IndraLab

Statements

EIF3H leads to the phosphorylation of ERK. 3 / 3
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"Our results show that HAX1 binds to RAF1 directly and EIF3H or HAX1 deletion in CRC cells can reduce the phosphorylation of ERK1/2."
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"Given that activation of Wnt/β-catenin signaling induced EIF3H expression and that EIF3H-HAX1 enhanced phosphorylation of ERK1/2 in CRC, we next investigated whether combined targeting Wnt and RAF1-ERK1/2 signaling synergistically inhibited CRC cell growth."
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"Mechanistically, EIF3H functions as a deubiquitinase for HAX1 and stabilize it, which in turn enhanced the interaction between RAF1, MEK1 and ERK1, thereby potentiating phosphorylation of ERK1/2 and subsequent growth/metastasis promotion."
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