IndraLab

Statements

USP48 inhibits BRCA1. 4 / 4
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"In cells we reveal that USP48 antagonizes BRCA1 E3 ligase function and in BRCA1-proficient cells loss of USP48 results in positioning 53BP1 further from the break site and in extended resection lengths."
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"USP48 loss enhances BRCA1 and RAD51 localization in FA cells."
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"Interestingly , in the absence of USP48 , single-stranded annealing is promoted , which is likely due to the increased resection that occurs if BRCA1 is not properly constrained by USP48 ."
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"Moreover, both the increased GC and SSA repair seen in USP48 depleted cells required BRCA1, as well as CtIP."
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