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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

EIF3H activates competence. 2 / 2

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"In plants, eIF3 non core subunit h (eIF3h) greatly elevates the reinitiation competence of mRNAs coding for the Arabidopsis basic zipper transcription factors (bZIPs) and several ARFs; while the 60S ribosomal protein L24B (RPL24B), which is encoded by SHORT VALVE1, lifts translation of uORF containing mRNAs that encode ARF3 (ETTIN) and ARF5."

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"It was proposed that, by analogy with the function of yeast eIF3a and Tif32 discussed above, eIF3h (specifically its N-terminal part) might support efficient REI by preserving the competence of a fraction of uORF translating ribosomes to resume traversing downstream."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...