IndraLab

Statements

USP48 is modified
12 | 10 1
USP48 is phosphorylated.
11 | 8 1
USP48 is phosphorylated. 9 / 9
| 8 1
sparser
"Exposure to TNFα caused GSK3β-mediated phosphorylation of USP48, leading to deubiquitination of TRAF2 in beas2B cells, increasing JNK signaling upon TNF-α-induction [ xref ]."
31208841
sparser
"In response to TNF however, phosphorylation of USP48 is transient ( Fig. 8 C)."
25486460
sparser
"Exposure to TNFα caused GSK3β-mediated phosphorylation of USP48, leading to deubiquitination of TRAF2 in beas2B cells, increasing JNK signaling upon TNF-α-induction [71]."
31208841
sparser
"Interestingly, association of CK2 with the CSN and CK2-mediated phosphorylation of its subunits CSN2 and CSN7 have been observed [46] , implying potential reciprocal regulation of CK2 and CSN activit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
rlimsp
"We show that USP48 trims rather than completely disassembles long K48-linked free and substrate-anchored Ub-chains, a catalytic property only shared with ataxin-3 (Atx3) and otubain-1 (OTU1), and that USP48 Ub-chain-trimming activity is regulated by casein-kinase-2 (CK2)-mediated phosphorylation in response to cytokine-stimulation."
25486460
sparser
"The ability of CK2 to phosphorylate USP48 at C-terminal sites was confirmed in kinase assays with recombinant USP48 variants, tagged at the N-term with GST ( Fig. 6 A )."
25486460
sparser
"When USP48-FL was subjected to an in vitro kinase assay prior to and during the labeling reaction, labeling was suppressed indicating that phosphorylation of USP48 in the C-term changes its catalytic [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
sparser
"In contrast to HA-Ub-VS-labeling of USP48, which was (transiently) lost after TNF stimulation and upon CK2-mediated phosphorylation ( Fig. 7 A), phosphorylation of USP48 in response to 2 h TNF stimula[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
sparser
"USP48 phosphorylation at its C-terminal CK2 phosphorylation sites in response to TNF was confirmed after knockdown of endogenous USP48, followed by reexpression of either siRNA-resistant USP48-FL WT [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
USP48 is phosphorylated on S886. 4 / 4
4 |
hprd
No evidence text available
20068231
hprd
No evidence text available
19651622
hprd
No evidence text available
17081983
hprd
No evidence text available
19413330
USP48 is phosphorylated on S887. 3 / 3
3 |
hprd
No evidence text available
17081983
hprd
No evidence text available
19651622
hprd
No evidence text available
20068231
USP48 is phosphorylated on S888. 3 / 3
3 |
hprd
No evidence text available
20068231
hprd
No evidence text available
19651622
hprd
No evidence text available
17081983
USP48 is phosphorylated on T890. 1 / 1
1 |
hprd
No evidence text available
17081983
USP48 is acetylated.
1 | 1
USP48 is acetylated on K956. 1 / 1
1 |
hprd
No evidence text available
19608861
USP48 is acetylated. 1 / 1
| 1
sparser
"To further investigate its activity in tumorigenesis, deacetylase sirtuin 1 (Sirt1) was shown to interact with USP31 by co-immunoprecipitation and blocking the function of Sirt1 by knockdown or the inhibitor nicotinamide could increase the acetylation of USP31."
34184746
USP48 is dephosphorylated.
| 1
USP48 is dephosphorylated. 1 / 1
| 1
sparser
"Thus, dephosphorylation of USP48 and/or its release from RelA and the CSN through an unknown mechanism finally allow efficient polyubiquitination of RelA by ECS SOCS1 , mediating its proteasomal degra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
USP48 affects MDM2
| 12 3
USP48 activates MDM2.
| 9
USP48 activates MDM2. 9 / 9
| 9
reach
"Moreover, these results also suggested that USP48 does not mediate Mdm2 stabilization through the deubiquitination of other Mdm2 regulators."
28233861
reach
"Recently, USP48 has also been shown to promote the stability of Mdm2 that in turn results in enhanced degradation of p53 42, which has been associated to FA cell death 43."
29891926
reach
"To determine whether the observed USP48 mediated Mdm2 upregulation might reflect increased stability on the protein level, we performed a cycloheximide (CHX) chase assay in U2OS cells transfected either with the Mdm2 construct alone or in combination with USP48."
28233861
reach
"Interestingly, when we analyzed the pattern of Mdm2 ubiquitination in the presence of the deubiquitinase defective mutant USP48 C98S, we again observed that less ubiquitin was attached to Mdm2 via lysine 48 compared to other lysines, suggesting that the deubiquitinase activity of USP48 was not responsible for the previously observed difference and supporting our notion that USP48 did not target Mdm2 with its deubiquitinase activity."
28233861
reach
"We were surprised to find that USP48 caused Mdm2 stabilization that was not accompanied by a significant decrease in the overall levels of Mdm2 ubiquitination, which was unexpected (XREF_FIG)."
28233861
reach
"Nevertheless, we can not exclude the possibility that USP48 (and its deubiquitinase inactive mutants) are capable of recruiting another deubiquitinase responsible for trimming K48 linked ubiquitin, and future studies are necessary to determine the exact mechanism by which USP48 promotes Mdm2 stability."
28233861
reach
"As Mdm2 is best known as a critical negative regulator of p53, in the next set of experiments, we analyzed the impact of the observed USP48 mediated Mdm2 stabilization on cellular p53 protein levels and p53 ubiquitination."
28233861
reach
"USP48 promotes Mdm2 stability."
28233861
reach
"Moreover, two previously characterized USP48 mutants lacking deubiquitinase activity were also capable of efficiently stabilizing Mdm2, indicating that USP48 utilizes a non canonical, deubiquitination independent mechanism to promote Mdm2 oncoprotein stability."
28233861
USP48 binds MDM2.
| 3
USP48 binds MDM2. 3 / 3
| 3
sparser
"More detailed subsequent analyses of Mdm2-USP48 interactions suggested the presence of two independent USP48-binding sites in Mdm2 ( xref , xref )."
28233861
sparser
"To test the possible effect of USP48-Mdm2 interactions on Mdm2 protein stability, Mdm2 was expressed in U2OS cells together with increasing amounts of USP48."
28233861
sparser
"One possible explanation could be provided by our finding that USP48 binds to the central acidic domain of Mdm2, a region that was shown by us and others to independently contribute to p53 ubiquitination and to p53 and Mdm2 stability xref xref xref xref xref ."
28233861
USP48 increases the amount of MDM2.
| 1
USP48 increases the amount of MDM2. 1 / 1
| 1
reach
"However, if the active trimming of K48 linked ubiquitin was responsible for Mdm2 stabilization, USP48 protein lacking deubiquitinase activity should not be able to modulate Mdm2 protein levels."
28233861
USP48 deubiquitinates MDM2.
| 1
USP48 leads to the deubiquitination of MDM2. 1 / 1
| 1
reach
"In contrast to other deubiquitinating enzymes (DUBs) that have been previously implicated in the regulation of Mdm2 protein stability, USP48 did not induce Mdm2 stabilization by significantly reducing Mdm2 ubiquitination levels."
28233861
USP48 decreases the amount of MDM2.
| 1
USP48 decreases the amount of MDM2. 1 / 1
| 1
reach
"In contrast to other deubiquitinating enzymes (DUBs) that have been previously implicated in the regulation of Mdm2 protein stability, USP48 did not induce Mdm2 stabilization by significantly reducing Mdm2 ubiquitination levels."
28233861
USP48 affects GLI1
1 | 4 6
USP48 binds GLI1.
| 1 6
USP48 binds GLI1. 7 / 7
| 1 6
sparser
"The deubiquitinase USP48 is able to interact directly with GLI1, cleaving off its ubiquitin and thus enhancing its lifetime. xref In GBM cells, knockdown of USP48 inhibits cell proliferation and expression of GLI1’s downstream targets, leading to repressed tumorigenesis."
29628779
sparser
"Zhou and colleagues sustained a positive feedback loop by which HH signaling activates USP48 through the binding of GLI1 to Usp48 promoter."
32531973
reach
"Mechanistically, USP48 interacts with Gli1 and cleaves its ubiquitin off directly."
28623188
sparser
"USP48 interacts with Gli1 through its C-terminal DUSP domain to remove ubiquitin moiety from Gli1."
| PMC
sparser
"In human glioblastoma, USP48 and Gli1 expression levels were positively correlated, and high USP48 expression levels correlated with higher grades of glioma malignancy [ xref ], suggesting that the USP48-Gli1 regulatory axis is critical for glioma cell proliferation and glioblastoma tumorigenesis."
| PMC
sparser
"This evidence underlies the relevance of USP48-GLI1 regulatory axis for glioma cell proliferation and glioblastoma tumorigenesis [ xref ]."
32531973
sparser
"Depletion of USP48 inhibits glioma cell viability and tumor generation by partially stabilizing Gli1, which incidates a critical role of the USP48‐Gli1 axis in glioblastoma tumorigenesis ( xref ) ( xref )."
32133826
USP48 activates GLI1.
| 2
USP48 activates GLI1. 2 / 2
| 2
reach
"In addition to USP7 and OTUB2, the deubiquitinase USP48 was found to activate Hh signaling by stabilizing Gli1 protein in glioma cells [65]."
| PMC
reach
"Gli1 induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1."
28623188
USP48 increases the amount of GLI1.
| 1
USP48 increases the amount of GLI1. 1 / 1
| 1
reach
"Knockdown of USP48 inhibited the expression of Gli1 target genes and repressed cell proliferation and tumorigenesis [65]."
| PMC
USP48 deubiquitinates GLI1.
1 |
USP48 deubiquitinates GLI1. 1 / 1
1 |
ubibrowser
"Gli1-induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1"
28623188
GLI1 affects USP48
| 3 7
GLI1 binds USP48.
| 1 6
USP48 binds GLI1. 7 / 7
| 1 6
sparser
"The deubiquitinase USP48 is able to interact directly with GLI1, cleaving off its ubiquitin and thus enhancing its lifetime. xref In GBM cells, knockdown of USP48 inhibits cell proliferation and expression of GLI1’s downstream targets, leading to repressed tumorigenesis."
29628779
sparser
"Zhou and colleagues sustained a positive feedback loop by which HH signaling activates USP48 through the binding of GLI1 to Usp48 promoter."
32531973
reach
"Mechanistically, USP48 interacts with Gli1 and cleaves its ubiquitin off directly."
28623188
sparser
"USP48 interacts with Gli1 through its C-terminal DUSP domain to remove ubiquitin moiety from Gli1."
| PMC
sparser
"In human glioblastoma, USP48 and Gli1 expression levels were positively correlated, and high USP48 expression levels correlated with higher grades of glioma malignancy [ xref ], suggesting that the USP48-Gli1 regulatory axis is critical for glioma cell proliferation and glioblastoma tumorigenesis."
| PMC
sparser
"This evidence underlies the relevance of USP48-GLI1 regulatory axis for glioma cell proliferation and glioblastoma tumorigenesis [ xref ]."
32531973
sparser
"Depletion of USP48 inhibits glioma cell viability and tumor generation by partially stabilizing Gli1, which incidates a critical role of the USP48‐Gli1 axis in glioblastoma tumorigenesis ( xref ) ( xref )."
32133826
GLI1 activates USP48.
| 1 1
GLI1 activates USP48. 2 / 2
| 1 1
reach
"Interestingly, USP48 is transcriptionally activated by Gli1 in glioma cells, thus forms a positive feedback loop to regulate Hh signaling [65]."
| PMC
sparser
"Interestingly, USP48 is transcriptionally activated by Gli1 in glioma cells, thus forms a positive feedback loop to regulate Hh signaling [ xref ]."
| PMC
GLI1 increases the amount of USP48.
| 1
GLI1 increases the amount of USP48. 1 / 1
| 1
reach
"We find that deubiquitinase USP48 activates Gli dependent transcription by stabilizing Gli1 protein."
28623188
USP48 affects TRAF2
2 | 4 3
USP48 binds TRAF2.
| 1 3
TRAF2 binds USP48. 4 / 4
| 1 3
sparser
"These results show that USP31 and TRAF2 interact specifically in mammalian cells and their interaction requires an intact RING finger domain of TRAF2 and the amino terminal 483 residues of USP31."
16214042
reach
"USP48 (also known as USP31) interacted with and deubiquitinated TRAF2 in beas2B cells [71]."
31208841
sparser
"Co-immunoprecipitation experiments indicated that USP31 does not interact with a mutated TRAF2 that lacks the RING finger domain (C)."
16214042
sparser
"To confirm that the interaction between TRAF2 and USP31 in mammalian cells occurs via the RING finger domain of TRAF2, as indicated by our two-hybrid results, a mutated form of TRAF2 with a RING finge[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16214042
USP48 deubiquitinates TRAF2.
2 | 1
USP48 deubiquitinates TRAF2. 3 / 3
2 | 1
ubibrowser
"Here we reveal USP48 as the first identified DUB to deubiquitinate and stabilize TRAF2 in epithelial cells."
28874458
ubibrowser
"The deubiquitinating enzyme USP48 stabilizes TRAF2 and reduces E-cadherin-mediated adherens junctions"
28874458
reach
"USP48 (also known as USP31) interacted with and deubiquitinated TRAF2 in beas2B cells [71]."
31208841
USP48 decreases the amount of TRAF2.
| 1
USP48 decreases the amount of TRAF2. 1 / 1
| 1
reach
"Down-regulation of USP48 increases K48 linked polyubiquitination of TRAF2 and reduces TRAF2 protein levels."
28874458
USP48 activates TRAF2.
| 1
USP48 activates TRAF2. 1 / 1
| 1
reach
"A noteworthy fact is that TRAF2 in JNK pathway was targeted by USP48, but not TRAF2 in NF-kappaB signaling [XREF_BIBR]."
31208841
USP48 affects RELA
| 4 5
USP48 binds RELA.
| 3 5
USP48 binds RELA. 7 / 7
| 3 4
sparser
"The association of USP48 with RelA is likely strengthened upon RelA ubiquitination."
25486460
reach
"It is however possible, that TNF induced ubiquitination of RelA and/or other yet to be identified inducible PTMs of RelA, USP48 or unknown interaction partners are required to mediate this interaction[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
sparser
"Initial studies found that overexpression of USP48 inhibits NF-κB activity downstream of IKKβ and that USP48 also interacts with p65."
27187478
sparser
"A candidate target of USP31 could be p65/RelA, since there is a physical interaction between USP31 and p65 as indicated by the immunoprecipitation experiments."
16214042
reach
"In this study we observed that USP48, a DUB of hitherto ill defined function identified through a siRNA screen, associates with the CSN and RelA in the nucleus."
25486460
reach
"Initial studies found that overexpression of USP48 inhibits NF-kappaB activity downstream of IKKbeta and that USP48 also interacts with p65."
27187478
sparser
"In this study we report that USP48 interacts physically with RelA in the nucleus."
30628021
BLNK binds USP48, REL, RELA, and USP. 1 / 1
| 1
sparser
"Further, we show by overexpression of truncated proteins that the catalytic USP domain of USP48 interacts with the N-terminal region of the Rel homology domain (RHD) of RelA."
30628021
USP48 activates RELA.
| 1
USP48 activates RELA. 1 / 1
| 1
reach
"Interestingly, overexpressed USP48 promoted RelA nuclear accumulation 30 min after TNF stimulation independent of catalytic site Cys C98."
25486460
USP48 affects BRCA1
| 1 5
USP48 inhibits BRCA1.
| 1 3
USP48 inhibits BRCA1. 4 / 4
| 1 3
reach
"In cells we reveal that USP48 antagonizes BRCA1 E3 ligase function and in BRCA1-proficient cells loss of USP48 results in positioning 53BP1 further from the break site and in extended resection lengths."
29335415
reach
"USP48 loss enhances BRCA1 and RAD51 localization in FA cells."
29891926
eidos
"Interestingly , in the absence of USP48 , single-stranded annealing is promoted , which is likely due to the increased resection that occurs if BRCA1 is not properly constrained by USP48 ."
31164001
reach
"Moreover, both the increased GC and SSA repair seen in USP48 depleted cells required BRCA1, as well as CtIP."
29335415
USP48 activates BRCA1.
| 2
USP48 activates BRCA1. 2 / 2
| 2
reach
"Thus, high levels or activity of USP48 would be expected to decrease resection lengths and thus reduce GC, and phenocopy aspects of BRCA1 loss."
29335415
reach
"We propose that USP48 promotes genome stability by antagonizing BRCA1 E3 ligase function."
29335415
CK2 affects USP48
| 1 5
CK2 phosphorylates USP48. 6 / 6
| 1 5
sparser
"These results indicate that CK2-mediated phosphorylation of USP48 at its C-terminal CK2 consensus sites and its binding to K48-linked Ub-chains ( Fig. 5 H), both of which promote USP48 Ub-chain-trimmi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
sparser
"CK2-mediated phosphorylation of USP48 at C-terminal CK2 consensus sites, in vitro and in response to TNF, enhances its Ub-chain-trimming activity ( Fig. 8 A–C)."
25486460
sparser
"We demonstrate that (I) USP48 preferentially trims long (K48-linked) Ub-chains, an as yet unique property within the USP family, (II) CK2 phosphorylates USP48 at C-terminal CK2 consensus sites, thereb[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
sparser
"Phosphorylation of USP48 at its C-terminal CK2 consensus sites was evidenced in in vitro phosphorylation assays with recombinant CK2 and epitope-tagged USP48 variants, which, after overexpression, had[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
reach
"The ability of CK2 to phosphorylate USP48 at C-terminal sites was confirmed in kinase assays with recombinant USP48 variants, tagged at the N-term with GST."
25486460
sparser
"In support of a functional role of CK2 in the regulation of USP48 catalytic activity, phosphorylation of USP48 at CK2 consensus sites as well as co-IP of CK2α and CSN (CSN3) were observed 2 h after TN[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
USP48 affects TP53
| 1 1 3
USP48 ubiquitinates TP53.
| 1 3
USP48 ubiquitinates TP53. 3 / 3
| 3
sparser
"USP48 can enhance Mdm2-mediated p53 ubiquitination and degradation."
28233861
sparser
"Importantly, p53 degradation assay showed that the USP48-induced increase in Mdm2-mediated p53 ubiquitination could also lead to more efficient p53 degradation ( xref )."
28233861
sparser
"While the co-expression of Mdm2 and USP48 strongly enhanced p53 ubiquitination ( xref ), USP48 was not capable of inducing p53 ubiquitination in the absence of Mdm2 ( xref ), suggesting that the observed increase in Mdm2 levels was largely responsible for the enhancement of p53 ubiquitination in the presence of USP48."
28233861
Modified USP48 leads to the ubiquitination of TP53. 1 / 1
| 1
reach
"While the co-expression of Mdm2 and USP48 strongly enhanced p53 ubiquitination (XREF_FIG), USP48 was not capable of inducing p53 ubiquitination in the absence of Mdm2 (XREF_FIG), suggesting that the observed increase in Mdm2 levels was largely responsible for the enhancement of p53 ubiquitination in the presence of USP48."
28233861
USP48 inhibits TP53.
| 1
USP48 inhibits TP53. 1 / 1
| 1
eidos
"Apoptosis induced by GLI silencing was associated with a downregulation in the expression of KIT and of genes that influence p53 stability and function including USP48 , which promotes p53 degradation ; and iASPP , which inhibits p53-induced transcription , thus leading to the induction of p53-regulated apoptotic genes ."
35251038
USP48 affects NFkappaB
| 4 1
USP48 activates NFkappaB.
| 2 1
USP48 activates NFkappaB. 3 / 3
| 2 1
sparser
"The inhibition of NF-κB activation by USP31 was not due to a reduction of effector protein expression, since Western blot analysis revealed that the levels of all effector proteins were unaffected by [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16214042
reach
"Here, we show that maybe the stability of NF-kappaB is controlled by proteasome mediated degradation and ubiquitin specific protease 48 (USP48), also known as synaptic ubiquitin specific protease (synUSP) or USP31, can enhance NF-kappaB stability through proteasome dependent regulation in the nucleus."
29775759
reach
"However, subsequent studies demonstrated that in fact USP48 promotes NF-kappaB activity by co-operating with the COP9 signalosome to trim K48 linked polyubiquitin chains from p65 in the nucleus [XREF_BIBR]."
27187478
USP48 inhibits NFkappaB.
| 2
USP48 inhibits NFkappaB. 2 / 2
| 2
reach
"Depletion of USP48 decreases NF-kappaB target gene expression [XREF_BIBR]."
28881649
reach
"Initial studies found that overexpression of USP48 inhibits NF-kappaB activity downstream of IKKbeta and that USP48 also interacts with p65."
27187478
GSK3B affects USP48
| 2 2 1
GSK3B phosphorylates USP48. 3 / 3
| 1 2
sparser
"In response to TNF-α, serine phosphorylation of USP48 by GSK3β increases USP48 activity."
33466790
reach
"Exposure to TNFalpha caused GSK3beta mediated phosphorylation of USP48, leading to deubiquitination of TRAF2 in beas2B cells, increasing JNK signaling upon TNF-alpha-induction [XREF_BIBR]."
31208841
sparser
"We have shown that GSK3β phosphorylates USP48, ultimately resulting increases in deubiquitinase activity ( xref )."
33400290
GSK3B phosphorylates USP48 on serine. 2 / 2
| 1 1
reach
"In response to TNF-alpha, serine phosphorylation of USP48 by GSK3beta increases USP48 activity."
33466790
rlimsp
"USP48 is serine phosphorylated in response to TNF-α. The phosphorylation is catalyzed by glycogen synthase kinase 3β (GSK3β), ultimately resulting in increases in USP48 DUB activity."
28874458
Valproic acid affects USP48
4 |
Valproic acid increases the amount of USP48. 4 / 4
4 |
ctd
No evidence text available
27188386
ctd
No evidence text available
23179753
ctd
No evidence text available
24383497
ctd
No evidence text available
26272509
reach
"By contrast, USP48 depletion did not enhance MMC induced RAD51 focus formation in control cells, suggesting that USP48 may inhibit HR processes specifically in an FA deficient background."
29891926
reach
"Together, the findings indicate that USP48 antagonizes BRCA1/BARD1 Ub ligase-dependent activities in HR, creating a balance that regulates DNA end-resection tract length [78, 80] (Figure 5B)."
35351360
reach
"As we had found that USP48 loss enhances HR in DeltaFANCC cells, we determined whether it could also alleviate chromosome breaks in DeltaFANCC cells."
29891926
reach
"At 18h after MMC treatment, recruitment of RAD51 into foci was significantly higher in U2OS cells simultaneously depleted for both FANCC and USP48 by siRNA treatment, compared to cells depleted for FANCC alone, implying that USP48 loss restores HR efficiency at replication forks encountering ICL damage in FA deficient cells."
29891926
USP48 affects SLC9A3
1 | 3
USP48 activates SLC9A3.
| 2
USP48 activates SLC9A3. 2 / 2
| 2
reach
"USP48 silencing decreased NHE3 's half-life (USP48 siRNA t1/2 = 6.1 h vs. vehicle t1/2 = 12.9 h), whereas overexpression of USP48 increased NHE3 half-life (t1/2 = 21.8 h), indicating that USP48 protects NHE3 from degradation via deubiquitinylation."
24308971
reach
"That is, the dopamine D3 receptor inhibits USP48 expression, which promotes NHE3 degradation."
26807585
USP48 inhibits SLC9A3.
| 1
USP48 inhibits SLC9A3. 1 / 1
| 1
reach
"That is, the dopamine D3 receptor inhibits USP48 expression, which promotes NHE3 degradation."
26807585
USP48 binds SLC9A3.
1 |
SLC9A3 binds USP48. 1 / 1
1 |
biogrid
No evidence text available
24308971
USP48 affects POMC
| 2 2
USP48 activates POMC. 3 / 3
| 1 2
reach
"In contrast, we provide the evidence to demonstrate that the NF-κB pathway is involved in USP48-mediated transcriptional activation of POMC."
30093687
sparser
"Different from BRAF V600E, USP48 mutation-mediated transcriptional activation of POMC appears not be linked to the activation of Erk1/2 or its downstream signaling cascade."
30093687
sparser
"In contrast, we provide the evidence to demonstrate that the NF-κB pathway is involved in USP48 -mediated transcriptional activation of POMC ."
30093687
Mutated USP48 activates POMC. 1 / 1
| 1
reach
"Different from BRAF V600E, USP48 mutation-mediated transcriptional activation of POMC appears not be linked to the activation of Erk1/2 or its downstream signaling cascade."
30093687
TRAF2 affects USP48
| 1 3
TRAF2 binds USP48. 4 / 4
| 1 3
sparser
"These results show that USP31 and TRAF2 interact specifically in mammalian cells and their interaction requires an intact RING finger domain of TRAF2 and the amino terminal 483 residues of USP31."
16214042
reach
"USP48 (also known as USP31) interacted with and deubiquitinated TRAF2 in beas2B cells [71]."
31208841
sparser
"Co-immunoprecipitation experiments indicated that USP31 does not interact with a mutated TRAF2 that lacks the RING finger domain (C)."
16214042
sparser
"To confirm that the interaction between TRAF2 and USP31 in mammalian cells occurs via the RING finger domain of TRAF2, as indicated by our two-hybrid results, a mutated form of TRAF2 with a RING finge[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16214042
CREB1 affects USP48
4 |
CREB1 decreases the amount of USP48. 4 / 4
4 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
Csn affects USP48
| 3
USP48 binds csn. 3 / 3
| 3
sparser
"Co-IPs between human purified CSN, recombinant RelA and recombinant full length USP48 (USP48-FL) revealed direct interactions between CSN and USP48 ( Fig. 3 D) and between CSN and RelA ( Fig. 3 E) but[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
sparser
"An intriguing example presented by Michael Naumann (Germany) is USP48, directly interacting with CSN in the nucleus, regulates the turnover of active NF-κB/RelA."
28837155
sparser
"USP48 and the CSN constitutively interact in the nucleus."
25486460
Copper(II) sulfate decreases the amount of USP48.
2 |
Copper(II) sulfate decreases the amount of USP48. 2 / 2
2 |
ctd
No evidence text available
19549813
ctd
No evidence text available
20599845
Copper(II) sulfate increases the amount of USP48.
1 |
Copper(II) sulfate increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
20599845
Bisphenol A affects USP48
3 |
Bisphenol A methylates USP48.
1 |
Bisphenol A methylates USP48. 1 / 1
1 |
ctd
No evidence text available
30906313
Bisphenol A increases the amount of USP48.
1 |
Bisphenol A increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
26063408
Bisphenol A decreases the amount of USP48.
1 |
Bisphenol A decreases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
30816183
Ubiquitin affects USP48
| 3
Ubiquitin activates USP48. 3 / 3
| 3
reach
"On both substrates the addition of free ubiquitin did activate USP48."
29335415
reach
"Detailed biochemical analysis shows that an auxiliary ubiquitin, an additional ubiquitin that itself does not get cleaved, modulates USP48 activity, which has possible implications for its regulation in vivo."
29335415
reach
"An auxiliary ubiquitin on the nucleosome promotes USP48 activity."
29335415
USP48 affects pyroptosis
| 1 2
USP48 activates pyroptosis. 3 / 3
| 1 2
reach
"USP48 promoted pyroptosis by stabilizing gasdermin E (GSDME)."
36607699
eidos
"USP48 promoted pyroptosis by stabilizing gasdermin E ( GSDME ) ."
36607699
reach
"A CRISPR-Cas9 screen identified that loss of USP48, a deubiquitinating enzyme, significantly inhibited cell pyroptosis."
36607699
USP48 affects csn
| 3
USP48 binds csn. 3 / 3
| 3
sparser
"Co-IPs between human purified CSN, recombinant RelA and recombinant full length USP48 (USP48-FL) revealed direct interactions between CSN and USP48 ( Fig. 3 D) and between CSN and RelA ( Fig. 3 E) but[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
sparser
"An intriguing example presented by Michael Naumann (Germany) is USP48, directly interacting with CSN in the nucleus, regulates the turnover of active NF-κB/RelA."
28837155
sparser
"USP48 and the CSN constitutively interact in the nucleus."
25486460
USP48 affects SIRT6
1 | 1 1
SIRT6 binds USP48. 2 / 2
1 | 1
sparser
"USP48 physically bound and stabilized SIRT6 by K48-linked deubiquitination at the K33 and K128 sites of SIRT6, which impeded metabolic reprogramming to hamper HCC tumorigenesis."
33903120
biogrid
No evidence text available
24169447
SIRT6 binds USP48 and K48. 1 / 1
| 1
reach
"USP48 physically bound and stabilized SIRT6 by K48 linked deubiquitination at the K33 and K128 sites of SIRT6, which impeded metabolic reprogramming to hamper HCC tumorigenesis."
33903120
USP48 affects ICL
| 3
USP48 inhibits ICL. 2 / 2
| 2
reach
"Our data demonstrate that loss of USP48 does not restore FANCI and FANCD2 monoubiquitylation or FANCD2 recruitment at ICLs, but if USP48 targets one or more sites on H2A that can be recognized by these nucleases, then loss of USP48 might bypass the requirement of the FA proteins and allow the recruitment of FAN1 or SLX4 and subsequent unhooking of the ICL in an FA deficient background."
29891926
reach
"Re-introduction of exogenous wild-type USP48, but not the catalytically inactive C98S USP48 mutant, partially reduced ICL resistance of DeltaUSP48DeltaFANCC cells, thus indicating that lack of USP48 catalytic activity is important for the increased survival of DeltaUSP48DeltaFANCC cells."
29891926
USP48-C98S inhibits ICL. 1 / 1
| 1
reach
"Re-introduction of exogenous wild-type USP48, but not the catalytically inactive C98S USP48 mutant, partially reduced ICL resistance of DeltaUSP48DeltaFANCC cells, thus indicating that lack of USP48 catalytic activity is important for the increased survival of DeltaUSP48DeltaFANCC cells."
29891926
USP48 affects E3_Ub_ligase
| 3
USP48 inhibits E3_Ub_ligase.
| 2
USP48 inhibits E3_Ub_ligase. 2 / 2
| 2
reach
"In cells we reveal that USP48 antagonizes BRCA1 E3 ligase function and in BRCA1-proficient cells loss of USP48 results in positioning 53BP1 further from the break site and in extended resection lengths."
29335415
reach
"Further, USP48 promotes cell survival and antagonizes also other E3 ligase functions which are involved in genome stability and DNA repair."
30628021
USP48 activates E3_Ub_ligase.
| 1
USP48 activates E3_Ub_ligase. 1 / 1
| 1
reach
"We propose that USP48 promotes genome stability by antagonizing BRCA1 E3 ligase function."
29335415
TNF affects USP48
| 2 1
TNF phosphorylates USP48.
| 1 1
TNF leads to the phosphorylation of USP48. 1 / 1
| 1
reach
"USP48 phosphorylation at its C-terminal CK2 phosphorylation sites in response to TNF was confirmed after knockdown of endogenous USP48, followed by reexpression of either siRNA resistant USP48-FL WT o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
TNF phosphorylates USP48 on serine. 1 / 1
| 1
rlimsp
"USP48 is serine phosphorylated in response to TNF-α."
28874458
TNF activates USP48.
| 1
TNF activates USP48. 1 / 1
| 1
reach
"TNF induced degradation and reaccumulation of IkappaBalpha were not affected in USP48 depleted cells, indicating unperturbed upstream signaling to NF-kappaB activation."
25486460
SIRT6 affects USP48
1 | 1 1
SIRT6 binds USP48. 2 / 2
1 | 1
sparser
"USP48 physically bound and stabilized SIRT6 by K48-linked deubiquitination at the K33 and K128 sites of SIRT6, which impeded metabolic reprogramming to hamper HCC tumorigenesis."
33903120
biogrid
No evidence text available
24169447
SIRT6 binds USP48 and K48. 1 / 1
| 1
reach
"USP48 physically bound and stabilized SIRT6 by K48 linked deubiquitination at the K33 and K128 sites of SIRT6, which impeded metabolic reprogramming to hamper HCC tumorigenesis."
33903120
MDM2 affects USP48
| 3
USP48 binds MDM2. 3 / 3
| 3
sparser
"More detailed subsequent analyses of Mdm2-USP48 interactions suggested the presence of two independent USP48-binding sites in Mdm2 ( xref , xref )."
28233861
sparser
"To test the possible effect of USP48-Mdm2 interactions on Mdm2 protein stability, Mdm2 was expressed in U2OS cells together with increasing amounts of USP48."
28233861
sparser
"One possible explanation could be provided by our finding that USP48 binds to the central acidic domain of Mdm2, a region that was shown by us and others to independently contribute to p53 ubiquitination and to p53 and Mdm2 stability xref xref xref xref xref ."
28233861
Paracetamol affects USP48
2 |
Paracetamol increases the amount of USP48.
1 |
Paracetamol increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
22230336
Paracetamol decreases the amount of USP48.
1 |
Paracetamol decreases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
21420995
Hsa-miR-6838-5p affects USP48
2 |
Hsa-miR-6838-5p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-646 affects USP48
2 |
Hsa-miR-646 decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-561-3p affects USP48
2 |
Hsa-miR-561-3p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-5590-3p affects USP48
2 |
Hsa-miR-5590-3p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-548p affects USP48
2 |
Hsa-miR-548p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-548at-5p affects USP48
2 |
Hsa-miR-548at-5p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-545-3p affects USP48
2 |
Hsa-miR-545-3p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-503-5p affects USP48
2 |
Hsa-miR-503-5p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-497-5p affects USP48
2 |
Hsa-miR-497-5p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4524b-5p affects USP48
2 |
Hsa-miR-4524b-5p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4524a-5p affects USP48
2 |
Hsa-miR-4524a-5p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-424-5p affects USP48
2 |
Hsa-miR-424-5p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-374b-3p affects USP48
2 |
Hsa-miR-374b-3p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-195-5p affects USP48
2 |
Hsa-miR-195-5p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-16-5p affects USP48
2 |
Hsa-miR-16-5p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-15b-5p affects USP48
2 |
Hsa-miR-15b-5p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-15a-5p affects USP48
2 |
Hsa-miR-15a-5p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-1468-3p affects USP48
2 |
Hsa-miR-1468-3p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-142-5p affects USP48
2 |
Hsa-miR-142-5p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
21572407
biopax:mirtarbase
No evidence text available
20371350
Hsa-let-7i-3p affects USP48
2 |
Hsa-let-7i-3p decreases the amount of USP48. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
20371350
biopax:mirtarbase
No evidence text available
21572407
VPS35 affects USP48
2 |
VPS35 binds USP48. 2 / 2
2 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
22863883
reach
"We next searched for the molecular mechanisms underlying USP48 mutation-mediated POMC transcription."
30093687
sparser
"We find that deubiquitinase USP48 activates Gli-dependent transcription by stabilizing Gli1 protein."
28623188
reach
"Deubiquitinase USP48 promotes ATRA induced granulocytic differentiation of acute promyelocytic leukemia cells."
29901102
reach
"In conclusion, the present study highlights the function of USP48 in the ATRA induced granulocytic differentiation of APL cells and provides a theoretical basis for identifying novel targets for differentiation therapy of APL."
29901102
USP48 affects apoptotic process
| 2
USP48 inhibits apoptotic process.
| 1
reach
"USP48 thus enhances the activity of A20 to reduce apoptotic cell death in cells infected with H. pylori."
35913642
USP48 activates apoptotic process.
| 1
USP48 activates apoptotic process. 1 / 1
| 1
reach
"After carboplatin (CBP) treatment, the USP48 ablation increases the apoptosis rate, and the cleaved PARP and cleaved caspase 3 expression levels in ES2, 3AO and A2780 cells."
32359336
reach
"Deubiquitinase USP48 promotes ATRA induced granulocytic differentiation of acute promyelocytic leukemia cells."
29901102
reach
"Deubiquitinase USP48 promotes ATRA induced granulocytic differentiation of acute promyelocytic leukemia cells [XREF_BIBR]."
30898977
USP48 affects VPS35
2 |
VPS35 binds USP48. 2 / 2
2 |
biogrid
No evidence text available
22939629
biogrid
No evidence text available
22863883
USP48 affects USP48
| 2
USP48 activates USP48. 2 / 2
| 2
reach
"These results indicate that CK2 mediated phosphorylation of USP48 at its C-terminal CK2 consensus sites and its binding to K48 linked Ub-chains, both of which promote USP48 Ub-chain-trimming activity,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
reach
"In response to TNF-alpha, serine phosphorylation of USP48 by GSK3beta increases USP48 activity."
33466790
USP48 affects UBA6
2 |
USP48 binds UBA6. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
22939629
USP48 affects RO60
| 2
USP48 inhibits RO60.
| 1
USP48 inhibits RO60. 1 / 1
| 1
reach
"Moreover, we provide evidence that USP48 acts to prevent extensive resection and restrict the use of SSA."
29335415
USP48 activates RO60.
| 1
USP48 activates RO60. 1 / 1
| 1
reach
"Depletion of USP48 increases SSA and confers a RAD52 dependent survival benefit to cells treated with camptothecin."
29335415
USP48 affects Mrgprx1
| 2
USP48 binds Mrgprx1.
| 1
USP48 binds Mrgprx1. 1 / 1
| 1
reach
"USP48 and MrgC interactions were studied by immunoprecipitation."
36864656
USP48 activates Mrgprx1.
| 1
USP48 activates Mrgprx1. 1 / 1
| 1
reach
"USP48 antagonizes ubiquitin-mediated autophagic degradation of MrgC and alleviates bone cancer pain in a murine animal model."
36864656
USP48 affects K48
| 2
SIRT6 binds USP48 and K48. 1 / 1
| 1
reach
"USP48 physically bound and stabilized SIRT6 by K48 linked deubiquitination at the K33 and K128 sites of SIRT6, which impeded metabolic reprogramming to hamper HCC tumorigenesis."
33903120
USP48 binds GSDME and K48. 1 / 1
| 1
reach
"USP48 bound GSDME and removed K48-linked ubiquitination at positions K120 and K189."
36607699
reach
"We propose that USP48 promotes genome stability by antagonizing BRCA1 E3 ligase function."
29335415
reach
"Importantly, the results of the present study show that loss of USP48 improves DNA repair and prevents genomic instability of FA defective cells, thus highlighting the potential of developing USP48 inhibitory molecules as novel therapeutic approaches that could potentially alleviate the phenotypes of FA patients."
29891926
USP48 affects GSDME
| 2
USP48 binds GSDME.
| 1
USP48 binds GSDME and K48. 1 / 1
| 1
reach
"USP48 bound GSDME and removed K48-linked ubiquitination at positions K120 and K189."
36607699
USP48 activates GSDME.
| 1
USP48 activates GSDME. 1 / 1
| 1
reach
"USP48 promoted pyroptosis by stabilizing gasdermin E (GSDME)."
36607699
USP48 affects GPS1
1 | 1
USP48 binds GPS1. 2 / 2
1 | 1
biogrid
No evidence text available
25486460
sparser
"We found that deubiquitinylase (DUB) ubiquitin specific protease 48 (USP48), which interacts with the COP9 signalosome (CSN) subunit CSN1, stabilises RelA by deubiquitinylation and thereby promotes the transcriptional activity of RelA to prolong de novo synthesis of DUB A20 in H. pylori infection."
35913642
USP48 affects FANCD2
| 2
USP48 ubiquitinates FANCD2.
| 1
USP48 leads to the ubiquitination of FANCD2. 1 / 1
| 1
reach
"Since monoubiquitylation of components of the FANCI and FANCD2 complex is an important step of ICL repair XREF_BIBR, XREF_BIBR and considering that USP48 is a DUB, we tested whether USP48 depletion could rescue the FANCI and FANCD2 monoubiquitylation defect of DeltaFANCC cells."
29891926
USP48 deubiquitinates FANCD2.
| 1
Modified USP48 leads to the deubiquitination of FANCD2. 1 / 1
| 1
reach
"Our data demonstrate that loss of USP48 does not restore FANCI and FANCD2 monoubiquitylation or FANCD2 recruitment at ICLs, but if USP48 targets one or more sites on H2A that can be recognized by these nucleases, then loss of USP48 might bypass the requirement of the FA proteins and allow the recruitment of FAN1 or SLX4 and subsequent unhooking of the ICL in an FA deficient background."
29891926
USP48 affects DRD3
2 |
USP48 binds DRD3. 2 / 2
2 |
biogrid
No evidence text available
24308971
biogrid
No evidence text available
24308971
USP48 affects Cell Survival
| 2
USP48 activates Cell Survival. 2 / 2
| 2
reach
"USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection."
35913642
reach
"Further, USP48 promotes cell survival and antagonizes also other E3 ligase functions which are involved in genome stability and DNA repair."
30628021
USP48 affects CDH1
| 2
USP48 increases the amount of CDH1. 2 / 2
| 2
reach
"Inhibition of TRAF2 and JNK pathway increases E-cadherin expression and enhances epithelial barrier integrity, while knockdown of USP48 attenuates TNF-alpha and JNK pathway and increases E-cadherin expression and cell-cell junction in epithelial cells."
28874458
reach
"Further, down-regulation of USP48 increases E-cadherin expression and epithelial barrier integrity through reducing TRAF2 stability.-Li, S., Wang, D., Zhao, J., Weathington, N. M., Shang, D., Zhao, Y."
28874458
UBA6 affects USP48
2 |
USP48 binds UBA6. 2 / 2
2 |
biogrid
No evidence text available
26344197
biogrid
No evidence text available
22939629
SLC9A3 affects USP48
1 | 1
SLC9A3 inhibits USP48.
| 1
SLC9A3 inhibits USP48. 1 / 1
| 1
reach
"We found that stimulation with the D3R specific agonist PD128907 (1 muM, 30 min) promoted the interaction and colocalization among D3R, NHE3, and USP48; inhibited USP48 activity (-35+/-6%, vs. vehicle), resulting in increased ubiquitinylated NHE3 (+140 +/-10%); and decreased NHE3 expression (-50+/-9%) in human renal proximal tubule cells (hRPTCs)."
24308971
SLC9A3 binds USP48.
1 |
SLC9A3 binds USP48. 1 / 1
1 |
biogrid
No evidence text available
24308971
POMC affects USP48
| 2
POMC increases the amount of USP48. 2 / 2
| 2
sparser
"Collectively, these results demonstrate that the molecular mechanisms underlying USP48 mutation-mediated POMC transcription do not involve Erk1/2 or its downstream signaling cascade."
30093687
sparser
"We next searched for the molecular mechanisms underlying USP48 mutation-mediated POMC transcription."
30093687
METTL14 affects USP48
| 1 1
METTL14 activates USP48. 2 / 2
| 1 1
eidos
"USP48 is upregulated by Mettl14 to attenuate hepatocellular carcinoma via regulating SIRT6 stabilization ."
33903120
reach
"USP48 is upregulated by Mettl14 to attenuate hepatocellular carcinoma via regulating SIRT6 stabilization."
33903120
LINC00467 affects USP48
| 2
LINC00467 increases the amount of USP48. 2 / 2
| 2
reach
"LINC00467 enhances HNSCC progression by serving as a sponge of miR-299-5p to increase USP48 expression."
32159247
reach
"LINC00467 could upregulate USP48 expression via sponging miR-299-5p."
32159247
K48 affects USP48
| 2
SIRT6 binds USP48 and K48. 1 / 1
| 1
reach
"USP48 physically bound and stabilized SIRT6 by K48 linked deubiquitination at the K33 and K128 sites of SIRT6, which impeded metabolic reprogramming to hamper HCC tumorigenesis."
33903120
USP48 binds GSDME and K48. 1 / 1
| 1
reach
"USP48 bound GSDME and removed K48-linked ubiquitination at positions K120 and K189."
36607699
Hedgehog affects USP48
| 2
Hedgehog increases the amount of USP48. 2 / 2
| 2
reach
"In addition, we find that the Sonic Hedgehog (SHH) pathway induces USP48 expression through Gli1 mediated transcriptional activation, which forms thus a positive feedback loop to regulate Hh signaling."
28623188
reach
"USP48 provides a positive feedback loop in Hh signaling as USP48 expression is induced by Hh activation."
30754706
GSK3 affects USP48
| 2
GSK3 phosphorylates USP48. 2 / 2
| 2
reach
"Exposure to TNFα caused GSK3β-mediated phosphorylation of USP48, leading to deubiquitination of TRAF2 in beas2B cells, increasing JNK signaling upon TNF-α-induction [71]."
31208841
reach
"We have shown that GSK3β phosphorylates USP48, ultimately resulting increases in deubiquitinase activity (S. Li et al., 2018)."
33400290
GPS1 affects USP48
1 | 1
USP48 binds GPS1. 2 / 2
1 | 1
biogrid
No evidence text available
25486460
sparser
"We found that deubiquitinylase (DUB) ubiquitin specific protease 48 (USP48), which interacts with the COP9 signalosome (CSN) subunit CSN1, stabilises RelA by deubiquitinylation and thereby promotes the transcriptional activity of RelA to prolong de novo synthesis of DUB A20 in H. pylori infection."
35913642
DRD3 affects USP48
2 |
USP48 binds DRD3. 2 / 2
2 |
biogrid
No evidence text available
24308971
biogrid
No evidence text available
24308971
ATF3 affects USP48
2 |
ATF3 decreases the amount of USP48. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP48. 2 / 2
2 |
ctd
No evidence text available
17942748
ctd
No evidence text available
19770486
17alpha-ethynylestradiol increases the amount of USP48.
1 |
17alpha-ethynylestradiol increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
17942748
17alpha-ethynylestradiol decreases the amount of USP48.
1 |
17alpha-ethynylestradiol decreases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
23129252
Vinclozolin affects USP48
1 |
Vinclozolin decreases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
23034163
Tungsten affects USP48
1 |
Tungsten decreases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
30912803
Serine phosphorylation USP48 GSK3beta affects USP48
| 1
Serine phosphorylation USP48 GSK3beta activates USP48. 1 / 1
| 1
eidos
"In response to TNF-alpha , serine phosphorylation of USP48 by GSK3beta increases USP48 activity ."
33466790
Phorbol 13-acetate 12-myristate increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
25613284
MiR-301a-3p affects USP48
| 1
MiR-301a-3p inhibits USP48. 1 / 1
| 1
eidos
"Moreover , by reducing miR-301a-3p to increase ubiquitin-specific protease 48 ( USP48 ) , RA is effective in APL differentiation ( Li et al ., 2018 ) ."
32359650
Methyltestosterone increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
29191790
Methylparaben affects USP48
1 |
Methylparaben increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
31745603
Ionomycin affects USP48
1 |
Ionomycin increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
25613284
Hsa-miR-943 affects USP48
1 |
Hsa-miR-943 decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-93-5p affects USP48
1 |
Hsa-miR-93-5p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-892a affects USP48
1 |
Hsa-miR-892a decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-876-5p affects USP48
1 |
Hsa-miR-876-5p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-8063 affects USP48
1 |
Hsa-miR-8063 decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-7153-5p affects USP48
1 |
Hsa-miR-7153-5p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-589-5p affects USP48
1 |
Hsa-miR-589-5p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-580-3p affects USP48
1 |
Hsa-miR-580-3p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-548ah-5p affects USP48
1 |
Hsa-miR-548ah-5p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-545-5p affects USP48
1 |
Hsa-miR-545-5p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-526b-3p affects USP48
1 |
Hsa-miR-526b-3p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-519d-3p affects USP48
1 |
Hsa-miR-519d-3p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4796-3p affects USP48
1 |
Hsa-miR-4796-3p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-4539 affects USP48
1 |
Hsa-miR-4539 decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-3609 affects USP48
1 |
Hsa-miR-3609 decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3167 affects USP48
1 |
Hsa-miR-3167 decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-3118 affects USP48
1 |
Hsa-miR-3118 decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-20b-5p affects USP48
1 |
Hsa-miR-20b-5p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-20a-5p affects USP48
1 |
Hsa-miR-20a-5p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-17-5p affects USP48
1 |
Hsa-miR-17-5p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-148b-3p affects USP48
1 |
Hsa-miR-148b-3p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
17612493
Hsa-miR-146b-5p affects USP48
1 |
Hsa-miR-146b-5p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-146a-5p affects USP48
1 |
Hsa-miR-146a-5p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22012620
Hsa-miR-134-5p affects USP48
1 |
Hsa-miR-134-5p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-1305 affects USP48
1 |
Hsa-miR-1305 decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-1290 affects USP48
1 |
Hsa-miR-1290 decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-1246 affects USP48
1 |
Hsa-miR-1246 decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-124-3p affects USP48
1 |
Hsa-miR-124-3p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
15685193
Hsa-miR-106b-5p affects USP48
1 |
Hsa-miR-106b-5p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hsa-miR-106a-5p affects USP48
1 |
Hsa-miR-106a-5p decreases the amount of USP48. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
21572407
Hexabromocyclododecane decreases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
29177809
Gentamycin affects USP48
1 |
Gentamycin increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
22061828
Flutamide affects USP48
1 |
Flutamide decreases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
24793618
Enzyme inhibitor affects USP48
1 |
ctd
No evidence text available
23301498
Dorsomorphin affects USP48
1 |
Dorsomorphin increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
27188386
Dopamine affects USP48
| 1
Dopamine decreases the amount of USP48. 1 / 1
| 1
reach
"That is, the dopamine D3 receptor inhibits USP48 expression, which promotes NHE3 degradation."
26807585
Casein-kinase 2 affects USP48
| 1
Casein-kinase 2 phosphorylates USP48. 1 / 1
| 1
reach
"The activity of UPS48 on NF-kappaB is enhanced by casein-kinase 2 mediated phosphorylation of USP48 which occurs following TNFalpha stimulation."
27187478
Casein affects USP48
| 1
Casein phosphorylates USP48. 1 / 1
| 1
sparser
"The activity of UPS48 on NF-κB is enhanced by casein-kinase 2 mediated phosphorylation of USP48 which occurs following TNFα stimulation."
27187478
Cas9 affects USP48
| 1
Cas9 inhibits USP48. 1 / 1
| 1
sparser
"Further confirming that the synthetic rescue was indeed dependent on USP48, when we subjected USP48 to short-hairpin RNA (shRNA) depletion (Supplementary Fig.  xref ) or carried out USP48 gene inactivation by CRISPR-Cas9 editing by using a different single guide (sg)RNA targeting a different exon (Supplementary Fig.  xref ) in Δ FANCC cells, we observed similar results."
29891926
Benzo[a]pyrene diol epoxide I increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
26238291
Atrazine affects USP48
1 |
Atrazine decreases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
22378314
Apigenin affects USP48
1 |
Apigenin increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
22359648
Aflatoxin B1 affects USP48
1 |
Aflatoxin B1 increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
19770486
Acrylamide affects USP48
1 |
Acrylamide increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
28959563
Acetamide affects USP48
1 |
Acetamide decreases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
31881176
ZNF232 affects USP48
1 |
ZNF232 binds USP48. 1 / 1
1 |
biogrid
No evidence text available
28514442
ZFR affects USP48
1 |
ZFR binds USP48. 1 / 1
1 |
biogrid
No evidence text available
22939629
ZEB1 affects USP48
1 |
ZEB1 decreases the amount of USP48. 1 / 1
1 |
biopax:msigdb
No evidence text available
ZC3HAV1 affects USP48
1 |
USP48 binds ZC3HAV1. 1 / 1
1 |
biogrid
No evidence text available
22939629
ZBTB14 affects USP48
1 |
ZBTB14 decreases the amount of USP48. 1 / 1
1 |
biopax:msigdb
No evidence text available
USP7 affects USP48
| 1
USP25 binds USP7 and USP48. 1 / 1
| 1
sparser
"Among them, USP7, USP21, and USP48 have been associated with HR xref – xref ."
30874560
USP48
| 1
USP48 translocates to the nucleus. 1 / 1
| 1
sparser
"Furthermore, the expression of USP48 was increased in the nucleus upon ATRA exposure for ≤24 h, suggesting that USP48 was translocated into the nucleus."
29901102
USP48 affects ubiquitination
| 1
USP48 inhibits ubiquitination. 1 / 1
| 1
sparser
"Collectively, these data indicated that USP48 inhibits TNF-induced RelA ubiquitination through its DUB activity."
25486460
USP48 affects transcription encoding proopiomelanocortin
| 1
USP48 activates transcription encoding proopiomelanocortin. 1 / 1
| 1
eidos
"Similar to USP8 mutants , both USP48 and BRAF mutants enhance the promoter activity and transcription of the gene encoding proopiomelanocortin ( POMC ) , which is the precursor of ACTH ."
30093687
USP48 affects transcription encoding proopiomelanocortin POMC is precursor ACTH potential mechanism ACTH overproduction
| 1
USP48 activates transcription encoding proopiomelanocortin POMC is precursor ACTH potential mechanism ACTH overproduction. 1 / 1
| 1
eidos
"Similar to USP8 mutants , both USP48 and BRAF mutants enhance the promoter activity and transcription of the gene encoding proopiomelanocortin ( POMC ) , which is the precursor of ACTH , providing a potential mechanism for ACTH overproduction in corticotroph adenomas ."
30093687
USP48 affects sodium atom
| 1
USP48 activates sodium atom. 1 / 1
| 1
reach
"We now offer and describe a novel mechanism by which D3R decreases sodium transport in the long term by inhibiting the deubiquitinylating activity of ubiquitin specific peptidase 48 (USP48), thereby promoting Na (+)-H (+) exchanger (NHE) -3 degradation."
24308971
USP48 affects responsiveness
| 1
USP48 inhibits responsiveness. 1 / 1
| 1
eidos
"The subcutaneous tumor and intraperitoneally injected experiments demonstrated that the USP48 knockdown significantly increases responsiveness to CBP , and alleviates the metastasis in vivo ."
32359336
USP48 affects processes
| 1
USP48 inhibits processes. 1 / 1
| 1
sparser
"By contrast, USP48 depletion did not enhance MMC-induced RAD51 focus formation in control cells (Fig.  xref and Supplementary Fig.  xref ), suggesting that USP48 may inhibit HR processes specifically in an FA-deficient background."
29891926
USP48 affects localization
| 1
USP48 inhibits localization. 1 / 1
| 1
reach
"USP48 loss enhances BRCA1 and RAD51 localization in FA cells."
29891926
eidos
"USP48 is upregulated by Mettl14 to attenuate hepatocellular carcinoma via regulating SIRT6 stabilization ."
33903120
reach
"Notably, the authors in this study showed the activity of USP48 counteracts BRCA1 mediated ubquitylation of H2A K127/129 and thereby preventing chromatin remodeling and resection during double-strand break repair after IR and camptothecin treatment 35."
29891926
USP48 affects cell survival Helicobacter pylori infection
| 1
USP48 activates cell survival Helicobacter pylori infection. 1 / 1
| 1
eidos
"USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection ."
35913642
USP48 activates cell population proliferation. 1 / 1
| 1
reach
"XREF_BIBR In GBM cells, knockdown of USP48 inhibits cell proliferation and expression of GLI1 's downstream targets, leading to repressed tumorigenesis."
29628779
USP48 affects cell migration
| 1
reach
"The present study reveals that USP48 knockdown could significantly inhibit cell migration and invasion in ES2, 3AO and A2780 cells, without affecting cell proliferation."
32359336
USP48 affects cell migration invasion cells
| 1
USP48 activates cell migration invasion cells. 1 / 1
| 1
eidos
"The present study reveals that USP48 knockdown could significantly inhibit cell migration and invasion in ES2 , 3AO and A2780 cells , without affecting cell proliferation ."
32359336
USP48 affects activation
| 1
USP48 inhibits activation. 1 / 1
| 1
sparser
"USP31 also inhibited NF-κB activation mediated by two TRAF proteins (TRAF2 and TRAF6), as well as by the IKKβ kinase ()."
16214042
USP48 affects abundance lysine K48 linked ubiquitination K63-linked ubiquitination TRAF2 stability
| 1
USP48 activates abundance lysine K48 linked ubiquitination K63-linked ubiquitination TRAF2 stability. 1 / 1
| 1
eidos
"Surprisingly , USP48 knockdown increased the abundance of lysine 48 ( K48 ) - linked ubiquitination but not the K63-linked ubiquitination of TRAF2 , and subsequently reduced its stability ( Li et al ., 2018b ) ."
33224951
USP48 affects ZNF232
1 |
ZNF232 binds USP48. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP48 affects ZFR
1 |
ZFR binds USP48. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP48 affects ZC3HAV1
1 |
USP48 binds ZC3HAV1. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP48 affects Ubiquitin
| 1
USP48 activates Ubiquitin. 1 / 1
| 1
reach
"USP48 antagonizes ubiquitin-mediated autophagic degradation of MrgC and alleviates bone cancer pain in a murine animal model."
36864656
USP48 affects USP7
| 1
USP25 binds USP7 and USP48. 1 / 1
| 1
sparser
"Among them, USP7, USP21, and USP48 have been associated with HR xref – xref ."
30874560
USP48 affects USP21
1 |
USP21 binds USP48. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP48 affects USP
| 1
BLNK binds USP48, REL, RELA, and USP. 1 / 1
| 1
sparser
"Further, we show by overexpression of truncated proteins that the catalytic USP domain of USP48 interacts with the N-terminal region of the Rel homology domain (RHD) of RelA."
30628021
USP48 affects UCHL3
1 |
UCHL3 binds USP48. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP48 affects UBC
1 |
UBC binds USP48. 1 / 1
1 |
biogrid
No evidence text available
23287719
USP48 affects UBB
1 |
UBB binds USP48. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP48 affects UBAC1
1 |
USP48 binds UBAC1. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP48 affects UACA
1 |
UACA binds USP48. 1 / 1
1 |
biogrid
No evidence text available
22939629
USP48 affects TYRP1
| 1
TYRP1 binds USP48. 1 / 1
| 1
reach
"Here, we report that USP48 interacts with and stabilizes the Aurora B protein."
34445214
USP48 affects TP53BP1
| 1
USP48 inhibits TP53BP1. 1 / 1
| 1
reach
"USP48 loss increases resection and intriguingly, depletion of USP48 or 53BP1 or their co-depletion, all result in a similar increase in RAD51 foci, suggesting that loss of either protein has a similar impact and acts in the same pathway to restrict RAD51 accumulation."
29335415
USP48 affects TNF
| 1
USP48 inhibits TNF. 1 / 1
| 1
sparser
"For example, USP11 negatively regulates TNFα-induced NF-κB activation associated with IκBα and attenuates IκBα degradation [34] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1β (IL-1β)-and Tax-induced NF-κB activation [40] ; Katrin et al. showed that USP15 regulates IκBα/NF-κB by deubiquitinylation IκBα [44] ; and USP31 inhibits TNFα, CD40, TRAF2, TRAF6 and IKKβ-mediated NF-κB activation [45] ."
24260525
USP48 affects SNW1
1 |
SNW1 binds USP48. 1 / 1
1 |
biogrid
No evidence text available
20467437
USP48 affects SMARCAD1
| 1
USP48 activates SMARCAD1. 1 / 1
| 1
reach
"Our data suggest a model in which USP48 mediated removal of the H2A BRCA1ub mark on chromatin restrains subsequent SMARCAD1 function, thereby halting the mobilization of 53BP1 and providing a boundary for resection."
29335415
USP48 affects SLX4
| 1
USP48 inhibits SLX4. 1 / 1
| 1
reach
"Our data demonstrate that loss of USP48 does not restore FANCI and FANCD2 monoubiquitylation or FANCD2 recruitment at ICLs, but if USP48 targets one or more sites on H2A that can be recognized by these nucleases, then loss of USP48 might bypass the requirement of the FA proteins and allow the recruitment of FAN1 or SLX4 and subsequent unhooking of the ICL in an FA deficient background."
29891926
USP48 affects SEC24D
1 |
SEC24D binds USP48. 1 / 1
1 |
biogrid
No evidence text available
22863883
reach
"USP48 depleted cells showed a slight reduction in NHEJ and slightly increased sensitivity to IR."
29335415
USP48 affects RPA
| 1
USP48 activates RPA. 1 / 1
| 1
reach
"Irradiated S-phase cells depleted of USP48 had more RPA foci compared with controls and complementation with either siRNA resistant USP48 Iso1 -WT or USP48 Iso2 -WT, but not USP48 Iso2 -C98S, restored RPA foci numbers to control levels."
29335415
USP48 affects RNF123
1 |
USP48 binds RNF123. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP48 affects REL
| 1
BLNK binds USP48, REL, RELA, and USP. 1 / 1
| 1
sparser
"Further, we show by overexpression of truncated proteins that the catalytic USP domain of USP48 interacts with the N-terminal region of the Rel homology domain (RHD) of RelA."
30628021
USP48 affects RBBP8
| 1
USP48 inhibits RBBP8. 1 / 1
| 1
reach
"Moreover, both the increased GC and SSA repair seen in USP48 depleted cells required BRCA1, as well as CtIP."
29335415
USP48 affects RAD51
| 1
USP48 inhibits RAD51. 1 / 1
| 1
reach
"USP48 loss enhances BRCA1 and RAD51 localization in FA cells."
29891926
USP48 activates Pituitary ACTH Hypersecretion. 1 / 1
| 1
eidos
"In this study the authors report USP48 and BRAF are frequently mutated in USP8 wild-type corticotroph adenomas , and cause Cushing 's disease mainly through promoting the promoter activity of POMC ."
30093687
USP48 affects PXK
1 |
USP48 binds PXK. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP48 affects PSAP
1 |
USP48 binds PSAP. 1 / 1
1 |
biogrid
No evidence text available
22863883
USP48 affects POMC promoter
| 1
USP48 activates POMC promoter. 1 / 1
| 1
reach
"A luciferase report assay showed that USP48 M415I/V promoted the POMC promoter activity."
30093687
USP48 affects POMC gene
| 1
USP48 increases the amount of POMC gene. 1 / 1
| 1
reach
"Accordingly, USP48-mediated inhibition of NF-κB activity could promote the transcription of POMC gene."
30093687
USP48 affects PD-1 inhibitors
| 1
USP48 inhibits PD-1 inhibitors. 1 / 1
| 1
reach
"Finally, overexpression of USP48 enhanced the therapeutic efficacy of PD-1 inhibitors in tumors in mouse models."
36607699
USP48 affects PARP1
| 1
USP48 activates PARP1. 1 / 1
| 1
reach
"After carboplatin (CBP) treatment, the USP48 ablation increases the apoptosis rate, and the cleaved PARP and cleaved caspase 3 expression levels in ES2, 3AO and A2780 cells."
32359336
USP48 affects Neoplasms
| 1
USP48 activates Neoplasms. 1 / 1
| 1
reach
"Finally, overexpression of USP48 enhanced the therapeutic efficacy of PD-1 inhibitors in tumors in mouse models."
36607699
USP48 inhibits Neoplasm Metastasis. 1 / 1
| 1
eidos
"The subcutaneous tumor and intraperitoneally injected experiments demonstrated that the USP48 knockdown significantly increases responsiveness to CBP , and alleviates the metastasis in vivo ."
32359336
USP48 activates Neoplasm Invasiveness. 1 / 1
| 1
reach
"The present study reveals that USP48 knockdown could significantly inhibit cell migration and invasion in ES2, 3AO and A2780 cells, without affecting cell proliferation."
32359336
USP48 affects NUP188
1 |
NUP188 binds USP48. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP48 affects NTRK1
1 |
USP48 binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
USP48 affects NR1D2
1 |
USP48 binds NR1D2. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP48 affects NDUFAF7
1 |
USP48 binds NDUFAF7. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP48 affects NCBP2
1 |
USP48 binds NCBP2. 1 / 1
1 |
biogrid
No evidence text available
26344197
USP48 affects Mdm2 stability
| 1
USP48 activates Mdm2 stability. 1 / 1
| 1
eidos
"In addition to USP2 , USP48 has also been shown recently to contribute to Mdm2 stability to enhance Mdm2-mediated degradation of p53119 ."
32201366
USP48 affects Leu-Ile
| 1
USP48 activates Leu-Ile. 1 / 1
| 1
reach
"Surprisingly, USP48 knockdown increased the abundance of lysine 48 (K48)-linked ubiquitination but not the K63 linked ubiquitination of TRAF2, and subsequently reduced its stability (Li et al., 2018b)."
33224951
USP48 affects Infections
| 1
USP48 activates Infections. 1 / 1
| 1
reach
"USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection."
35913642
USP48 affects IKBKB
| 1
USP48 inhibits IKBKB. 1 / 1
| 1
reach
"Initial studies found that overexpression of USP48 inhibits NF-kappaB activity downstream of IKKbeta and that USP48 also interacts with p65."
27187478
USP48 affects Hedgehog
| 1
USP48 activates Hedgehog. 1 / 1
| 1
reach
"In addition to USP7 and OTUB2, the deubiquitinase USP48 was found to activate Hh signaling by stabilizing Gli1 protein in glioma cells [65]."
| PMC
USP48 affects H3C1
1 |
USP48 binds H3C1. 1 / 1
1 |
biogrid
No evidence text available
25281560
USP48 affects H2BC8
1 |
USP48 binds H2BC8. 1 / 1
1 |
biogrid
No evidence text available
25281560
USP48 affects H2BC11
1 |
USP48 binds H2BC11. 1 / 1
1 |
biogrid
No evidence text available
28514442
USP48 affects H2AC8
1 |
USP48 deubiquitinates H2AC8. 1 / 1
1 |
ubibrowser
"USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A"
29335415
USP48 affects H2AC19
1 |
USP48 deubiquitinates H2AC19. 1 / 1
1 |
ubibrowser
"Here we identify ubiquitin specific protease-48 (USP48) as a H2A DUB, specific for the C-terminal BRCA1 ubiquitination site."
29335415
USP48 affects GPX4
| 1
USP48 binds GPX4. 1 / 1
| 1
sparser
"Furthermore, GPX4 protein specifically binds the deubiquitinase USP31, but not other deubiquitinases such as CYLD, USP1, USP14, USP20, USP30, USP38, UCHL1, UCHL3, and UCHL5."
37011699
USP48 affects GC
| 1
USP48 inhibits GC. 1 / 1
| 1
reach
"Thus, high levels or activity of USP48 would be expected to decrease resection lengths and thus reduce GC, and phenocopy aspects of BRCA1 loss."
29335415
USP48 affects FSCN1
| 1
USP48 inhibits FSCN1. 1 / 1
| 1
reach
"Our data demonstrate that loss of USP48 does not restore FANCI and FANCD2 monoubiquitylation or FANCD2 recruitment at ICLs, but if USP48 targets one or more sites on H2A that can be recognized by these nucleases, then loss of USP48 might bypass the requirement of the FA proteins and allow the recruitment of FAN1 or SLX4 and subsequent unhooking of the ICL in an FA deficient background."
29891926
USP48 affects FASLG
| 1
USP48 activates FASLG. 1 / 1
| 1
reach
"In conclusion, the present study highlights the function of USP48 in the ATRA induced granulocytic differentiation of APL cells and provides a theoretical basis for identifying novel targets for differentiation therapy of APL."
29901102
USP48 affects FANCI
| 1
Modified USP48 leads to the deubiquitination of FANCI. 1 / 1
| 1
reach
"Our data demonstrate that loss of USP48 does not restore FANCI and FANCD2 monoubiquitylation or FANCD2 recruitment at ICLs, but if USP48 targets one or more sites on H2A that can be recognized by these nucleases, then loss of USP48 might bypass the requirement of the FA proteins and allow the recruitment of FAN1 or SLX4 and subsequent unhooking of the ICL in an FA deficient background."
29891926
USP48 affects ESS2
| 1
USP48 activates ESS2. 1 / 1
| 1
reach
"The present study reveals that USP48 knockdown could significantly inhibit cell migration and invasion in ES2, 3AO and A2780 cells, without affecting cell proliferation."
32359336
USP48 affects EEF1B2P5
1 |
biogrid
No evidence text available
19615732
USP48 affects DYNC1LI1
1 |
biogrid
No evidence text available
26344197
USP48 affects DNA repair
| 1
USP48 inhibits DNA repair. 1 / 1
| 1
reach
"We next determined whether the effect of USP48 loss on survival of FA defective cells after treatment with DNA crosslinking agents correlated with less DNA damage induction and/or increased DNA repair."
29891926
USP48 affects Cushing Syndrome
| 1
reach
"Moreover, mutations in the Usp8 and Usp48 loci in pituitary tumors cause Cushing syndrome."
36834633
USP48 affects Cell Plasticity
| 1
USP48 inhibits Cell Plasticity. 1 / 1
| 1
eidos
"We identified a ubiquitin hydrolase , usp-48 , that restricts cellular plasticity with a notable cellular specificity ."
33877339
USP48 affects Carcinogenesis
| 1
reach
"Intriguingly, GLI1 is the downstream target of sonic hedgehog (SHH) signaling that is deregulated in corticotroph tumors [57] indicating that both USP8 and USP48 might trigger corticotroph tumorigenesis via the same pathway."
31845722
USP48 affects CTNNB1
| 1
USP48 inhibits CTNNB1. 1 / 1
| 1
eidos
"Additionally , miR-489-3p inactivates Wnt / beta-catenin signaling pathway and regulates USP48 to inhibit the ubiquitination of beta-catenin ."
35413838
USP48 affects CSNK2A1
1 |
USP48 binds CSNK2A1. 1 / 1
1 |
biogrid
No evidence text available
25486460
USP48 affects CRH
| 1
USP48 activates CRH. 1 / 1
| 1
reach
"The USP48 variant identified potentiated the stimulatory action of hypothalamic corticotropin-releasing hormone (CRH) on ACTH synthesis in a GLI1-dependent manner."
31845722
USP48 affects CREBBP
| 1
USP48 inhibits CREBBP. 1 / 1
| 1
reach
"The subcutaneous tumor and intraperitoneally injected experiments demonstrated that the USP48 knockdown significantly increases responsiveness to CBP, and alleviates the metastasis in vivo."
32359336
USP48 affects COPS5
| 1
USP48 binds COPS5. 1 / 1
| 1
sparser
"A recent study showed that USP48 associates with the COP9 signalosome complex and promotes the nuclear accumulation of NF-κB RelA through its DUB activity, trimming K48-linked ubiquitin chains xref ."
28233861
USP48 affects BRCA1-H2Aub-SMARCAD1
| 1
USP48 inhibits BRCA1-H2Aub-SMARCAD1. 1 / 1
| 1
reach
"USP48 antagonizes the BRCA1-H2Aub-SMARCAD1 resection pathway."
29335415
USP48 affects BRCA1-BARD1
| 1
USP48 inhibits BRCA1-BARD1. 1 / 1
| 1
reach
"Consistent with a role for USP48 in antagonizing BRCA1-BARD1, USP48 depleted cells have higher numbers of RAD51 and RPA foci and these foci were more intense following IR."
32708614
USP48 affects BRAT1
1 |
USP48 binds BRAT1. 1 / 1
1 |
biogrid
No evidence text available
22863883
USP48 affects BLNK
| 1
BLNK binds USP48, REL, RELA, and USP. 1 / 1
| 1
sparser
"Further, we show by overexpression of truncated proteins that the catalytic USP domain of USP48 interacts with the N-terminal region of the Rel homology domain (RHD) of RelA."
30628021
USP48 affects ARL3
| 1
USP48 binds ARL3. 1 / 1
| 1
sparser
"The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3."
36293380
USP48 affects APP
1 |
USP48 binds APP. 1 / 1
1 |
biogrid
No evidence text available
21832049
USP48 affects A20 apoptotic cell death cells infected H. pylori
| 1
USP48 inhibits A20 apoptotic cell death cells infected H. pylori. 1 / 1
| 1
eidos
"USP48 thus enhances the activity of A20 to reduce apoptotic cell death in cells infected with H. pylori ."
35913642
USP48 affects )-H(+) exchanger
| 1
USP48 activates )-H(+) exchanger. 1 / 1
| 1
reach
"We now offer and describe a novel mechanism by which D3R decreases sodium transport in the long term by inhibiting the deubiquitinylating activity of ubiquitin specific peptidase 48 (USP48), thereby promoting Na (+)-H (+) exchanger (NHE) -3 degradation."
24308971
USP48 GSK3beta affects USP48
| 1
USP48 GSK3beta activates USP48. 1 / 1
| 1
eidos
"USP48 by GSK3beta increases USP48 activity ."
33466790
USP25 affects USP7
| 1
USP25 binds USP7 and USP48. 1 / 1
| 1
sparser
"Among them, USP7, USP21, and USP48 have been associated with HR xref – xref ."
30874560
USP21 affects USP48
1 |
USP21 binds USP48. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP affects USP48
| 1
BLNK binds USP48, REL, RELA, and USP. 1 / 1
| 1
sparser
"Further, we show by overexpression of truncated proteins that the catalytic USP domain of USP48 interacts with the N-terminal region of the Rel homology domain (RHD) of RelA."
30628021
UCHL3 affects USP48
1 |
UCHL3 binds USP48. 1 / 1
1 |
biogrid
No evidence text available
22939629
UBC affects USP48
1 |
UBC binds USP48. 1 / 1
1 |
biogrid
No evidence text available
23287719
UBB affects USP48
1 |
UBB binds USP48. 1 / 1
1 |
biogrid
No evidence text available
28514442
UBAC1 affects USP48
1 |
USP48 binds UBAC1. 1 / 1
1 |
biogrid
No evidence text available
28514442
UACA affects USP48
1 |
UACA binds USP48. 1 / 1
1 |
biogrid
No evidence text available
22939629
TYRP1 affects USP48
| 1
TYRP1 binds USP48. 1 / 1
| 1
reach
"Here, we report that USP48 interacts with and stabilizes the Aurora B protein."
34445214
TP53 affects USP48
1 |
TP53 decreases the amount of USP48. 1 / 1
1 |
biopax:msigdb
No evidence text available
TFDP1 affects USP48
1 |
TFDP1 decreases the amount of USP48. 1 / 1
1 |
biopax:msigdb
No evidence text available
TCF3 affects USP48
1 |
TCF3 decreases the amount of USP48. 1 / 1
1 |
biopax:msigdb
No evidence text available
STAT5A affects USP48
1 |
STAT5A decreases the amount of USP48. 1 / 1
1 |
biopax:msigdb
No evidence text available
SNW1 affects USP48
1 |
SNW1 binds USP48. 1 / 1
1 |
biogrid
No evidence text available
20467437
SIRT6 affects K48
| 1
SIRT6 binds USP48 and K48. 1 / 1
| 1
reach
"USP48 physically bound and stabilized SIRT6 by K48 linked deubiquitination at the K33 and K128 sites of SIRT6, which impeded metabolic reprogramming to hamper HCC tumorigenesis."
33903120
SHH affects USP48
| 1
SHH increases the amount of USP48. 1 / 1
| 1
reach
"In addition, we find that the Sonic Hedgehog (SHH) pathway induces USP48 expression through Gli1 mediated transcriptional activation, which forms thus a positive feedback loop to regulate Hh signaling."
28623188
SEC24D affects USP48
1 |
SEC24D binds USP48. 1 / 1
1 |
biogrid
No evidence text available
22863883
Rimonabant affects USP48
1 |
Rimonabant increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
19030233
RNF123 affects USP48
1 |
USP48 binds RNF123. 1 / 1
1 |
biogrid
No evidence text available
28514442
RELA affects USP
| 1
BLNK binds USP48, REL, RELA, and USP. 1 / 1
| 1
sparser
"Further, we show by overexpression of truncated proteins that the catalytic USP domain of USP48 interacts with the N-terminal region of the Rel homology domain (RHD) of RelA."
30628021
Plant Extracts affects USP48
1 |
Plant Extracts increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
23557933
PXK affects USP48
1 |
USP48 binds PXK. 1 / 1
1 |
biogrid
No evidence text available
28514442
PSAP affects USP48
1 |
USP48 binds PSAP. 1 / 1
1 |
biogrid
No evidence text available
22863883
NUP188 affects USP48
1 |
NUP188 binds USP48. 1 / 1
1 |
biogrid
No evidence text available
26344197
NTRK1 affects USP48
1 |
USP48 binds NTRK1. 1 / 1
1 |
biogrid
No evidence text available
25921289
NR1D2 affects USP48
1 |
USP48 binds NR1D2. 1 / 1
1 |
biogrid
No evidence text available
28514442
NFkappaB affects USP48
| 1
NFkappaB activates USP48. 1 / 1
| 1
reach
"Consistent with diminished TNF induced nuclear accumulation and accelerated degradation of RelA in USP48 depleted cells, induction of NF-kappaB target gene expression was decreased and/or delayed, whe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25486460
NDUFAF7 affects USP48
1 |
USP48 binds NDUFAF7. 1 / 1
1 |
biogrid
No evidence text available
28514442
NCBP2 affects USP48
1 |
USP48 binds NCBP2. 1 / 1
1 |
biogrid
No evidence text available
26344197
NAMPT affects USP48
| 1
NAMPT acetylates USP48. 1 / 1
| 1
sparser
"To further investigate its activity in tumorigenesis, deacetylase sirtuin 1 (Sirt1) was shown to interact with USP31 by co-immunoprecipitation and blocking the function of Sirt1 by knockdown or the inhibitor nicotinamide could increase the acetylation of USP31."
34184746
Mrgprx1 affects USP48
| 1
USP48 binds Mrgprx1. 1 / 1
| 1
reach
"USP48 and MrgC interactions were studied by immunoprecipitation."
36864656
MIR124-1 affects USP48
1 |
MIR124-1 decreases the amount of USP48. 1 / 1
1 |
bel
"See Supplemental Table 2. All genes are downregulated by greater than or equal to 1.5."
15685193
Ketolides affects USP48
1 |
Ketolides decreases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
24967691
K48 affects SIRT6, and USP48
| 1
SIRT6 binds USP48 and K48. 1 / 1
| 1
reach
"USP48 physically bound and stabilized SIRT6 by K48 linked deubiquitination at the K33 and K128 sites of SIRT6, which impeded metabolic reprogramming to hamper HCC tumorigenesis."
33903120
K48 affects GSDME
| 1
USP48 binds GSDME and K48. 1 / 1
| 1
reach
"USP48 bound GSDME and removed K48-linked ubiquitination at positions K120 and K189."
36607699
JUN affects USP48
1 |
JUN decreases the amount of USP48. 1 / 1
1 |
biopax:msigdb
No evidence text available
IC 50 affects USP48
| 1
IC 50 inhibits USP48. 1 / 1
| 1
reach
"The IC 50 concentrations of the new compounds to inhibit USP48 were determined in a deubiquitinylase activity assay by measuring the fluorescence intensity using tetra-ubiquitin rhodamine110 as substrate."
37196427
H3C1 affects USP48
1 |
USP48 binds H3C1. 1 / 1
1 |
biogrid
No evidence text available
25281560
H2BC8 affects USP48
1 |
USP48 binds H2BC8. 1 / 1
1 |
biogrid
No evidence text available
25281560
H2BC11 affects USP48
1 |
USP48 binds H2BC11. 1 / 1
1 |
biogrid
No evidence text available
28514442
Glioma affects USP48
| 1
Glioma activates USP48. 1 / 1
| 1
reach
"Interestingly, USP48 is transcriptionally activated by Gli1 in glioma cells, thus forms a positive feedback loop to regulate Hh signaling [65]."
| PMC
GTF3A affects USP48
1 |
GTF3A decreases the amount of USP48. 1 / 1
1 |
biopax:msigdb
No evidence text available
GSDME affects USP48
| 1
USP48 binds GSDME and K48. 1 / 1
| 1
reach
"USP48 bound GSDME and removed K48-linked ubiquitination at positions K120 and K189."
36607699
GPX4 affects USP48
| 1
USP48 binds GPX4. 1 / 1
| 1
sparser
"Furthermore, GPX4 protein specifically binds the deubiquitinase USP31, but not other deubiquitinases such as CYLD, USP1, USP14, USP20, USP30, USP38, UCHL1, UCHL3, and UCHL5."
37011699
GPR88 affects HPCAL1, PSMD4, SWAP70, TBCD, TMEM201, and USP48
| 1
sparser
"However, no previous studies have reported on the association of TMEM201, C1orf43, ANKRD31, TBCD, SWAP70, AF131216.1, USP48, HPCAL1, GPR88 or VSTM2A and LACA."
31853300
EEF1B2P5 affects USP48
1 |
biogrid
No evidence text available
19615732
E4F1 affects USP48
1 |
E4F1 decreases the amount of USP48. 1 / 1
1 |
biopax:msigdb
No evidence text available
Dietary Fats affects USP48
1 |
Dietary Fats increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
19030233
DYNC1LI1 affects USP48
1 |
biogrid
No evidence text available
26344197
D-glucopyranose affects USP48
1 |
D-glucopyranose increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
22634610
CSNK2A1 affects USP48
1 |
USP48 binds CSNK2A1. 1 / 1
1 |
biogrid
No evidence text available
25486460
CRISPR-Cas9 affects USP48
| 1
CRISPR-Cas9 inhibits USP48. 1 / 1
| 1
reach
"Further confirming that the synthetic rescue was indeed dependent on USP48, when we subjected USP48 to short-hairpin RNA (shRNA) depletion or carried out USP48 gene inactivation by CRISPR-Cas9 editing by using a different single guide (sg) RNA targeting a different exon in DeltaFANCC cells, we observed similar results."
29891926
COPS5 affects USP48
| 1
USP48 binds COPS5. 1 / 1
| 1
sparser
"A recent study showed that USP48 associates with the COP9 signalosome complex and promotes the nuclear accumulation of NF-κB RelA through its DUB activity, trimming K48-linked ubiquitin chains xref ."
28233861
BRCA1 affects USP48
| 1
BRCA1 activates USP48. 1 / 1
| 1
reach
"These data are consistent with a requirement for Brca1 driving increased resection and subsequent Rad51 loading in the absence of Usp48."
29335415
BRAT1 affects USP48
1 |
USP48 binds BRAT1. 1 / 1
1 |
biogrid
No evidence text available
22863883
BLNK affects USP48
| 1
BLNK binds USP48, REL, RELA, and USP. 1 / 1
| 1
sparser
"Further, we show by overexpression of truncated proteins that the catalytic USP domain of USP48 interacts with the N-terminal region of the Rel homology domain (RHD) of RelA."
30628021
Antirheumatic Agents increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
24449571
ATF4 affects USP48
1 |
ATF4 decreases the amount of USP48. 1 / 1
1 |
biopax:msigdb
No evidence text available
ATF2 affects USP48
1 |
ATF2 decreases the amount of USP48. 1 / 1
1 |
biopax:msigdb
No evidence text available
ATF1 affects USP48
1 |
ATF1 decreases the amount of USP48. 1 / 1
1 |
biopax:msigdb
No evidence text available
ARL3 affects USP48
| 1
USP48 binds ARL3. 1 / 1
| 1
sparser
"The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3."
36293380
APP affects USP48
1 |
USP48 binds APP. 1 / 1
1 |
biogrid
No evidence text available
21832049
6-propyl-2-thiouracil decreases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
24780913
3,4-methylenedioxymethamphetamine decreases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
26251327
1,3-dinitrobenzene increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
24140754
2,3',4,4',5-pentachlorobiphenyl increases the amount of USP48. 1 / 1
1 |
ctd
No evidence text available
31388691
ctd
No evidence text available
19114083