IndraLab

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EIF3H increases the amount of OGT. 6 / 6
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"By employing two nonoverlapping siRNAs targeting EIF3H, we further explored that EIF3H depletion decreased the OGT protein levels in both LM3 and Hep3B cells (Fig. 1B)."

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"Depletion of EIF3H significantly reduced OGT protein levels and inhibited O-GlcNac signaling activity."

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"We found that the knockdown of EIF3H significantly repressed OGT protein levels."

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"Besides, we demonstrated that the knockdown of EIF3H significantly reduced OGT protein expression, cell proliferation and invasion, and caused G1/S arrest of HCC."

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"Taken together, these results confirmed that EIF3H promoted OGT expression and inhibited ferroptosis in HCC cells."

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"We discovered that EIF3H depletion caused a decrease in total O-GlcNac levels (Fig. 1A)."