IndraLab
Statements
reach
"55
To comprehensively address the mechanism by which the interplay of OGT‐mediated YAP‐ GlcNAcylation and EIF3H‐mediated deubiquitylation regulates YAP stability control, we conducted structural modeling of the interaction between YAP, OGT, and EIF3H by integrated use of docking simulations followed by experimental validation."
reach
"This will provide a clearer understanding of how O‐GlcNAcylation regulates YAP stability and interacts with EIF3H in breast tumorigenesis and therapeutic outcomes.In addition, previous findings suggest that EIF3H can interact with and stabilize OGT, enhancing its activity in a deubiquitinase‐dependent manner."