IndraLab

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EIF3H is phosphorylated. 36 / 36
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"The loading of the translation initiation factor eIF3h into polysomes in response to auxin is impaired in TOR-deficient mutants with an inactive S6K form, suggesting that eIF3h is possibly phosphorylated by the TOR/S6K1 pathway ( xref )."
28491073
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"We therefore analyzed the levels of phosphorylation of eIF3H in the cervical cancer cell line HeLa."
22304650
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"Upregulated TOR is recruited to polysomes where it phosphorylates S6K1, which shortly before its release from polysomes phosphorylates eIF3h."
29281028
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"As shown in xref and xref – xref , we found that the inhibitors for PI3K (LY294002), S6K1 (PF4708671), Src (dasatinib) and mTOR (rapamycin) block EIF3H Ser/Thr phosphorylation, EIF3H-YAP binding and EIF3H-governed YAP accumulation but no effect for EIF3H/EIF3A binding."
32269044
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"Among novel biochemical markers of brain damage neuroserpin may be a promising predictor of type 2 neurological complications and may express neuroregeneration after off-pump CABG, while glial fibrillary acidic protein, phosphorylated axonal neurofilament subunit H and visinin-like protein 1 may not be suitable for this clinical setting."
31863758
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"Serum concentrations of glial fibrillary acidic protein, neuroserpin, phosphorylated axonal neurofilament subunit H and visinin-like protein 1 were evaluated at baseline, end of surgery as well as on postoperative day 1 and 7."
31863758
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"TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h."
33659803
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"Another possible plasma biomarker of CRCI is axonal phosphorylated neurofilament subunit H (pNF-H)."
34970595
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"It is theoretically possible that eIF3h phosphorylation is a trigger for S6K1 departure from polysomes."
29281028
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"The phytohormone auxin activates TOR kinase, promoting S6K1 phosphorylation at T449 and translation reinitiation of upstream open reading frame (uORF)-containing mRNAs via phosphorylation of eIF3h (eukaryotic initiation factor 3, subunit h) ( xref )."
25399018
rlimsp
"TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h."
23524850
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"Active TOR can up-regulate translation reinitiation via phosphorylation of the plant reinitiation factor eIF3h in polysomes to maintain the high phosphorylation status of eIF3h-promoting reinitiation events ( xref )."
28659957
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"TOR mediated ribosomal protein S6 kinase (S6K) activity was proposed to be important to maintain eukaryotic translation initiation factor 3 subunit H (eIF3h) phosphorylation, which is needed for translation reinitiation and thus for translation of uORF containing mRNAs ( xref )."
25101105
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"Moreover, TOR positively regulates initiation of translation in plants, possibly by stimulation of phosphorylation of the translation initiation factor eIF3h via S6K [ xref ]."
32164165
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"Elevated serum tau protein [ xref ], phosphorylated axonal neurofilament subunit H (pNF-H) [ xref ], and blood glutamate [ xref ] were also found to predict poor outcome in ICH."
25208676
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"Hemorrhagic injury to the central nervous system causes cellular activation and disintegration, leading to the release of cell-type-specific proteins such as myelin basic protein (MBP), glial fibrilla[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24657424
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"Another candidate plasma marker for cognitive dysfunction following therapy-induced brain damage is axonal phosphorylated neurofilament subunit H (pNF-H), levels of which are increased in the blood of patients who have had acute brain ischemic stroke compared with controls, and are associated with the severity of the stroke (Singh et al., xref ; Andreano et al., xref )."
28377717
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"Quantification of phosphorylation of eIF3H."
22304650
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"Phosphorylated axonal neurofilament subunit H (pNF-H) is a biomarker of axonal injury."
23810564
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"The phosphorylated S6K1, released from both platforms, becomes fully activated and capable to phosphorylate eIF3h."
29692761
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"Many found prognostic cell-type-specific proteins for STBI exist including myelin basic protein (MBP), glial fibrillary astrocyte protein (GFAP), the calcium-binding protein S100B, neuron-specific eno[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25076464
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"Regulation of REI of short uORF(s)-containing mRNAs by eIF3h phosphorylation in Arabidopsis thaliana ."
29281028
sparser
"Predictive value of phosphorylated axonal neurofilament subunit H for clinical outcome in patients with acute intracerebral hemorrhage."
23810564
rlimsp
"This novel method was then applied to quantify phosphorylations on eukaryotic initiation factor 3H (eIF3H), a protein integral to overall eukaryotic protein translation initiation."
22304650
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"Levels of phosphorylated axonal neurofilament subunit H (pNfH) are increased in acute ischemic stroke."
21349546
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"Ribosome fractionation experiments indicated that, in response to auxin, polysomes show increased accumulation of uORF-containing mRNAs (indicating enhanced translation), phosphorylated and thus activated TOR, and, interestingly, phosphorylated eIF3h."
29281028
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"New data are currently appearing on the involvement of pRPS6K1 in the promotion of translation reinitiation of upstream open reading frame (uORF)-containing viral and cellular mRNAs via phosphorylation of eIF3h (Schepetilnikov et al., 2013) and in regulation of translation initiation under energy-deficient conditions via formation of the functional eIF4F complex (Lee et al., 2017)."
33659803
sparser
"This regulation is possibly modulated by the TOR signaling cascade, which can promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h ( xref )."
25514925
sparser
"As revealed by Western blotting, application of strain resulted in significant upregulation of mammalian target of rapamycin (mTOR) and S6 signaling in nerves, increased myelin basic protein (MBP) and β-actin levels, and increased phosphorylation of neurofilament subunit H (NF-H) compared with unstrained (sham) contralateral nerves ( P < 0.05 for all comparisons, paired two-tailed t -test)."
28250148
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"Plasma concentrations of microRNA-1-3p, microRNA-21-5p, glial fibrillary acidic protein (GFAP), neuroserpin (NSP), phosphorylated axonal neurofilament subunit H (pNfH) and visinin-like protein 1 (VILIP-1) were investigated in 30 patients undergoing elective off-pump coronary artery bypass grafting."
34300256
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"We measured levels of phosphorylated neurofilament subunit H (pNF-H), tau (reflecting axonal damage), myelin basic protein (MBP) (reflecting demyelination), S100b (reflecting astrocyte damage), and neuron-specific enolase (NSE) (reflecting neuronal damage)."
29557051
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"RGCs were immunoidentified with anti-Brn3a, and their axons with anti-highly phosphorylated axonal neurofilament subunit H (pNFH)."
29452106
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"Upon auxin treatment, AtTORC1 associate with the polysome, phosphorylates AtS6K1, which in turns phosphorylates eIF3h."
33778006
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"Results of a recent study show that phosphorylated neurofilament subunit H (pNF-H) and tau protein, which reflect axonal damage to the spinal cord, become elevated in the cerebrospinal fluid (CSF) of patients with acutely worsening compression myelopathy [ xref , xref ]."
31810443
sparser
"Specifically, SARM1 knockout mice experience less axonal injury and maintained axonal integrity, as evidenced by decreased ß-amyloid precursor protein aggregates in corpus collusum axons and suppressed plasma levels of phosphorylated neurofilament subunit H ( xref )."
31761689
sparser
"Unilateral ocular hypertension or optic nerve axotomy (crush or transection) in rodents cause macrogliosis, microglial activation, division and phagocytosis, up-regulation of the major histocompatibility complex class II (MHCII), and aberrant expression of the highly phosphorylated axonal neurofilament subunit H [ xref , xref , xref , xref , xref , xref , xref ] in the un-injured retina."
31731684