IndraLab

Statements

EIF3H activates translation. 9 / 9
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"These risk variants, conferring an approximate 10%-18% increase in risk per allele, are located either inside or near protein coding genes that include TFEB (lysosome biogenesis and autophagy), EIF3H (initiation of translation), CYP17A1 (steroidogenesis), SPSB2 (proteasome degradation), and RPS21 (ribosome biogenesis)."
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"Our results are in agreement with these ideas and suggest an eIF3H mediated control of HIF-1alpha translation that could explain in part its oncogenic properties."
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"In any case, polysomal microarray analysis clearly demonstrated that eIF3h is a general stimulator of efficient translation of short uORF (s)-containing mRNAs throughout the transcriptome."
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"In agreement with this, our data show that, as CCT is required for the correct folding of eIF3h and eIF3i subunits, it indirectly influences gene expression with eIF3i overexpression enhancing both cap- and IRES (internal ribosome entry segment)-dependent translation initiation, whereas eIF3h overexpression selectively increases IRES dependent translation initiation."
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"Together with the study which suggests that eIF3h may play an important regulatory role in translation of specific mRNAs [75] as discussed above, these findings suggest that aberrant over-expression o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Earlier studies found that the elevation of eIF3h could stimulate protein synthesis."
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"This is an important TOR effect, since the S6K pathway not only stimulates overall protein synthesis but also eIF3h mediated translation reinitiation after an upstream open reading frame (uORF), a frequent feature found in plant mRNAs."
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"Interestingly, the oncogenic function of METTL3 in NSCLC is complicated, where METTL3 could methylate YAP mRNA and recruit YTHDF1/3 and eIF3b to promote translation of YAP mRNA, or could interact with eIF3h to promote translation of target mRNAs (e.g., BRD4) independent of its enzymatic activity."
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"Translation assays revealed that eIF3h supports the efficient translation of the mRNAs for CLV1 and the leaf transcription factor, AS1, which contain uORFs in their 5 ' UTR."
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