IndraLab

Statements



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"EIF3h potentiates the cell proliferation and inhibits the cell apoptosis of gastric cancer cells 13."

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"As shown in XREF_FIG, knockdown of endogenous EIF3H significantly inhibited the proliferation of Saos-2 and U2OS cells at 24, 48, 72, 96 and 120 h after viral infection."

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"Besides , we demonstrated that the knockdown of EIF3H significantly reduced OGT protein expression , cell proliferation and invasion , and caused G1 / S arrest of HCC ."

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"Our results suggest that eIF3h content is near a threshold in Hap1 cells, since overexpression of SNAP-eIF3H appears to diminish wild-type eIF3h protein levels and fails to increase the proliferation rate of wild-type cells."

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"At the cellular level, EIF3H overexpression increases proliferation, growth and survival."

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"Hong et al. (2018) observed that the knockdown of EIF3H inhibited the proliferation and colony formation of Saos-2 and U2OS cells."

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"EIF3H overexpression increases tumor cell proliferation, growth, and survival."

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"Reduction of EIF3H has previously been shown to reduce cell proliferation and anchorage independent growth in soft agar [XREF_BIBR]."

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"The elevation of EIF3H activity could promote cell proliferation through regulating protein biosynthesis [ 26 ]."

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"We observed that EIF3H overexpression in both KYSE150 and KYSE510 cells increased cell proliferation in vitro, whereas depletion of EIF3H significantly reduced cell proliferation."

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"Knockdown of EIF3H could effectively inhibit cell proliferation through inducing cell apoptosis and arrest of cell cycle."

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"Moreover, we also observed that EIF3H promoted cell proliferation and invasion by regulating ferroptosis."

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"EIF3H knockdown reduced the proliferation of CRC cells, as determined by cell proliferation and foci formation assays (Supplementary Fig. 3d, e)."

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"The results demonstrated that the depletion of EIF3H decreased cell proliferation dramatically (Fig. 4A)."

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"Finally, reduction of eIF3h levels in breast and prostate cancer cell lines by short interfering RNA methods reduces their rates of proliferation and anchorage independent growth in soft agar."

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"When compared to the corresponding cell lines infected with shCon, HCT116 and SW1116 cell proliferation was significantly inhibited by EIF3H knockdown (p < 0.001, Figure 3 (a))."

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"We observed that the depletion of EIF3H decreased cell proliferation rate (Fig. 5A, B) and clonogenic potential (Fig. 5C, D) in both LM3 and Hep3B cell lines in response to different concentrations of Erastin."

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"Thus, we come to the conclusion that EIF3H promotes proliferation and migration of iCCAs, inhibiting apoptosis of iCCA cells at the same time by stabilizing the CCND1 protein structure."

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"These results suggested that EIF3H promoted hepatocellular carcinoma cell proliferation via the regulation of OGT."

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"The knockdown of EIF3H could inhibit ATC cell proliferation, invasion, and ferroptosis resistance by regulating β-catenin."

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"Our results showed that the depletion of EIF3H markedly decreased the proliferation and migration of HCC both in vitro and in vivo."

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"Taken together, these results confirmed that EIF3H accelerated the proliferation and migration through increasing OGT stability.Ferroptosis is a new non-apoptotic programmed cell death triggered by lipid ROS and has been regarded as a potential therapeutic target for cancer therapy."

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"We observed that EIF3H overexpression in both KYSE150 and KYSE510 cells increased cell proliferation in vitro ( Fig. 2e and f ) , whereas depletion of EIF3H significantly reduced cell proliferation ( Fig. 2g and h ) ."

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"The higher polyp number associated with the C allele of rs16892766 could be explained by the location of this SNP in the EIF3H gene, which increases cell proliferation, growth, and survival when overexpressed."

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"Also, eIF3h has been found to enhance tumorigenicity, invasion, and proliferation in hepatocellular carcinoma via TGF-β and MAPK pathways, making it a prognostic marker for hepatocellular cancer patients [37]."

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"Knockdown of EIF3H inhibited cell proliferation and colony formation ."

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"In the LoVo CRC line, reduction of EIF3H levels by short interfering RNA (shRNA) reduced cell proliferation (XREF_FIG)."

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"XREF_BIBR At the cellular level, EIF3H overexpression increases proliferation, growth and survival."

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"Conversely, EIF3H up-regulation by transfection with lentivirus carrying an EIF3H expression vector (pWP1-EIF3H) increased cellular proliferation (XREF_FIG)."

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"Reduction of eIF3h levels in breast and prostate cancer cell lines by shRNA methods has previously been shown to reduce cell proliferation and anchorage independent growth in soft agar XREF_BIBR."

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"Previous studies have shown that RFFL and HDAC2 are known to also promote tumor formation by inhibiting the apoptosis process [XREF_BIBR, XREF_BIBR, XREF_BIBR], whereas EIF3H is known to increase cell proliferation, growth and survival and inhibit the apoptosis process [XREF_BIBR]."

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"In addition, we also confirmed that EIF3H promoted HCC cell proliferation and migration via upregulation of OGT."

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"Knockdown of EIF3H inhibits the development and progression of pancreatic cancer by regulating cell proliferation and apoptosis in vitro."

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"EIF3h, a subunit of eIF3 can promote protein synthesis and cell proliferation."