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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

EIF3H activates CPEB2B. 1 / 1

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"Furthermore, we provide data indicating that the EIF3H subunit of the pre and initiation complex may aid CPEB2B in initiating HIF1alpha translation via preferential association with this protein.Therefore, the alternative splicing of CPEB2 is a novel regulator of HIF1alpha during hypoxia and targeting the expression of CPEB2B could in turn be used to regulate HIF1 in patients suffering from chronic hypoxic disorders.Seminal studies in the field have demonstrated that CPEB2 localizes via a low complexity sequence to stress granules which also contain mRNA transcripts (22)."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...