IndraLab

Statements

EIF3H activates Neoplasms. 6 / 6
| 6
reach
"We analyzed change in mRNA level of Eif3h from datasets of colon tumors isolated from Apc and AOM-treated mice (GSE5204), and found that Eif3h mRNA level was elevated in tumors of Apc and AOM-induced mice compared with normal mice colon tissues (Supplementary Fig. 8a)."
38514606
reach
"Therefore, targeting HAX1 may also attenuate the activation of RAF.In the orthotopic CRC model, EIF3H knockdown decreases orthotopic tumor growth, and attenuates liver and lung metastasis, while HAX1 can rescue these phenomena under EIF3H knockdown."
38514606
reach
"In some of the earliest studies of advanced PCa, researchers found that upregulated eIF3S3 gene expression was a common phenomenon, suggesting that eIF3S3 overexpression promoted tumor growth (55–57)."
35856412
reach
"EIF3H can enhance protein synthesis and promote tumor progression, especially promote the translation of certain oncogenes ."
38514606
reach
"The results illustrated that EIF3H depletion by lentivirus-based shRNA suppressed the HCC tumor growth markedly (Fig. 4G, H)."
37559097
reach
"While our study focused on EIF3H‐YAP interactions, future investigations should also explore whether EIF3H‐mediated OGT stabilization contributes to YAP regulation and obesity‐driven tumor progression.3.3 Retatrutide: A Metabolic Drug's Potential in Reversing Chemoresistance in TNBC."
39868848