IndraLab

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EIF3H activates YAP1. 4 / 4
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"Further analysis through immunohistochemical staining of the tumor tissues indicated that EIF3H suppression reduced YAP accumulation (Figure 7C)."
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"Overall, these findings reveal a critical interplay between adipocyte-mediated metabolic reprogramming and EIF3H-mediated YAP proteolytic control, offering promising therapeutic strategies to mitigate the adverse effects of obesity on TNBC progression."
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"EIF3H catalyzed YAP for deubiquitylation , resulting in its stabilization ."
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"It was also reported that EIF3H could enhance the Hippo signal by stabilizing YAP, and that it promotes breast cancer invasion and metastasis."
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