IndraLab

Statements



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"The present study reveals that USP48 knockdown could significantly inhibit cell migration and invasion in ES2, 3AO and A2780 cells, without affecting cell proliferation."

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"Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis."

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"The results showed that USP48 overexpression significantly enhanced the migration and invasion abilities of CRC cells, while blocking HMGA2 expression reversed the phenotype caused by USP48 overexpression (Fig. 4H‒J and Fig. S4H‒J)."