IndraLab

Statements

EIF3H binds HAX1. 12 / 12
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"Co-immunoprecipitation (co-IP) studies indicated the exogenous and endogenous interaction between EIF3H and HAX1 (Fig.  xref )."
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"Future screening of inhibitors targeting EIF3H/HAX1 or molecules blocking EIF3H-HAX1 binding may provide a promising therapeutic approach for CRC treatment."
38514606
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"Given the HAX1-EIF3H link, EIF3H KD also decreased the interaction of RAF1 with MEK1 and with ERK1/2 (Fig.  xref )."
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"The EIF3H-HAX1 increased RAF-MEK-ERK signaling activity to enhance colorectal cancer progression [ xref ]."
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"In situ proximity ligation assay (PLA) confirmed EIF3H–HAX1 proximity in HCT116 cells, and most interactions between EIF3H and HAX1 were detected in the cytoplasm though few was present in the nucleus (Fig.  xref )."
38514606
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"Taken together, these data suggest that EIF3H interacts with HAX1."
38514606
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"To further support that EIF3H and HAX1 can form a complex in vivo, cellular proteins extracted from HCT116 cells were fractionated by gel-filtration chromatography."
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"Taken together, these results indicate that mutated EIF3H catalytic core compromises EIF3H-HAX1 interaction/regulation, and subsequent biological activities."
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"Given that activation of Wnt/β-catenin signaling induced EIF3H expression and that EIF3H-HAX1 enhanced phosphorylation of ERK1/2 in CRC, we next investigated whether combined targeting Wnt and RAF1-ERK1/2 signaling synergistically inhibited CRC cell growth."
38514606
reach
"Co-immunoprecipitation (co-IP) studies indicated the exogenous and endogenous interaction between EIF3H and HAX1 (Fig. 2b)."
38514606
reach
"In situ proximity ligation assay (PLA) confirmed EIF3H–HAX1 proximity in HCT116 cells, and most interactions between EIF3H and HAX1 were detected in the cytoplasm though few was present in the nucleus (Fig. 2c)."
38514606
reach
"To further support that EIF3H and HAX1 can form a complex in vivo, cellular proteins extracted from HCT116 cells were fractionated by gel-filtration chromatography."
38514606