IndraLab

Statements

USP48 activates GLI1. 3 / 3
| 3
reach
"Gli1 induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1."
28623188
reach
"Conversely, the activation of HH signaling induced by the agonist purmorphamine results in an up-regulation of USP37 gene expression, subsequently leading to the stabilization of GLI1 and influencing EMT in breast CSCs.295 Furthermore, Zhou et al discovered that USP48, a deubiquitinase enzyme, activates the Hh signaling pathway by enhancing the stability of the Gli1 protein in glioma cells.296 Through its C-terminal DUSP structural domain, USP48 interacts with Gli1 and removes Ub molecules from it."
40034124
reach
"In addition to USP7 and OTUB2, the deubiquitinase USP48 was found to activate Hh signaling by stabilizing Gli1 protein in glioma cells [65]."
| PMC