the Arabidopsis regulatory subunit eIF3e and eIF3h in yeast and plant cells."
20444226
EIF3H affects Apc2
1 |
Apc2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
32129710
EIF3H affects ATM
| 1
EIF3H activates ATM. 1 / 1
| 1
reach
"The knockdown of EIF3H could inhibit ATC cell proliferation, invasion, and ferroptosis resistance by regulating β-catenin."
39984062
EIF3H affects ATG4B
1 |
ATG4B binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects ATG16L1
1 |
ATG16L1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
30196744
EIF3H affects ATG13
1 |
ATG13 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EIF3H affects ARPC5
1 |
EIF3H binds ARPC5. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects ARIH1
1 |
EIF3H binds ARIH1. 1 / 1
1 |
biogrid
No evidence text available
35831314
EIF3H affects ARHGEF9
| 1
ARHGEF9 binds EIF3H. 1 / 1
| 1
reach
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
EIF3H affects ANGEL1
1 |
EIF3H binds ANGEL1. 1 / 1
1 |
biogrid
No evidence text available
24981860
EIF3H affects AIFM1
1 |
EIF3H binds AIFM1. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects ADGRB1
1 |
EIF3H binds ADGRB1. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3H affects ACTR3
1 |
EIF3H binds ACTR3. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects ACTB
1 |
EIF3H binds ACTB. 1 / 1
1 |
biogrid
No evidence text available
32269044
EIF3H affects ABI1
1 |
ABI1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
32296183
EIF3H affects A18
| 1
HNRNP binds EIF3H and A18. 1 / 1
| 1
reach
"RNP-IP performed with hnRNP A18 antibody validated this prediction and indicated that indeed hnRNP A18 could efficiently bind to eIF3H, eEF1A1, eIF4E-BP1, eIF5A and eIF4G3."
26824423
EIF3H affects 6 A
| 1
METTL3 binds EIF3H and 6 A. 1 / 1
| 1
reach
"The authors thus proposed a novel " mRNA looping " mechanism, in which METTL3 binds to the m 6 A modified 3 ' UTR of target mRNA and then recruits eIF3h as well as translation initiation factors such as CBP800 and eIF4e, thus facilitating the ribosome recycling and promoting translation efficiency [XREF_BIBR, XREF_BIBR]."
32854717
EIF3H affects 293T
| 1
GPHN binds EIF3H and 293T. 1 / 1
| 1
reach
"In addition, we showed that gephyrin also interacts with eIF3H in 293T cells and that CB, gephyrin and eIF3H seem to assemble into a trimeric protein complex."
20858277
EIF3FP3 affects EIF3H
1 |
EIF3H binds EIF3FP3. 1 / 1
1 |
biogrid
No evidence text available
19615732
EIF3F affects EIF3L
| 1
EIF3D binds EIF3E, EIF3F, EIF3H, and EIF3L. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3E affects EIF3C
| 1
EIF3H binds EIF3A, EIF3B, EIF3C, and EIF3E. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3D affects EIF3L
| 1
EIF3D binds EIF3E, EIF3F, EIF3H, and EIF3L. 1 / 1
| 1
sparser
"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."
31171919
EIF3D affects EIF3B
| 1
EIF3B binds EIF3D and EIF3H. 1 / 1
| 1
sparser
"For instance, we observe that the association of eukaryote translation initiation factor 3 (eIF3) components, such as EIF3B, EIF3D and EIF3H, with translating ribosomes was significantly stabilized upon formaldehyde cross-linking ( xref ), consistent with previously published studies ( xref )."
28625553
EIF3C affects EIF3E
| 1
EIF3H binds EIF3A, EIF3B, EIF3C, and EIF3E. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3B affects EIF3D, and EIF3H
| 1
EIF3B binds EIF3D and EIF3H. 1 / 1
| 1
sparser
"For instance, we observe that the association of eukaryote translation initiation factor 3 (eIF3) components, such as EIF3B, EIF3D and EIF3H, with translating ribosomes was significantly stabilized upon formaldehyde cross-linking ( xref ), consistent with previously published studies ( xref )."
28625553
EIF3B affects EIF3C
| 1
EIF3H binds EIF3A, EIF3B, EIF3C, and EIF3E. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3A affects EIF3D, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, and EIF3K
| 1
EIF3A binds EIF3D, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, and EIF3K. 1 / 1
| 1
sparser
"In , it has also been shown that eIF3a interacts with eIF3d, eIF3f, eIF3g, eIF3h , eIF3i , eIF3j and eIF3k ."
20647036
EIF3A affects EIF3C
| 1
EIF3H binds EIF3A, EIF3B, EIF3C, and EIF3E. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF3A affects EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, and EIF3K
1 |
EIF3A binds EIF3E, EIF3K, EIF3J, EIF3I, EIF3H, EIF3G, EIF3F, EIF3D, EIF3C, and EIF3B. 1 / 1
1 |
hprd
No evidence text available
14519125
EIF3A affects EIF3B
| 1
EIF3H binds EIF3A, EIF3B, EIF3C, and EIF3E. 1 / 1
| 1
sparser
"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."
27703462
EIF2S3 affects EIF3H
1 |
EIF2S3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
EEF1A1 affects EIF3H
1 |
EIF3H binds EEF1A1. 1 / 1
1 |
biogrid
No evidence text available
32269044
DHX29 affects EIF3H
1 |
EIF3H binds DHX29. 1 / 1
1 |
biogrid
No evidence text available
32269044
DDX21 affects EIF3H
1 |
DDX21 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
DCP1A affects EIF3H
1 |
EIF3H binds DCP1A. 1 / 1
1 |
biogrid
No evidence text available
32269044
Cebpb affects EIF3H
1 |
Cebpb binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
30884312
CSNK2B affects EIF3H
1 |
EIF3H binds CSNK2B. 1 / 1
1 |
biogrid
No evidence text available
19615732
CSNK2A3 affects EIF3H
1 |
CSNK2A3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
36736316
CSN7 affects EIF3H
| 1
EIF3H binds CSN7. 1 / 1
| 1
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
COPS8 affects EIF3H
| 1
EIF3H binds COPS8. 1 / 1
| 1
reach
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."
20444226
EIF3H binds EIF3A, EIF3B, EIF3C, EIF3E, CSN7 subfamily, and COPS8. 1 / 1
| 1
sparser
"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 ( xref )."
20444226
COPS5 affects EIF3H
| 1
COPS5 inhibits EIF3H. 1 / 1
| 1
reach
"Reducing the copy number of eIF3f or eIF3h reduced the growth inhibitory phenotype of DTrc8 over-expression, much like reduction of the COP9 signalosome subunits, CSN5 and 6."
20068067
CLTC affects EIF3H
1 |
EIF3H binds CLTC. 1 / 1
1 |
biogrid
No evidence text available
32269044
CIC affects EIF3H
1 |
CIC binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
29844126
CDK2 affects EIF3H
1 |
CDK2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
21319273
CDK12 affects EIF3H
1 |
CDK12 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
36736316
CDK11B affects EIF3H
1 |
CDK11B binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
36736316
CDK11A affects EIF3H
1 |
CDK11A binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
36736316
CDH1 affects EIF3H
1 |
CDH1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
37756605
CD81 affects EIF3H
1 |
CD81 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
23463506
CD74 affects EIF3H
1 |
CD74 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
30833792
CCT3 affects EIF3H
1 |
EIF3H binds CCT3. 1 / 1
1 |
biogrid
No evidence text available
35831314
CCNF affects EIF3H
1 |
CCNF binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
33729478
CAPZB affects EIF3H
1 |
CAPZB binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
CAMKK2 affects EIF3H
| 1
CAMKK2 activates EIF3H. 1 / 1
| 1
reach
"1, TPT1-AS1, PXN-AS1, and AC107464.3 were up-regulated; LINC00922, FENDRR, and AC107375.1 were down-regulated), nine TFs (U2AF1, PTBP1, GTF2F1, NONO, ZNF184, RBFOX2, TARDBP, FUS, and LARP7), one RBP (SRSF1 was up-regulated), two miRNAs (hsa-miR-15b-5p was up-regulated, and hsa-miR-29c-3p was down-regulated) and eight mRNAs (TAB1, CAMKK2, TRAM2, DLL4, and RBBP6 were up-regulated; FRMD4B, PLPP1, and EIF3H were down-regulated)."
38200098
CALM3 affects EIF3H
1 |
CALM3 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
CALD1 affects EIF3H
1 |
CALD1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
BRCA1 affects EIF3H
1 |
BRCA1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26831064
BIRC5 affects EIF3H
| 1
BIRC5 binds EIF3H. 1 / 1
| 1
sparser
"Survivin binds histone subunit H3, localizing the chromosomal passenger complex to the inner centromere."
28564620
BAP1 affects EIF3H
1 |
BAP1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35446349
BAG6 affects EIF3H
1 |
BAG6 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
26496610
AteIF3f protein affects EIF3H
| 1
AteIF3f protein binds EIF3H. 1 / 1
| 1
reach
"AteIF3f protein interacts with the Arabidopsis regulatory subunit eIF3e and eIF3h in yeast and plant cells."
20444226
Asbestos, Serpentine increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
21148743
Apc2 affects EIF3H
1 |
Apc2 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
32129710
Aflatoxin B2 alpha demethylates EIF3H. 1 / 1
1 |
ctd
No evidence text available
30157460
ATG4B affects EIF3H
1 |
ATG4B binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
ATG16L1 affects EIF3H
1 |
ATG16L1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
30196744
ATG13 affects EIF3H
1 |
ATG13 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
35271311
AS1 mRNA affects EIF3H
| 1
AS1 mRNA inhibits mutated EIF3H. 1 / 1
| 1
reach
"In addition, the AS1 mRNA has reduced ribosome occupancy in the eif3h mutant (XREF_TABLE)."
24736281
ARPC5 affects EIF3H
1 |
EIF3H binds ARPC5. 1 / 1
1 |
biogrid
No evidence text available
19615732
ARIH1 affects EIF3H
1 |
EIF3H binds ARIH1. 1 / 1
1 |
biogrid
No evidence text available
35831314
ARHGEF9 affects EIF3H
| 1
ARHGEF9 binds EIF3H. 1 / 1
| 1
reach
"Collybistin and gephyrin associate with eIF3H in mammalian cells."
20858277
ANGEL1 affects EIF3H
1 |
EIF3H binds ANGEL1. 1 / 1
1 |
biogrid
No evidence text available
24981860
AIFM1 affects EIF3H
1 |
EIF3H binds AIFM1. 1 / 1
1 |
biogrid
No evidence text available
32269044
ADGRB1 affects EIF3H
1 |
EIF3H binds ADGRB1. 1 / 1
1 |
biogrid
No evidence text available
19615732
ACTR3 affects EIF3H
1 |
EIF3H binds ACTR3. 1 / 1
1 |
biogrid
No evidence text available
32269044
ACTB affects EIF3H
1 |
EIF3H binds ACTB. 1 / 1
1 |
biogrid
No evidence text available
32269044
ABI1 affects EIF3H
1 |
ABI1 binds EIF3H. 1 / 1
1 |
biogrid
No evidence text available
32296183
A18 affects HNRNP
| 1
HNRNP binds EIF3H and A18. 1 / 1
| 1
reach
"RNP-IP performed with hnRNP A18 antibody validated this prediction and indicated that indeed hnRNP A18 could efficiently bind to eIF3H, eEF1A1, eIF4E-BP1, eIF5A and eIF4G3."
26824423
6 A affects METTL3
| 1
METTL3 binds EIF3H and 6 A. 1 / 1
| 1
reach
"The authors thus proposed a novel " mRNA looping " mechanism, in which METTL3 binds to the m 6 A modified 3 ' UTR of target mRNA and then recruits eIF3h as well as translation initiation factors such as CBP800 and eIF4e, thus facilitating the ribosome recycling and promoting translation efficiency [XREF_BIBR, XREF_BIBR]."
32854717
4-hydroxyphenyl 4-isopropoxyphenylsulfone decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
39298647
3-methylcholanthrene increases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
18804290
293T affects GPHN
| 1
GPHN binds EIF3H and 293T. 1 / 1
| 1
reach
"In addition, we showed that gephyrin also interacts with eIF3H in 293T cells and that CB, gephyrin and eIF3H seem to assemble into a trimeric protein complex."
20858277
2,4,6-tribromophenol decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
31675489
17alpha-ethynylestradiol decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
23129252
ctd
No evidence text available
34186270
3,3',5,5'-tetrabromobisphenol A decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
31675489
2,2',4,4'-tetrabromodiphenyl ether decreases the amount of EIF3H. 1 / 1
1 |
ctd
No evidence text available
31675489