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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SLC9A3 inhibits USP48. 1 / 1

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"We found that stimulation with the D3R specific agonist PD128907 (1 muM, 30 min) promoted the interaction and colocalization among D3R, NHE3, and USP48; inhibited USP48 activity (-35+/-6%, vs. vehicle), resulting in increased ubiquitinylated NHE3 (+140 +/-10%); and decreased NHE3 expression (-50+/-9%) in human renal proximal tubule cells (hRPTCs)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...