IndraLab

Statements

RPS6KB1 phosphorylates EIF3H. 4 / 4
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"S6K1 in turn phosphorylates the subunit h of eukaryotic Initiation Factor 3 (eIF3h), which promotes loading of mRNAs that carry upstream open reading frames (uORFs) within their 5' untranslated regions (5'UTRs) into the ribosome for translation re-initiation (Figure 1) (Schepetilnikov et al., 2013)."
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"Upregulated TOR is recruited to polysomes where it phosphorylates S6K1, which shortly before its release from polysomes phosphorylates eIF3h."
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"The previous report demonstrated EIF3H is regulated in response to mTOR-S6K1 cascade, where EIF3H can be phosphorylated by S6K1 kinase through the serine 183 on EIF3H ( xref )."
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"The loading of the translation initiation factor eIF3h into polysomes in response to auxin is impaired in TOR deficient mutants with an inactive S6K form, suggesting that eIF3h is possibly phosphorylated by the TOR and S6K1 pathway."
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