IndraLab

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USP48 activates USP48. 4 / 4
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"We hypothesize that the SUMOylation of USP48 may interact with a non-classically conserved SIM motif (V-V-Q-K) in the HMGA2 protein, or induce conformational changes in USP48 to better accommodate the HMGA2 protein44."
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"The findings suggest that SUMOylation of USP48 significantly enhances its ability to stabilize HMGA2 and promote CRC invasion and metastasis in a HMGA2-dependent manner.3.6 DUB-IN-2 hinders the deubiquitinating activity of USP48 and induces the degradation of HMGA2."
38572092
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"These results indicate that CK2 mediated phosphorylation of USP48 at its C-terminal CK2 consensus sites and its binding to K48 linked Ub-chains, both of which promote USP48 Ub-chain-trimming activity,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In response to TNF-alpha, serine phosphorylation of USP48 by GSK3beta increases USP48 activity."
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