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EIF3H decreases the amount of HAX1. 3 / 3
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"We also re-introduced shRNA-resistant WT and mutant EIF3H (EIF3H and EIF3H ) expression plasmids into EIF3H stable knockdown cells, and found that knockdown EIF3H could decrease steady-state expression of HAX1, while re-introduced WT EIF3H or EIF3H , but not EIF3H , could rescue steady-state expression of HAX1 caused by EIF3H knockdown (Supplementary Fig. 5c)."
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"Furthermore, EIF3H overexpression decreased the ubiquitination level of HAX1 (Fig. 2h)."
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"Immunohistochemistry (IHC) staining on orthotopic tumor showed that EIF3H KD led to reduced levels of EIF3H, HAX1 and pERK1/2, and repressed cell proliferation (Ki67 staining), while HAX1 overexpression reversed these impacts caused by EIF3H KD (Fig. 5d)."
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