IndraLab

Statements

USP48 activates POMC. 5 / 5
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"Different from BRAF V600E, USP48 mutation-mediated transcriptional activation of POMC appears not be linked to the activation of Erk1/2 or its downstream signaling cascade."
30093687
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"Herein we show that Gli1 is pivotal for USP48 action on CRH-induced ACTH synthesis and suggest that the USP48 mutants decrease Gli1 ubiquitination that in turn stabilizes and amplifies the stimulatory action of CRH on ACTH synthesis.It is notable that both deubiquitinases mutated in corticotroph tumors, USP8 and USP48, have among their targets members of the SHH pathway: Smoothened and Gli1, respectively."
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"In contrast, we provide the evidence to demonstrate that the NF-κB pathway is involved in USP48 -mediated transcriptional activation of POMC ."
30093687
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"Mutations in the deubiquitinating enzymes USP8 and USP48 have been shown to promote the development of ACTH PitNETs, suggesting that these enzymes play a crucial role in the pathogenesis of the disease [10, 11]."
39910602
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"In contrast, we provide the evidence to demonstrate that the NF-κB pathway is involved in USP48-mediated transcriptional activation of POMC."
30093687