IndraLab

Statements

USP48 activates pyroptosis. 10 / 10
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"USP48 promotes pyroptosis in cancer cells by removing K48-linked ubiquitination at positions K120 and K189 of the GSDME [21]."
38245760
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"It was found that deletion of USP48 significantly inhibited tumor cell pyroptosis."
40201182
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"USP48 stabilized GSDME to promote pyroptosis by removing K48-linked ubiquitination at K120 and K189 on GSDME (23)."
40201182
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"A CRISPR-Cas9 screen identified that loss of USP48, a deubiquitinating enzyme, significantly inhibited cell pyroptosis."
36607699
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"USP48 promoted pyroptosis by stabilizing gasdermin E (GSDME)."
36607699
eidos
"USP48 promoted pyroptosis by stabilizing gasdermin E ( GSDME ) ."
36607699
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"USP48 is implicated in activation of NF-κB (Mirra et al. 2022; Schweitzer and Naumann 2015; Ghanem et al. 2019), induces pyroptosis by stabilization of Gasdermin E (Ren et al. 2023) and promotes cell survival in Helicobacter pylori infection (Jantaree et al. 2022)."
39985644
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"A CRISPR-Cas9 screen approach for identifying regulators of pyroptosis in cancer revealed that loss of USP48, a deubiquitinating enzyme, remarkably suppressed cell pyroptosis."
39075259
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"USP48 enhanced pyroptosis through stabilizing GSDME."
39075259
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"What’s more, understanding how to regulate GSDME expression has become a current research hotspot, including one research about USP48 promoting cell pyroptosis by stabilizing GSDME [20]."
38853246