IndraLab

Statements

SIRT6 binds USP48. 16 / 16
5 | 11
sparser
"These findings suggest that CAPZA1 acts as a scaffold to mediate the interaction between USP48 and SIRT6, thus decreasing the ubiquitination-mediated degradation of SIRT6."
41354870
sparser
"Conversely, overexpression of CAPZA1 promoted the interaction of SIRT6 with USP48 and reduced the ubiquitination of SIRT6, whereas knockdown of USP48 increased the ubiquitination of SIRT6 (Fig. xref )."
41354870
sparser
"Du et al. described that after being stabilized by methyltransferase-like 14 (Mettl14), USP48 binds and stabilizes SIRT6 by K48-linked deubiquitination of this SIRT (K33/K128)."
37127248
sparser
"USP48 physically bound and stabilized SIRT6 by K48-linked deubiquitination at the K33 and K128 sites of SIRT6, which impeded metabolic reprogramming to hamper HCC tumorigenesis."
33903120
sparser
"CAPZA1 promotes SIRT6 stabilization by mediating the interaction of USP48 with SIRT6."
41354870
sparser
"Knockdown of CAPZA1 largely reduced the interaction between USP48 and SIRT6 (Fig. xref )."
41354870
sparser
"This dysregulation consequently affects glycolysis through the USP48-SIRT6 axis and contributes to the deterioration of HCC ( xref )."
39229278
sparser
"METTL14 also regulates the glycolytic pathway and inhibits tumor proliferation through the USP48-SIRT6 pathway xref ."
38965238
biogrid
No evidence text available
36607699
sparser
"However, knockdown of CAPZA1 reduced SIRT6 binding to USP48 and thus increased SIRT6 ubiquitination (Fig. xref )."
41354870
biogrid
No evidence text available
24169447
sparser
"USP48 physically binds and stabilizes SIRT6 by K48-linked deubiquitination to impede glucose metabolic reprogramming and hamper HCC tumorigenesis."
35798087
biogrid
No evidence text available
33903120
biogrid
No evidence text available
33903120
sparser
"These findings indicate that specifically targeting hepatocyte USP48 or the USP48-SIRT6 axis may be a potential therapeutic strategy for future HCC treatment."
39229278
biogrid
No evidence text available
33903120