IndraLab

Statements

SIRT6 binds USP48. 6 / 11
5 | 6
sparser
"Du et al. described that after being stabilized by methyltransferase-like 14 (Mettl14), USP48 binds and stabilizes SIRT6 by K48-linked deubiquitination of this SIRT (K33/K128)."
37127248
sparser
"USP48 physically bound and stabilized SIRT6 by K48-linked deubiquitination at the K33 and K128 sites of SIRT6, which impeded metabolic reprogramming to hamper HCC tumorigenesis."
33903120
sparser
"This dysregulation consequently affects glycolysis through the USP48-SIRT6 axis and contributes to the deterioration of HCC ( xref )."
39229278
sparser
"METTL14 also regulates the glycolytic pathway and inhibits tumor proliferation through the USP48-SIRT6 pathway xref ."
38965238
sparser
"These findings indicate that specifically targeting hepatocyte USP48 or the USP48-SIRT6 axis may be a potential therapeutic strategy for future HCC treatment."
39229278
sparser
"USP48 physically binds and stabilizes SIRT6 by K48-linked deubiquitination to impede glucose metabolic reprogramming and hamper HCC tumorigenesis."
35798087