IndraLab

Statements

reach
"Thus, functional knockdown of EIF3H expression inhibits HCC growth and metastasis in vitro and in vivo."
27340783
reach
"EIF3H/HAX1 axis promotes CRC tumorigenesis and metastasis in mouse orthotopic cancer model."
38514606
reach
"PSMD14, OTUB1, USP26, and EIF3H, by stabilizing Snail, promote the occurrence of metastasis[24-27]."
38463028
reach
"Further, EIF3H promotes CRC tumorigenesis and metastasis via HAX1 activity in mouse model."
38514606
reach
"Conversely, genetic inhibition of EIF3H represses ESCC tumor growth and metastasis in vitro and in vivo."
32867821
reach
"To find out whether EIF3H enhances cancer metastasis ability in vivo, we then performed lung metastatic model assay."
32867821
reach
"EIF3H promotes CRC tumorigenesis/metastasis via HAX1 in an orthotopic CRC model."
38514606
reach
"Importantly, HAX1 overexpression increased tumorigenicity and demonstrated strong metastatic capability; therefore, it could reverse reduced tumor growth and restore compromised lung and liver metastasis caused by EIF3H KD (Fig. 5a–c)."
38514606
reach
"Taken together, these results indicate that EIF3H knockdown inhibits cell mobility and tumor metastasis in ESCC."
32867821
eidos
"Other than the translation-initiation function of EIF3H , in the present study , our finding that EIF3H promotes metastasis through stabilizing YAP addresses a knowledge gap for YAP turnover regulation ."
32269044
reach
"Besides, it also takes part in EMT process and the knockdown of EIF3H suppressed tumor metastasis in vivo."
32867821
reach
"Our results exhibited that ectopic expression of EIF3H promoted ESCC metastasis with the increase of Snail, N-Cadherin and Vimentin, and decrease of E-cadherin, while knockdown of EIF3H exerted an opposite effect."
32867821
reach
"Taken together, these results suggest that EIF3H/HAX1 axis promotes CRC tumorigenesis and metastasis."
38514606
reach
"Functional analyses showed that EIF3H overexpression promoted LUAD cell migration and invasion in vitro as well as metastasis in nude mice by activating epithelial-mesenchymal transition (EMT) signaling."
32064160
reach
"Therefore, targeting HAX1 may also attenuate the activation of RAF.In the orthotopic CRC model, EIF3H knockdown decreases orthotopic tumor growth, and attenuates liver and lung metastasis, while HAX1 can rescue these phenomena under EIF3H knockdown."
38514606
reach
"In the spontaneous lung metastasis model, we observed that loss of EIF3H significantly decreased lung metastasis nodules."
32269044
eidos
"To find out whether EIF3H enhances cancer metastasis ability in vivo , we then performed lung metastatic model assay ."
32867821
reach
"Other than the translation initiation function of EIF3H, in the present study, our finding that EIF3H promotes metastasis through stabilizing YAP addresses a knowledge gap for YAP turnover regulation."
32269044
eidos
"Taken together , these results indicate that EIF3H knockdown inhibits cell mobility and tumor metastasis in ESCC ."
32867821
eidos
"Besides , it also takes part in EMT process and the knockdown of EIF3H suppressed tumor metastasis in vivo ."
32867821