IndraLab

Statements

EIF3H inhibits ferroptosis. 4 / 4
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"Inhibition of EIF3H induces ferroptosis, which is reversed by OGT overexpression (120)."
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"In addition, we further explored whether EIF3H inhibits the HCC cell ferroptosis through OGT."
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"Taken together, our results indicate that the deletion of EIF3H promoted the ferroptosis in HCC cells."
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"Correspondingly, our findings are the first to reveal that EIF3H inhibits ferroptosis by interacting with OGT, thereby accelerating HCC cell growth and tumor progression.In conclusion, our study investigated the biological functions of EIF3H in HCC, and we revealed that EIF3H is a post-translational modulator in regulating OGT stabilization and deubiquitination."
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