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"We found that stimulation with the D3R specific agonist PD128907 (1 muM, 30 min) promoted the interaction and colocalization among D3R, NHE3, and USP48; inhibited USP48 activity (-35+/-6%, vs. vehicle), resulting in increased ubiquitinylated NHE3 (+140 +/-10%); and decreased NHE3 expression (-50+/-9%) in human renal proximal tubule cells (hRPTCs)."