IndraLab

Statements

USP48 activates Hedgehog. 3 / 3
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"In addition to USP7 and OTUB2, the deubiquitinase USP48 was found to activate Hh signaling by stabilizing Gli1 protein in glioma cells [65]."
| PMC
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"However, the observation that USP8 and USP48 rather positively regulate HH signaling, whereas GNAS, MEN1, PRKAR1A, DICER1 and VHL rather negatively regulate this signaling pathway in PitNETs, does not allow a definitive conclusion, whether it is active or inactive HH signaling that is involved in formation of these tumors."
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"Conversely, the activation of HH signaling induced by the agonist purmorphamine results in an up-regulation of USP37 gene expression, subsequently leading to the stabilization of GLI1 and influencing EMT in breast CSCs.295 Furthermore, Zhou et al discovered that USP48, a deubiquitinase enzyme, activates the Hh signaling pathway by enhancing the stability of the Gli1 protein in glioma cells.296 Through its C-terminal DUSP structural domain, USP48 interacts with Gli1 and removes Ub molecules from it."
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