IndraLab

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"Among patients with amplification of both HER2 and MYC , the addition of trastuzumab to chemotherapy reduced the risk of cancer recurrence by 76% and reduced the risk of death by 64%, while in individuals with HER2 amplification alone the addition of trastuzumab to chemotherapy did not reduce the risk of death. xref In our study, we observed that both MYC and EIF3H were associated with a better outcome after gefitinib therapy, and among EGFR+ patients (FISH+ and/or mutated), only individuals with increased MYC/EIF3H gene copy number had a significant tumor shrinkage."