IndraLab

Statements

USP48 inhibits SLX4. 1 / 1

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reach

"Our data demonstrate that loss of USP48 does not restore FANCI and FANCD2 monoubiquitylation or FANCD2 recruitment at ICLs, but if USP48 targets one or more sites on H2A that can be recognized by these nucleases, then loss of USP48 might bypass the requirement of the FA proteins and allow the recruitment of FAN1 or SLX4 and subsequent unhooking of the ICL in an FA deficient background."

29891926

INDRA sources:

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IndraLab

Statements

USP48 inhibits SLX4. 1 / 1

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