IndraLab

Statements

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"Besides, it also takes part in EMT process and the knockdown of EIF3H suppressed tumor metastasis in vivo."
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"Taken together, these results indicate that EIF3H knockdown inhibits cell mobility and tumor metastasis in ESCC."
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"To find out whether EIF3H enhances cancer metastasis ability in vivo, we then performed lung metastatic model assay."
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"Our results exhibited that ectopic expression of EIF3H promoted ESCC metastasis with the increase of Snail, N-Cadherin and Vimentin, and decrease of E-cadherin, while knockdown of EIF3H exerted an opposite effect."
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"In the spontaneous lung metastasis model, we observed that loss of EIF3H significantly decreased lung metastasis nodules."
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"Other than the translation-initiation function of EIF3H , in the present study , our finding that EIF3H promotes metastasis through stabilizing YAP addresses a knowledge gap for YAP turnover regulation ."
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"Besides , it also takes part in EMT process and the knockdown of EIF3H suppressed tumor metastasis in vivo ."
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"Thus, functional knockdown of EIF3H expression inhibits HCC growth and metastasis in vitro and in vivo."
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"To find out whether EIF3H enhances cancer metastasis ability in vivo , we then performed lung metastatic model assay ."
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"Taken together , these results indicate that EIF3H knockdown inhibits cell mobility and tumor metastasis in ESCC ."
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"Other than the translation initiation function of EIF3H, in the present study, our finding that EIF3H promotes metastasis through stabilizing YAP addresses a knowledge gap for YAP turnover regulation."
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"Functional analyses showed that EIF3H overexpression promoted LUAD cell migration and invasion in vitro as well as metastasis in nude mice by activating epithelial-mesenchymal transition (EMT) signaling."
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"Conversely, genetic inhibition of EIF3H represses ESCC tumor growth and metastasis in vitro and in vivo."
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