IndraLab

Statements

EIF3H binds SNAI1. 18 / 18
4 | 13 1
biogrid
No evidence text available
32867821
reach
"The interaction between EIF3H and Snail suggests the ability of EIF3H to regulate Snail expression."
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"Our study reveals a critical EIF3H-Snail signaling axis in tumor aggressiveness in ESCC and provides EIF3H as a promising biomarker for ESCC treatment."
32867821
biogrid
No evidence text available
32867821
biogrid
No evidence text available
32867821
biogrid
No evidence text available
32867821
reach
"We demonstrated that EIF3H interacts with and stabilizes Snail through deubiquitination."
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"In order to get a comprehensive understanding about the significance of EIF3H and the mechanism of its function in ESCC, we performed a liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis and identified that EIF3H could interact with Snail and correlate positively with Snail expression."
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"EIF3H interacts with Snail."
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"To confirm the interaction between EIF3H and Snail, we then performed a co-IP assay with co-expressed EIF3H-Flag and Snail in HEK293T cells."
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"We performed a co-IP assay combined with the mass spectrometry analysis and identified that an EMT associated transcription factor, Snail could interact with EIF3H."
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"In vivo co-IP assays in EIF3H knockdown cells were also carried out to confirm the specificity of the interaction between Snail and EIF3H, but there is no interaction with other EIF3 subunits (EIF3A and EIF3I)."
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"Next, immunoprecipitation of endogenous Snail from KYSE510 cells also confirmed the interaction between endogenous Snail and EIF3H."
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"Additional in vivo co-IP assay was performed in HEK293T and KYSE510 EIF3H-knockdown cells to test the specificity of the interaction between Snail and EIF3H."
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"To shed light on how EIF3H interacts with Snail, we further determined their cellular localization by immunofluorescence analysis."
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"These results revealed the interaction between EIF3H and Snail mediated by the S-P rich domain of Snail."
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"EIF3H interacts with and deubiquitinates Snail to prolong its half-life."
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"In esophageal cancer, EIF3H interacts and stabilizes Snail through deubiquitination."
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