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EIF3H is phosphorylated. 48 / 48
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sparser
"Ribosome fractionation experiments indicated that, in response to auxin, polysomes show increased accumulation of uORF-containing mRNAs (indicating enhanced translation), phosphorylated and thus activated TOR, and, interestingly, phosphorylated eIF3h."
29281028
sparser
"We therefore analyzed the levels of phosphorylation of eIF3H in the cervical cancer cell line HeLa."
22304650
sparser
"Upon auxin treatment, AtTORC1 associate with the polysome, phosphorylates AtS6K1, which in turns phosphorylates eIF3h."
33778006
sparser
"TAV triggers TOR hyperactivation and S6 kinase1 (S6K1) phosphorylation in planta , and the whole process is fueled by a kinase cascade involving phosphorylation of TOR, S6K1, RISP and eIF3h ( Figure 4[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24063990
sparser
"We measured levels of phosphorylated neurofilament subunit H (pNF-H), tau (reflecting axonal damage), myelin basic protein (MBP) (reflecting demyelination), S100b (reflecting astrocyte damage), and neuron-specific enolase (NSE) (reflecting neuronal damage)."
29557051
sparser
"SAA1 levels also correlated with markers such as S100B and GFAP, NSE, tau and phosphorylated axonal neurofilament subunit H (pNFH)."
39001884
sparser
"Elevated serum tau protein [ xref ], phosphorylated axonal neurofilament subunit H (pNF-H) [ xref ], and blood glutamate [ xref ] were also found to predict poor outcome in ICH."
25208676
sparser
"This regulation is possibly modulated by the TOR signaling cascade, which can promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h ( xref )."
25514925
sparser
"The loading of the translation initiation factor eIF3h into polysomes in response to auxin is impaired in TOR-deficient mutants with an inactive S6K form, suggesting that eIF3h is possibly phosphorylated by the TOR/S6K1 pathway ( xref )."
28491073
sparser
"In Arabidopsis, TOR promotes the translational re-initiation of uORF-containing mRNAs by directly phosphorylating eIF3h, a factor known to promote re-initiation."
37437121
sparser
"Active TOR can up-regulate translation reinitiation via phosphorylation of the plant reinitiation factor eIF3h in polysomes to maintain the high phosphorylation status of eIF3h-promoting reinitiation events ( xref )."
28659957
sparser
"Another possible plasma biomarker of CRCI is axonal phosphorylated neurofilament subunit H (pNF-H)."
34970595
sparser
"Sanchez-Migallón et al. (2018) showed that some RGCs in the contralateral retina expressed the highly phosphorylated axonal neurofilament subunit H in their somas, a hallmark of RGC degeneration and death (Parrilla-Reverter et al., 2009; Rovere et al., 2015)."
33818483
sparser
"Phosphorylated axonal neurofilament subunit H (pNF-H) is a biomarker of axonal injury."
23810564
sparser
"TOR mediated ribosomal protein S6 kinase (S6K) activity was proposed to be important to maintain eukaryotic translation initiation factor 3 subunit H (eIF3h) phosphorylation, which is needed for translation reinitiation and thus for translation of uORF containing mRNAs ( xref )."
25101105
sparser
"Results of a recent study show that phosphorylated neurofilament subunit H (pNF-H) and tau protein, which reflect axonal damage to the spinal cord, become elevated in the cerebrospinal fluid (CSF) of patients with acutely worsening compression myelopathy [ xref , xref ]."
31810443
sparser
"Many found prognostic cell-type-specific proteins for STBI exist including myelin basic protein (MBP), glial fibrillary astrocyte protein (GFAP), the calcium-binding protein S100B, neuron-specific eno[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25076464
sparser
"In response to auxin, eIF3h phosphorylation by TOR-activated S6K1 enhances translation reinitiation of mRNAs with uORFs ( xref )."
36909402
sparser
"The phytohormone auxin activates TOR kinase, promoting S6K1 phosphorylation at T449 and translation reinitiation of upstream open reading frame (uORF)-containing mRNAs via phosphorylation of eIF3h (eukaryotic initiation factor 3, subunit h) ( xref )."
25399018
sparser
"Upregulated TOR is recruited to polysomes where it phosphorylates S6K1, which shortly before its release from polysomes phosphorylates eIF3h."
29281028
sparser
"Quantification of phosphorylation of eIF3H."
22304650
sparser
"As shown in xref and xref – xref , we found that the inhibitors for PI3K (LY294002), S6K1 (PF4708671), Src (dasatinib) and mTOR (rapamycin) block EIF3H Ser/Thr phosphorylation, EIF3H-YAP binding and EIF3H-governed YAP accumulation but no effect for EIF3H/EIF3A binding."
32269044
sparser
"Regulation of REI of short uORF(s)-containing mRNAs by eIF3h phosphorylation in Arabidopsis thaliana ."
29281028
rlimsp
"TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h."
23524850
sparser
"Moreover, TOR positively regulates initiation of translation in plants, possibly by stimulation of phosphorylation of the translation initiation factor eIF3h via S6K [ xref ]."
32164165
sparser
"Although 4E-BP-like proteins have not yet been found in Arabidopsis ( xref ), Arabidopsis TOR, when activated by the plant hormone auxin in a small GTPase ROP2 (Rho of Plants 2) dependent manner, promotes translation reinitiation of mRNAs that harbour uORFs within their leader regions by phosphorylating eIF3h, which bolsters the reinitiation capacity of post-terminating ribosomes, although the underlying molecular mechanisms remain enigmatic ( xref , xref )."
34133725
sparser
"In addition, neurological markers, N-acetylaspartate/choline, N-acetylaspartate/myo-inositol, and serum axonal phosphorylated neurofilament heavy subunit H (pNF-H) are detected in patients undergoing cancer treatments [ xref , xref , xref , xref ], suggesting the potential applications as biomarkers in clinical practice."
36765598
sparser
"For example, a mean concentration of the phosphorylated axonal neurofilament subunit H has been identified in men with the disease whilst the mean value of vascular endothelial growth factor (VEGF)-β [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37127082
sparser
"Unilateral ocular hypertension or optic nerve axotomy (crush or transection) in rodents cause macrogliosis, microglial activation, division and phagocytosis, up-regulation of the major histocompatibility complex class II (MHCII), and aberrant expression of the highly phosphorylated axonal neurofilament subunit H [ xref , xref , xref , xref , xref , xref , xref ] in the un-injured retina."
31731684
sparser
"Predictive value of phosphorylated axonal neurofilament subunit H for clinical outcome in patients with acute intracerebral hemorrhage."
23810564
sparser
"The authors proposed that TOR, when activated, promotes phosphorylation of eIF3h and maintains its active phosphorylation status in Arabidopsis to ensure efficient reinitiation events ( xref )."
30984977
sparser
"It is theoretically possible that eIF3h phosphorylation is a trigger for S6K1 departure from polysomes."
29281028
sparser
"When TOR is inactive, S6K1 binds to eIF3h; when TOR is activated by auxin, TOR binds to and phosphorylates eIF3h."
37437121
sparser
"Specifically, absence of SARM protected mice from brain trauma induced axonal loss and as a consequence displayed less of an axon injury marker, phosphorylated neurofilament subunit H, in the blood."
30633870
rlimsp
"This novel method was then applied to quantify phosphorylations on eukaryotic initiation factor 3H (eIF3H), a protein integral to overall eukaryotic protein translation initiation."
22304650
sparser
"Serum concentrations of glial fibrillary acidic protein, neuroserpin, phosphorylated axonal neurofilament subunit H and visinin-like protein 1 were evaluated at baseline, end of surgery as well as on postoperative day 1 and 7."
31863758
sparser
"Another candidate plasma marker for cognitive dysfunction following therapy-induced brain damage is axonal phosphorylated neurofilament subunit H (pNF-H), levels of which are increased in the blood of patients who have had acute brain ischemic stroke compared with controls, and are associated with the severity of the stroke (Singh et al., xref ; Andreano et al., xref )."
28377717
sparser
"Among novel biochemical markers of brain damage neuroserpin may be a promising predictor of type 2 neurological complications and may express neuroregeneration after off-pump CABG, while glial fibrillary acidic protein, phosphorylated axonal neurofilament subunit H and visinin-like protein 1 may not be suitable for this clinical setting."
31863758
sparser
"Hemorrhagic injury to the central nervous system causes cellular activation and disintegration, leading to the release of cell-type-specific proteins such as myelin basic protein (MBP), glial fibrilla[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24657424
sparser
"New data are currently appearing on the involvement of pRPS6K1 in the promotion of translation reinitiation of upstream open reading frame (uORF)-containing viral and cellular mRNAs via phosphorylation of eIF3h (Schepetilnikov et al., 2013) and in regulation of translation initiation under energy-deficient conditions via formation of the functional eIF4F complex (Lee et al., 2017)."
33659803
sparser
"As revealed by Western blotting, application of strain resulted in significant upregulation of mammalian target of rapamycin (mTOR) and S6 signaling in nerves, increased myelin basic protein (MBP) and β-actin levels, and increased phosphorylation of neurofilament subunit H (NF-H) compared with unstrained (sham) contralateral nerves ( P < 0.05 for all comparisons, paired two-tailed t -test)."
28250148
sparser
"It has been shown that in rats, ON injury induces changes in the expression pattern of the highly phosphorylated axonal neurofilament subunit H (pNFH) ( Dräger and Hofbauer, 1984; Vidal-Sanz et al., 1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29452106
reach
"Moreover, TOR-mediated phosphorylation of the 40S RIBOSOMAL S6 KINASE 1 (S6K1) triggers phosphorylation of the eukaryotic translation initiation factor 3 subunit h (elF3h) which promotes translation r[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37603910
sparser
"The phosphorylated S6K1, released from both platforms, becomes fully activated and capable to phosphorylate eIF3h."
29692761
sparser
"TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h."
33659803
sparser
"Specifically, SARM1 knockout mice experience less axonal injury and maintained axonal integrity, as evidenced by decreased ß-amyloid precursor protein aggregates in corpus collusum axons and suppressed plasma levels of phosphorylated neurofilament subunit H ( xref )."
31761689
sparser
"TOR activation by auxin results in the phosphorylation of eIF3h, a component of elF3 complex that promotes translation reinitiation [80] ."
26684391
sparser
"Intra-retinal ganglion cell axons were detected using mouse IgG1 α-highly phosphorylated axonal neurofilament subunit H (pNFH, clone RT-97, MCA1321, Bio-Rad, Bionova Cientifica SL, Madrid, Spain), dil[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29452106