IndraLab

Statements

EIF3H is modified

9 | 37 3

EIF3H is phosphorylated.

9 | 35 3

EIF3H is phosphorylated. 10 / 36

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"The loading of the translation initiation factor eIF3h into polysomes in response to auxin is impaired in TOR-deficient mutants with an inactive S6K form, suggesting that eIF3h is possibly phosphorylated by the TOR/S6K1 pathway ( xref )."

28491073

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"We therefore analyzed the levels of phosphorylation of eIF3H in the cervical cancer cell line HeLa."

22304650

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"Upregulated TOR is recruited to polysomes where it phosphorylates S6K1, which shortly before its release from polysomes phosphorylates eIF3h."

29281028

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"As shown in xref and xref – xref , we found that the inhibitors for PI3K (LY294002), S6K1 (PF4708671), Src (dasatinib) and mTOR (rapamycin) block EIF3H Ser/Thr phosphorylation, EIF3H-YAP binding and EIF3H-governed YAP accumulation but no effect for EIF3H/EIF3A binding."

32269044

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"Among novel biochemical markers of brain damage neuroserpin may be a promising predictor of type 2 neurological complications and may express neuroregeneration after off-pump CABG, while glial fibrillary acidic protein, phosphorylated axonal neurofilament subunit H and visinin-like protein 1 may not be suitable for this clinical setting."

31863758

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"Serum concentrations of glial fibrillary acidic protein, neuroserpin, phosphorylated axonal neurofilament subunit H and visinin-like protein 1 were evaluated at baseline, end of surgery as well as on postoperative day 1 and 7."

31863758

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"TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h."

33659803

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"Another possible plasma biomarker of CRCI is axonal phosphorylated neurofilament subunit H (pNF-H)."

34970595

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"It is theoretically possible that eIF3h phosphorylation is a trigger for S6K1 departure from polysomes."

29281028

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"The phytohormone auxin activates TOR kinase, promoting S6K1 phosphorylation at T449 and translation reinitiation of upstream open reading frame (uORF)-containing mRNAs via phosphorylation of eIF3h (eukaryotic initiation factor 3, subunit h) ( xref )."

25399018

EIF3H is phosphorylated on S183. 7 / 7

5 | 1 1

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hprd

No evidence text available

20068231

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No evidence text available

17322306

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hprd

No evidence text available

18691976

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hprd

No evidence text available

19651622

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"This observation coincides with the critical in vivo effects of eIF3h’s ser-183 phosphorylation during malignant transformation of NIH 3T3 cells [ xref , xref ]."

24979134

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rlimsp

"This oncogenic potential of eIF3h is enhanced by phosphorylation at Ser(183)."

18544531

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hprd

No evidence text available

18767875

EIF3H is phosphorylated on T11. 1 / 1

1 |

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hprd

No evidence text available

17924679

EIF3H is phosphorylated on S10. 1 / 1

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hprd

No evidence text available

17924679

EIF3H is phosphorylated on T8. 1 / 1

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hprd

No evidence text available

17924679

EIF3H is phosphorylated on S31. 1 / 1

| 10 30

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"The interaction between METTL3 and eIF3h is essential for translation and oncogenic transformation in lung cancer (31)."

34568001

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"Mechanistically, exosomal circLPAR1 was internalized by CRC cells, and it suppressed tumor growth, likely because exosomal circLPAR1 directly bound with eIF3h specifically suppressed the METTL3-eIF3h interaction, decreasing the translation of oncogene BRD4."

35164758

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"We next tested the functional interaction between METTL3 and eIF3h, and found depletion of eIF3h abrogated the enhanced translation by METTL3 ( xref and xref )."

30232453

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"In particular mRNA looping generated by METTL3-eIF3h interaction enhances translation of a large subset of oncogenic mRNAs, paving the way for the development of new cancer therapeutic strategies [ xref ]."

33202605

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"In mammals, a direct functional and physical interaction between METTL3 and eIF3h supports the mRNA looping mechanism for ribosome recycling and translational control [ xref ], since eIF3 is essential for the attachment of the recycled 40S subunits to mRNA to start a new round [ xref , xref ]."

34070794

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"In addition, direct physical and functional interactions between eIF3h and METTL3 have been reported to be required for enhanced translation of oncogenic mRNAs, formation of densely packed polyribosomes and oncogenic transformation of lung adenocarcinoma ( xref )."

36118041

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"The METTL3-eIF3h interaction is required for enhanced translation, formation of densely packed polyribosomes, and oncogenic transformation."

30232453

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"This is supported by; 1) the position-dependent effects of METTL3 tethering on mRNA translation, 2) EM visualization of METTL3 bound to endogenous polyribosomes and its proximity to cap-binding proteins, 3) METTL3 interaction with eIF3h, and 4) Disruption of METTL3-eIF3h interaction abolishes the ability of METTL3 to promote translation, affect polysome conformation, or promote oncogenic transformation."

30232453

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"For example, METTL3, METTL14 and WTAP compose a complex that promotes the localization of MTC at nuclear speckles [ xref ] and METTL3 interacts with eIF3h to enhance mRNA translation [ xref ]."

33808751

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"We next tested the functional interaction between METTL3 and eIF3h, and found depletion of eIF3h abrogated the enhanced translation by METTL3 (XREF_FIG and XREF_FIG)."

30232453

METTL3 binds EIF3H and 6 A. 1 / 1

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"The authors thus proposed a novel " mRNA looping " mechanism, in which METTL3 binds to the m 6 A modified 3 ' UTR of target mRNA and then recruits eIF3h as well as translation initiation factors such as CBP800 and eIF4e, thus facilitating the ribosome recycling and promoting translation efficiency [XREF_BIBR, XREF_BIBR]."

32854717

METTL3 activates EIF3H.

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METTL3 activates EIF3H. 2 / 2

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"In addition, METTL3 can promote oncogene translation independently of m A readers by recruiting eIF3h."

31921660

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"METTL3 can promote cancer cell growth, survival, and invasion by recruiting eIF3h to the translation initiation complex and directly promotes oncogene translation independently of its MTase activity (34)."

31921660

EIF3H affects METTL3

| 12 30

EIF3H binds METTL3.

| 11 30

METTL3 binds EIF3H. 10 / 40

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"The interaction between METTL3 and eIF3h is essential for translation and oncogenic transformation in lung cancer (31)."

34568001

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35164758

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"We next tested the functional interaction between METTL3 and eIF3h, and found depletion of eIF3h abrogated the enhanced translation by METTL3 ( xref and xref )."

30232453

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33202605

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34070794

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36118041

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"The METTL3-eIF3h interaction is required for enhanced translation, formation of densely packed polyribosomes, and oncogenic transformation."

30232453

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30232453

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"For example, METTL3, METTL14 and WTAP compose a complex that promotes the localization of MTC at nuclear speckles [ xref ] and METTL3 interacts with eIF3h to enhance mRNA translation [ xref ]."

33808751

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"We next tested the functional interaction between METTL3 and eIF3h, and found depletion of eIF3h abrogated the enhanced translation by METTL3 (XREF_FIG and XREF_FIG)."

30232453

METTL3 binds EIF3H and 6 A. 1 / 1

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32854717

EIF3H inhibits METTL3.

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EIF3H inhibits METTL3. 1 / 1

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"Knockdown of eIF3h suppressed the ability of METTL3 to promote cellular invasion (XREF_FIG and XREF_FIG)."

30232453

EIF3H affects EIF3E

7 | 2 22

EIF3H binds EIF3E. 10 / 24

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"AteIF3f protein interacts with the Arabidopsis regulatory subunit eIF3e and eIF3h in yeast and plant cells 2004)."

20444226

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biogrid

No evidence text available

22863883

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"In support of this, the association of the eIF3k : eIF3l dimer with eIF3 requires prior recruitment of eIF3e and eIF3h to the complex; knocking down eIF3h or eIF3e results in the strong and simultaneous downregulation of both eIF3k and l."

27924037

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"AteIF3f protein interacts with the Arabidopsis regulatory subunit eIF3e and eIF3h in yeast and plant cells."

20444226

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"In addition, the eIF3f subunit has been confirmed to interact with eIF3e and eIF3h ( xref )."

27703462

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"EIF3e and eIF3h interact directly with each other in Arabidopsis (Kim et al., 2004)."

20444226

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"Co‐expression of these bait and target constructs showed that AteIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast (Figure 10)."

20444226

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"EIF3e and eIF3h interact directly with each other in Arabidopsis ( xref )."

20444226

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biogrid

No evidence text available

26344197

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"AteIF3f protein interacts with Arabidopsis eIF3e and eIF3h in yeast."

20444226

EIF3H binds EIF3F and EIF3E. 5 / 5

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"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."

20444226

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"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."

20444226

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"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."

20444226

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sparser

"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."

20444226

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"A polysome mRNA analysis on HeLa, HEK293 and NIH3T3 cells has revealed that eIF3e, eIF3f and eIF3h mRNAs are mainly associated with subpolysomal particles in quiescent or growth-arrested cells, but mostly associated with polysomes in growing cells [ xref ]."

23354061

EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1

| 1

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"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."

31171919

EIF3A binds EIF3H, EIF3E, EIF3C, and EIF3B. 1 / 1

| 1

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"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."

27703462

EIF3H affects SNAI1

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EIF3H binds SNAI1.

| 12 1 1

SNAI1 binds EIF3H. 10 / 13

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"Next, immunoprecipitation of endogenous Snail from KYSE510 cells also confirmed the interaction between endogenous Snail and EIF3H."

32867821

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"EIF3H interacts with Snail."

32867821

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"To shed light on how EIF3H interacts with Snail, we further determined their cellular localization by immunofluorescence analysis."

32867821

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"Our study reveals a critical EIF3H-Snail signaling axis in tumor aggressiveness in ESCC and provides EIF3H as a promising biomarker for ESCC treatment."

32867821

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"We performed a co-IP assay combined with the mass spectrometry analysis and identified that an EMT associated transcription factor, Snail could interact with EIF3H."

32867821

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"In order to get a comprehensive understanding about the significance of EIF3H and the mechanism of its function in ESCC, we performed a liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis and identified that EIF3H could interact with Snail and correlate positively with Snail expression."

32867821

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"We demonstrated that EIF3H interacts with and stabilizes Snail through deubiquitination."

32867821

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"Additional in vivo co-IP assay was performed in HEK293T and KYSE510 EIF3H-knockdown cells to test the specificity of the interaction between Snail and EIF3H."

32867821

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"EIF3H interacts with and deubiquitinates Snail to prolong its half-life."

32867821

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"The interaction between EIF3H and Snail suggests the ability of EIF3H to regulate Snail expression."

32867821

SNAI1 binds EIF3H. 1 / 1

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isi

"EIF3H interacts with Snail"

32867821

EIF3H increases the amount of SNAI1.

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EIF3H increases the amount of SNAI1. 5 / 5

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"The interaction between EIF3H and Snail suggests the ability of EIF3H to regulate Snail expression."

32867821

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isi

"Expression of Snail and EIF3H was detected (left) and the intensity of Snail expression was quantified by Image J software (right).cSnail-Flag, HA-UB plasmids with or without EIF3H were co-transfected in HEK293T cells for 24 h. After another 4 h 10 muM MG132 incubation, the ubiquitination assay was performed to detect the poly-ubiquitination of Snail.dandeThe CHX pulse-chase assay was performed on EIF3H stably overexpressed in KYSE150 and KYSE510 cells."

32867821

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isi

"Clinically, the levels of EIF3H were positively correlated with Snail expression."

32867821

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isi

"In concordance with our findings in xenograft model, the expression levels of EIF3H were positively correlated with Snail expression in the ESCC tissue samples (Fig.7c)."

32867821

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isi

"The Snail and EIF3H expression were analyzed by immunoblotting (left panel)."

32867821

Modified EIF3H increases the amount of SNAI1. 1 / 1

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"XREF_FIG a, EIF3H expression increased Snail protein level."

reach

"Meanwhile, knockdown EIF3F, which directly binds to EIF3H and could function as deubiquitinase, has no effect on YAP expression and cytosol and nuclear ratios (XREF_FIG - XREF_FIG and XREF_SUPPLEMENTARY)."

32269044

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"To test whether eIF3f and eIF3h actually interact with the eIF4GI682-1130-MS2 fusion protein, we co-expressed both factors transiently in HEK 293T cells, immunoprecipitated the eIF4G core domain via its MS2 fusion in presence of RNase A and tested for its association of eIF3f and eIF3h ( xref )."

25148142

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biogrid

No evidence text available

28514442

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biogrid

No evidence text available

22939629

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sparser

"Our results show that At eIF3f interacts with eIF3h."

20444226

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biogrid

No evidence text available

19615732

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"In fact, interactions between DTrc8 and eIF3f or eIF3h were stronger than observed with Csn5."

20068067

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"xDnd1 directly binds eIF3f and in IP experiments, brings down eIF3m and eIF3h, which associate with eIF3f ( xref )."

30230100

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"Based on the convincing fit of the eIF3a and eIF3c structure into the EM density, we attempted to dock the recently solved paralogs of eIF3e (CSN1) and the eIF3h and eIF3f heterodimer (Rpn8 and Rpn11) into the eIF3.IRES EM density along with older models for eIF3k, eIF3m, and eIF3l (XREF_FIG A)."

25171412

EIF3H binds EIF3F and EIF3E. 5 / 5

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"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."

20444226

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sparser

"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."

20444226

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sparser

"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."

20444226

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sparser

"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."

20444226

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23354061

RNF139 binds EIF3H and EIF3F. 2 / 2

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"The subunit eIF3g interacts with Paip1, a Poly (A)-binding protein and stimulates translation initiation [ xref ], whereas the subunits eIF3h and eIF3f interact with TRC8, a ubiquitin E3 ligase, and inhibit protein synthesis, possibly through ubiquitilation of eIF3 or some other translational components [ xref ]."

23354061

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"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."

20068067

EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1

| 1

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"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."

31171919

GNPTAB binds EIF3H and EIF3F. 1 / 1

| 1

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"DTrc8 genetically and physicially interacted with two eIF3 subunits, eIF3f and eIF3h."

20068067

EIF3H binds EIF3F and EIF4G1. 1 / 1

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"The same study however also suggests a close association of eIF3f and eIF3h (among other subunits) with eIF4GI."

25148142

EIF3H affects cell population proliferation

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EIF3H activates cell population proliferation.

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EIF3H activates cell population proliferation. 10 / 21

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"The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H."

30022709

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"Our results suggest that eIF3h content is near a threshold in Hap1 cells, since overexpression of SNAP-eIF3H appears to diminish wild-type eIF3h protein levels and fails to increase the proliferation rate of wild-type cells."

29136179

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"EIF3h potentiates the cell proliferation and inhibits the cell apoptosis of gastric cancer cells 13."

31423012

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eidos

"Knockdown of EIF3H inhibited cell proliferation and colony formation ."

32867821

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"Previous studies have shown that RFFL and HDAC2 are known to also promote tumor formation by inhibiting the apoptosis process [XREF_BIBR, XREF_BIBR, XREF_BIBR], whereas EIF3H is known to increase cell proliferation, growth and survival and inhibit the apoptosis process [XREF_BIBR]."

24377043

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"EIF3H overexpression increases tumor cell proliferation, growth, and survival."

27340783

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"Finally, reduction of eIF3h levels in breast and prostate cancer cell lines by short interfering RNA methods reduces their rates of proliferation and anchorage independent growth in soft agar."

18544531

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"The higher polyp number associated with the C allele of rs16892766 could be explained by the location of this SNP in the EIF3H gene, which increases cell proliferation, growth, and survival when overexpressed."

26880076

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"Reduction of eIF3h levels in breast and prostate cancer cell lines by shRNA methods has previously been shown to reduce cell proliferation and anchorage independent growth in soft agar XREF_BIBR."

20862326

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"XREF_BIBR At the cellular level, EIF3H overexpression increases proliferation, growth and survival."

19204574

EIF3H inhibits cell population proliferation.

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EIF3H inhibits cell population proliferation. 6 / 6

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"Furthermore, the loss-of-function assays demonstrated that knockdown of EIF3H could inhibit the progression of pancreatic cancer cells by reducing proliferation capacity, promoting apoptosis, arresting cell cycle in G2 and suppressing cell migration."

35809300

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"Knockdown of the translation initiation factor EIF3H, which scored as essential in 8 BrCa, 5 PDAC, and 3 HGS-OvCa cell lines, by any of three independent shRNAs significantly reduced cell proliferation in the HGS-OvCa cell lines tested (OVCAR5, OVCAR8 and A2780) (XREF_FIG)."

22585861

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"The in vitro results indicated that silencing EIF3H in MM cells could significantly suppress cell proliferation, promote cell apoptosis and induce cell cycle arrest."

33508274

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"We observed that EIF3H overexpression in both KYSE150 and KYSE510 cells increased cell proliferation in vitro, whereas depletion of EIF3H significantly reduced cell proliferation."

32867821

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"Knockdown of EIF3H significantly inhibited the proliferation and colony formation of OS cells in vitro, and tumour growth in nude mice in vivo."

29805516

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"EIF3H depletion in ESCC cells significantly decreased the ability of cell proliferation and mobility, examined by CCK8 assay, colony formation assay and transwell assay in vitro and xenograft and tail-vein lung metastatic mouse models in vivo."

32867821

EIF3H affects YAP1

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EIF3H binds YAP1.

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YAP1 binds EIF3H. 10 / 21

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"In addition, the interaction between endogenous EIF3H and YAP in both cytosol and nucleus was further confirmed by confocal immunofluorescence and in situ Proximity Ligation Assay ( xref and xref )."

32269044

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32269044

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"We further observed, while EIF3H cofractionated with EIF3A in peak I (Fraction 2-4), EIF3H cofractionated with YAP in peak II (Fraction 8-12), suggesting the presence of two endogenous EIF3H complexes, one eIF3 complex and another EIF3H-YAP complex."

32269044

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"Mutated EIF3H catalytic core or disrupted EIF3H-YAP binding affect YAP expression independent on translation."

32269044

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"These results implicated that mutated EIF3H catalytic core (EIF3H DDQ/AAA ) or disrupted EIF3H-YAP binding (EIF3H YW/AA ) has no effect on eIF3 complex integrity, YAP mRNA binds to eIF3 complex."

32269044

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"The above analysis has indicated the importance of the N-terminal 14 amino acids on YAP and the amino acid stretch 34-146 on EIF3H in mediating the interaction between YAP and EIF3H. To further identify the pivotal amino acid residues in EIF3H responsible for recognition of YAP by EIF3H, we have further performed molecular docking simulations by homology modelling service iTASSER and Haddock ( xref – xref )."

32269044

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"As shown in xref – xref , replacement of Trp119, Tyr140 alone or combine by alanines significantly destabilized EIF3H-binding to YAP, presumably due to the perturbation of the interfacial interactions between EIF3H and YAP ( xref ), and reduced the deubiquitylation capacity of EIF3H, which function same as the catalytic core mutant EIF3H DDQ/AAA ( xref )."

32269044

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"Our blast analysis further suggests the potential role for the four conserved proline residues in this region that facilitate the interaction between YAP and EIF3H ( xref )."

32269044

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"The identification of an interaction between EIF3H and YAP brings us a puzzle because EIF3H was previously thought as a member of the eIF3 complex involved in regulating protein translational initiation and elongation ( xref )."

32269044

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"To our surprise, we observed, while only overexpression of the wild-type EIF3H fully recapitulates lung metastasis, the expression of mutant EIF3H fails to restore lung metastasis, indicating that EIF3H-YAP axis is critical for EIF3H-driven tumor invasion and metastasis ( xref and xref )."

32269044

EIF3H activates YAP1.

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EIF3H activates YAP1. 1 / 1

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eidos

"EIF3H catalyzed YAP for deubiquitylation , resulting in its stabilization ."

32269044

SNAI1 affects EIF3H

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SNAI1 binds EIF3H.

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SNAI1 binds EIF3H. 10 / 13

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"Next, immunoprecipitation of endogenous Snail from KYSE510 cells also confirmed the interaction between endogenous Snail and EIF3H."

32867821

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"EIF3H interacts with Snail."

32867821

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"To shed light on how EIF3H interacts with Snail, we further determined their cellular localization by immunofluorescence analysis."

32867821

➶

sparser

"Our study reveals a critical EIF3H-Snail signaling axis in tumor aggressiveness in ESCC and provides EIF3H as a promising biomarker for ESCC treatment."

32867821

➶

reach

"We performed a co-IP assay combined with the mass spectrometry analysis and identified that an EMT associated transcription factor, Snail could interact with EIF3H."

32867821

➶

reach

32867821

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"We demonstrated that EIF3H interacts with and stabilizes Snail through deubiquitination."

32867821

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"Additional in vivo co-IP assay was performed in HEK293T and KYSE510 EIF3H-knockdown cells to test the specificity of the interaction between Snail and EIF3H."

32867821

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"EIF3H interacts with and deubiquitinates Snail to prolong its half-life."

32867821

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"The interaction between EIF3H and Snail suggests the ability of EIF3H to regulate Snail expression."

32867821

SNAI1 binds EIF3H. 1 / 1

| 1

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"EIF3H interacts with Snail"

32867821

SNAI1 increases the amount of EIF3H.

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SNAI1 increases the amount of EIF3H. 3 / 3

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32867821

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isi

"In clinical ESCC samples, there is also a positive correlation between EIF3H and Snail expression."

32867821

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isi

"Scale bars, 100 mum.cThe positive correlation was obtained in ESCC samples between EIF3H and Snail protein expression"

32867821

SNAI1 decreases the amount of EIF3H.

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SNAI1 decreases the amount of EIF3H. 1 / 1

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"Knockdown of Snail strikingly reversed the promoting effects of ectopic expression of EIF3H."

32867821

EIF3H affects apoptotic process

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EIF3H inhibits apoptotic process.

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EIF3H inhibits apoptotic process. 9 / 10

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"Overexpression of eIF3h has recently been shown to inhibit Myc dependent induction of apoptosis of primary prostate cells and EIF3H and MYC and may cooperate in enhanced protein translation either in a general way or for a specific subset of mRNAs XREF_BIBR."

20862326

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"As shown in XREF_FIG, EIF3H knockdown also increased the rate of apoptosis in the two OS cell lines based on flow cytometry using Annexin V and 7-AAD double staining at both the early and late phases of apoptosis (Saos2 cells : 14.13 and 3.83% vs. 4.97 and 0.67% in controls, respectively, P < 0.05; U2OS cells : 7.96 and 12.53% vs. 6.89 and 7.14% in controls, respectively, P < 0.01)."

29805516

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"Mahmood et al demonstrated that EIF3H knockdown with specific small interfering RNA induced cell cycle arrest and apoptosis in breast tumour cells."

29805516

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"Furthermore, overexpressed eIF3h inhibits Myc dependent induction of apoptosis of primary prostate cells."

18544531

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"EIF3h potentiates the cell proliferation and inhibits the cell apoptosis of gastric cancer cells 13."

31423012

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reach

"Thus, we come to the conclusion that EIF3H promotes proliferation and migration of iCCAs, inhibiting apoptosis of iCCA cells at the same time by stabilizing the CCND1 protein structure."

36350008

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"XREF_BIBR Coamplification of EIF3H may also reduce MYC dependent apoptosis in prostate epithelial cells."

19204574

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"EIF3H knockdown inhibited cell growth, migration, colony formation, and promoted apoptosis, and this was confirmed with GFP expressing infected cells that were counted daily for 5 days."

27340783

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reach

"The knockdown of EIF3H, TPPP3, or DOCK2 promoted apoptosis of stem cells."

33509274

EIF3H activates apoptotic process.

| 5

EIF3H activates apoptotic process. 5 / 5

| 5

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"Knockdown of EIF3H inhibits the development and progression of pancreatic cancer by regulating cell proliferation and apoptosis in vitro."

35809300

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"In addition, we showed that EIF3H knock-down led to cell apoptosis."

30022709

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reach

"Knockdown of EIF3H led to cell cycle arrest and promoted apoptosis in OS cells."

29805516

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reach

"The in vitro results indicated that silencing EIF3H in MM cells could significantly suppress cell proliferation, promote cell apoptosis and induce cell cycle arrest."

33508274

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35809300

EIF3H affects Neoplasm Metastasis

| 4 11

EIF3H activates Neoplasm Metastasis. 10 / 13

| 4 9

➶

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"Besides, it also takes part in EMT process and the knockdown of EIF3H suppressed tumor metastasis in vivo."

32867821

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"Taken together, these results indicate that EIF3H knockdown inhibits cell mobility and tumor metastasis in ESCC."

32867821

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reach

"To find out whether EIF3H enhances cancer metastasis ability in vivo, we then performed lung metastatic model assay."

32867821

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reach

"Our results exhibited that ectopic expression of EIF3H promoted ESCC metastasis with the increase of Snail, N-Cadherin and Vimentin, and decrease of E-cadherin, while knockdown of EIF3H exerted an opposite effect."

32867821

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reach

"In the spontaneous lung metastasis model, we observed that loss of EIF3H significantly decreased lung metastasis nodules."

32269044

➶

eidos

"Other than the translation-initiation function of EIF3H , in the present study , our finding that EIF3H promotes metastasis through stabilizing YAP addresses a knowledge gap for YAP turnover regulation ."

32269044

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eidos

"Besides , it also takes part in EMT process and the knockdown of EIF3H suppressed tumor metastasis in vivo ."

32867821

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reach

"Thus, functional knockdown of EIF3H expression inhibits HCC growth and metastasis in vitro and in vivo."

27340783

➶

eidos

"To find out whether EIF3H enhances cancer metastasis ability in vivo , we then performed lung metastatic model assay ."

32867821

➶

eidos

"Taken together , these results indicate that EIF3H knockdown inhibits cell mobility and tumor metastasis in ESCC ."

32867821

EIF3H bound to PDCD4 activates Neoplasm Metastasis. 1 / 1

| 1

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reach

"EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis."

32064160

Mutated EIF3H activates Neoplasm Metastasis. 1 / 1

| 1

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reach

"To our surprise, we observed, while only overexpression of the wild-type EIF3H fully recapitulates lung metastasis, the expression of mutant EIF3H fails to restore lung metastasis, indicating that EIF3H-YAP axis is critical for EIF3H driven tumor invasion and metastasis (XREF_FIG and XREF_SUPPLEMENTARY)."

32269044

GPHN affects EIF3H

| 6 6

GPHN binds EIF3H. 8 / 8

| 5 3

➶

sparser

"These results demonstrate that gephyrin also interacts with eIF3H in mammalian cells."

20858277

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sparser

"In addition, we demonstrated that gephyrin also interacts with eIF3H in non-neuronal cells and forms a complex with eIF3 in the brain."

20858277

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sparser

"In addition, we showed that gephyrin also interacts with eIF3H in 293T cells and that CB, gephyrin and eIF3H seem to assemble into a trimeric protein complex."

20858277

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reach

"In addition, we demonstrated that gephyrin also interacts with eIF3H in non neuronal cells and forms a complex with eIF3 in the brain."

20858277

➶

reach

"Collybistin and gephyrin associate with eIF3H in mammalian cells."

20858277

➶

reach

"These results demonstrate that gephyrin also interacts with eIF3H in mammalian cells."

20858277

➶

reach

"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."

20858277

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reach

"We then examined the possibility that gephyrin may also interact with eIF3H."

20858277

GPHN binds EIF3H and CB. 2 / 2

| 2

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"Although we cannot rule out the possibility that these results are due to the formation of two independent protein complexes, CB-gephyrin and gephyrin-eIF3H, they suggest that these interactions are not mutually exclusive (as both could potentially form at the same time), and raise the possibility that CB, gephyrin and eIF3H can form a trimeric protein complex in mammalian cells."

20858277

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sparser

"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."

20858277

GPHN binds EIF3H and 293T. 1 / 1

| 1

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reach

"In addition, we showed that gephyrin also interacts with eIF3H in 293T cells and that CB, gephyrin and eIF3H seem to assemble into a trimeric protein complex."

20858277

GPHN binds EIF3H and collybistin. 1 / 1

| 1

➶

sparser

"Collybistin and gephyrin associate with eIF3H in mammalian cells."

20858277

EIF3H affects EIF3B

8 | 1 2

EIF3H binds EIF3B. 9 / 9

8 | 1

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"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."

20444226

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26344197

EIF3A binds EIF3H, EIF3E, EIF3C, and EIF3B. 1 / 1

| 1

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sparser

"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."

27703462

EIF3H binds EIF3D and EIF3B. 1 / 1

| 1

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sparser

"For instance, we observe that the association of eukaryote translation initiation factor 3 (eIF3) components, such as EIF3B, EIF3D and EIF3H, with translating ribosomes was significantly stabilized upon formaldehyde cross-linking ( xref ), consistent with previously published studies ( xref )."

28625553

EIF3H affects translation

| 10

EIF3H activates translation.

| 9

EIF3H activates translation. 9 / 9

| 9

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"These risk variants, conferring an approximate 10%-18% increase in risk per allele, are located either inside or near protein coding genes that include TFEB (lysosome biogenesis and autophagy), EIF3H (initiation of translation), CYP17A1 (steroidogenesis), SPSB2 (proteasome degradation), and RPS21 (ribosome biogenesis)."

26965516

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"Our results are in agreement with these ideas and suggest an eIF3H mediated control of HIF-1alpha translation that could explain in part its oncogenic properties."

25166596

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reach

"In any case, polysomal microarray analysis clearly demonstrated that eIF3h is a general stimulator of efficient translation of short uORF (s)-containing mRNAs throughout the transcriptome."

29281028

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reach

"In agreement with this, our data show that, as CCT is required for the correct folding of eIF3h and eIF3i subunits, it indirectly influences gene expression with eIF3i overexpression enhancing both cap- and IRES (internal ribosome entry segment)-dependent translation initiation, whereas eIF3h overexpression selectively increases IRES dependent translation initiation."

24320561

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"Together with the study which suggests that eIF3h may play an important regulatory role in translation of specific mRNAs [75] as discussed above, these findings suggest that aberrant over-expression o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

16829125

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"Earlier studies found that the elevation of eIF3h could stimulate protein synthesis."

32708122

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reach

"This is an important TOR effect, since the S6K pathway not only stimulates overall protein synthesis but also eIF3h mediated translation reinitiation after an upstream open reading frame (uORF), a frequent feature found in plant mRNAs."

28491073

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"Interestingly, the oncogenic function of METTL3 in NSCLC is complicated, where METTL3 could methylate YAP mRNA and recruit YTHDF1/3 and eIF3b to promote translation of YAP mRNA, or could interact with eIF3h to promote translation of target mRNAs (e.g., BRD4) independent of its enzymatic activity."

32183948

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reach

"Translation assays revealed that eIF3h supports the efficient translation of the mRNAs for CLV1 and the leaf transcription factor, AS1, which contain uORFs in their 5 ' UTR."

24736281

EIF3H inhibits translation.

| 1

EIF3H inhibits translation. 1 / 1

| 1

➶

reach

"We next tested the functional interaction between METTL3 and eIF3h, and found depletion of eIF3h abrogated the enhanced translation by METTL3 (XREF_FIG and XREF_FIG)."

30232453

EIF3H affects EIF3D

7 | 1 2

EIF3H binds EIF3D.

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EIF3H binds EIF3D. 7 / 7

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22863883

EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1

| 1

➶

sparser

"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."

31171919

EIF3H binds EIF3D and EIF3B. 1 / 1

| 1

➶

sparser

28625553

EIF3H inhibits EIF3D.

| 1

EIF3H inhibits EIF3D. 1 / 1

| 1

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reach

"Depletion of eIF3d, but not eIF3e or eIF3h, reduced the inhibitory effect of SXL, suggesting that eIF3d is a potential target of the repressor complex within the translational machinery."

29635389

EIF3H affects EIF3A

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EIF3A binds EIF3H. 9 / 9

9 |

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17353931

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9822659

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19615732

EIF3A binds EIF3H, EIF3E, EIF3C, and EIF3B. 1 / 1

| 1

➶

sparser

"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."

27703462

EIF3H affects Neoplasm Invasiveness

| 9

EIF3H activates Neoplasm Invasiveness.

| 8

EIF3H activates Neoplasm Invasiveness. 8 / 8

| 8

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"We found that EIF3H overexpression significantly increased the abilities of migration and invasion in KYSE150 and KYSE510 cells."

32867821

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reach

"Functional analyses showed that EIF3H overexpression promoted LUAD cell migration and invasion in vitro as well as metastasis in nude mice by activating epithelial-mesenchymal transition (EMT) signaling."

32064160

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reach

"Increased expression of EIF3H gene increases CRC growth and invasiveness thereby providing a biological mechanism for the 8q23.3 association XREF_BIBR."

25609216

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reach

"We found that EIF3H is significantly upregulated in esophageal cancer and ectopic expression of EIF3H in ESCC cell lines promotes cell proliferation, colony formation, migration and invasion."

32867821

➶

reach

"We observed, while the elevation of EIF3H drastically increases the tumor invasion in various breast cancer cell lines, including MDA-MB-231, 4T1, depletion of EIF3H by RNA interference largely attenuates tumor invasion (XREF_FIG - XREF_FIG & XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."

32269044

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"As shown in XREF_FIG - XREF_FIG and XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY, knockdown of either the YAP and CTGF expression abrogated EIF3H driven tumor cell invasion."

32269044

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reach

"We show that increased expression of EIF3H gene increases CRC growth and invasiveness thereby providing a biological mechanism for the 8q23.3 association."

20862326

➶

reach

"To further determine whether YAP is a physiologically relevant substrate for EIF3H that mediates EIF3H promoted tumor cell invasion, we have characterized catalytic function for EIF3H in regulating YAP abundance, YAP turnover rate and YAP ubiquitylation."

32269044

EIF3H inhibits Neoplasm Invasiveness.

| 1

EIF3H inhibits Neoplasm Invasiveness. 1 / 1

| 1

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32269044

EIF3H affects EIF3C

6 | 2 1

EIF3H binds EIF3C. 8 / 8

6 | 2

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22863883

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26344197

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"In Arabidopsis, eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits."

27703462

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26186194

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22939629

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"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."

20444226

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28514442

EIF3A binds EIF3H, EIF3E, EIF3C, and EIF3B. 1 / 1

| 1

➶

sparser

"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."

27703462

EIF3D affects EIF3H

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EIF3H binds EIF3D. 7 / 7

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22863883

EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1

| 1

➶

sparser

"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."

31171919

EIF3H binds EIF3D and EIF3B. 1 / 1

| 1

➶

sparser

28625553

EIF3C affects EIF3H

6 | 2 1

EIF3H binds EIF3C. 8 / 8

6 | 2

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No evidence text available

22863883

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26344197

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"In Arabidopsis, eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits."

27703462

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26186194

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22939629

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"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."

20444226

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28514442

EIF3A binds EIF3H, EIF3E, EIF3C, and EIF3B. 1 / 1

| 1

➶

sparser

"In Arabidopsis , eIF3h interacts directly with the eIF3a, eIF3b, eIF3c, and eIF3e subunits ( xref )."

27703462

RPS6KB1 affects EIF3H

1 | 5 2

RPS6KB1 phosphorylates EIF3H.

| 4 1

RPS6KB1 phosphorylates EIF3H. 4 / 4

| 3 1

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reach

"S6K1 in turn phosphorylates the subunit h of eukaryotic Initiation Factor 3 (eIF3h), which promotes loading of mRNAs that carry upstream open reading frames (uORFs) within their 5' untranslated regions (5'UTRs) into the ribosome for translation re-initiation (Figure 1) (Schepetilnikov et al., 2013)."

32117365

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"Upregulated TOR is recruited to polysomes where it phosphorylates S6K1, which shortly before its release from polysomes phosphorylates eIF3h."

29281028

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"The previous report demonstrated EIF3H is regulated in response to mTOR-S6K1 cascade, where EIF3H can be phosphorylated by S6K1 kinase through the serine 183 on EIF3H ( xref )."

32269044

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reach

"The loading of the translation initiation factor eIF3h into polysomes in response to auxin is impaired in TOR deficient mutants with an inactive S6K form, suggesting that eIF3h is possibly phosphorylated by the TOR and S6K1 pathway."

1 | 1 5 1

PDCD4 binds EIF3H.

1 | 1 2 1

EIF3H binds PDCD4. 5 / 5

1 | 1 2 1

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"EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis."

32064160

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reach

"EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis."

32064160

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sparser

"Co-immunoprecipitation assays combined with mass spectrometry and immunofluorescent co-localization indicated that PDCD4 interacted with EIF3H. Overexpression of PDCD4 in LUAD cells reduced EIF3H mRNA and protein levels by suppressing c-Jun-induced EIF3H transcription."

32064160

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| 4

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"These results demonstrate that CB interacts with eIF3H in mammalian cells."

20858277

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sparser

"To investigate whether CB and eIF3H associate in a mammalian cell context, coimmunoprecipitation assays were carried out."

20858277

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sparser

"Yeast-two-hybrid assay using the human CB lacking the SH3 domain (bait protein GAL4BD-CB SH3- ) showed that this truncated form of CB can also interact with eIF3H, indicating that this domain is not required to mediate the interaction with eIF3H (Figure xref )."

20858277

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sparser

"Also, through YTH assay, we showed that the SH3 domain of CB is not required for interaction with eIF3H. Interaction of CB and eIF3H was further substantiated by coimmunoprecipitation of transiently expressed proteins in 293T cells."

20858277

EIF3H binds CB. 2 / 2

| 2

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reach

"These results demonstrate that CB interacts with eIF3H in mammalian cells."

20858277

➶

reach

"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."

20858277

GPHN binds EIF3H and CB. 2 / 2

No evidence text available

26789921

EIF3L affects EIF3H

6 | 1

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6 |

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| 3

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"We resorted to surface plasmon resonance assays to obtain further confirmation of a direct interaction between eIF3h and M, and to determine the characteristics of such an interaction."

17287294

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17287294

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17287294

EIF3H binds M. 1 / 1

1 |

➶

virhostnet

No evidence text available

26789921

EIF3H affects EIF3L

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26344197

EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1

| 1

➶

sparser

"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."

31171919

EIF3H affects EIF3G

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EIF3H binds EIF3G. 7 / 7

6 1 |

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22939629

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hprd

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9822659

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28514442

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9822659

MYH9 affects EIF3H

| 6

EIF3H binds MYH9. 6 / 6

| 6

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"Driver_result reports the “MYH9-EIF3H” fusion gene as a driver for the HCC1395BL sample."

35113898

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sparser

"Driver_correlation_coefficient calculates the correlation coefficient of the input fusion gene “MYH9-EIF3H” in the HCC1395BL sample."

35113898

➶

sparser

"Driver_domain plots domain information of the driver fusion gene “MYH9-EIF3H”."

35113898

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sparser

"Driver_plot visualizes supporting SV and CNV profile in the HCC1395BL sample for driver fusion gene “MYH9-EIF3H”."

35113898

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sparser

"Driver_object reports SV and CNV profile in the HCC1395BL sample responsible for the formation of driver fusion gene “MYH9-EIF3H”."

35113898

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"In the case of the breast cancer dataset, DriverFuse reports the “MYH9-EIF3H” fusion gene as a driver for the HCC1395BL sample."

35113898

EIF3M affects EIF3H

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26344197

EIF3K affects EIF3H

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EIF3K binds EIF3H. 6 / 6

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26186194

EIF3I affects EIF3H

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EIF3I binds EIF3H. 5 / 5

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"Thus it is not clear what functional role the interactions between eIF3i and eIF3h may play, if any, in eIF3 assembly."

27210288

EIF3I binds EIF3H, SXL, and pic. 1 / 1

| 1

➶

sparser

"Yeast two-hybrid experiments revealed specific interaction of Sxl with eIF3h and eIF3i PIC subunits, but the authors [ xref ] were unable to obtain evidence for a role of these interactions in stalling or locking the PIC on the uORF."

21787382

EIF3H affects MYH9

| 6

EIF3H binds MYH9. 6 / 6

| 6

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sparser

"Driver_result reports the “MYH9-EIF3H” fusion gene as a driver for the HCC1395BL sample."

35113898

➶

sparser

"Driver_correlation_coefficient calculates the correlation coefficient of the input fusion gene “MYH9-EIF3H” in the HCC1395BL sample."

35113898

➶

sparser

"Driver_domain plots domain information of the driver fusion gene “MYH9-EIF3H”."

35113898

➶

sparser

"Driver_plot visualizes supporting SV and CNV profile in the HCC1395BL sample for driver fusion gene “MYH9-EIF3H”."

35113898

➶

sparser

"Driver_object reports SV and CNV profile in the HCC1395BL sample responsible for the formation of driver fusion gene “MYH9-EIF3H”."

35113898

➶

sparser

"In the case of the breast cancer dataset, DriverFuse reports the “MYH9-EIF3H” fusion gene as a driver for the HCC1395BL sample."

35113898

EIF3H affects EIF3M

6 |

EIF3M binds EIF3H. 6 / 6

6 |

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biogrid

No evidence text available

17403899

➶

biogrid

No evidence text available

26186194

➶

biogrid

No evidence text available

28514442

➶

biogrid

No evidence text available

19615732

➶

biogrid

No evidence text available

22939629

➶

biogrid

No evidence text available

26344197

EIF3H affects EIF3K

5 1 |

EIF3K binds EIF3H. 6 / 6

5 1 |

➶

biogrid

No evidence text available

28514442

➶

biogrid

No evidence text available

26344197

➶

hprd

No evidence text available

14519125

➶

biogrid

No evidence text available

22939629

➶

biogrid

No evidence text available

19615732

➶

biogrid

No evidence text available

26186194

EIF3H affects EIF3I

4 | 1 1

EIF3I binds EIF3H. 5 / 5

4 | 1

➶

biogrid

No evidence text available

22939629

➶

biogrid

No evidence text available

26186194

➶

biogrid

No evidence text available

28514442

➶

biogrid

No evidence text available

19615732

➶

reach

"Thus it is not clear what functional role the interactions between eIF3i and eIF3h may play, if any, in eIF3 assembly."

27210288

EIF3I binds EIF3H, SXL, and pic. 1 / 1

| 1

➶

sparser

21787382

EIF3F affects EIF3E

| 6

EIF3H binds EIF3F and EIF3E. 5 / 5

| 5

➶

sparser

"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."

20444226

➶

sparser

"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."

20444226

➶

sparser

"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."

20444226

➶

sparser

"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."

20444226

➶

sparser

23354061

EIF3L binds EIF3H, EIF3F, EIF3E, and EIF3D. 1 / 1

| 1

➶

sparser

"In both the CGGA and TCGA datasets, the expression levels of eIF3d, eIF3e, eIF3f, eIF3h and eIF3l highly were associated with the IDH mutant status of gliomas."

31171919

RPL24 affects EIF3H

| 3 2

RPL24 binds EIF3H. 5 / 5

| 3 2

➶

sparser

"An indirect interaction between RPL24 and eIF3h would occur if eIF3 was attached to an 80S ribosome."

20799971

➶

sparser

"The mode of interaction between eIF3h and RPL24 could be physically direct or indirect, or they may act independently."

20799971

➶

reach

"The mode of interaction between eIF3h and RPL24 could be physically direct or indirect, or they may act independently."

20799971

➶

reach

"An indirect interaction between RPL24 and eIF3h would occur if eIF3 was attached to an 80S ribosome."

20799971

➶

reach

"However, the precise role of Rpl24 and eL24 and the molecular details of the functional interaction between eIF3h and Rpl24 and eL24 are unknown."

29281028

PTPRA affects EIF3H

| 5

EIF3H binds PTPRA. 5 / 5

| 5

➶

sparser

"PtpA also binds to subunit H of macrophage V-ATPase and blocks its activity required for phagosome acidification xref ."

24346161

➶

sparser

"Wong et al. ( xref ) demonstrated that PtpA directly binds to the V1 subunit H to: i) block the trafficking of this subunit to the mycobacterial phagosome and ii) block its interaction with Vps33B ( xref )."

33717183

➶

sparser

"PtpA, which binds subunit H of V-ATPase and thereby excludes the proton pump from phagosomes, is a candidate for this missing SecA2-exported effector [ xref ]."

29709019

➶

sparser

"PtpA binds subunit H of the V-ATPase (Wong et al., xref ) and it also binds to and dephosphorylates VPS33B (Bach et al., xref ), a protein enabling endosome to lysosome trafficking (Galmes et al., xref )."

33194845

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sparser

"In a subsequent study from the same group, Wong et al. demonstrated that PtpA binds to subunit H of the host vacuolar ATPase (V-ATPase) in the phagosome membrane and that the macrophage class C sorting complex associates with the V-ATPase during phagosome maturation ( xref )."

25429354

EIF3H affects cell growth

| 5

EIF3H activates cell growth. 5 / 5

| 5

➶

reach

"Overexpression of EIF3H promotes cancer cell growth [XREF_BIBR], results in a malignant phenotype [XREF_BIBR], and serves as a prognostic marker of recurrence and metastasis [XREF_BIBR, XREF_BIBR]."

32867821

➶

reach

"EIF3H knockdown inhibited cell growth, migration, colony formation, and promoted apoptosis, and this was confirmed with GFP expressing infected cells that were counted daily for 5 days."

27340783

➶

reach

"Overexpression of EIF3S3 promotes cancer cell growth."

16652384

➶

reach

"50 Recent studies have shown that EIF3H promoted cancer cell growth by stimulating protein synthesis."

26965516

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reach

"Besides, the mechanism of EIF3H mediated cell growth and migration also needs further study."

32867821

EIF3H affects RPL24

| 3 2

RPL24 binds EIF3H. 5 / 5

| 3 2

➶

sparser

"An indirect interaction between RPL24 and eIF3h would occur if eIF3 was attached to an 80S ribosome."

20799971

➶

sparser

"The mode of interaction between eIF3h and RPL24 could be physically direct or indirect, or they may act independently."

20799971

➶

reach

"The mode of interaction between eIF3h and RPL24 could be physically direct or indirect, or they may act independently."

20799971

➶

reach

"An indirect interaction between RPL24 and eIF3h would occur if eIF3 was attached to an 80S ribosome."

20799971

➶

reach

"However, the precise role of Rpl24 and eL24 and the molecular details of the functional interaction between eIF3h and Rpl24 and eL24 are unknown."

29281028

EIF3H affects PTPRA

| 5

EIF3H binds PTPRA. 5 / 5

| 5

➶

sparser

"PtpA also binds to subunit H of macrophage V-ATPase and blocks its activity required for phagosome acidification xref ."

24346161

➶

sparser

33717183

➶

sparser

"PtpA, which binds subunit H of V-ATPase and thereby excludes the proton pump from phagosomes, is a candidate for this missing SecA2-exported effector [ xref ]."

29709019

➶

sparser

33194845

➶

sparser

25429354

EIF3H affects PDCD4

1 | 1 2 1

EIF3H binds PDCD4. 5 / 5

1 | 1 2 1

➶

trips

"EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis."

32064160

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reach

"EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis."

32064160

➶

sparser

32064160

➶

reach

"Co-immunoprecipitation assays combined with mass spectrometry and immunofluorescent co-localization indicated that PDCD4 interacted with EIF3H."

32064160

➶

biogrid

No evidence text available

26344197

EIF3H affects AteIF3f

| 5

EIF3H binds AteIF3f. 5 / 5

| 5

➶

reach

"Our results show that AteIF3f interacts with eIF3h."

20444226

➶

reach

"In this study, we demonstrated that AteIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."

20444226

➶

reach

"Co-expression of these bait and target constructs showed that AteIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast (XREF_FIG)."

20444226

➶

reach

"This result shows that AteIF3f interacts with eIF3e and eIF3h in plant cells."

20444226

➶

reach

"We also demonstrated that AteIF3f interacts with Arabidopsis eIF3e and eIF3h."

20444226

EIF3E affects EIF3F, and EIF3H

| 5

EIF3H binds EIF3F and EIF3E. 5 / 5

| 5

➶

sparser

"Co‐expression of these bait and target constructs showed that At eIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast ( xref )."

20444226

➶

sparser

"In this study, we demonstrated that At eIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."

20444226

➶

sparser

"We also demonstrated that At eIF3f interacts with Arabidopsis eIF3e and eIF3h."

20444226

➶

sparser

"This result shows that At eIF3f interacts with eIF3e and eIF3h in plant cells."

20444226

➶

sparser

23354061

AteIF3f affects EIF3H

| 5

EIF3H binds AteIF3f. 5 / 5

| 5

➶

reach

"Our results show that AteIF3f interacts with eIF3h."

20444226

➶

reach

"In this study, we demonstrated that AteIF3f interacts with both Arabidopsis eIF3e and eIF3h in Y2H and BiFC assays."

20444226

➶

reach

"Co-expression of these bait and target constructs showed that AteIF3f interacts with Arabidopsis eIF3e and eIF3h in yeast (XREF_FIG)."

20444226

➶

reach

"This result shows that AteIF3f interacts with eIF3e and eIF3h in plant cells."

20444226

➶

reach

"We also demonstrated that AteIF3f interacts with Arabidopsis eIF3e and eIF3h."

20444226

V ATPase I affects EIF3H

| 4

EIF3H binds V ATPase I. 4 / 4

| 4

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sparser

"Although the function of these importin domains is not known, it has been suggested that they might mediate the interaction of subunit H with other V-ATPase subunits or with other cellular proteins ou[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

12788495

➶

sparser

"Characterization of the Binding Interaction between JW-3 and the Subunit H of V-ATPase by Isothermal Titration Calorimetry Measurements."

29019960

➶

sparser

"By contrast, the experiments of V-ATPase activity and interaction with subunit H were conducted in vitro , where the compounds form direct contact with proteins."

26999207

➶

sparser

"Mtb PtpA can prevent phagosome-lysosome fusion by dephosphorylating host protein VPS33B, and prevent phagosome acidification by binding to subunit H of the macrophage V-ATPase complex to block V-ATPase trafficking xref , xref ."

28811474

EIF3H affects epithelial to mesenchymal transition

| 1 3

EIF3H activates epithelial to mesenchymal transition.

| 1 2

EIF3H activates epithelial to mesenchymal transition. 3 / 3

| 1 2

➶

reach

"We observed that disruption of EIF3H by RNA interference results in attenuation of EMT as indicated by upregulation of E-cadherin and suppression of vimentin as well as fibronectin, while elevation of EIF3H significantly enhances EMT phenotypes in breast cancer cells with dramatic alteration of morphology, loss of E-cadherin and accumulation of vimentin as well as fibronectin (XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."

32269044

➶

reach

"A recent publication in lung adenocarcinoma demonstrated that EIF3H overexpression could also induce EMT signaling pathway [XREF_BIBR]."

32867821

➶

eidos

"We observed that disruption of EIF3H by RNA interference results in attenuation of EMT as indicated by upregulation of E-cadherin and suppression of vimentin as well as fibronectin , while elevation of EIF3H significantly enhances EMT phenotypes in breast cancer cells with dramatic alteration of morphology , loss of E-cadherin and accumulation of vimentin as well as fibronectin ( Fig. S1G-J ) ."

32269044

EIF3H inhibits epithelial to mesenchymal transition.

| 1

EIF3H inhibits epithelial to mesenchymal transition. 1 / 1

| 1

➶

reach

"Knockdown of EIF3H inhibits the EMT process and cell mobility induced by Snail."

32867821

EIF3H affects V ATPase I

| 4

EIF3H binds V ATPase I. 4 / 4

| 4

➶

sparser

12788495

➶

sparser

"Characterization of the Binding Interaction between JW-3 and the Subunit H of V-ATPase by Isothermal Titration Calorimetry Measurements."

29019960

➶

sparser

"By contrast, the experiments of V-ATPase activity and interaction with subunit H were conducted in vitro , where the compounds form direct contact with proteins."

26999207

➶

sparser

28811474

EIF3H affects RPS6KB1

1 | 2 1

EIF3H binds RPS6KB1.

1 | 1 1

RPS6KB1 binds EIF3H. 3 / 3

1 | 1 1

➶

biogrid

No evidence text available

16286006

➶

reach

"Because plant eIF3h physically interacts with S6K1, it was further suggested that eIF3h might be the downstream target of activated S6K1."

29281028

➶

sparser

"Because plant eIF3h physically interacts with S6K1, it was further suggested that eIF3h might be the downstream target of activated S6K1 (Schepetilnikov et al. xref )."

29281028

EIF3H activates RPS6KB1.

| 1

EIF3H activates RPS6KB1. 1 / 1

| 1

➶

reach

"Because plant eIF3h physically interacts with S6K1, it was further suggested that eIF3h might be the downstream target of activated S6K1."

29281028

EIF3H affects MYC

| 3 1

EIF3H inhibits MYC.

| 3

EIF3H inhibits MYC. 3 / 3

| 3

➶

reach

"XREF_BIBR Coamplification of EIF3H may also reduce MYC dependent apoptosis in prostate epithelial cells."

19204574

➶

reach

20862326

➶

reach

"Furthermore, overexpressed eIF3h inhibits Myc dependent induction of apoptosis of primary prostate cells."

18544531

EIF3H binds MYC.

| 1

EIF3H binds MYC. 1 / 1

| 1

➶

sparser

"Among patients with amplification of both HER2 and MYC , the addition of trastuzumab to chemotherapy reduced the risk of cancer recurrence by 76% and reduced the risk of death by 64%, while in individuals with HER2 amplification alone the addition of trastuzumab to chemotherapy did not reduce the risk of death. xref In our study, we observed that both MYC and EIF3H were associated with a better outcome after gefitinib therapy, and among EGFR+ patients (FISH+ and/or mutated), only individuals with increased MYC/EIF3H gene copy number had a significant tumor shrinkage."

19204574

EIF3H affects DTrc8

| 4

EIF3H binds DTrc8.

| 3

EIF3H binds DTrc8. 3 / 3

| 3

➶

reach

"In fact, interactions between DTrc8 and eIF3f or eIF3h were stronger than observed with Csn5."

20068067

➶

reach

"DTrc8 genetically and physicially interacted with two eIF3 subunits, eIF3f and eIF3h."

20068067

➶

reach

"In vitro GST-pulldown experiments confirmed that DTrc8 specifically interacted with eIF3f and eIF3h in addition to Csn5 (XREF_FIG)."

20068067

EIF3H inhibits DTrc8.

| 1

EIF3H inhibits DTrc8. 1 / 1

| 1

➶

reach

"Because downregulation of eIF3f or eIF3h suppresses DTrc8 induced growth inhibition in flies, we suspect these components form a bridge by which TRC8 affects its targets."

20068067

EIF3H affects DISC1

3 1 |

DISC1 binds EIF3H. 4 / 4

3 1 |

➶

biogrid

No evidence text available

12812986

➶

hprd

No evidence text available

12812986

➶

biogrid

No evidence text available

17043677

➶

biogrid

No evidence text available

12812986

EIF3H affects ABI3

3 1 |

ABI3 binds EIF3H. 4 / 4

3 1 |

➶

hprd

No evidence text available

16189514

➶

biogrid

No evidence text available

25416956

➶

biogrid

No evidence text available

16189514

➶

biogrid

No evidence text available

19060904

DISC1 affects EIF3H

3 1 |

DISC1 binds EIF3H. 4 / 4

3 1 |

➶

biogrid

No evidence text available

12812986

➶

hprd

No evidence text available

12812986

➶

biogrid

No evidence text available

17043677

➶

biogrid

No evidence text available

12812986

ABI3 affects EIF3H

3 1 |

ABI3 binds EIF3H. 4 / 4

3 1 |

➶

hprd

No evidence text available

16189514

➶

biogrid

No evidence text available

25416956

➶

biogrid

No evidence text available

16189514

➶

biogrid

No evidence text available

19060904

RNF139 affects EIF3H

| 1 2

RNF139 binds EIF3H and EIF3F. 2 / 2

| 2

➶

sparser

23354061

➶

sparser

"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."

| 3

EIF3H activates competence.

| 2

EIF3H activates competence. 2 / 2

| 2

➶

reach

"In plants, eIF3 non core subunit h (eIF3h) greatly elevates the reinitiation competence of mRNAs coding for the Arabidopsis basic zipper transcription factors (bZIPs) and several ARFs; while the 60S ribosomal protein L24B (RPL24B), which is encoded by SHORT VALVE1, lifts translation of uORF containing mRNAs that encode ARF3 (ETTIN) and ARF5."

28659957

➶

reach

"It was proposed that, by analogy with the function of yeast eIF3a and Tif32 discussed above, eIF3h (specifically its N-terminal part) might support efficient REI by preserving the competence of a fraction of uORF translating ribosomes to resume traversing downstream."

29281028

EIF3H increases the amount of competence.

| 1

EIF3H increases the amount of competence. 1 / 1

| 1

➶

reach

"Besides, in plants, the eIF3h subunit helps to prevent the permanent loss of reinitiation competence, suggesting that this subunit might also be involved in tethering 40S to eIF4G."

21989405

EIF3H affects cell cycle

| 3

EIF3H inhibits cell cycle.

| 2

EIF3H inhibits cell cycle. 2 / 2

| 2

➶

reach

35809300

➶

reach

"Mahmood et al demonstrated that EIF3H knockdown with specific small interfering RNA induced cell cycle arrest and apoptosis in breast tumour cells."

29805516

EIF3H activates cell cycle.

"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."

20068067

RNF139 binds EIF3H. 1 / 1

| 1

➶

reach

23354061

EIF3H affects PRRC2B

3 |

PRRC2B binds EIF3H. 3 / 3

3 |

➶

biogrid

No evidence text available

26186194

➶

biogrid

No evidence text available

28514442

➶

biogrid

No evidence text available

19615732

EIF3H affects HIV1gp1

3 |

EIF3H binds HIV1gp1. 3 / 3

3 |

➶

biogrid

No evidence text available

20016921

➶

biogrid

No evidence text available

20016921

➶

biogrid

No evidence text available

22190034

EIF3H affects ESCC cells

| 3

EIF3H activates ESCC cells. 3 / 3

| 3

➶

eidos

"* * * P < 0.001 ; NS : not significant EIF3H promotes Snail-mediated EMT in ESCC cells Considering that Snail is a pivotal EMT-related transcription factor [ 45 ] , we investigated the expression of Snail and EMT-related markers in EIF3H overexpression cells ."

32867821

➶

eidos

"In summary , we demonstrated that EIF3H is responsible for tumorigenesis , tumor growth and metastasis of ESCC through stabilizing Snail , thus promoting the EMT phenotype in ESCC cells ."

32867821

➶

eidos

"Collectively , these results indicate that EIF3H could promote Snail-mediated EMT in ESCC cells ."

32867821

EIF3H affects EIF3CL

3 |

EIF3CL binds EIF3H. 3 / 3

3 |

➶

biogrid

No evidence text available

26186194

➶

biogrid

No evidence text available

26344197

➶

biogrid

No evidence text available

28514442

EIF3H affects ATPase activity

| 3

EIF3H inhibits ATPase activity.

| 2

EIF3H inhibits ATPase activity. 2 / 2

| 2

➶

sparser

"This structure appears to be an inhibitory state wherein the subunit H inhibits the ATPase activity by stabilizing ADP binding to the catalytic site."

27807367

➶

sparser

"Together with biochemical data, the structure supports a mechanistic model wherein subunit H inhibits ATPase activity by stabilizing an open catalytic site that results in tight binding of inhibitory ADP at another site."

27295975

EIF3H binds ATPase activity.

| 1

➶

| 2

➶

sparser

23354061

➶

sparser

"Here, we demonstrate that Drosophila and human TRC8 proteins also interact with eIF3f and eIF3h ( xref )."

20068067

RNA-directed RNA polymerase NS5 affects EIF3H

2 |

EIF3H binds RNA-directed RNA polymerase NS5. 1 / 1

1 |

➶

| 1

➶

reach

"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD 92."

33441873

EIF3H binds MTOR and collybistin. 1 / 1

| 1

2 |

➶

biogrid

No evidence text available

25476789

➶

biogrid

No evidence text available

25476789

GPHN affects CB

| 2

GPHN binds EIF3H and CB. 2 / 2

| 2

➶

sparser

20858277

➶

sparser

"We next examined whether CB and gephyrin associate with eIF3H in mouse brain."

20858277

EIF6 affects EIF3H

| 2

EIF3H binds EIF6. 2 / 2

| 2

➶

reach

"In Arabidopsis, previous studies have shown that eIF3h directly interacts with eIF3a, eIF3b, eIF3c, eIF3e, CSN7 and CSN8 (Kim etal., 2004)."

| 1

EIF3H decreases the amount of poly-ubiquitin. 1 / 1

| 1

➶

reach

"EIF3H significantly decreased the poly-ubiquitin level of ubiquitinated Snail in an in vitro ubiquitination assay."

32867821

EIF3H activates poly-ubiquitin.

| 1

EIF3H activates poly-ubiquitin. 1 / 1

| 1

➶

reach

"Thus, Trp119 and Tyr140 on EIF3H are critical to ensuring the EIF3H mediated removal of YAP poly-ubiquitin conjugates."

32269044

EIF3H affects collybistin

| 2

EIF3H binds MTOR and collybistin. 1 / 1

| 1

➶

sparser

33441873

GPHN binds EIF3H and collybistin. 1 / 1

| 1

➶

sparser

| 1

EIF3I binds EIF3H, SXL, and pic. 1 / 1

| 1

➶

sparser

21787382

EIF3H activates SXL.

| 1

EIF3H activates SXL. 1 / 1

| 1

➶

reach

"Depletion of eIF3d, but not eIF3e or eIF3h, reduced the inhibitory effect of SXL, suggesting that eIF3d is a potential target of the repressor complex within the translational machinery."

29635389

EIF3H affects RSPH9

2 |

RSPH9 binds EIF3H. 2 / 2

2 |

➶

biogrid

No evidence text available

26186194

➶

2 |

EIF3H binds N. 2 / 2

2 |

➶

virhostnet

No evidence text available

17686838

➶

virhostnet

No evidence text available

17686838

EIF3H affects Membrane protein

| 2

EIF3H binds Membrane protein. 2 / 2

| 2

➶

sparser

"Measles N protein binds eIF3g, whereas rabies M protein binds eIF3h to impede host translation [ xref , xref ]."

32455727

➶

sparser

"Measles N protein binds eIF3g, whereas rabies M protein binds eIF3h to impede host translation [115,116]."

32455727

EIF3H affects MTOR

| 1 1

EIF3H binds MTOR. 1 / 1

| 1

➶

reach

"Although the role of Eif3h in ASD is not clearly understood, a recent study has shown that Eif3h can directly interact with the mammalian target of rapamycin (mTOR) and collybistin (a neuron specific Rho-GEF) to downregulate the mTORC1 signaling cascade which is highly implicated in ASD 92."

33441873

EIF3H binds MTOR and collybistin. 1 / 1

| 1

➶

sparser

33441873

EIF3H affects MAPK

| 2

EIF3H activates MAPK. 2 / 2

| 2

➶

reach

"Zhu and colleagues identified that the transforming growth factor-beta and mitogen activated protein kinase pathways are potentially targeted by EIF3H using microarray analysis."

29805516

➶