IndraLab

Statements


EIF3H activates OGT. 7 / 7
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"The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT [17]."

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"EIF3H depletion inhibits O-GlcNac pathway activity in HCC."

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"We then treated cells by CHX to inhibit protein synthesis, and discovered that EIF3H depletion reduced OGT half-life, whereas overexpression of wild-type EIF3H prolonged it."

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"EIF3H enhances the stability of OGT in HCC."

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"These findings demonstrated that EIF3H increased the stability of OGT in a DUB-dependent manner."

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"EIF3H has been found to promote HCC progression by stabilizing OGT (O-GlcNAc transferase) and inhibiting ferroptosis, a form of regulated cell death."

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"The deubiquitinase EIF3H promotes hepatocellular carcinoma progression by stabilizing OGT and inhibiting ferroptosis."