IndraLab

Statements


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reach
"EIF3H could interact with, deubiquitylate, and stabilize OGT in a deubiquitylase-dependent manner."

No evidence text available

No evidence text available

sparser
"Consistently, we performed an immunohistochemistry analysis of tissue microarrays from Xiangya hospital, which showed that OGT was positively associated with EIF3H, and that high expression of EIF3H was associated with unfavorable prognosis (Fig.  xref F-H)."

sparser
"EIF3H interacts with OGT in HCC."

reach
"55 To comprehensively address the mechanism by which the interplay of OGT‐mediated YAP‐ GlcNAcylation and EIF3H‐mediated deubiquitylation regulates YAP stability control, we conducted structural modeling of the interaction between YAP, OGT, and EIF3H by integrated use of docking simulations followed by experimental validation."

reach
"We further analyzed the linkage of ubiquitin chains in interaction between EIF3H and OGT."

reach
"This will provide a clearer understanding of how O‐GlcNAcylation regulates YAP stability and interacts with EIF3H in breast tumorigenesis and therapeutic outcomes.In addition, previous findings suggest that EIF3H can interact with and stabilize OGT, enhancing its activity in a deubiquitinase‐dependent manner."

sparser
"Firstly, EIF3H and OGT interacted with each other directly."

sparser
"Endogenous EIF3H and OGT were co-immunoprecipitated in LM3 cells, suggesting that the interaction between EIF3H and OGT is physiological."

reach
"Endogenous EIF3H and OGT were co-immunoprecipitated in LM3 cells, suggesting that the interaction between EIF3H and OGT is physiological."

sparser
"We further analyzed the linkage of ubiquitin chains in interaction between EIF3H and OGT."