IndraLab

Statements

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"We observed, while the elevation of EIF3H drastically increases the tumor invasion in various breast cancer cell lines, including MDA-MB-231, 4T1, depletion of EIF3H by RNA interference largely attenuates tumor invasion (XREF_FIG - XREF_FIG & XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."
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"We found that EIF3H overexpression significantly increased the abilities of migration and invasion in KYSE150 and KYSE510 cells."
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"Besides , we demonstrated that the knockdown of EIF3H significantly reduced OGT protein expression , cell proliferation and invasion , and caused G1 / S arrest of HCC ."
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"EIF3H promotes CRC cell growth, migration and invasion."
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"Moreover, we also observed that EIF3H promoted cell proliferation and invasion by regulating ferroptosis."
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"A comparison of 1964 CRC cases and 2081 healthy controls identified the region harbouring rs16888589 as an allele specific transcriptional repressor that interacts with the promoter of EIF3H, which increases CRC growth and invasiveness [29]."
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"These data suggest that EIF3H promotes CRC cell growth, migration and invasion."
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"Also, eIF3h has been found to enhance tumorigenicity, invasion, and proliferation in hepatocellular carcinoma via TGF-β and MAPK pathways, making it a prognostic marker for hepatocellular cancer patients [37]."
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"The knockdown of EIF3H could inhibit ATC cell proliferation, invasion, and ferroptosis resistance by regulating β-catenin."
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"Increased expression of EIF3H gene increases CRC growth and invasiveness thereby providing a biological mechanism for the 8q23.3 association XREF_BIBR."
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"Functional analyses showed that EIF3H overexpression promoted LUAD cell migration and invasion in vitro as well as metastasis in nude mice by activating epithelial-mesenchymal transition (EMT) signaling."
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"We found that EIF3H is significantly upregulated in esophageal cancer and ectopic expression of EIF3H in ESCC cell lines promotes cell proliferation, colony formation, migration and invasion."
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"To further determine whether YAP is a physiologically relevant substrate for EIF3H that mediates EIF3H promoted tumor cell invasion, we have characterized catalytic function for EIF3H in regulating YAP abundance, YAP turnover rate and YAP ubiquitylation."
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"Transwell assays showed EIF3H silencing decreased the migration and invasion of CRC cells (Supplementary Fig. 3f, g)."
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"We show that increased expression of EIF3H gene increases CRC growth and invasiveness thereby providing a biological mechanism for the 8q23.3 association."
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"As shown in XREF_FIG - XREF_FIG and XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY, knockdown of either the YAP and CTGF expression abrogated EIF3H driven tumor cell invasion."
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